scholarly journals Workflow and Human-Centered Risk Analysis for Novel Mechatronic Rescue Aids II.

2020 ◽  
Vol 6 (3) ◽  
pp. 616-619
Author(s):  
Sergey Drobinsky ◽  
Mark Verjans ◽  
Philipp Schleer ◽  
Benedikt Kolk ◽  
Henrike Bensiek ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Stair Climbing ◽  
Use Case ◽  
The Novel ◽  
Urban Context ◽  
Patient Transport ◽  
Slowing Down ◽  
Physical Workloads ◽  
High Level ◽  
Intelligent Assistance

AbstractParamedics face rising numbers of deployments every year. As obstacles like stairs occur often, paramedics must frequently manually carry patients and are thereby exposed to loads multitudes higher than recommended. This creates the need for patient transport aids (PTA), which can physically support paramedics in a wide variety of transport situations, without slowing down the transport. In this paper a workflow analysis for transport missions in an urban context and basic tasks for PTAs are presented. Subsequently, the high-level task modelling and human-centered risk analysis according to the HiFEM method are presented for the use case of a patient transport over stairs with a passive PTA, like a rescue chair, and an active PTA like the novel SEBARES prototype. The analysis shows that conventional PTA’s have a simple linear use process, however, impose excessive physical workloads, which cause risks like the paramedic or the PTA falling down the stairs. Contrary, active PTA’s reduce physical workloads, however, introduce additional concurrent steps, like identifying and correcting misalignments, which create further risks. In order to mitigate risks with active, stair climbing PTAs, either new kinematic designs or intelligent assistance functions, like automatic stair detection, are necessary.

scholarly journals Workflow and Human-Centered Risk Analysis for Novel Mechatronic Rescue Aids I.

2020 ◽  
Vol 6 (3) ◽  
pp. 612-615
Author(s):  
Sergey Drobinsky ◽  
Mark Verjans ◽  
Philipp Schleer ◽  
Benedikt Kolk ◽  
Henrike Bensiek ◽  
...  
Keyword(s):  
Risk Analysis ◽  
Stair Climbing ◽  
Use Case ◽  
The Novel ◽  
Urban Context ◽  
Patient Transport ◽  
Slowing Down ◽  
Physical Workloads ◽  
High Level ◽  
Intelligent Assistance

AbstractParamedics face rising numbers of deployments every year. As obstacles like stairs occur often, paramedics must frequently manually carry patients and are thereby exposed to loads multitudes higher than recommended. This creates the need for patient transport aids (PTA), which can physically support paramedics in a wide variety of transport situations, without slowing down the transport. In this paper a workflow analysis for transport missions in an urban context and basic tasks for PTAs are presented. Subsequently, the high-level task modelling and human-centered risk analysis according to the HiFEM method are presented for the use case of a patient transport over stairs with a passive PTA, like a rescue chair, and an active PTA like the novel SEBARES prototype. The analysis shows that conventional PTA’s have a simple linear use process, however, impose excessive physical workloads, which cause risks like the paramedic or the PTA falling down the stairs. Contrary, active PTA’s reduce physical workloads, however, introduce additional concurrent steps, like identifying and correcting misalignments, which create further risks. In order to mitigate risks with active, stair climbing PTAs either new kinematic designs or intelligent assistance functions, like automatic stair detection, are necessary.

scholarly journals FGF16 regulated by miR-520b enhances the cell proliferation of lung cancer

Open Medicine ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. 419-427
Author(s):  
Wenfeng He ◽  
Xia Liu ◽  
Zhijie Luo ◽  
Longmei Li ◽  
Xisheng Fang
Keyword(s):  
Lung Cancer ◽  
Cancer Progression ◽  
Untranslated Region ◽  
Target Gene ◽  
Regulatory Mechanism ◽  
The Novel ◽  
Accelerated Growth ◽  
High Level ◽  
Cancer Tissues ◽  
Great Damage

Abstract FGF16 is implicated in the progression of some specific types of cancers, such as embryonic carcinoma, ovarian cancer, and liver cancer. Yet, the function of FGF16 in the development of lung cancer remains largely unexplored. In this study, we present the novel function of FGF16 and the regulation of miR-520b on FGF16 in lung cancer progression. In clinical lung cancer tissues, FGF16 is overexpressed and its high level is negatively associated with the low level of miR-520b. Furthermore, both the transcription and translation levels of FGF16 are restrained by miR-520b in lung cancer cells. For the regulatory mechanism investigation, miR-520b is able to directly bind to the 3′-untranslated region (3′UTR) of FGF16 mRNA, leading to its mRNA cleavage in the cells. Functionally, miR-520b reduces the growth of lung cancer and its inhibitor anti-miR520b is able to promote the growth through competing endogenous miR-520b. Moreover, FGF16 silence using RNA interference is capable of doing great damage to anti-miR-520b-accelerated growth of lung cancer. Thus, our finding indicates that FGF16 is a new target gene of miR-520b in lung cancer. For lung cancer, FGF16 may serve as a novel biomarker and miR-520b/FGF16 may be useful in clinical treatment.

scholarly journals Novel start codons introduce novel coding sequences in the human genomes

2020 ◽  
Author(s):  
He Zhang ◽  
Yang Xie
Keyword(s):  
Translation Initiation ◽  
Genomic Analysis ◽  
Comparative Genomic ◽  
Human Populations ◽  
The Novel ◽  
Coding Sequences ◽  
Human Genomes ◽  
High Level ◽  
Selection Signal ◽  
Human Specific

AbstractStart-gain mutations can introduce novel start codons and generate novel coding sequences that may affect the function of genes. In this study, we systematically investigated the novel start codons that were either polymorphic or fixed in the human genomes. 829 polymorphic start-gain SNVs were identified in the human populations, and the novel start codons introduced by these SNVs have significantly higher activity in translation initiation. Some of these start-gain SNVs were reported to be associated with phenotypes and diseases in previous studies. By comparative genomic analysis, we found 26 human-specific start codons that were fixed after the divergence between the human and chimpanzee, and high-level translation initiation activity was observed on them. The negative selection signal was detected in the novel coding sequences introduced by these human-specific start codons, indicating the important function of these novel coding sequences. This study reveals start-gain mutations are keeping appearing in the human genomes during the evolution and may be important sources altering the function of genes which may further affect the phenotypes or cause diseases.

scholarly journals Iris Hanika's Treffen Sich Zwei: Reception, Analysis and Interpretation

2021 ◽  
Author(s):  
◽  
Kerry Alistair Nitz
Keyword(s):  
Quantitative Analysis ◽  
Qualitative Approach ◽  
The Other ◽  
The Novel ◽  
Quantitative Evidence ◽  
Literary Context ◽  
Narrative Functions ◽  
The One ◽  
High Level ◽  
The Relationship

<p>Iris Hanika’s commercially and critically successful novel Treffen sich zwei makes use of several techniques in the characterisation of its protagonists. Many of its reviews focus on the author’s deliberate placement of links to a wider literary context. Their interest extends from questions of genre-mixing through to the identification of direct quotes from other authors’ works. The critical preoccupation with intertexts demonstrates their importance for the readers’ response to the novel. More specifically, certain reviews highlight the important role intertexts play in the characterisation of the protagonists. This study catalogues the intertexts, metaphors and parodies in Treffen sich zwei and, by means of quantitative analysis, identifies high-level patterns in the use of these techniques. In particular, patterns are identified between, on the one hand, the different narrative functions of the intertexts and, on the other hand, the different ways in which they are interwoven in the text. The data also shows that distinct patterns are associated with each of the two protagonists and that certain patterns change in the course of the novel in parallel with the changes in the relationship between them. This quantitative evidence is supported by a more detailed, qualitative approach, which examines how specific intertexts or metaphors are used for the purposes of characterisation. In addition, variations in voice are used to distinguish the two main protagonists in a manner consistent with the intertexts and metaphors. It is thanks to the combination of these techniques that the theme of meeting encapsulated in the title, Treffen sich zwei, is woven into the textual fabric of the novel.</p>

scholarly journals Pulmonary Cavitation – An Under-recognized Late Complication of Severe COVID-19 Lung Disease

2020 ◽  
Author(s):  
Zaid Zoumot ◽  
Maria-Fernanda Bonilla ◽  
Ali S. Wahla ◽  
Irfan Shafiq ◽  
Mateen Uzbeck ◽  
...  
Keyword(s):  
Lung Disease ◽  
Medical Records ◽  
Late Complication ◽  
Ground Glass ◽  
The Novel ◽  
Radiological Findings ◽  
Imaging Characteristics ◽  
Microbiological Parameters ◽  
Novel Coronavirus ◽  
High Level

Abstract Background: Pulmonary radiological findings of the novel coronavirus disease 2019 (COVID-19) have been well documented and range from scattered ground-glass infiltrates in milder cases to confluent ground-glass change, dense consolidation, and crazy paving in the critically ill. However, lung cavitation has not been commonly described in these patients. The objective of this study was to assess the incidence of pulmonary cavitation in patients with COVID-19 and describe its characteristics and evolution.Methods: We conducted a retrospective review of all patients admitted to our institution with COVID-19 and reviewed electronic medical records and imaging to identify patients who developed pulmonary cavitation.Results: Twelve out of 689 (1.7%) patients admitted to our institution with COVID-19 developed pulmonary cavitation, comprising 3.3% (n=12/359) of patients who developed COVID-19 pneumonia, and 11% (n=12/110) of those admitted to the intensive care unit. We describe the imaging characteristics of the cavitation and present the clinical, pharmacological, laboratory, and microbiological parameters for these patients. In this cohort six patients have died, two are recovering in hospital and four have been discharged home. Conclusion: Cavitary lung disease in patients with severe COVID-19 disease is not uncommon, and is associated with a high level of morbidity and mortality.

scholarly journals ANALISIS RISIKO KEKERINGAN DI KABUPATEN BANTUL PROVINSI D.I. YOGYAKARTA

2021 ◽  
Vol 18 (2) ◽  
pp. 143
Author(s):  
Annisa Mu'awanah Sukmawati ◽  
Puji Utomo
Keyword(s):  
Risk Analysis ◽  
Rural Areas ◽  
Hazard Analysis ◽  
Drought Risk ◽  
Drought Event ◽  
Quantitative Research Methods ◽  
Risk Areas ◽  
High Level ◽  
The Impact ◽  
Very High

Bantul Regency is a district in Yogyakarta Province which has geographic, geological, hydrological, and demographic characteristics that are likely to cause drought. Drought event in Bantul Regency may have significant impacts on various aspects in line with the characteristics of drought impacts which are complex and cross-sectoral. This study addresses to analyze the level of risk of drought with observation units in 75 villages in the Bantul Regency. The risk analysis was carried out by comparing the time period of the 10 years, i.e. 2008 and 2018 to observe the shift of risk areas of drought in Bantul Regency. The research was conducted using quantitative research methods with quantitative descriptive and mapping analysis. The analysis steps are drought hazard analysis, vulnerability analysis, and drought risk analysis. The analysis shows that during the last 10 years, Kabupaten Bantul has been experiencing an increasing number of villages classified as high risk of drought, both in urban and rural areas. In 2008 there were 15 villages (20%) and increased to 21 villages (28%) in 2018 that were classified as very very high level. Meanwhile, in 2008 there were 30 villages (40%) in 2008 and increased to 32 villages (42.7%) in 2018 that were classified as very high level. It caused by the increasing probability of drought as well as vulnerability. The analysis results can be used as input for stakeholders to take mitigation and anticipation actions to reduce the impact of drought based on the spatial characteristics of the risk areas.

A Hostile World

2014 ◽  
pp. 232-253
Author(s):  
Maresa Bertolo ◽  
Ilaria Mariani
Keyword(s):  
Everyday Life ◽  
Urban Context ◽  
High Level ◽  
Persuasive Game

A Hostile World is a persuasive game designed for an urban context with a high level of multiethnic presence, a recurrent feature of the contemporary megalopolis. Our players are ordinary native citizens who are plunged into an alternative reality where they can realize how complex and demanding it is to deal with gestures and tasks of everyday life in a foreign context, trusting them to live a destabilizing experience that aims to increase the sensitivity, understanding, and empathy towards foreigners, soothing the existing multicultural tensions. The game is a quest-based system; quests recreate situations of everyday-life needs, from shopping to bureaucratic adventures; it's designed to be modular and its sessions may change in the number and quality of quests adapting to different cities, contexts, and targets. The authors identify its effectiveness through the analysis of data collected during and after actual gameplay.

The Automatic Basketball Rebound System

2018 ◽  
Author(s):  
Thomas Smith ◽  
Vidya K. Nandikolla
Keyword(s):  
Inertial Measurement Unit ◽  
High Efficiency ◽  
Dead Reckoning ◽  
Measurement Unit ◽  
System Response ◽  
The Novel ◽  
Rotary Table ◽  
Inertial Measurement ◽  
Correct Orientation ◽  
High Level

In the sport of basketball, it is important to practice shooting the ball to develop the skill of making the shot in the basket at a high efficiency. Making shots at a high efficiency allows the player to succeed at a high level in the sport. The main focus of the paper describes the design and development of an automatic basketball rebound (ABR) system. The developed ABR provides a system that will launch the ball back to the player at any position on the court within a 50-foot radius. This is accomplished by a variable spring loaded launching mechanism that will compress a spring, depending on the players location, to generate the appropriate force required to launch the ball back to the player. The novel launching mechanism developed is mounted to a rotary table that ensures the launching mechanism is in the correct orientation with the player once the ball is launched. The player is outfitted with an inertial measurement unit to track their position using a method known as dead reckoning. This information is relayed back to a microcontroller that determines the system response. The ABR system is made from lightweight materials and is compact such that it is easy to move around compared to its predecessors.

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