scholarly journals Dual Effects of Cellular Immunotherapy in Inhibition of Virus Replication and Prolongation of Survival in HCV-Positive Hepatocellular Carcinoma Patients

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Lei Qian ◽  
Nanya Wang ◽  
Huimin Tian ◽  
Haofan Jin ◽  
Hengjun Zhao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Viral Load ◽  
Conventional Therapy ◽  
Mononuclear Cells ◽  
Progression Free Survival ◽  
Cellular Immunotherapy ◽  
Control Group ◽  
Study Group ◽  
Before And After ◽  
And Control

Immune cells play an important role in the development and progression of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC). We conducted a retrospective study to evaluate the influence of adoptive cellular immunotherapy (CIT) on viral load and progression-free survival (PFS) for HCC patients infected with HCV. Patients (n=104) were divided into a control group (conventional therapy,n=73) and study group (combination of CIT and conventional therapy,n=31). Autologous mononuclear cells were induced into natural killer,γδT, and cytokine-induced killer cells and infused intravenously to study group patients. More patients had shown viral load decrease or were stable in study group (100% versus 75%) (p=0.014). The median PFS of the study group and control group was 16 and 10 months, respectively (p=0.0041), and only CIT was an independent prognostic factor for PFS (hazard ratio, 0.422;p=0.005). Three patients developed transient moderate fever after infusion, and there were no significant differences in alanine aminotransferase and aspartate aminotransferase levels before and after treatment in both groups. Our results show that CIT contributes to improvement of prognosis and inhibition of viral replication in HCV-related HCC patients, without impairment of liver function.

scholarly journals The Effect of Pilates Training on the Balance of Elderly

2019 ◽  
Vol 1 (16) ◽  
Author(s):  
Kristina Zaičenkovienė ◽  
Renata Rakovaitė
Keyword(s):  
Dynamic Balance ◽  
Step Test ◽  
Control Group ◽  
Static Balance ◽  
Study Group ◽  
Timed Up And Go ◽  
Physically Active ◽  
Before And After ◽  
Four Square ◽  
And Control

Research background. Falling is one of the most important problems in the elderly’s mobility disorder, which is most often affected by the loss of balance. It is known that Pilates exercises could help to increase the deep muscle strength, improve posture and proprioception, which affects the improvement of the balance. Objective – to evaluate the effects of Pilates exercises on the elderly’s static and dynamic balance. Methodology. The study population consisted of 20 volunteers, men and women, who were divided into Pilates exercises (n = 10, age 65.1 ± 2.6) and control (n = 10, age 68.6 ± 4.9) groups. The study group participated in Pilates classes 2 times per week for six weeks (session duration 60 minutes). The control group did not participate in any physical activity, but they were physically active as usually in their daily life. The main outcome measures were assessed before and after the intervention. The static balance was assessed by measuring posturographic parameters using the force platform, dynamic balance was measured with the Timed up and Go Test (TUG) and the Four Square Step Test (FSST). Results. The results showed signifcant improvement in static balance of the experimental group after the Pilates exercises during standing tests when the feet were apart, eyes opened and closed and when the feet together with eyes opened, and when the foot was in front of the other foot. The results of the control group did not differ during both tests. The results of both groups did not differ in the static balance tests before and after the study, but after the Pilates exercises, the results of the Pilates group signifcantly differed from the control group test results when the feet were in shoulder line with open eyes. The results of the dynamic balance after Pilates exercises signifcantly improved in both tests in the study group. Before the study, there were not statistically signifcant differences in the dynamic balance results between the groups. Conclusions. Six-week Pilates exercises had a positive effect on the elderly’s static and dynamic balance.Keywords: Pilates training, static balance, dynamic balance.

scholarly journals Level Achieved in the Development of Skills for the Sexual and Reproductive Life of University Students After the Application of a Sexual Education Strategy

2021 ◽  
Author(s):  
Rosa Del Carmen Saeteros Hernández ◽  
Eida Ortiz Zayas ◽  
Angélica María Saeteros Hernández
Keyword(s):  
Sex Education ◽  
Life Skills ◽  
Sexuality Education ◽  
Control Group ◽  
Study Group ◽  
Significance Level ◽  
Education Strategy ◽  
Before And After ◽  
Reproductive Life ◽  
And Control

Introduction: Sexuality education must develop life skills. Methodology: The level of life skills was evaluated using a quasi- experimental design from before after with a control group, random   samples of   40   students   were selected in the study and control group, respectively. The sex education strategy was implemented in the study group and a pre and post test was applied; before and after the strategy. Statistical techniques were used for dependent and independent samples, with a significance level of p = 0,05. Results: The comparisons of the study and control groups before, the control group before and after, and the measurement after the implementation of the strategy of the satisfied needs of life skills in the study group, were within expectations, the most of the variables studied regarding the need to develop life skills are homogeneous in the study and control group before implementing the strategy; and no significant differences were found in the comparison of the control group before and after. Subsequent measurement regarding needs met or level achieved in the development of skills for sexual and reproductive life in the study group was high, even for some of them, 100% of students appreciated that they had achieved it. Conclusion: The sex education strategy was effective in developing skills for sexual and reproductive life due to the high level achieved by the students who participated in the strategy. Keywords: education, sex, life skills, sexual and reproductive health. RESUMEN Introducción: La educación sexual debe desarrollar habilidades para la vida. Metodología: Se evaluó el nivel de habilidades para la vida mediante un diseño cuasi experimental de antes después con grupo control, se seleccionaron muestras aleatorias de 40 estudiantes en el grupo de estudio y control respectivamente, se implementó la estrategia de educación sexual en el grupo de estudio y se aplicó una pre y post prueba; antes y después de la estrategia. Se utilizaron técnicas estadísticas para muestras dependientes e independientes, con un nivel de significación p = 0,05. Resultados: Las comparaciones de los grupos de estudio y control antes, grupo control antes y después y la medición posterior a la implementación de la estrategia de las necesidades satisfechas de habilidades para la vida en el grupo de estudio, estuvieron dentro de lo esperado, la mayoría de variables estudiadas respecto a la necesidad de desarrollar habilidades para la vida son homogéneas en el grupo de estudio y control antes de implementar la estrategia; y no se encontraron diferencias significativas en la comparación del grupo control antes y después. La medición posterior respecto a necesidades satisfechas o nivel conseguido en el desarrollo de habilidades para la vida sexual y reproductiva en el grupo de estudio fue elevado, incluso para algunas de ellas, el 100% de estudiantes apreció que lo había logrado. Conclusiones: La estrategia de educación sexual fue efectiva para desarrollar habilidades para la vida sexual y reproductiva debido al nivel elevado conseguido por los estudiantes que participaron en la estrategia. Palabras clave: educación sexual, habilidades para la vida, salud sexual, reproductiva.

scholarly journals The Effectiveness of 0.6% Povidone Iodine Eye Drops in Reducing the Conjunctival Bacterial Load and Needle Contamination in Patients Undergoing Anti-VEGF Intravitreal Injection: A Prospective, Randomized Study

2019 ◽  
Vol 8 (7) ◽  
pp. 1031 ◽  
Author(s):  
Michele Reibaldi ◽  
Teresio Avitabile ◽  
Francesco Bandello ◽  
Antonio Longo ◽  
Vincenza Bonfiglio ◽  
...  
Keyword(s):  
Prophylactic Treatment ◽  
Povidone Iodine ◽  
Bacterial Load ◽  
Randomized Study ◽  
Control Group ◽  
Study Group ◽  
Eye Drops ◽  
Injection Needle ◽  
Before And After ◽  
And Control

The study purpose was to assess the efficacy of a preservative-free 0.6% povidone iodine eye drops as perioperative prophylactic treatment for reducing conjunctival bacterial load and the rate of needle contamination in patients undergoing intravitreal anti-vascular endothelial growth factor injection. Enrolled patients were randomized to either the study group (0.6% povidone iodine, three day-prophylactic treatment before the injection) or to the control group (placebo, three day-prophylactic treatment). Conjunctival swabs were obtained before and after the prophylactic treatment in both groups. Intravitreal injections were performed in a sterile fashion. The injection needle and a control needle were collected for microbiological culture. Data from 254 and 253 eyes in the study group and control group, respectively, were analyzed. Bacterial growth from conjunctival swab cultures was significantly lower after 0.6% povidone iodine prophylaxis compared to baseline and to placebo prophylaxis (p < 0.001), showing an 82% eradication rate in the study group. No injection needle showed bacterial contamination in the study group, whereas six needles were culture-positive in the control group (p = 0.015). No serious ocular and non-ocular adverse events were recorded. The 0.6% povidone iodine solution proved an effective treatment in reducing conjunctival bacterial load and risk of needle contamination.

scholarly journals Study on the Regulation of Qinxitong Combined with Methotrexate Tablets on Multiple Inflammatory Indicators and Mechanism Factors in Rheumatoid Arthritis

2021 ◽  
Vol 5 (6) ◽  
pp. 113-117
Author(s):  
Zhaoyang Dong ◽  
Jichao Yin
Keyword(s):  
Rheumatoid Arthritis ◽  
Control Group ◽  
Study Group ◽  
Observation Group ◽  
Regulatory Effect ◽  
Inflammatory Index ◽  
Normal People ◽  
Before And After ◽  
And Control ◽  
Better Than

Objective: To study the changes of several inflammatory index mechanism factors in the clinical efficacy of tablet and methotrexate in rheumatoid arthritis. Methods: 20 patients with rheumatoid arthritis were randomly divided into observation (n =10) and control (n =10), then normal people as normal (n=10), all three groups were given methotrexate and the observation group were treated with Qin interest pain tablets. Expression of inflammatory index mechanism factors in each group. Results: After treatment, inflammatory index mechanism factors were detected; a significant decrease of IFN-g, IL-1b, IL-10, IL-37, TNF-a and other factors was found before and after combination treatment (P <0); IL-8 and IL-13 expression (P <0); the CRP, ESR score of the study group was lower than the control group (P <0.05); and the inflammatory index mechanism factors were affected by drug combination. Conclusion: Tablets combined with methotrexate in rheumatoid arthritis patients is better than methotrexate. It obviously changed the expression of the patient’s inflammatory index mechanistic factors, which has a regulatory effect on the inflammatory mechanistic factors.

scholarly journals Evaluation the Effects of Led Photo-Activated Disinfection on Periodontal Clinical Parameters in Patients with Chronic Periodontitis

2016 ◽  
Vol 20 (1) ◽  
pp. 29-32
Author(s):  
Alexandra Martu Maria ◽  
Irina-Georgeta Ursarescu ◽  
Sorina Solomon ◽  
Liliana Foia
Keyword(s):  
Periodontal Disease ◽  
Chronic Periodontitis ◽  
Conventional Therapy ◽  
Control Group ◽  
Study Group ◽  
Clinical Parameters ◽  
Systemic Diseases ◽  
And Control ◽  
Tolonium Chloride ◽  
Post Therapy

SummaryThe purpose of the study was to assess the effects of LED-PAD and tolonium chloride on periodontal clinical parameters in chronic periodontitis. Materials and Methods: The study was conducted on patients with chronic periodontitis, divided in 2 groups (study group and control group of patients who, besides the conventional therapy measures, also received PAD therapy). The periodontal clinical parameters were registered at baseline and after 3 months. Results and Discussions: The post-therapy evaluation revealed significantly improved results of periodontal clinical parameters in the study group, when compared to the control group. Our results support the literature studies conducted on chronic periodontitis patients but without any systemic diseases. Conclusion: The PAD disinfection determined a significant improvement for the periodontal clinical parameters in patients with periodontal disease.

scholarly journals Superior training efficacy of beginning movement load training for the baseball throwers

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Wen-Yi Chou ◽  
Jih-Yang Ko ◽  
Shu-Fang Chen ◽  
Chia-Feng Wu ◽  
Kuan-Ting Wu ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Isometric Contraction ◽  
External Rotation ◽  
Control Group ◽  
Study Group ◽  
Maximal Voluntary Isometric Contraction ◽  
Baseball Players ◽  
Before And After ◽  
Shoulder Motion ◽  
And Control

Abstract Background Superior shoulder motion with rotator cuff activation are essential for the performance of the throwing athletes. The present study compared the novel beginning movement load training (BMLT) and popular throwers ten program regarding the training efficacy of baseball throwers. We hypothesized that the BMLT contributed the superior training efficacy than popular throwers ten program. Methods Forty adult baseball players were randomized into study group and control group equally. In study group, the cyclic shoulder motion was repeatedly operated 3 days in a week and lasted for 6 weeks using three different BMLT training machines. As for control group, three popular cyclic training in the throwers ten program were adopted for the shoulder trainings as the same protocol in study group. The evaluations before and after training included the static range of motion (ROM), the maximal voluntary isometric contraction (MVICs) of the target muscle (pectoralis major, middle deltoid and supraspinatus) and throwing velocity. Result After 6-week course, study group had significant wider static ROM in saggital adduction (p = 0.002), coronal internal rotation (p = 0.018) and external rotation (p = 0.044) than in control group. The maximal voluntary isometric contraction (MVIC) ratio of middle deltoid/supraspinatus was significant lower in study group (Study:Control = 1.14 ± 0.76:3.56 ± 5.57, p = 0.049) which indicated the enhanced supraspinatus maximal contraction in the study group after training. In addition, the study group had significant improvement in throwing speed (117 ± 10 vs. 109 ± 10 km/h, p = 0.040). Conclusion The BMLT contributed the superiority in range of motion, recruitment of supraspinatus and throwing velocity than the popular thrower’s ten program. It could be a favourable training for the overhead activity.

Risk of HCC recurrence with cellular immunotherapy following radiofrequency ablation.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 3031-3031
Author(s):  
Jiuwei Cui ◽  
Wei Li ◽  
Nanya Wang ◽  
Hengjun Zhao ◽  
Haofan Jin ◽  
...  
Keyword(s):  
Viral Load ◽  
Radiofrequency Ablation ◽  
Mononuclear Cells ◽  
Progression Free Survival ◽  
Hepatic Function ◽  
Cellular Immunotherapy ◽  
Survival Prognosis ◽  
Killer Cells ◽  
Γδt Cells ◽  
Hcc Recurrence

3031 Background: Although radiofrequency ablation (RFA) has brought promising therapeutic outcome in hepatocellular carcinoma (HCC) treatment, the curative rate was compromised by high recurrence and metastasis after RFA. Immunosupression in patients with HCC is an important factor leading to its recurrence and metastasis. This study was designed to observe the efficiency and safety of application of cellular immunotherapy (CIT) after RFA for HCC patients. Methods: Sixty-two patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer cells, γδT cells, cytokine-induced killer cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for 3 or 6 courses. The tumor recurrent status of these patients was evaluated with computed tomography (CT) every 3 months after RFA. Progression-free survival (PFS), liver function, viral load, and adverse effects were examined. Results: The median PFS in RFA group was 12.0 (9.1-14.8) months while median PFS in RFA/CIT group has not yet been reached. It indicated that sequential RFA/CIT significantly reduced the risk of HCC recurrence [hazard ratio (HR) = 0.136]. In RFA/CIT group, six courses had better survival prognosis than three courses (P <0.05). Viral load of hepatitis C decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA alone group. The RFA/CIT group maintained the hepatic function at the level before CIT. The hepatic function in 28.1% (9/32 cases) patients in RFA group was deteriorated. Only one developed fever (38.5 °C) after one infusion and recovered 2 hours later. Otherwise, there was no toxic effect in the RFA/CIT group. Conclusions: These preliminary results suggested that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA. It also suggested that the CIT may reduce the risk of recurrence by dual effects of anti-tumor and anti-virus.

scholarly journals Superior Training Efficacy of Beginning Movement Load Training for the Baseball Throwers

2021 ◽  
Author(s):  
Wen-Yi Chou ◽  
Jih-Yang Ko ◽  
Shu-Fang Chen ◽  
Chia-Feng Wu ◽  
Kuan-Ting Wu ◽  
...  
Keyword(s):  
Range Of Motion ◽  
Isometric Contraction ◽  
External Rotation ◽  
Control Group ◽  
Study Group ◽  
Maximal Voluntary Isometric Contraction ◽  
Baseball Players ◽  
Before And After ◽  
Shoulder Motion ◽  
And Control

Abstract Background : Superior shoulder motion with rotator cuff activation are essential for the performance of the throwing athletes. The present study compared the novel beginning movement load training (BMLT) and popular throwers ten program regarding the training efficacy of baseball throwers. We hypothesized that the BMLT contributed the superior training efficacy than popular throwers ten program. Methods : Forty adult baseball players were randomized into study group and control group equally. In study group, the cyclic shoulder motion was repeatedly operated 3 days in a week and lasted for 6 weeks using three different BMLT training machines. As for control group, three popular cyclic training in the throwers ten program were adopted for the shoulder trainings as the same protocol in study group. The evaluations before and after training included the static range of motion (ROM), the maximal voluntary isometric contraction (MVICs) of the target muscle (pectoralis major, middle deltoid and supraspinatus) and throwing velocity. Result : After 6-week course, study group had significant wider static ROM in saggital adduction (p=0.034), coronal internal rotation (p=0.038) and external rotation (p=0.04) than in control group. The maximal voluntary isometric contraction (MVIC) ratio of middle deltoid/supraspinatus was significant lower in study group (Study : Control = 1.14±0.76 : 3.56 ±5.57, p = 0.044) which indicated the enhanced supraspinatus maximal contraction in the study group after training. In addition, the study group had significant improvement in throwing speed (117±10 vs 109±10 Km/hr, p=0.031). Conclusion : The BMLT contributed the superiority in range of motion, recruitment of supraspinatus and throwing velocity than the popular thrower`s ten program. It could be a favourable training for the overhead activity.

scholarly journals Combination of Adoptive Cellular Immunotherapy and Bortezomib-Based Regimens Increase the Progression Free Survival of the Patients with Multiple Myeloma

Blood ◽  
2014 ◽  
Vol 124 (21) ◽  
pp. 2143-2143
Author(s):  
Jiuwei Cui ◽  
Wei Li ◽  
Lei Qian ◽  
Chunshui Liu ◽  
Haofan Jin ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Peripheral Blood ◽  
Progression Free Survival ◽  
Cellular Immunotherapy ◽  
Control Group ◽  
Study Group ◽  
Free Survival ◽  
Adoptive Cellular Immunotherapy ◽  
Cik Cells ◽  
Significant Difference

Abstract Objective: In our previous studies show that bortezomib can enhance the sensitivity of multiple myeloma (MM) cells to the cytotoxity of γδT, nature killer (NK) cells and cytokine-induced killer (CIK) cells, and there is synergistic effect among these three types of cells as well. Therefore, the efficacy and safety of combination of adoptive cellular immunotherapy (ACI) with NK, γδT and CIK cells and bortezomib-based chemotherapy was investigated in this study. Method: 27 patients were recruited in this study with newly-diagnosed MM and received Bortezomib-based therapy during September 2008 and September 2013 in the First Hospital of Jilin University. The patients were divided into study group (ACI plus bortezomib-based therapy) and control group (bortezomib-based therapy alone). There are 14 patients in study group with median age of 60.5 (54-73) years old, while 13 patients in control group with median age of 56 (41-80) years old. In the study group, autologous peripheral blood mononuclear cells (PBMCs) were collected from the peripheral blood by apheresis at the first day, and were induced into NK, γδT and CIK cells, then the expanded immunocytes were infused back to the patients after 14 days culture ex vivo. The number of cells for each transfusion ranged from 1.2×109- 2.0×109 cells. Progression-free survival (PFS) and adverse effects were investigated. One course of ACI would be done within 3 weeks and contain six times of infusion in total. This study was approved by the Ethical Committee of the First Hospital of Jilin University. Written informed consent was obtained from all patients before their enrollment into the study. Result:In this study, the percentage of CIK (CD56+CD3+), NK (CD56+CD3-) and γδT (Vγ9+) before and after induction were 4.39% (1.5%-8%) vs 46.32% (27%-50%), 10.35% (5.1%-12.6%) vs 95.28% (70.1%-99.6%), 4.72% (2.61%-11.2%) vs 90.64% (60.5%-97.9%), respectively. The median follow-up time was 18 months. The characteristics including age, gender, stage, chemotherapy regimen etc. had no significant difference between the two groups. The median PFS in study group was 24.5m (12-48), and the median PFS was 12m (5-32) in control group (P=0.018). For subgroup analysis, the median PFS in the study group receiving >3 courses and ≦3 courses group were 36m (24-48) and 20m (12-36), respectively (P=0.141). Among the patients receiving ACI, one patient felt mild fatigue after infusion. One patient had transient fever after one infusion (38 °C) and recovered 1 h later. No other significant side effects were observed. Conclusion: Combination of NK, γδT and CIK cells based ACI and bortezomib-based chemotherapy is well tolerated and shows a great potential to improve the PFS of the patients with MM. This study provided a novel strategy for the treatment of MM, and it is worthwhile to study this combination strategy in multi-center randomized clinical trials. Disclosures No relevant conflicts of interest to declare.

scholarly journals Improving Ablation Safety for Hepatocellular Carcinoma Proximal to the Hilar Bile Ducts by Ultrasound-MR Fusion Imaging: A Preliminary Comparative Study

2021 ◽  
Vol 11 ◽  
Author(s):  
Yujia You ◽  
Yinglin Long ◽  
Ronghua Yan ◽  
Liping Luo ◽  
Man Zhang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Comparative Study ◽  
Bile Ducts ◽  
Fusion Imaging ◽  
Control Group ◽  
Study Group ◽  
Local Progression ◽  
Significant Difference ◽  
Conventional Ultrasound ◽  
And Control

AimTo explore whether ablation safety could be improved by ultrasound (US)-magnetic resonance (MR) fusion imaging for hepatocellular carcinoma (HCC) proximal to the hilar bile ducts (HBDs) through a preliminary comparative study.MethodsBetween January 2014 and June 2019, 18 HCC nodules proximal to the HBDs were included in a US-MR fusion imaging-assisted radiofrequency ablation (RFA) group (study group), while 13 HCC nodules in a similar location were included as a control group. For the study group, the tumor and adjacent bile ducts were outlined on preprocedural MR images. Procedural ablation planning was conducted to assess the feasibility of ablating the tumors while avoiding biliary injury. Such tumors were then ablated under US-MR fusion imaging guidance. The control group nodules were ablated under conventional ultrasound guidance. Baseline characteristics and outcomes were compared between the groups.ResultsAfter preprocedural assessment, 14 of 18 patients with tumors that were feasible to ablate underwent US-MR fusion imaging-assisted RFA. No biliary complications were observed in these 14 patients; the complication rate was significantly lower in the study group than in the control group (30.8%, 4/13) (P = 0.041). There was no significant difference in the technique efficacy rates [92.9% (13/14) versus 100% (13/13), P = 1] or local progression rates [7.1% (1/14) versus 7.7% (1/13), P = 1] between the study and control groups.ConclusionsUS-MR fusion imaging may be a non-invasive means for assisting RFA of HCC nodules proximal to the HBDs and ensuring ablation safety.

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