scholarly journals Prognostic value of HE4 in patients with ovarian cancer

2018 ◽  
Vol 56 (7) ◽  
pp. 1026-1034 ◽  
Author(s):  
Cunzhong Yuan ◽  
Rongrong Li ◽  
Shi Yan ◽  
Beihua Kong
Keyword(s):  
Ovarian Cancer ◽  
Random Effects ◽  
Fixed Effects ◽  
Large Scale ◽  
Meta Analysis ◽  
Serum Levels ◽  
Medical Community ◽  
Random Effects Model ◽  
Poor Overall Survival ◽  
Preoperative Serum

Abstract Background There is no consensus in the medical community about the prognostic role of preoperative serum levels of human epididymis protein 4 (HE4) in ovarian cancer (OC). The purpose of this meta-analysis was to establish whether preoperative serum levels of HE4 are associated with OC prognosis. Content Eligible studies were searched for in PubMed, ClinicalTrials.gov, CNKI and Wanfang Med Online. We performed a meta-analysis of 1315 OC cases from 14 published articles. Summary Our meta-analysis demonstrated that high HE4 was associated with poor overall survival (OS) (random effects model, hazard ratio [HR]=1.91, 95% confidence interval [CI]=1.40–2.614, p<0.0001; I2=52%, p=0.04) and; progression-free survival (PFS) (random effects model, HR=1.38, 95% CI=1.13–1.69, p=0.002; I2=85%, p<0.00001). However, subgroup analysis showed that high HE4 was not associated with poor OS (fixed effects model, HR=1.86, 95% CI=0.89–3.89, p=0.1; I2=34%, p=0.22) or PFS (random effects model, HR=1.34, 95% CI=0.95–1.88, p=0.1; I2=69%, p=0.007) for studies including only Asian populations. Outlook In conclusion, this meta-analysis shows that high HE4 was associated with poor OC OS and PFS overall. However, the association of high HE4 with poor OS and PFS was not observed for Asians. Large-scale, multi-center investigations should be performed.

scholarly journals Comparison of efficacy of robotic surgery, laparoscopy, and laparotomy in the treatment of ovarian cancer: a meta-analysis

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Can Shi ◽  
Yingchun Gao ◽  
Yijun Yang ◽  
Lei Zhang ◽  
Juanpeng Yu ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Robotic Surgery ◽  
Publication Bias ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Random Effects Model ◽  
Fixed Effects Model ◽  
Estimated Blood Loss

Abstract Background We intended to compare the clinical effect of robotic surgery with laparoscopy and laparotomy in ovarian cancer treatment. Methods The included studies were retrieved from PubMed, Embase, and the Cochrane Library databases. The Methodological Index for Nonrandomized Studies (MINORS) was used to evaluate the study quality. Effect measures were presented with weighted mean difference (WMD)/odds ratio (OR) and 95% confidence interval (CI), and heterogeneity test was assessed using Q test and I2 statistics to determine the use of the random effects model or fixed effects model. Egger’s test was used to assess the publication bias. Results A total of eight studies was included in this meta-analysis with a MINORS score of 16–18. In the random effects model, estimated blood loss (EBL) of robotic surgery was significantly less compared with laparotomy (WMD = − 521.7027, 95% CI − 809.7816; − 233.6238). In the fixed effects model, length of hospital stay (LHS) (WMD = − 5.2225, 95% CI − 6.1485; − 4.2965) and postoperative complication (PC) (OR = 0.4710, 95% CI 0.2537; 0.8747) of robotic surgery were significantly less, and overall survival (OS) rate (OR = 6.4355, 95% CI 1.6722; 24.7678, P = 0.0070) of robotic surgery was significantly higher compared with laparotomy. There was no difference in the effect size of all variables between robotic surgery and laparoscopy. Meanwhile, a publication bias (t = 6.8290, P = 0.002405) was only identified for PC in robotic surgery and laparotomy groups; no publication bias was identified for the other variables. Conclusions Despite the above results, it failed to show oncological safety and recurrence by pathological stages or histologic types in this meta-analysis, and those confounding factors might affect the clinical outcome. Future meta-analyses with a larger number of eligible randomized controlled trial studies were needed to determine the most suitable treatment method for patients with different stages and types of ovarian cancer.

The relationship between migraine and infant colic: A systematic review and meta-analysis

Cephalalgia ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Amy A Gelfand ◽  
Peter J Goadsby ◽  
I Elaine Allen
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Odds Ratio ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Random Effects Model ◽  
Fixed Effects Model ◽  
Primary Analysis ◽  
Infant Colic ◽  
The Relationship

Context Infant colic is a common and distressing disorder of early infancy. Its etiology is unknown, making treatment challenging. Several articles have suggested a link to migraine. Objective The objective of this article was to perform a systematic review and, if appropriate, a meta-analysis of the studies on the relationship between infant colic and migraine. Data sources Studies were identified by searching PubMed and ScienceDirect and by hand-searching references and conference proceedings. Study selection For the primary analysis, studies specifically designed to measure the association between colic and migraine were included. For the secondary analysis, studies that collected data on colic and migraine but were designed for another primary research question were also included. Data extraction Data were abstracted from the original studies, through communication with study authors, or both. Two authors independently abstracted data. Main outcomes and measures The main outcome measure was the association between infant colic and migraine using both a fixed-effects model and a more conservative random-effects model. Results Three studies were included in the primary analysis; the odds ratio for the association between migraine and infant colic was 6.5 (4.6–8.9, p < 0.001) for the fixed-effects model and 5.6 (3.3–9.5, p = 0.004) for the random-effects model. In a sensitivity analysis wherein the study with the largest effect size was removed, the odds ratio was 3.6 (95% CI 1.7–7.6, p = 0.001) for both the fixed-effects model and random-effects model. Conclusions In this meta-analysis, infant colic was associated with increased odds of migraine. If infant colic is a migrainous disorder, this would have important implications for treatment. The main limitation of this meta-analysis was the relatively small number of studies included.

Meta Analysis of Study Habits and Academic Achievement

2021 ◽  
Vol 8 (4) ◽  
pp. 139-145
Author(s):  
M Elango ◽  
G Manimozhi
Keyword(s):  
College Students ◽  
Academic Achievement ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Study Habits ◽  
Random Effects Model ◽  
Inclusion Criteria ◽  
Analytical Review ◽  
The Relationship

A Meta analytical review investigated the study habits and academic achievement of school and college students. In this study the sample consists of twenty seven reviews based on study habits and academic achievement/ performance. The sample of the review based on inclusion criteria such as study habits and academic achievement. The review was collected by following details such as title of the study, Name of the author, Sample of the study, correlation Value and findings of the study. The Meta analysis is on the relationship between study habits and academic achievement. The main aim of the study is to find the fixed effects, random effects model values, Heterogeneity and forest plots. A Meta analysis of research paper was formed the conclusion.

scholarly journals A review and meta-analysis of red and processed meat consumption and breast cancer

2010 ◽  
Vol 23 (2) ◽  
pp. 349-365 ◽  
Author(s):  
Dominik D. Alexander ◽  
Libby M. Morimoto ◽  
Pamela J. Mink ◽  
Colleen A. Cushing
Keyword(s):  
Breast Cancer ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Random Effect ◽  
Red Meat ◽  
Processed Meat ◽  
Random Effects Model ◽  
Fixed Effects Model ◽  
Meat Intake

The relationship between meat consumption and breast cancer has been the focus of several epidemiological investigations, yet there has been no clear scientific consensus as to whether red or processed meat intake increases the risk of breast cancer. We conducted a comprehensive meta-analysis incorporating data from several recently published prospective studies of red or processed meat intake and breast cancer. In the meta-analysis utilising data from the Pooling Project publication (includes data from eight cohorts) combined with data from nine studies published between 2004 and 2009 and one study published in 1996, the fixed-effect summary relative risk estimate (SRRE) for red meat intake (high v. low) and breast cancer was 1·02 (95 % CI 0·98, 1·07; P value for heterogeneity = 0·001) and the random-effects SRRE was 1·07 (95 % CI 0·98, 1·17). The SRRE for each 100 g increment of red meat was 1·04 (95 % CI 1·00, 1·07), based on a fixed-effects model, and 1·12 (95 % CI 1·03, 1·23) based on a random-effects model. No association was observed for each 100 g increment of red meat among premenopausal women (SRRE 1·01; 95 % CI 0·92, 1·11) but a statistically significant SRRE of 1·22 (95 % CI 1·04, 1·44) was observed among postmenopausal women using a random-effects model. However, the association for postmenopausal women was attenuated and non-significant when using a fixed-effects model (SRRE 1·03; 95 % CI 0·98, 1·08). The fixed- and random-effect SRRE for high (v. low) processed meat intake and breast cancer were 1·00 (95 % CI 0·98, 1·01; P value for heterogeneity = 0·005) and 1·08 (95 % CI 1·01, 1·16), respectively. The fixed- and random-effect SRRE for each 30 g increment of processed meat were 1·03 (95 % CI 1·00, 1·06) and 1·06 (95 % CI 0·99, 1·14), respectively. Overall, weak positive summary associations were observed across all meta-analysis models, with the majority being non-statistically significant. Heterogeneity was evident in most analyses, summary associations were sensitive to the choice of analytical model (fixed v. random effects), and publication bias appeared to have produced slightly elevated summary associations. On the basis of this quantitative assessment, red meat and processed meat intake does not appear to be independently associated with increasing the risk of breast cancer, although further investigations of potential effect modifiers, such as analyses by hormone receptor status, may provide valuable insight to potential patterns of associations.

scholarly journals The effect of cooperative learning on academic achievement: A meta-analysis on the relationship between the study group size and effect size İşbirlikli öğrenmenin başarıya etkisi: Çalışma grubu ile etki büyüklüğü arasındaki ilişkiye dair bir meta analiz çalışması

2017 ◽  
Vol 14 (1) ◽  
pp. 473 ◽  
Author(s):  
Murat Tuncer ◽  
Melih Dikmen
Keyword(s):  
Cooperative Learning ◽  
Random Effects ◽  
Effect Size ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Experimental Studies ◽  
Study Group ◽  
Random Effects Model ◽  
Learning Groups ◽  
The Relationship

The purpose of this study was to determine the effect of cooperative learning on achievement and the relationship between the study group and effect size by means of meta-analysis. Meta-analysis is the method employed in order to statistically analyze the quantitative data collected in independent and multiple studies carried out on similar topics, and to reach a general judgment regarding the results of these studies.  Certain criteria were used in order to decide which researches would be included in the meta-analysis. Based on these criteria, it was decided to include 6 experimental studies in the meta-analysis. As a result, for the six studies, the effect size calculated within 95 % confidence interval has proved to be .518 based on random effects model. When two studies with the largest learning groups are excluded from the research respectively, firstly this effect size increases to .528, later it is calculated as .817 without any model discrimination. When effect size intervals in literature (≥ 0.5: strong, ≥ 0.3: moderate and  ≥ .01 weak) is taken into consideration, the effect of cooperative learning on achievement has been observed as  “Strong”. In addition to this, contrary to some views in literature, it has been seen that large learning groups have higher standard errors and a bigger effect size has been achieved when such studies have been excluded from the analysis. What is more, even the limitation of fixed effects model has disappeared, and the effect size calculated in fixed effects and random effects model has been balanced.  ÖzetBu araştırmanın amacı, işbirlikli öğrenmenin başarı üzerindeki etkisini ve çalışma grubu ile etki büyüklüğü arasındaki ilişkiyi meta-analiz yöntemiyle belirlemektir. Meta-analiz, benzer konularda yapılmış birbirinden bağımsız ve çok sayıda çalışmadan elde edilmiş sayısal verileri istatistiksel olarak analiz etme ve bu çalışmaların sonuçları hakkında genel bir yargıya varma yöntemidir. Hangi araştırmaların meta-analize dâhil edileceğine yönelik seçimlerin yapılmasında belirli ölçütler kullanılmıştır. Bu ölçütlere dayalı olarak 6 adet deneysel araştırmanın meta-analize dâhil edilmesine karar verilmiştir. Sonuç olarak; altı çalışma için %95 güven aralığında hesaplanan etki büyüklüğü rastgele etkiler modeline göre .518’dir. En büyük çalışma grubuna sahip iki araştırma sırasıyla araştırma dışında tutulduğunda bu etki büyüklüğü önce .528’ e çıkmakta, sonrasında ise model ayrımı olmaksızın .817 olarak hesaplanmaktadır. Alan yazındaki etki büyüklüğü aralıkları (≥ 0.5: güçlü, ≥ 0.3: orta düzey ve ≥ .01 zayıf) dikkate alındığında işbirlikli öğrenmenin başarı üzerindeki etkisi “Güçlü” bir etki olarak gözlenmiştir. Ayrıca alan yazındaki bazı görüşlerin aksine büyük çalışma gruplarının standart hatalarının daha yüksek olduğu, bu araştırmaların analiz dışında tutulması ile daha büyük etki büyüklüklerine ulaşıldığı, hatta sabit etki modelinin sınırlılığının bile ortadan kalktığı, sabit etki ve rastgele etki modelinde hesaplanan etki büyüklüğünün eşitlendiği görülmüştür.

scholarly journals Ear mould for congenital auricular deformities: a protocol for systematic review and meta-analysis

2020 ◽  
Author(s):  
Jincheng Huang ◽  
Kun Zou ◽  
Ping Yuan ◽  
Longhao Zhang ◽  
Min Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Evidence Base ◽  
Small Sample ◽  
Cochrane Library ◽  
Random Effects Model ◽  
High Quality ◽  
Effectiveness Rate

Abstract Background: Congenital auricle deformities (CADs) not only affect the appearance, but may also result in social inferiority or difficulties, influence the hearing and mental health of the children. Although some studies have pointed out CADs have a natural improvement trend, there is still a lack of high-quality research to demonstrate the degree of that. Therefore, related studies agree that early treatment are necessary. Ear mold correction is currently main non-surgical treatment for CADs, but the existing research often involves a small sample size, and the research conclusions are inconsistent. More importantly, there is still no systematic review on ear mold correction for CADs. This study aims to systematically evaluate the effectiveness and safety of ear mold correction for CADs, so as to provide an evidence base for further research.Methods: The study has been designed according to the Preferred Reporting program for Systems Evaluation and Meta-analysis Protocol (PRISMA-P). We will search electronic literature databases of PubMed, Embase, Cochrane Library, Web of science, CBM, CNKI, Wanfang and VIP from their initiative to 1 June 2020 for interventional studies on ear mould for children with CADs. The study selection, data extraction and quality assessment will be performed by two authors. Meta-analysis will be conducted on primary outcome effectiveness rate of physician assessment and secondary outcomes of effectiveness rate of parents’ assessment, effectiveness score, hearing assessment, and adverse reactions using relative ratio or mean difference and their 95% confidence intervals. The heterogeneity of the included studies will be tested using Chi square test and I2, and random-effects model will be used when significant heterogeneity was found, otherwise, fixed-effects model will be used. Sensitivity analysis will be performed using trials with high quality and using alternative [1]models (fixed-effects or random effects model). Publication bias will be tested using funnel plot and Egger’s test. Discussion: This study will be the first to systematically evaluate the effectiveness and safety of ear mold correction for CADs, to provide evidence base for clinical guideline making, clinical decision and future research. Systematic review registration : CRD42020190982.

Impact of Estrogen Receptor Expression on Prognosis of Ovarian Cancer According to Antibody Clone Used for Immunohistochemistry: A Meta-analysis

2021 ◽  
Author(s):  
Chun Wai Ng ◽  
Kwong-kwok Wong
Keyword(s):  
Ovarian Cancer ◽  
Estrogen Receptor ◽  
Random Effects ◽  
Fixed Effects ◽  
Meta Analysis ◽  
Receptor Expression ◽  
Cancer Prognosis ◽  
Ovarian Cancer Prognosis ◽  
The Impact ◽  
Er Expression

Abstract BackgroundThe prognostic value of the expression of estrogen receptor (ER) subtypes ER⍺ and ERβ in ovarian cancer has previously been evaluated by meta-analyses. However, the results are contradictory and controversial. MethodsWe conducted an updated meta-analysis with stringent inclusion criteria to ensure homogeneous studies to determine the effect of ER subtypes on ovarian cancer prognosis. Articles were retrieved by systematic search of PubMed and Web of Science for articles dated up to June 2021. Only studies with known hazard ratio (HR) and antibody clone for immunochemistry (IHC) were included. Pooled HRs with the corresponding 95% confidence intervals (CIs) were calculated for the effect of ER⍺ and ERβ expression on ovarian cancer patient progression-free survival (PFS) and overall survival (OS).ResultsA total of 17 studies were included, of which 11 and 13 studies examined the relationships between ER⍺ expression and PFS and OS, respectively, and 5 and 7 studies examined the relationships between ERβ expression and PFS and OS, respectively. Neither ER⍺ expression (random-effects model; HR=0.99, 95% CI=0.83-1.18) nor ERβ expression (fixed-effects model; HR=0.94, 95% CI=0.69-1.27) was associated with PFS. Random-effects models showed that ER⍺ expression (HR=0.81, 95% CI=0.64-1.02) and ERβ expression (HR=0.75, 95% CI=0.50-1.13) were only marginally and not significantly associated with better OS. Subgroup analysis revealed that ER⍺ expression determined using antibody clone 1D5 (HR=0.75, 95% CI=0.64-0.88) and ERβ expression determined using ERβ1-specific-antibody clone PPG5/10 or EMR02 (HR=0.65, 95% CI=0.50-0.86) were associated with significantly better OS, but ER expression determined using other antibodies was not.ConclusionsBoth ER⍺ expression and ERβ expression determined using certain antibody clones are significantly associated with OS of ovarian cancer patients, which suggests that both ER subtypes are prognostic biomarkers for ovarian cancer. The findings of this study provide new insight into the impact of ER expression on ovarian cancer prognosis.

scholarly journals Comparison of coated meshes for intraperitoneal placement in animal studies: a systematic review and meta-analysis

Hernia ◽  
2019 ◽  
Vol 24 (6) ◽  
pp. 1253-1261 ◽  
Author(s):  
H. Liu ◽  
S. van Steensel ◽  
M. Gielen ◽  
T. Vercoulen ◽  
J. Melenhorst ◽  
...  
Keyword(s):  
Systematic Review ◽  
Random Effects ◽  
Fixed Effects ◽  
Animal Studies ◽  
Meta Analysis ◽  
Adhesion Formation ◽  
Mean Difference ◽  
Random Effects Model ◽  
Fixed Effects Model

Abstract Purpose Laparoscopic intraperitoneal onlay mesh in hernia repair can result in adhesions leading to intestinal obstruction and fistulation. The aim of this systematic review is to compare the effects of mesh coatings reducing the tissue-to-mesh adhesion in animal studies. Methods Pubmed and Embase were systematically searched. Animal experiments comparing intraperitoneally placed meshes with coatings were eligible for inclusion. Only studies with comparable follow-up, measurements, and species were included for data pooling and subsequent meta-analysis. Results A total of 131 articles met inclusion criteria, with four studies integrated into one comparison and five studies integrated into another comparison. Compared to uncoated polypropylene (PP) mesh, PP mesh coated with hyaluronic acid/carboxymethyl cellulose (HA/CMC) showed significantly reduced adhesion formation at follow-up of 4 weeks measured with adhesion score of extent (random effects model, mean difference,−  0.96, 95% CI − 1.32 to − 0.61, P < 0.001, I2 = 23%; fixed effects model, mean difference,− 0.94, 95% CI − 1.25 to − 0.63, P < 0.001, I2 = 23%). Compared to PP mesh, polyester mesh coated with collagen (PC mesh) showed no significant difference at follow-up of 4 weeks regarding percentage of adhesion-area on a mesh, using random effects model (mean difference − 11.69, 95% CI − 44.14 to 20.76, P = 0.48, I2 = 92%). However, this result differed using fixed effects model (mean difference − 25.55, 95% CI − 33.70 to − 7.40, P < 0.001, I2 = 92%). Conclusion HA/CMC coating reduces adhesion formation to PP mesh effectively at a follow-up of 4 weeks, while the anti-adhesive properties of PC mesh are inclusive comparing all study data.

scholarly journals Pancreatogastrostomy versus Pancreatojejunostomy: An Up-to-Date Meta-Analysis of RCTs

2017 ◽  
Vol 2017 ◽  
pp. 1-18 ◽  
Author(s):  
Konstantinos Perivoliotis ◽  
Eleni Sioka ◽  
Athina Tatsioni ◽  
Ioannis Stefanidis ◽  
Elias Zintzaras ◽  
...  
Keyword(s):  
Fixed Effects ◽  
Large Scale ◽  
Delayed Gastric Emptying ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Cochrane Central Register ◽  
Random Effects Model ◽  
Controlled Clinical Trials ◽  
Central Register ◽  
Clinically Significant

Background. A meta-analysis was conducted in order to provide an up-to-date comparison of pancreatogastrostomy (PG) and pancreatojejunostomy (PJ), after pancreatoduodenectomy (PD), in terms of clinically significant postoperative pancreatic fistula (POPF) and other postoperative complications. Methods. This meta-analysis was conducted according to the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. A systematic literature search in MEDLINE and Cochrane Central Register of Controlled Clinical Trials was performed. Fixed Effects or Random Effects model was used, based on the Cochran Q test. Results. In total, 10 studies (1629 patients) were included. There was no statistical significance between PG and PJ regarding the rate of clinically significant POPF (OR: 0.70, 95%CI: 0.46–1.06). PG was associated with a higher rate of postpancreatoduodenectomy haemorrhage (PPH) (OR: 1.52, 95%CI: 1.08–2.14). There was no difference between the two techniques in terms of clinically significant PPH (OR: 1.35, 95%CI: 0.95–1.93) and clinically significant postoperative delayed gastric emptying (DGE) (OR: 0.98, 95%CI: 0.59–1.63). Discussion. There is no difference between the two anastomotic techniques regarding the rate of clinically significant POPF. Given several limitations, more large scale high quality RCTs are required.

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