scholarly journals Evaluation the Effects of Led Photo-Activated Disinfection on Periodontal Clinical Parameters in Patients with Chronic Periodontitis

2016 ◽  
Vol 20 (1) ◽  
pp. 29-32
Author(s):  
Alexandra Martu Maria ◽  
Irina-Georgeta Ursarescu ◽  
Sorina Solomon ◽  
Liliana Foia
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Conventional Therapy ◽  
Control Group ◽  
Study Group ◽  
Clinical Parameters ◽  
Systemic Diseases ◽  
And Control ◽  
Tolonium Chloride ◽  
Post Therapy

SummaryThe purpose of the study was to assess the effects of LED-PAD and tolonium chloride on periodontal clinical parameters in chronic periodontitis. Materials and Methods: The study was conducted on patients with chronic periodontitis, divided in 2 groups (study group and control group of patients who, besides the conventional therapy measures, also received PAD therapy). The periodontal clinical parameters were registered at baseline and after 3 months. Results and Discussions: The post-therapy evaluation revealed significantly improved results of periodontal clinical parameters in the study group, when compared to the control group. Our results support the literature studies conducted on chronic periodontitis patients but without any systemic diseases. Conclusion: The PAD disinfection determined a significant improvement for the periodontal clinical parameters in patients with periodontal disease.

scholarly journals Effect of Alox-15 Polymorphism on GCF Levels of Lipoxin-A4 in Chronic Periodontitis: A Preliminary Study

2017 ◽  
Vol 28 (2) ◽  
pp. 140-147 ◽  
Author(s):  
Fouzia Tarannum ◽  
Mohamed Faizuddin
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Control Group ◽  
Study Group ◽  
Lipoxin A4 ◽  
Disease Pathogenesis ◽  
Clinical Attachment Loss ◽  
Probing Depth ◽  
Crevicular Fluid

Lipoxins play an important role in periodontal resolution, hence, investigation of genetic polymorphism of lipoxin gene may provide important information on the role of lipoxins in periodontal disease pathogenesis. The aim of this study was to investigate a polymorphism of C-to-T substitution at position c.-292 in ALOX15 (reticulocyte-type 15 lipoxygenase 1) gene in patients with chronic periodontitis and to associate the polymorphism with gingival crevicular fluid (GCF) lipoxin A4 (LXA4) levels. Forty-five chronic periodontitis and 45 periodontally healthy patients were included in this case-control study. Plaque index, calculus index, sulcus bleeding index, full mouth probing depth (PD) and clinical attachment loss (CAL) were recorded. GCF and blood samples were collected. GCF was analyzed for LXA4 levels by enzyme linked immunosorbant assay. Genotyping of ALOX15 polymorphism was studied using PCR. Mean LXA4 was lower in periodontitis group compared to the periodontally healthy group. There was a negative correlation between CAL and LXA4. The CC genotype was higher in the study group than in the control group. In the study group, mean CAL was significantly lower among individuals with the CT genotype. Mean LXA4 was significantly lower in CC genotype (45.0±7.11 ng/mL) compared to CT genotype (50.81±5.81 ng/mL) among the patients with periodontitis. The results suggest that LXA4 and c.-292T allele are associated with periodontal health. Polymorphisms in the ALOX15 gene may influence periodontal disease pathogenesis. Hence, investigation of such polymorphisms could benefit the evaluation of lipoxins role in periodontal disease.

Assessment of Dental Calculus, Plaque and GingivalInflammation in Patients with Urinary Stone

2019 ◽  
Vol 31 (1) ◽  
pp. 14-18
Author(s):  
Maher B Mohammed ◽  
Maha Sh. Mahmood
Keyword(s):  
Healthy Subjects ◽  
Urinary Stone ◽  
Control Group ◽  
Study Group ◽  
Clinical Parameters ◽  
Dental Calculus ◽  
Gingival Inflammation ◽  
Gingival Health ◽  
And Control ◽  
Healthy Participants

Background: Dental calculus is mineralized dental plaque formed on teeth and dental prosthesis surfaces in the oral cavity. Urinary stone is a crystal aggregation formed in urinary system due to minerals saturation present in urine. The structure of dental calculus is similar to that of urinary stone. Objective: To assess oral hygiene and gingival status in patients with urinary stone. And compared with healthy subjects. Patients and Methods: Sixty participants, 25-40 years, were involved in this study who were divided into study and control group. The study group involved patients with urinary stone while the control group involved healthy subjects. Clinical parameters including plaque, calculus and gingival indices were recorded for all participants. The correlation between the recorded clinical parameters was estimated. Results: The study group mean (±SD) plaque (1.435±0.499), gingival (0.995±0.288) and calculus (1.28 ±0.66) indices were found to be significantly high compared with control group(0.868±0.265), (0.602±0.265) (0.501±0.457 ) respectively. The formed calculus was positively associated with accumulated plaque (r: 0.608, p < 0.05) and gingival inflammation(r: 0.612, p < 0.05). Conclusion: Urinary stone patients were associated with more plaque and calculus accumulation, and had worse gingival inflammation compared to healthy participants. Thus, they need to be more aware of their gingival health status and improved preventive care of oral health.

scholarly journals Comparative Evaluation of Salivary Interleukin-8 Levels in Diabetics, Hypertensives and Smokers with Chronic Periodontitis

2014 ◽  
Vol 02 (03) ◽  
pp. 145-149
Author(s):  
Sanjeev Jain ◽  
Harjit Kaur ◽  
Nisha Aggarwal ◽  
Milli Gupta ◽  
Divya Saxena ◽  
...  
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Systemic Diseases ◽  
Host Parasite Relationship ◽  
Parasite Relationship ◽  
Systemic Factors ◽  
Unstimulated Saliva ◽  
Host Parasite

Abstract Background: Cytokines are pivotal to the pathogenesis of periodontal disease and may be used as markers in diagnosis. Systemic diseases and smoking are considered risk factors that have been associated with periodontal disease progression. Cytokine production may also be influenced by smoking and systemic diseases leading to an imbalance that disturbs the host–parasite relationship. Aim: The aim of the present study was to determine and compare the levels of salivary IL-8 in diabetics, smokers and hypertensive patients with chronic periodontitis. Materials and method: A total of 80 patients with chronic periodontitis were included in the study. They were divided into four groups: 20 controls, 20 diabetics, 20 hypertensives and 20 smokers. Unstimulated saliva samples were collected at first visit and IL-8 levels were measured by enzyme linked immunosorbent assay (ELISA). Results: It was found that as compared to control group, diabetic group presented with higher levels of IL-8 whereas hypertensive and smoker groups presented with lower levels of IL-8. After statistical analysis it was found that this alteration was significant in smokers group only. Conclusion It can be concluded from the study that the levels of inflammatory biomarkers in chronic periodontitis patients are altered with systemic factors.

scholarly journals Dual Effects of Cellular Immunotherapy in Inhibition of Virus Replication and Prolongation of Survival in HCV-Positive Hepatocellular Carcinoma Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Lei Qian ◽  
Nanya Wang ◽  
Huimin Tian ◽  
Haofan Jin ◽  
Hengjun Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Viral Load ◽  
Conventional Therapy ◽  
Mononuclear Cells ◽  
Progression Free Survival ◽  
Cellular Immunotherapy ◽  
Control Group ◽  
Study Group ◽  
Before And After ◽  
And Control

Immune cells play an important role in the development and progression of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC). We conducted a retrospective study to evaluate the influence of adoptive cellular immunotherapy (CIT) on viral load and progression-free survival (PFS) for HCC patients infected with HCV. Patients (n=104) were divided into a control group (conventional therapy,n=73) and study group (combination of CIT and conventional therapy,n=31). Autologous mononuclear cells were induced into natural killer,γδT, and cytokine-induced killer cells and infused intravenously to study group patients. More patients had shown viral load decrease or were stable in study group (100% versus 75%) (p=0.014). The median PFS of the study group and control group was 16 and 10 months, respectively (p=0.0041), and only CIT was an independent prognostic factor for PFS (hazard ratio, 0.422;p=0.005). Three patients developed transient moderate fever after infusion, and there were no significant differences in alanine aminotransferase and aspartate aminotransferase levels before and after treatment in both groups. Our results show that CIT contributes to improvement of prognosis and inhibition of viral replication in HCV-related HCC patients, without impairment of liver function.

scholarly journals The effect of injectable platelet-rich fibrin use in the initial treatment of chronic periodontitis

2020 ◽  
Vol 148 (5-6) ◽  
pp. 280-285
Author(s):  
Mila Vuckovic ◽  
Nadja Nikolic ◽  
Jelena Milasin ◽  
Vladan Djordjevic ◽  
Iva Milinkovic ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Periodontal Therapy ◽  
Treatment Modalities ◽  
Control Group ◽  
Study Group ◽  
Clinical Parameters ◽  
Pocket Depth ◽  
Platelet Rich Fibrin ◽  
Number Of Patients ◽  
Significant Difference

Introduction/Objective. The objective of the study was to investigate whether there are differences in therapeutic effect between initial treatments of chronic periodontitis [scaling and root planning (SRP)] alone and SRP in conjunction with injectable platelet-rich fibrin (I-PRF) application, comparing clinical parameters after three months. Methods. Twenty-four patients with chronic periodontitis who had at least two sites with probing pocket depth (PPD) ? 5 mm on contralateral side participated in the study. Using a split-mouth design, the patients were treated with SRP + I-PRF (study group) or SRP only (control group). The clinical parameters, clinical attachment level (CAL), gingival margin level (GML), PPD, bleeding on probing, and plaque index, were recorded on both sides. Results. Compared to baseline, both treatment modalities demonstrated an improvement in investigated clinical parameters. The mean value of CAL was reduced from 1.97 ? 0.75 (0.25?3.31) to 1.07 ? 0.44 (0.12?1.78) in the study group, whereas it decreased from 1.81 ? 0.66 (0.42?2.96) to 1.48 ? 0.55 (0.22?2.30) in the control group. Similarly, the corresponding values for GML and PPD showed statistically significant difference between the groups (p = 0.040 and p = 0.006, respectively). Conclusion. Regardless the limited number of patients in the study, initial periodontal therapy in conjunction with injectable platelet-rich fibrin proved to display significant improvement in all clinical parameters compared to initial periodontal therapy alone.

Optimization of the terms of supportive periodontal therapy using photoactivated disinfection

2019 ◽  
Vol 24 (2) ◽  
pp. 121-126 ◽  
Author(s):  
V. G. Atrushkevich ◽  
L. Yu. Orekhova ◽  
O. O. Yanushevich ◽  
E. Yu. Sokolova ◽  
E. S. Loboda
Keyword(s):  
Chronic Periodontitis ◽  
Adjunctive Treatment ◽  
Control Group ◽  
Clinical Parameters ◽  
Ozone Therapy ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Supportive Periodontal Therapy ◽  
Tannerella Forsythensis ◽  
Observation Period

Relevance: to indentify if periodontal treatment which is presented by photoactivated disinfection (PAD) adjunctively to scaling and root planing (SRP) yield better outcomes than ozone therapy as an adjunct to SRP in periodontitis.Materials and methods: we examined 57 (mean age 49,3 ± 1,02) patients with chronic periodontitis, divided into groups, SRP + PAD, SRP + ozone therapy and SRP alone. Subgingival plaque samples were subjected to DNA extraction and real time PCR amplifcation for detection Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Tannerella forsythensis (Tf), Treponema denticola (Td), Aggregatibacter actinomycetemcomitans (Aa). The amount of periodontopathogens and clinical parameters including plaque index, clinical attachment loss, pocket depth, bleeding on probing were measured at baseline, after 40, 90 and 180 days.Results: the results in groups of PAD+SRP and ozone therapy+SRP showed an improvement in all clinical parameters PI, BOP, PD, CAL and the quantity of Pg, Td and Tf compared to the control group during an observation period.Conclusion: the results showed additional benefts from PAD and ozone therapy as an adjunctive treatment to SRP for patients of chronic periodontitis.

Impression cytology and meibomian glands in conjunctivochalasis

2021 ◽  
pp. 112067212110087
Author(s):  
Ersin Muhafiz ◽  
Erdinç Bozkurt ◽  
Remzi Erten
Keyword(s):  
Dropout Rate ◽  
Meibomian Gland ◽  
Control Group ◽  
Study Group ◽  
Impression Cytology ◽  
Schirmer Test ◽  
Significant Difference ◽  
Meibomian Glands ◽  
And Control ◽  
Margin Cytology

Purpose: To evaluate the tear parameters, meibomian glands and lid margin and tarsal conjunctival impression cytology in patients with conjunctivochalasis (CCH). Methods: The study included 57 patients diagnosed with CCH and 35 healthy volunteers. Tear break-up time (TBUT) was measured and Schirmer test was performed. Meibomian gland morphologies, dropout rates, and meiboscores were evaluated using meibography. Finally, impression cytology samples were taken by pressing the impression filters on the lower lid margin and lower tarsal conjunctiva. The samples were evaluated according to the Nelson grading system. Results: Schirmer test was longer and TBUT was shorter in the study group ( p = 0.035 and p < 0.001, respectively). The median of meibomian gland dropout rate was 33.45% (Interquartile range [IQR]; 23.17%–49.75%) and 18.80% (IQR; 12.35%–26.50%) in the study and control groups, respectively ( p < 0.001). There was no significant difference in terms of lid-margin cytology between the two groups ( p = 0.481). In tarsal conjunctiva cytology, the median value of Nelson grade of the study group was 2 (IQR; 1–2) and that of the control group was 1 (IQR; 1–2) ( p = 0.040). When Nelson grade-2 and above was accepted as the pathological limit, it was found that 27.5% of the study group and 15.2% of the control group showed pathological findings ( p = 0.204). Conclusions: In patients with CCH, damage occurs in the tarsal conjunctiva with the effects of redundant conjunctival folds. In these patients, atrophy occurs in the meibomian glands and tear stability is impaired. Therefore, CCH should not be overlooked in clinical practice.

scholarly journals Sonographic Signs of Adenomyosis in Women with Endometriosis Are Associated with Infertility

2021 ◽  
Vol 10 (11) ◽  
pp. 2355
Author(s):  
Dean Decter ◽  
Nissim Arbib ◽  
Hila Markovitz ◽  
Daniel S. Seidman ◽  
Vered H. Eisenberg
Keyword(s):  
Laparoscopic Surgery ◽  
Retrospective Study ◽  
Statistical Analysis ◽  
Conservative Management ◽  
Transvaginal Ultrasound ◽  
Control Group ◽  
Study Group ◽  
Control Groups ◽  
Increased Risk ◽  
And Control

We compared the prevalence of ultrasound signs of adenomyosis in women with endometriosis who underwent surgery to those who were managed conservatively. This was a retrospective study of women evaluated at a tertiary endometriosis referral center who underwent 2D/3D transvaginal ultrasound. Adenomyosis diagnosis was based on the presence of at least three sonographic signs. The study group subsequently underwent laparoscopic surgery while the control group continued conservative management. Statistical analysis compared the two groups for demographics, symptoms, clinical data, and sonographic findings. The study and control groups included 244 and 158 women, respectively. The presence of any, 3+, or 5+ sonographic signs of adenomyosis was significantly more prevalent in the study group (OR = 1.93–2.7, p < 0.004, 95% CI; 1.24–4.09). After controlling for age, for all findings but linear striations, the OR for having a specific feature was higher in the study group. Women in the study group with ≥ 5 sonographic signs of adenomyosis had more than twice the risk of experiencing infertility (OR = 2.31, p = 0.012, 95% CI; 1.20–4.45). Sonographic signs of adenomyosis are more prevalent in women with symptomatic endometriosis who underwent surgery compared with those who continued conservative management. Women with 5+ findings have a significantly increased risk of infertility. Adenomyosis on ultrasound should be considered in the management decisions regarding these patients.

scholarly journals Implant Treatment with 12-Year Follow-Up in a Patient with Severe Chronic Periodontitis: A Case Report and Literature Review

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Keisuke Seki ◽  
Yoshiyuki Hagiwara
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Case Reports ◽  
English Literature ◽  
Supportive Therapy ◽  
Periodontal Treatment ◽  
Periodontal Tissues ◽  
Severe Periodontitis ◽  
And Control ◽  
Implant Treatment

Tooth loss among adults is associated with progressive periodontitis. Implant prosthetic treatment has long been utilized in periodontal patients. Even when the implants are applied, ongoing management of periodontal disease and control of inflammation is necessary to maintain a healthy oral cavity. Lack of appropriate periodontal treatment can result in recurrence of periodontal disease during a maintenance period; loss of the supportive capacity of the periodontal tissues will increase the susceptibility of residual teeth to traumatic force. For this reason, it is worthwhile to improve oral function by applying implants as a fixed device. Here, we report that implant treatment in a patient with generalized severe chronic periodontitis helped maintain the periodontal and peri-implant tissue for a long term. We propose that initial periodontal treatment and ongoing supportive therapy can help maintain implants in patients with severe periodontitis. In addition, we reviewed case reports in the English literature so far.

Effect of Aerosol Inhalation of Budesonide Suspension on Clinical Efficacy, Remission Time of Asthma and Disappearance Time of Rales in Children with Mycoplasma Pneumoniae Pneumonia

2021 ◽  
Vol 7 (5) ◽  
pp. 3057-3062
Author(s):  
TingTing Zheng ◽  
XiNi Liu ◽  
Xuechun Chen
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Clinical Efficacy ◽  
Oral Treatment ◽  
Control Group ◽  
Study Group ◽  
Aerosol Inhalation ◽  
Significant Difference ◽  
Disappearance Time ◽  
And Control ◽  
Mycoplasma Pneumoniae Pneumonia

To investigate the effect of aerosol inhalation of budesonide suspension on clinical efficacy, remission time of asthma and disappearance time of rales in children with mycoplasma pneumoniae pneumonia. Methods: 100 cases of mycoplasma pneumoniae pneumonia in our hospital from February 2019 to February 2021 were randomly divided into study group (n = 50) and control group (n = 50). The control group was given azithromycin intravenous drip followed by oral treatment, and the study group was given aerosol inhalation of budesonide suspension on the basis of the control group. Results: Compared with the control group, disappearance time of rales in the study group, remission time of cough, remission time of asthma and time of hospitalization in the study group were relatively short (P<0.05), and the efficacy in the study group was relatively high (P<0.05). There was no significant difference in the incidence of nausea, vomiting, abdominal pain, diarrhea and hoarseness between the two groups (P>0.05). The improvement of FVCS FEV1 and PEF and other indexes was relatively high in the study group by comparing with the control group (P<0.05). Conclusion: Aerosol inhalation of budesonide suspension in children with mycoplasma pneumoniae pneumonia can effectively enhance the therapeutic effect, promote the improvement of lung function, and reduce the disappearance time of rales and remission time of asthma, so it can be popularized.

Sign in / Sign up

Export Citation Format

Share Document