scholarly journals Thermomechanical properties of PEGDA in combination with different photo-curable comonomers

2019 ◽  
Vol 5 (1) ◽  
pp. 319-321
Author(s):  
Natalia Rekowska ◽  
Daniela Arbeiter ◽  
Thomas Eickner ◽  
Niels Grabow ◽  
Michael Teske ◽  
...  
Keyword(s):  
Glass Transition ◽  
Biomedical Application ◽  
Thermomechanical Properties ◽  
Glycol Diacrylate ◽  
Physico Chemical ◽  
3D Geometry ◽  
Pentaerythritol Triacrylate ◽  
Basic Characteristics ◽  
Poly Ethylene

AbstractThe technology of pharmaceutical drug delivery systems (DDS) as an individual and adjustable tool for drug administration has been intensively developed in the last years. Additive manufacturing (AM) techniques, such as stereolithography, are a promising approach towards DDS scaffold manufacturing. Stereolithography, by using layerby- photo-polymerisation, creates DDS scaffolds with highly controlled 3D geometry. Combined with inkjet printing it allows a very precise positioning of the drug depot in the basic scaffold and therefore also a better control of the drug release. Furthermore, this hybrid AM technique also allows for the creation of a multi-drug DDS with a several drug depots localized in desired positions within the scaffold. Determination of the scaffold and drug depot material properties is one of the initial steps for such novel DDS development. Basic characteristics, such as stiffness, elasticity or glass transition temperature (Tg), are important for designing and adapting the material for biomedical application. The photosensitive poly(ethylene glycol) diacrylate (PEGDA) can be easily formed into a desired biocompatible scaffold geometry via stereolithography. In this study we have focused on the evaluation of PEGDA (Mn=700 g/mol) as a pure and copolymer system in combination with other acrylates (butanediol diacrylate, pentaerythritol triacrylate) as possible materials for DDS using this novel hybrid AM technique. Irgacure 2959, a biocompatible photoinitiator (PI), was used as a radical starter for photopolymerisation. Samples varying in PI and coacrylate concentration were prepared by conventional photopolymerisation. Physico-chemical analyses of the samples were performed and several parameters, such as stiffness, elongation at break and glass transition temperatures, were determined.

Mechanical behavior of bioactive poly(ethylene glycol) diacrylate matrices for biomedical application

2020 ◽  
Vol 110 ◽  
pp. 103885 ◽  
Author(s):  
Francesca Della Sala ◽  
Marco Biondi ◽  
Daniela Guarnieri ◽  
Assunta Borzacchiello ◽  
Luigi Ambrosio ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Mechanical Behavior ◽  
Biomedical Application ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

scholarly journals Synthesis and Formulation of PCL-Based Urethane Acrylates for DLP 3D Printers

Polymers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1500
Author(s):  
Hsuan Chen ◽  
Shyh-Yuan Lee ◽  
Yuan-Min Lin
Keyword(s):  
Mechanical Properties ◽  
3D Printing ◽  
Biomedical Application ◽  
Complex Structure ◽  
Digital Light Processing ◽  
Glycol Diacrylate ◽  
Molecular Weights ◽  
3D Printers ◽  
Poly Ethylene ◽  
Tunable Mechanical Properties

In this study, three PCL-based polyurethane acrylates were synthesized and further formulated into twelve resins for digital light processing (DLP) 3D printing. Three PCL diols with different molecular weights were synthesized via ring-opening reaction of ε-caprolactone on diethylene glycol, with the catalyst stannous octoate. Isophorone diisocyanate (IPDI) was reacted with 2-hydroxyethyl acrylate (2-HEA) and the PCL diols form PCL-based polyurethane acrylates. Twelve resins composed of different percentages of PCL-based polyurethane acrylates, poly (ethylene glycol) diacrylate (PEGDA), propylene glycol (PPG) and photo-initiator were further printed from a DLP 3D printer. The viscosities of twelve resins decreased by 10 times and became printable after adding 30% of PEGDA. The degree of conversion for the twelve resins can reach more than 80% after the post-curing process. By changing the amount of PEGDA and PPG, the mechanical properties of the twelve resins could be adjusted. PUA530-PEG-PPG (70:30:0), PUA800-PEG-PPG (70:30:0), and PUA1000-PEG-PPG (70:30:0) were successfully printed into customized tissue scaffolds. Twelve PCL-based polyurethane photo-curable resins with tunable mechanical properties, cytotoxicity, and degradability were successfully prepared. With the DLP 3D printing technique, a complex structure could be achieved. These resins have great potential for customized tissue engineering and other biomedical application.

scholarly journals Thermomechanical properties of PEGDA and its co-polymers

2018 ◽  
Vol 4 (1) ◽  
pp. 669-672 ◽  
Author(s):  
Natalia Rekowska ◽  
Daniela Arbeiter ◽  
Jan Konasch ◽  
Alexander Riess ◽  
Robert Mau ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tensile Stress ◽  
Drug Application ◽  
Monomer Concentration ◽  
Thermomechanical Analysis ◽  
Biological Properties ◽  
Thermomechanical Properties ◽  
Glycol Diacrylate ◽  
Research Activities ◽  
Poly Ethylene

AbstractCurrent research activities focus on personalized, comfortable and safe products for systemic or local drug application in patients. Poly(ethylene glycol) diacrylate is in particular interest as a drug delivery material, as it shows appropriate biological properties such as hydrophilicity and low toxicity. Additionally, as an easily photopolymerizable compound it can be also utilized for the production of scaffolds with the use of different techniques such as stereolithography. Even though it is often used as a biomaterial or as a copolymer in many photopolymer systems for drug delivery, thermomechanical analysis and basic understanding are rare.Therefore, we investigated the tensile stress and the glass transition temperature of pure PEGDA and of its copolymers with 1,3-butanediol diacrylate or pentaerythritol triacrylate, as a function of the photoinitiator (PI) or acrylate concentration. Additionally, we demonstrated that the washing procedure decreases the tensile stress values. We showed, that by the means of composing PEGDA with these, it is possible to influence thermomechanical properties of the sample. Our outcomes have revealed, that there is no clear influence of the PI concentration on the thermomechanical properties. However there is an influence of the monomer concentration. Therefore, it should be possible to modify drug release profiles in future experiments.

Poly(ethylene glycol) diacrylate-based solid-phase extraction for determination of sulfonamides in meat samples

2020 ◽  
Vol 157 ◽  
pp. 104931
Author(s):  
Ancuta Moga ◽  
María Vergara-Barberán ◽  
María Jesús Lerma-García ◽  
José Manuel Herrero-Martínez ◽  
Ernesto Francisco Simó-Alfonso
Keyword(s):  
Ethylene Glycol ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Phase Extraction ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene ◽  
Meat Samples

scholarly journals A Combined Approach of Double Network Hydrogel and Nanocomposites Based on Hyaluronic Acid and Poly(ethylene glycol) Diacrylate Blend

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2454 ◽  
Author(s):  
Alfredo Ronca ◽  
Ugo D’Amora ◽  
Maria Raucci ◽  
Hai Lin ◽  
Yujiang Fan ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Ethylene Glycol ◽  
Sol Gel ◽  
Poly Ethylene Glycol ◽  
Double Network ◽  
Glycol Diacrylate ◽  
Physico Chemical ◽  
Hydrogel Matrix ◽  
Poly Ethylene ◽  
Sol Gel Synthesis

In this study, an innovative polymer blend, based on double network (DN) approach, has been developed by integrating a poly(ethylene glycol) diacrylate (PEGDA) network into a chemically modified hyaluronic acid sodium salt (HAs) hydrogel matrix. Here, the HAs was chemically functionalized with photocrosslinkable moieties by reacting with maleic anhydride (MAA) to obtain a maleated hyaluronic acid (MaHA). Furthermore, nanocomposite DN hydrogels were suitably prepared by physical blending of hydroxyapatite nanoparticles (HAp), obtained by sol-gel synthesis, within the hydrogel. Physico-chemical, thermal, morphological and mechanical analyses were performed. Results showed enhanced mechanical properties and a homogenous microstructure as highlighted by mechanical and morphological investigations. This suggests that nanocomposite DN hydrogels are promising candidates for biomedical applications.

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