Macroprolactinomas in male patients: efficiency of treatment with a new dopaminergic drug (CU 32-085-Sandoz), tumour calcification and relative significance of preoperative tumour volume regression as estimated by CT-scan

Author(s):  
J. Mockel ◽  
J. D'Haens ◽  
D. Désir ◽  
J. P. Denayer ◽  
R. Dayeh ◽  
...  
1993 ◽  
Vol 163 (5) ◽  
pp. 604-612 ◽  
Author(s):  
Pia Rubin ◽  
Agnete Karle ◽  
Ralf Hemmingsen ◽  
Ulla Noring ◽  
Susanne Møller-Madsen ◽  
...  

Patients with newly diagnosed schizophrenia (n = 27) or schizophreniform disorder (n = 22) and 24 healthy volunteers were investigated by CT scan, the investigators being blind to subject status. The patients had never received medication or had been treated only briefly with neuroleptics. The patients had significantly smaller brain volume and brain length than the controls. The patients had greater sulcal enlargement in the case of both Sylvian and interhemispheric fissures and surface sulci in the frontal and parietal regions. The sulcal enlargement was more pronounced in male patients and on the left hemisphere. The study revealed no enlargement of the lateral ventricles and only a trend towards enlargement of the third ventricle in the patients. The findings were not explained by substance abuse or level of education.


2015 ◽  
Vol 14 (2) ◽  
pp. 143-151 ◽  
Author(s):  
Saravanan Kandasamy ◽  
K. S. Reddy ◽  
Vivekanandan Nagarajan ◽  
Parthasarathy Vedasoundaram ◽  
Gunaseelan Karunanidhi

AbstractAimTo evaluate the inter-fraction variation in interstitial high-dose-rate (HDR) brachytherapy. To assess the positional displacement of catheters during the fractions and the resultant impact on dosimetry.BackgroundAlthough brachytherapy continues to be a key cornerstone of cancer care, it is clear that treatment innovations are needed to build on this success and ensure that brachytherapy continues to provide quality care for patients. The dosimetric advantages offered by HDR brachytherapy to the tumour volume rely on catheter positions being accurately reproduced for all fractions of treatment.Materials and methodsA total of 66 patients treated over a period of 22 months were considered for this study. All the patients underwent computer tomography (CT) scan and three-dimensional treatment planning was carried out. Brachytherapy treatment was delivered by the HDR afterloading system. On completing the last fraction, CT scan was repeated and treatment re-planning was done. The variation in position of the implanted applicators and their impact on dosimetric parameters were analysed using both the plans.ResultsFor all breast-implant patients, the catheter displacement and D90dose to clinical target volume were <3 mm and 3%, respectively. The displacement for carcinoma of the tongue, carcinoma of the buccal mucosa, carcinoma of the floor of mouth, carcinoma of the cervix, soft-tissue sarcoma and carcinoma of the lip were comparatively high.ConclusionInter-fraction errors occur frequently in interstitial HDR brachytherapy. If no action is taken, it will result in a significant risk of geometrical miss and overdose to the organs at risk. It is not recommended to use a single plan to deliver all the fractions. Imaging is recommended before each fraction and decision on re-planning must be taken.


2016 ◽  
Vol 9 (2) ◽  
pp. 62-64
Author(s):  
Rohit Sharma ◽  
Ashish Mehrotra ◽  
Vinit K Sharma ◽  
Zafar Iqbal ◽  
Kunal Nigam

ABSTRACT Erosion of bone with or without extension of disease into adjacent anatomic spaces is observed among some patients with fungal rhinosinusitis (FRS). Preoperative computed tomographies is very important to determine the sites of bony erosion. Patients with bony erosions are classified based on the involved subsite and the extent of erosion. Bony erosions was seen in 37.5% cases. Six patients were having bone erosions on CT scan. 40 % erosions were present in patients belonging to younger age group. Erosion of sinus boundaries were more common in male patients (60%). The ethmoid sinus complex was most commonly involved (46.6%). This was followed in frequency of involvement by the maxillary sinus (26.6%), the sphenoid sinus (20%) and the frontal sinus (6.6%). The most common site of erosion was the lamina papyracea (33.3%), followed by the medial maxillary wall (20%). Bony erosions due to FRS were mainly due to long-term mechanical compression by the fungal mass. A case of chronic rhinosinusitis with bony erosions in CT scan may indicate a fungal etiology. How to cite this article Sharma VK, Sharma R, Mehrotra A, Iqbal Z, Nigam K. A Retrospective Study of Bony Erosion Patterns in Cases of Fungal Rhinosinusitis. Clin Rhinol An Int J 2016;9(2):62-64.


2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Masood Ur Rauf ◽  
Hamid Hassan Shah ◽  
Kamran Manzoor ◽  
Masood ur Rauf

This descriptive study was carried out including 10 patients with periampullary carcinoma in Nishtar Hospital, Multan. The objectives were to study different clinical presentations of periampullary carcinoma and various means of investigations to diagnose it. All patients having suspicion of periampullary carcinoma were studied. Original study included ten patients having remaining four patients were female. All male patients were smoker. Eight patients were amongst lower class, one patient was from middle class and remaining one patient was from upper class. Common clinical features were progressive painless jaundice, anorexia, weight loss, pruritis, abdominal pain, vomiting and malena. All patients were evaluated on history, clinical examination and laboratory investigations. All patients found to be anemic. LFT`s were raised in all patients. ERCP was successful in 90% of cases in diagnosing the pathology and biopsy was possible in 40% of cases. Ultrasonography was quite good in differentiating the type of jaundice. It detected the tumour site in only 20% of cases. Ultrasonography was not able to detect the metastasis effectively. CT scan was quite helpful to detect metastasis. Ultrasonography and ERCP were quite good in diagnosing the biliary obstruction. CT% scan was helpful in staging purpose. We do not have the facilities of endoscopic ultrasonography, MRI, MRCP, PTHC, helical tomography and laparoscopy.


2016 ◽  
Vol 34 (2_suppl) ◽  
pp. 403-403 ◽  
Author(s):  
Rachel Anne Pearson ◽  
Pete E Thelwall ◽  
Jim Snell ◽  
Jill McKenna ◽  
Piotr Pieniazek ◽  
...  

403 Background: Functional imaging techniques which evaluate early treatment responses may identify non-responders who would benefit from a switch in therapy. This is a prospective feasibility study of serial diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) MRI scanning in patients undergoing neoadjuvant chemotherapy for muscle-invasive bladder cancer. Methods: Scans were performed before and during chemotherapy (10-17 days after the first and second cycles). A repeatability DW-MRI scan was acquired on the first visit. Regions-of-interest (ROI) encompassing the entire tumour were defined. Analysis of MRI parameters was undertaken and related to findings from the routine restaging CT scan performed after 3 cycles of chemotherapy. Results: 10/16 patients were male, median age 59 years, 14/16 had T3/4 disease, and 5/16 were node positive. 10/16 have completed 3 or 4 cycles of chemotherapy to date and attended for the restaging CT scan. Radiological response was identified in all cases. In the DW-MRI analysis there was no significant difference in mean tumour ADC or tumour volume between baseline and repeatability scans (mean ADC 1.19 and 1.2 respectively, n=16). Visual assessment showed a fall in contrast agent uptake within the primary bladder tumour after treatment. Conclusions: The scanning protocols enabled visualisation of the bladder tumours and derivation of kinetic parameters. DW-MRI measurements were comparable between baseline and repeat scan, suggesting that a change in ADC was more likely to be attributable to treatment response or disease progression than measurement error or inherent variation. Statistically significant rises in mean ADC and decreases in tumour volume were observed early in the treatment pathway. No patients progressed on treatment in this study. Larger studies of DCE and DW-MRI as surrogate response imaging biomarkers in bladder cancer are recommended. Clinical trial information: Study ID 14489. [Table: see text]


e-CliniC ◽  
2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Aaron K. U. Lonto ◽  
Elvie Loho ◽  
Yovana P. M. Mamesah ◽  
Joan F. J. Timban

Abstract: Subdural hemorrhage (SDH) is the most common form of intracranial lesions, approximately one-third of the incidence of severe head injury. However, it has been reported that about one-fifth of patients suffering subdural hemorrhage and other intracranial hemorrhage died undiagnosed.3 Examination computed tomography (CT) scan is the primary modality of choice when there is a suspected post-traumatic lesions. The purpose of research to know and study the SDH CT scan image. This study was a retrospective study conducted in the month of September to December 2014. The data were obtained through medical records and found 30 cases included in the study criteria. Overall the results, SDH more in male patients 27 people (90%). The largest age group in children (<12 years) 11 people (37%). Location SDH highest in the temporal 9 cases (30%).Keywords: subdural hemorhage, computed tomography scanAbstrak: Perdarahan subdural (PSD) adalah bentuk yang paling sering terjadi pada lesi intrakranial, kira-kira sepertiga dari kejadian cedera kepala berat. Namun, telah dilaporkan bahwa sekitar satu perlima dari penderita-penderita perdarahan subdural dan perdarahan intrakranial lainnya meninggal tidak terdiagnosis.3 Pemeriksaan computed tomography (CT) scan adalah modalitas pilihan utama bila diduga terdapat suatu lesi pasca trauma. Tujuan penelitian untuk mengetahui dan mempelajari gambaran CT scan PSD. Penelitian ini merupakan studi retrospektif yang dilakukan pada bulan September-Desember 2014. Data diperoleh melalui rekam medik dan didapatkan 30 kasus masuk dalam kriteria penelitian. Keseluruhan hasil penelitian didapatkan PSD lebih banyak pada penderita laki-laki 27 orang (90%). Golongan umur terbanyak pada anak-anak (<12 tahun) 11 orang (37%). Lokasi PSD terbanyak pada temporal 9 kasus (30%).Kata kunci: perdarahan subdural, computed tomography scan


1999 ◽  
Vol 1999 ◽  
pp. 102-102 ◽  
Author(s):  
M.J. Young ◽  
N.P.W. Jay ◽  
N.B. Jopson

Computer tomography (CT) has the potential to measure body composition and form in live farm animals accurately and objectively in ways not possible with longer established assessment methods. Preliminary reports (Young, Logan, Nsoso and Beatson, 1996) verified that this is so but concluded that registration errors and subjective interpretation of tissue boundaries during image analysis affect accuracy. However, their study did not allow an assessment of the relative significance of these effects. The trial reported here was designed to quantify such effects by determining the repeatability of CT scan measurements.


2021 ◽  
Vol 108 (Supplement_7) ◽  
Author(s):  
Laura Ballance ◽  
Chloe Withers ◽  
Dheepa Nair ◽  
Simon Galloway

Abstract Background Right iliac fossa pain is a common presenting complaint in males. Ultrasound is a cheap non-invasive investigation, yet results can be non-diagnostic. CT is becoming more accessible and available for patient assessment. Aim Our primary aim is to estimate how many unnecessary US scans are gained prior to CT imaging, thereby delaying surgery, increasing cost and increasing length of stay (LOS). Method We conducted a retrospective analysis of all male patients over the age of 16 admitted to a single unit with RIF pain over 12 months. Outcome and length of stay was recorded. Results 162 male patients were admitted to a single University teaching hospital between 2017 and 2018. 33% (n = 53) of patients having an US scan require further imaging, 40% ( n = 21 ) of these had a surgical pathology, 80% (n = 17) of these requiring appendicectomy. Patients (n = 39) who had an initial CT scan subsequently requiring surgery length of LOS 3.6 days compared with US imaging with additional imaging requiring surgery ( n = 17) LOS 5.8 days. Conclusion Evaluation of practice of males over the age of 16 shows that US is frequently non diagnostic, requiring further investigation with CT or MRI. Imaging initially with CT scan aid diagnosis and decrease length of stay. An education steering committee of surgical trainees, consultants and radiographers has been created to adapt practice in our centre through continued education and training.


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