scholarly journals Thermomechanical properties of PEGDA and its co-polymers

2018 ◽  
Vol 4 (1) ◽  
pp. 669-672 ◽  
Author(s):  
Natalia Rekowska ◽  
Daniela Arbeiter ◽  
Jan Konasch ◽  
Alexander Riess ◽  
Robert Mau ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tensile Stress ◽  
Drug Application ◽  
Monomer Concentration ◽  
Thermomechanical Analysis ◽  
Biological Properties ◽  
Thermomechanical Properties ◽  
Glycol Diacrylate ◽  
Research Activities ◽  
Poly Ethylene

AbstractCurrent research activities focus on personalized, comfortable and safe products for systemic or local drug application in patients. Poly(ethylene glycol) diacrylate is in particular interest as a drug delivery material, as it shows appropriate biological properties such as hydrophilicity and low toxicity. Additionally, as an easily photopolymerizable compound it can be also utilized for the production of scaffolds with the use of different techniques such as stereolithography. Even though it is often used as a biomaterial or as a copolymer in many photopolymer systems for drug delivery, thermomechanical analysis and basic understanding are rare.Therefore, we investigated the tensile stress and the glass transition temperature of pure PEGDA and of its copolymers with 1,3-butanediol diacrylate or pentaerythritol triacrylate, as a function of the photoinitiator (PI) or acrylate concentration. Additionally, we demonstrated that the washing procedure decreases the tensile stress values. We showed, that by the means of composing PEGDA with these, it is possible to influence thermomechanical properties of the sample. Our outcomes have revealed, that there is no clear influence of the PI concentration on the thermomechanical properties. However there is an influence of the monomer concentration. Therefore, it should be possible to modify drug release profiles in future experiments.

scholarly journals PEGDA drug delivery scaffolds prepared with UV curing process

2020 ◽  
Vol 6 (3) ◽  
pp. 193-195 ◽  
Author(s):  
Natalia Rekowska ◽  
Thomas Eickner ◽  
Niels Grabow ◽  
Michael Teske ◽  
Jan Konasch ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Uv Curing ◽  
Biological Properties ◽  
Glycol Diacrylate ◽  
Novel Approach ◽  
Model Drug ◽  
Poly Ethylene ◽  
Therapeutic Tools ◽  
Uv Curing Process

AbstractIndividually tailored drug delivery systems (DDSs) are considered one of the most promising therapeutic tools for the creation of safe and effective treatments. DDSs as a novel approach should be beneficial in curing systemic as well as local ailments, where a high topical concentration of the drug and a reduction of side effects are desirable. It could also be favorable for patients requiring customized treatments, showing atypical profiles of drug metabolism. Development of particular drug delivery devices require the selection of a suitable scaffold material, which should exhibit proper mechanical and biological properties, but also enable adjustment of the drug release according to a specific need. Thus, it is extremely important to expand the knowledge concerning potential DDS components. Poly(ethylene glycol) diacrylate (PEGDA) according to its properties can be easily used as a DDS resin and shaped into a desired structure with the employment of techniques based on photopolymerization, including some novel 3D printing techniques. As a continuation of our previous works, in this paper drug release studies from conventionally prepared PEGDA scaffolds are presented. We have shown that in PEGDA materials, the release profile of the low molecular weight model drug acetylsalicylic acid can be altered by water content. PEGDA as a delivery material should be further investigated to specify its potential as a comonomer and a matrix for pharmaceutical agents.

scholarly journals In vitro release of chlorhexidine from UV-cured PEGDA drug delivery scaffolds

2021 ◽  
Vol 7 (2) ◽  
pp. 519-522
Author(s):  
Natalia Rekowska ◽  
Alexander Riess ◽  
Robert Mau ◽  
Thomas Eickner ◽  
Hermann Seitz ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vitro Release ◽  
Biological Properties ◽  
Promising Candidate ◽  
Glycol Diacrylate ◽  
Pentaerythritol Triacrylate ◽  
Poly Ethylene ◽  
Vitro Release

Abstract Drug delivery systems (DDS) are suitable for controlled local drug release in order to ensure safety and effectiveness of medical treatment. The choice and characterization of biomaterials that can be used as a DDS is a challenging step in the administration of drugs. Novel 3D printing photopolymerization-based techniques create the possibility for designing individual, patient-tailored DDS. Poly(ethylene glycol) diacrylate`s (PEGDA`s) chemical and biological properties make it a suitable photopolymerisable resin for the creation of DDS. This study describes the in vitro release of the antiseptic drug chlorhexidine (CHX) from UV-cured PEGDA and its copolymers (butanediol diacrylate, pentaerythritol triacrylate and pentaerythritol tetraacrylate) samples. A substantial decrease in CHX release with increasing concentration of the copolymers in comparison to pure PEGDA was obtained only for butanediol diacrylate. For pentaerythritol triacrylate and pentaerythritol tetraacrylate only a tendency of decreased CHX release with increasing concentration was detected. Therefore, release profiles of the low molecular drug CHX from PEGDA samples could be modified by the addition of copolymers with a different number of acrylate groups and PEGDA can be considered as a promising candidate for the preparation of novel DDS.

scholarly journals Novel 3D printing concept for the fabrication of time-controlled drug delivery systems

2018 ◽  
Vol 4 (1) ◽  
pp. 141-144 ◽  
Author(s):  
Jan Konasch ◽  
Alexander Riess ◽  
Michael Teske ◽  
Natalia Rekowska ◽  
Natalia Rekowska ◽  
...  
Keyword(s):  
Drug Delivery ◽  
3D Printing ◽  
Inkjet Printing ◽  
Drug Delivery Systems ◽  
Three Dimensional ◽  
Delivery Systems ◽  
Glycol Diacrylate ◽  
Pharmaceutical Ingredients ◽  
Poly Ethylene ◽  
Novel Concept

AbstractThree-dimensional (3D) printing has become a popular technique in many areas. One emerging field is the use of 3D printing for the development of 3D drug delivery systems (DDS) and drug-loaded medical devices. This article describes a novel concept for the fabrication of timecontrolled drug delivery systems based on stereolithography combined with inkjet printing. An inkjet printhead and an UV-LED light source have been integrated into an existing stereolithography system. Inkjet printing is used to selectively incorporate active pharmaceutical ingredients (API) during a stereolithographic 3D printing process. In an initial experimental study, poly (ethylene glycol) diacrylate (PEGDA) was used as polymer whereas 2-Hydroxy-4´-(2- hydroxyethoxy)-2-methylpropiophenone (Irgacure 2959) and Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) were used as photoinitiators. Basic structures could be manufactured successfully by the new hybrid 3D printing system.

scholarly journals Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery

Nanomaterials ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 195 ◽  
Author(s):  
Catalina Paula Spatarelu ◽  
Anita-Laura (Radu) Chiriac ◽  
Bogdan Cursaru ◽  
Tanta-Verona Iordache ◽  
Ana-Mihaela Gavrila ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Natural Zeolite ◽  
Drug Loading ◽  
Controlled Drug Delivery ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Preparation Conditions ◽  
Transmission Electron ◽  
Poly Ethylene

This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite–nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.

Drug Delivery From Poly(ethylene glycol) Diacrylate Scaffolds Produced by DLC Based Micro-Stereolithography

2014 ◽  
Vol 346 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Mark Vehse ◽  
Svea Petersen ◽  
Katrin Sternberg ◽  
Klaus-Peter Schmitz ◽  
Hermann Seitz
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene

scholarly journals Thermomechanical properties of PEGDA in combination with different photo-curable comonomers

2019 ◽  
Vol 5 (1) ◽  
pp. 319-321
Author(s):  
Natalia Rekowska ◽  
Daniela Arbeiter ◽  
Thomas Eickner ◽  
Niels Grabow ◽  
Michael Teske ◽  
...  
Keyword(s):  
Glass Transition ◽  
Biomedical Application ◽  
Thermomechanical Properties ◽  
Glycol Diacrylate ◽  
Physico Chemical ◽  
3D Geometry ◽  
Pentaerythritol Triacrylate ◽  
Basic Characteristics ◽  
Poly Ethylene

AbstractThe technology of pharmaceutical drug delivery systems (DDS) as an individual and adjustable tool for drug administration has been intensively developed in the last years. Additive manufacturing (AM) techniques, such as stereolithography, are a promising approach towards DDS scaffold manufacturing. Stereolithography, by using layerby- photo-polymerisation, creates DDS scaffolds with highly controlled 3D geometry. Combined with inkjet printing it allows a very precise positioning of the drug depot in the basic scaffold and therefore also a better control of the drug release. Furthermore, this hybrid AM technique also allows for the creation of a multi-drug DDS with a several drug depots localized in desired positions within the scaffold. Determination of the scaffold and drug depot material properties is one of the initial steps for such novel DDS development. Basic characteristics, such as stiffness, elasticity or glass transition temperature (Tg), are important for designing and adapting the material for biomedical application. The photosensitive poly(ethylene glycol) diacrylate (PEGDA) can be easily formed into a desired biocompatible scaffold geometry via stereolithography. In this study we have focused on the evaluation of PEGDA (Mn=700 g/mol) as a pure and copolymer system in combination with other acrylates (butanediol diacrylate, pentaerythritol triacrylate) as possible materials for DDS using this novel hybrid AM technique. Irgacure 2959, a biocompatible photoinitiator (PI), was used as a radical starter for photopolymerisation. Samples varying in PI and coacrylate concentration were prepared by conventional photopolymerisation. Physico-chemical analyses of the samples were performed and several parameters, such as stiffness, elongation at break and glass transition temperatures, were determined.

scholarly journals Poly(ester amide)-Poly(ethylene oxide) Graft Copolymers: Towards Micellar Drug Delivery Vehicles

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Gregory J. Zilinskas ◽  
Abdolrasoul Soleimani ◽  
Elizabeth R. Gillies
Keyword(s):  
Drug Delivery ◽  
Ethylene Oxide ◽  
Graft Copolymers ◽  
Nile Red ◽  
Biological Properties ◽  
Amphiphilic Copolymers ◽  
Drug Molecules ◽  
Poly Ethylene Oxide ◽  
Model Drug ◽  
Poly Ethylene

Micelles formed from amphiphilic copolymers are promising materials for the delivery of drug molecules, potentially leading to enhanced biological properties and efficacy. In this work, new poly(ester amide)-poly(ethylene oxide) (PEA-PEO) graft copolymers were synthesized and their assembly into micelles in aqueous solution was investigated. It was possible to tune the sizes of the micelles by varying the PEO content of the polymers and the method of micelle preparation. Under optimized conditions, it was possible to obtain micelles with diameters less than 100 nm as measured by dynamic light scattering and transmission electron microscopy. These micelles were demonstrated to encapsulate and release a model drug, Nile Red, and were nontoxic to HeLa cells as measured by an MTT assay. Overall, the properties of these micelles suggest that they are promising new materials for drug delivery systems.

scholarly journals Modulating Functionalized Poly(ethylene glycol) Diacrylate Hydrogel Mechanical Properties through Competitive Crosslinking Mechanics for Soft Tissue Applications

Polymers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3000
Author(s):  
Rachel Chapla ◽  
Mera Alhaj Abed ◽  
Jennifer West
Keyword(s):  
Soft Tissue ◽  
Ethylene Glycol ◽  
Soft Tissues ◽  
Monomer Concentration ◽  
Tissue Type ◽  
Poly Ethylene Glycol ◽  
Average Cell ◽  
Glycol Diacrylate ◽  
Average Percentage ◽  
Poly Ethylene

Local mechanical stiffness influences cell behavior, and thus cell culture scaffolds should approximate the stiffness of the tissue type from which the cells are derived. In synthetic hydrogels, this has been difficult to achieve for very soft tissues such as neural. This work presents a method for reducing the stiffness of mechanically and biochemically tunable synthetic poly(ethylene glycol) diacrylate hydrogels to within the soft tissue stiffness regime by altering the organization of the crosslinking sites. A soluble allyl-presenting monomer, which has a higher propensity for chain termination than acrylate monomers, was introduced into the PEG-diacrylate hydrogel precursor solution before crosslinking, resulting in acrylate-allyl competition and a reduction in gel compressive modulus from 5.1 ± 0.48 kPa to 0.32 ± 0.09 kPa. Both allyl monomer concentration and chemical structure were shown to influence the effectiveness of competition and change in stiffness. Fibroblast cells demonstrated a 37% reduction in average cell spread area on the softest hydrogels produced as compared to cells on control hydrogels, while the average percentage of neural cells extending neurites increased by 41% on these hydrogels, demonstrating the potential for this technology to serve as a soft tissue culture system.

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