scholarly journals Towards an intraoperative feedback system for laparoscopic access with the Veress needle

2021 ◽  
Vol 7 (2) ◽  
pp. 29-32
Author(s):  
Moritz Spiller ◽  
Nazila Esmaeili ◽  
Thomas Sühn ◽  
Axel Boese ◽  
Salmai Turial ◽  
...  
Keyword(s):  
Pediatric Surgery ◽  
Effective Means ◽  
Acoustic Emissions ◽  
Feedback System ◽  
Veress Needle ◽  
Force Measurements ◽  
Tissue Layer ◽  
Non Invasive ◽  
Surgical Access ◽  
Guidance Information

Abstract About 50 % of complications during laparoscopy occur when surgical access is created. The Veress needle and proposed technical alternatives do not provide reliable information to support the surgeons in guiding the needle, or the feedback is not clearly perceivable. Based on acoustic emissions, Surgical Audio Guidance (SURAG) proposes a non-invasive and efficient way to enhance the perception of guidance information through acoustic and visual feedback displayed in real-time. This article demonstrates that the developed feedback matches the information about tissue layer crossings provided by force measurements. This indicates that SURAG can provide an effective means to make laparoscopic access more precise and safe, especially in pediatric surgery, where space for placing the needle is minimal.

scholarly journals Automatic differentiation between Veress needle events in laparoscopic access using proximally attached audio signal characterization

2019 ◽  
Vol 5 (1) ◽  
pp. 369-371 ◽  
Author(s):  
Anna Schaufler ◽  
T. Sühn ◽  
N. Esmaeili ◽  
A. Boese ◽  
C. Wex ◽  
...  
Keyword(s):  
Automatic Differentiation ◽  
Abdominal Cavity ◽  
Three Dimensional ◽  
Acoustic Emissions ◽  
Audio Signal ◽  
Veress Needle ◽  
Tissue Layer ◽  
Mems Microphone ◽  
Feature Subspace ◽  
Feature Dimensionality Reduction

Abstract The access to the abdomen and the creation of a pneumoperitoneum is an initial and particularly critical step of minimally invasive laparoscopic procedures. Insertion instruments such as the Veress needle need to be introduced blindly into the abdominal cavity, which is associated with inadvertent visceral and vascular injuries. To ensure safe positioning of the instrument, information about the entry path advancement of the tip through the abdominal wall is needed. The main objective of this work is to demonstrate the capability to acquire information about intracorporeal tissuetool interactions of the Veress needle tip, utilizing acoustic emissions recorded at the extracorporeal end of the needle. In an experimental setup, a Veress needle was inserted in a multitissue- layer phantom with a defined insertion speed. Acoustic emissions were recorded with a MEMS microphone attached to the extracorporeal end of the needle. In addition, the counteraction forces during insertion of the needle were measured and a video of the experiment was recorded as reference. With this setup, an audio database of characteristical insertion events was generated. For the classification of characteristic audio events and detection of tissue-layer crossing, features were calculated in the time and frequency domain. Subsequently, a feature dimensionality reduction was performed. The distribution clustering of the audio database in the three-dimensional feature subspace allows a distinction between certain characteristic audio events. The preliminary results show the capability of this acoustic emission based method to detect events related to the insertion of a Veress needle, such as tissue-layer crossing.

scholarly journals Hemodynamic forces can be accurately measured in vivo with optical tweezers

2017 ◽  
Author(s):  
Sébastien Harlepp ◽  
Fabrice Thalmann ◽  
Gautier Follain ◽  
Jacky G. Goetz
Keyword(s):  
Optical Tweezers ◽  
Cell Biology ◽  
Accurate Determination ◽  
Force Measurements ◽  
Hemodynamic Forces ◽  
Non Invasive ◽  
Drag Forces ◽  
Measured Flow ◽  
Living Organisms

AbstractForce sensing and generation at the tissular and cellular scale is central to many biological events. There is a growing interest in modern cell biology for methods enabling force measurements in vivo. Optical trapping allows non-invasive probing of pico-Newton forces and thus emerged as a promising mean for assessing biomechanics in vivo. Nevertheless, the main obstacles rely in the accurate determination of the trap stiffness in heterogeneous living organisms, at any position where the trap is used. A proper calibration of the trap stiffness is thus required for performing accurate and reliable force measurements in vivo. Here, we introduce a method that overcomes these difficulties by accurately measuring hemodynamic profiles in order to calibrate the trap stiffness. Doing so, and using numerical methods to assess the accuracy of the experimental data, we measured flow profiles and drag forces imposed to trapped red blood cells of living zebrafish embryos. Using treatments enabling blood flow tuning, we demonstrated that such method is powerful in measuring hemodynamic forces in vivo with accuracy and confidence. Altogether, this study demonstrates the power of optical tweezing in measuring low range hemodynamic forces in vivo and offers an unprecedented tool in both cell and developmental biology.

Measurement Tools for Non-Invasive Monitoring of the Plants Growth Conditions by Using Hyperspectral Imaging Methods: a Review

2021 ◽  
Vol 2 (43) ◽  
pp. 54-61
Author(s):  
Dmitriy A. Burynin ◽  
◽  
Aleksandr A. Smirnov
Keyword(s):  
Hyperspectral Imaging ◽  
Physiological State ◽  
Effective Means ◽  
Research Problem ◽  
High Spectral Resolution ◽  
Research Purpose ◽  
Imaging Method ◽  
Invasive Monitoring ◽  
Imaging Methods ◽  
Non Invasive

Portable spectroradiometers and hyperspectral cameras are increasingly being used to quickly assess the physiological state of plants. The operation of these devices is based on the registration of reflection or reflection and transmission spectra. (Research purpose) The research purpose is in analyzing the technical means and methods of non-invasive monitoring of the plant state based on the registration of the reflection spectra of leaves. (Materials and methods) The article presents a review of the work on the application of hyperspectral imaging methods. Authors classified and analyzed materials on spectroscopic radiometers and hyperspectral cameras, and outlined the prospects for implementation. Authors applied the methods of a systematic approach to the research problem. (Results and discussion) Hyperspectral imaging methods serve as an effective means of monitoring plants. It is possible to determine the pigment composition of plants, lack of nutrition, and detect biotic stress through hyperspectral imaging. The article presents methods of application of portable spectroradiometers and hyperspectral cameras. With the help of these devices it is possible to carry out measurements with high spectral resolution. The difficulty of accurately detecting the content of pigments in the leaves lies in the mutual overlap of the areas of light absorption by them. The main drawback of spectroradiometers is that they measure only at one point on a single sheet. The article presents the difficulties encountered in interpreting the results obtained by the hyperspectral camera. The background reflectivity of the soil, the geometry of the vegetation cover, and the uneven lighting can make errors in the measurements. (Conclusions) The article presents the disadvantages of the hyperspectral imaging method when using only the reflection spectrum. In order to increase the accuracy of the determination of pigments and stresses of various origins, it is necessary to develop a portable device that combines the methods of recording reflection and fluorescence.

scholarly journals Revealing the structure of information flows discriminates similar animal social behaviors

2019 ◽  
Author(s):  
Gabriele Valentini ◽  
Nobuaki Mizumoto ◽  
Stephen C. Pratt ◽  
Theodore P. Pavlic ◽  
Sara Imari Walker
Keyword(s):  
Effective Means ◽  
Communication Protocols ◽  
Coptotermes Formosanus ◽  
Directional Information ◽  
Tandem Running ◽  
Information Theoretic ◽  
Non Invasive ◽  
Types Of Information ◽  
Bidirectional Flow ◽  
Flow Of Information

Behavioral correlations stretching over time are an essential but often neglected aspect of interactions among animals. These correlations pose a challenge to current behavioral-analysis methods that lack effective means to analyze complex series of interactions. Here we show that non-invasive information-theoretic tools can be used to reveal communication protocols that guide complex social interactions by measuring simultaneous flows of different types of information between subjects. We demonstrate this approach by showing that the tandem-running behavior of the ant Temnothorax rugatulus and that of the termites Coptotermes formosanus and Reticulitermes speratus are governed by different communication protocols. Our discovery reconciles the diverse ultimate causes of tandem running across these two taxa with their apparently similar signaling mechanisms. We show that bidirectional flow of information is present only in ants and is consistent with the use of acknowledgement signals to regulate the flow of directional information.

scholarly journals Exploring the Solution of Bionic Prosthesis Lacking Perceptual Feedback System: Using Invasive and Non-invasive Techniques

2021 ◽  
Vol 271 ◽  
pp. 04026
Author(s):  
Xiaohan Hong
Keyword(s):  
Electrical Stimulation ◽  
Human Body ◽  
Feedback System ◽  
Research Direction ◽  
Normal Operation ◽  
Mechanical Prosthesis ◽  
Training Time ◽  
Feedback Information ◽  
Non Invasive

The bionic prosthesis is a more advanced research direction in the prosthesis, but there are still many shortcomings. One of them is the lack of an effective perceptual feedback system, which included the feedback of position, force, texture, roughness, temperature, and other environmental information, as well as the information perception ability of the prosthesis itself[1]. This defect limits the normal operation of the prosthesis and endanger the safety of users. By analyzing the sensory feedback mechanism of the human body, it is found in this paper, the main reason for the lack of an effective perceptual feedback system of the bionic prosthesis is that there is no structure connected with the internal nerves of the human body in the mechanical prosthesis. Therefore, the perceptual signals collected by artificial sensors cannot be transmitted to the cerebral cortex by invasive method, or lack specific in vitro devices to stimulate patients to produce specific perceptual feedback by non-invasive methods. At present, through the use of invasive and non-invasive technology, we have mastered the form of electrical stimulation, vibration stimulation, and other forms of perceptual feedback. Due to the larger amount of feedback information, shorter training time than other methods, non-invasive electrical stimulation feedback has become a promising research area in this field.

scholarly journals Revealing the structure of information flows discriminates similar animal social behaviors

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Gabriele Valentini ◽  
Nobuaki Mizumoto ◽  
Stephen C Pratt ◽  
Theodore P Pavlic ◽  
Sara I Walker
Keyword(s):  
Effective Means ◽  
Communication Protocols ◽  
Coptotermes Formosanus ◽  
Directional Information ◽  
Tandem Running ◽  
Information Theoretic ◽  
Non Invasive ◽  
Types Of Information ◽  
Bidirectional Flow ◽  
Flow Of Information

Behavioral correlations stretching over time are an essential but often neglected aspect of interactions among animals. These correlations pose a challenge to current behavioral-analysis methods that lack effective means to analyze complex series of interactions. Here we show that non-invasive information-theoretic tools can be used to reveal communication protocols that guide complex social interactions by measuring simultaneous flows of different types of information between subjects. We demonstrate this approach by showing that the tandem-running behavior of the ant Temnothorax rugatulus and that of the termites Coptotermes formosanus and Reticulitermes speratus are governed by different communication protocols. Our discovery reconciles the diverse ultimate causes of tandem running across these two taxa with their apparently similar signaling mechanisms. We show that bidirectional flow of information is present only in ants and is consistent with the use of acknowledgement signals to regulate the flow of directional information.

scholarly journals Identification and validation of plasma biomarkers for diagnosis of breast cancer in South Asian women

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Thangarajan Rajkumar ◽  
Sathyanarayanan Amritha ◽  
Veluswami Sridevi ◽  
Gopisetty Gopal ◽  
Kesavan Sabitha ◽  
...  
Keyword(s):  
Breast Cancer ◽  
South Asian ◽  
Effective Means ◽  
Methylation Status ◽  
Asian Women ◽  
Antibody Array ◽  
Diagnostic Efficiency ◽  
South Asian Women ◽  
Protein Markers ◽  
Non Invasive

AbstractBreast cancer is the most common malignancy among women globally. Development of a reliable plasma biomarker panel might serve as a non-invasive and cost-effective means for population-based screening of the disease. Transcriptomic profiling of breast tumour, paired normal and apparently normal tissues, followed by validation of the shortlisted genes using TaqMan® Low density arrays and Quantitative real-time PCR was performed in South Asian women. Fifteen candidate protein markers and 3 candidate epigenetic markers were validated first in primary breast tumours and then in plasma samples of cases [N = 202 invasive, 16 DCIS] and controls [N = 203 healthy, 37 benign] using antibody array and methylation specific PCR. Diagnostic efficiency of single and combined markers was assessed. Combination of 6 protein markers (Adipsin, Leptin, Syndecan-1, Basic fibroblast growth factor, Interleukin 17B and Dickopff-3) resulted in 65% sensitivity and 80% specificity in detecting breast cancer. Multivariate diagnostic analysis of methylation status of SOSTDC1, DACT2, WIF1 showed 100% sensitivity and up to 91% specificity in discriminating BC from benign and controls. Hence, combination of SOSTDC1, DACT2 and WIF1 was effective in differentiating breast cancer [non-invasive and invasive] from benign diseases of the breast and healthy individuals and could help as a complementary diagnostic tool for breast cancer.

scholarly journals An Add-On Device to Perform Dexterous Grasping Tasks With a Haptic Feedback System

2015 ◽  
Author(s):  
Jean-Claude Leon ◽  
Thomas Dupeux ◽  
Jean-Rémy Chardonnet ◽  
Jérôme Perret
Keyword(s):  
Real Time ◽  
Degrees Of Freedom ◽  
Haptic Feedback ◽  
Feedback System ◽  
Short Description ◽  
Finger Movements ◽  
Natural Manner ◽  
New Device ◽  
Non Invasive ◽  
Virtual Hand

Achieving grasping tasks in real time with haptic feedback may require the control of a large number of degrees of freedom (DOFs) to model hand and finger movements. This is mandatory to grasp objects with dexterity. Here, a new device called HaptiHand is proposed that can be added to a haptic feedback arm and provide the user with enough DOFs so that he/she can intuitively and dexterously grasp an object, modify the virtual hand configuration and number of fingers with respect to the object while manipulating the object. Furthermore, this device is non-invasive and enables the user to apply forces on the fingers of the virtual hand. The HaptiHand lies inside the user’s hand so that the user can apply and release pressure on it in a natural manner that is transferred to the virtual hand using metaphors. The focus is placed on the description of the technology and structure of the HaptiHand to justify the choices and explain the behavior of the HaptiHand during object grasping and releasing tasks. This is combined with a short description of the models used.

scholarly journals Disinvasive efficacy of chlorine-based preparations of domestic production for eggs of nematodes of the species Aonchotheca bovis parasitizing in sheep

2018 ◽  
Vol 1 (2) ◽  
pp. 15-18 ◽  
Author(s):  
V. Melnychuk ◽  
I. Yuskiv
Keyword(s):  
Effective Means ◽  
Destructive Effect ◽  
Domestic Production ◽  
Non Invasive ◽  
Invasive Test ◽  
Test Culture ◽  
Nematode Eggs ◽  
Egg Shell ◽  
High Level

The paper presents the results of experimental researches on the determination of the disinvasion efficiency of chlorinated chemical preparations of domestic production of “Brovades-plus”, “Bi-dez” and “Dezsans” of NPF “Brovafarma” (Ukraine). The conducted researches on the basis of the parasitology laboratory found that the studied disinfectants possess disinvasive properties in respect of non-invasive test culture of eggs of nematodes of the species Aonchotheca bovis (son Capillaria bovis) López-Neyra, 1947, isolated from gonads of females of worms. The dissimilar stability of eggs of capillaries to the effect of the tested agents in vitro is proved. The most effective disinfectant in the case of eggs of capillaries of the species A. bovis was the preparation “Dezsan”. The high level of its disinvasive efficacy (DE – 91.14–100.0%) was registered at the application of the preparation in 1.0–2.0% of the exposure concentration for 10–60 minutes. The chemicals “Bi-dez” and “Brovadez-plus” proved to be less effective in the relatively non-invasive test culture of A. bovis eggs. The high level of efficiency (DE –92.41–100.00%) of the “Bi-dez” was achieved with its use at concentrations of 1.5% (exposure of 30 and 60 min) and 2.0% (exposure of 10–60 minutes) The “Brovadez plus” preparation in vitro proved to be the least effective means of non-invasive test culture of nematode eggs of the species A. bovis, since a high level of disinvasive efficacy (DE – 100.00%) was achieved only with the use of 2.0% solution per exposure 10–60 min. It was established that the experimentally tested chlorine-based means of domestic production resulted in the death of eggs in the culture in due to the destructive effect of the components of the preparations on the shell, the caps of eggs of the capillaries, as well as on the germ in the middle of the egg. In experimental cultures treated with the means, the destruction of the shell of the egg in the location of the caps, the exit of morulae outside, the cessation of development or shrinkage of the embryo and deformation of the egg shell were recorded.

scholarly journals Improving prediction of amyloid deposition in Mild Cognitive Impairment with a timed motor task

2021 ◽  
Author(s):  
Sydney Y Schaefer ◽  
Kevin Duff ◽  
Andrew Hooyman ◽  
John M. Hoffman
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Effective Means ◽  
Motor Task ◽  
Positron Emission Tomography Imaging ◽  
Amyloid Deposition ◽  
Non Invasive ◽  
Positron Emission ◽  
Improved Model ◽  
Work Supports

Cortical amyloid deposition is one of the hallmark biomarkers of Alzheimer's disease. However, given how cost- and time-intensive amyloid imaging can be, there is a continued need for a lowcost, non-invasive, and accessible enrichment strategy to pre-screen individuals for their likelihood of amyloid prior to imaging. Previous work supports the use of coordinated limb movement as a potential screening tool, even after controlling for cognitive and daily function. Thirty-six patients diagnosed with amnestic Mild Cognitive Impairment over the age of 65 underwent 18F-Flutemetamol amyloid-positron emission tomography imaging, then completed a timed motor task involving upper limb coordination. This task takes ~5 minutes to administer and score. Multivariate linear regression and Receiver Operator Characteristic analyses showed that including motor task performance improved model prediction of amyloid burden. Results support the rationale for including functional upper extremity motor assessment as a cost- and time-effective means to screen participants for amyloid deposition.

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