„Denn das Falsche kann echt werden“

Author(s):  
Joachim Seng

Abstract : In his autobiographical accounts, Johann Wolfgang Goethe emphasizes the vital role that his father’s collections of books and art had for his own Bildung. In fact, the library of Johann Caspar Goethe (1710–1782) played a vital role in Goethe’s education and early studies while also attesting to his family background and status. However, soon after Johann Caspar’s death, his library was dissolved – and whereas Johann Wolfgang Goethe and other family members integrated some of the books into their own collections, the majority of objects were sold and dispersed. Today, a handwritten catalog commissioned by Goethe’s mother, Catharina Elisabeth Goethe, just before the sale (in 1793/1794), is a critical tool for reconstructing the collection. This article describes the history of Johann Caspar Goethe’s library, its dispersal as well as the efforts to reconstruct the collection. As the retrieval of the original copies from Johann Caspar’s library and the re-establishment of the original collection were impossible, the Freies Deutsches Hochstift has managed to collect equivalent titles and editions in order to restore a library that allows visitors to the Goethe-Haus in Frankfurt to learn about Goethe’s family background, the cultural setting of his upbringing, and early influences on his education.

1968 ◽  
Vol 20 (03/04) ◽  
pp. 534-541 ◽  
Author(s):  
O Egeberg

SummarySevere hemorrhagic disorder due to congenital factor XIII deficiency is described in two unrelated Norwegian girls.Plasma cephalin time was for both patients extraordinarily short during episodes of bleeding and hematomas. No such hyperactivity reaction was demonstrable in unaffected condition some months later.Estimations of blood factor XIII levels revealed a partial defect in the parents of both children, and also in some other family members, consistent with an autosomal incompletely recessive inheritance of the defect. Some of the presumptive heterozygotes had a history of light bleeding phenomenons; whether this was related to their partial lack of factor XIII is so far uncertain.


Author(s):  
Christopher Brooke

This is the first full-scale look at the essential place of Stoicism in the foundations of modern political thought. Spanning the period from Justus Lipsius's Politics in 1589 to Jean-Jacques Rousseau's Emile in 1762, and concentrating on arguments originating from England, France, and the Netherlands, the book considers how political writers of the period engaged with the ideas of the Roman and Greek Stoics that they found in works by Cicero, Seneca, Epictetus, and Marcus Aurelius. The book examines key texts in their historical context, paying special attention to the history of classical scholarship and the historiography of philosophy. The book delves into the persisting tension between Stoicism and the tradition of Augustinian anti-Stoic criticism, which held Stoicism to be a philosophy for the proud who denied their fallen condition. Concentrating on arguments in moral psychology surrounding the foundations of human sociability and self-love, the book details how the engagement with Roman Stoicism shaped early modern political philosophy and offers significant new interpretations of Lipsius and Rousseau together with fresh perspectives on the political thought of Hugo Grotius and Thomas Hobbes. The book shows how the legacy of the Stoics played a vital role in European intellectual life in the early modern era.


2003 ◽  
Vol 1 (1) ◽  
pp. 39-76 ◽  
Author(s):  
Graham Connah ◽  
S.G.H. Daniels

New archaeological research in Borno by the Johann-Wolfgang-Goethe-Universität, Frankfurt am Main, Germany, has included the analysis of pottery excavated from several sites during the 1990s. This important investigation made us search through our old files for a statistical analysis of pottery from the same region, which although completed in 1981 was never published. The material came from approximately one hundred surface collections and seven excavated sites, spread over a wide area, and resulted from fieldwork in the 1960s and 1970s. Although old, the analysis remains relevant because it provides a broad geographical context for the more recent work, as well as a large body of independent data with which the new findings can be compared. It also indicates variations in both time and space that have implications for the human history of the area, hinting at the ongoing potential of broadscale pottery analysis in this part of West Africa and having wider implications of relevance to the study of archaeological pottery elsewhere.


Author(s):  
Steven J. R. Ellis

Tabernae were ubiquitous among all Roman cities, lining the busiest streets and dominating their most crowded intersections, and in numbers not known by any other form of building. That they played a vital role in the operation of the city—indeed in the very definition of urbanization—is a point too often under-appreciated in Roman studies, or at best assumed. The Roman Retail Revolution is a thorough investigation into the social and economic worlds of the Roman shop. With a focus on food and drink outlets, and with a critical analysis of both archaeological material and textual sources, Ellis challenges many of the conventional ideas about the place of retailing in the Roman city. A new framework is forwarded, for example, to understand the motivations behind urban investment in tabernae. Their historical development is also unraveled to identify three major waves—or, revolutions—in the shaping of retail landscapes. Two new bodies of evidence underpin the volume. The first is generated from the University of Cincinnati’s recent archaeological excavations into a Pompeian neighborhood of close to twenty shop-fronts. The second comes from a field survey of the retail landscapes of more than a hundred cities from across the Roman world. The richness of this information, combined with an interdisciplinary approach to the lives of the Roman sub-elite, results in a refreshingly original look at the history of retailing and urbanism in the Roman world.


Oral Diseases ◽  
2021 ◽  
Author(s):  
Lucía Díaz‐Faes ◽  
Ana Soriano‐Lerma ◽  
Antonio Magan‐Fernandez ◽  
María López ◽  
Juan Gijon ◽  
...  
Keyword(s):  

2020 ◽  
Vol 11 (1) ◽  
pp. 120-126
Author(s):  
Pham Ngoc Dong ◽  
Le Xuan Cung ◽  
Tran Khanh Sam ◽  
Do Thi Thuy Hang ◽  
Doug D. Chung ◽  
...  

Meesmann epithelial corneal dystrophy (MECD) is a rare dominantly inherited disorder that is characterized by corneal epithelial microcysts and is associated with mutations in the keratin 3 (KRT3) and keratin 12 (KRT12) genes. In this study, we report a novel mutation in the KRT12 gene in a Vietnamese pedigree with MECD. Slit-lamp examination was performed on each of the 7 recruited members of a Vietnamese family to identify characteristic features of MECD. After informed consent was obtained from each individual, genomic DNA was isolated from saliva samples and screening of KRT3and KRT12 genes was performed by Sanger sequencing. The proband, a 31-year-old man, complained of a 1-year history of eye irritation and photophobia. Slit-lamp examination revealed intraepithelial microcysts involving only the corneal periphery in each eye with clear central corneas and no stromal or endothelial involvement. Three family members demonstrated similar intraepithelial microcysts, but with diffuse involvement, extended from limbus to limbus. Sanger sequencing of KRT3 (exon 7) and KRT12 (exons 1 and 6) in the proband revealed a novel heterozygous KRT12 variant (c.1273G>A [p.Glu425Lys]) that was present in the three affected family members but was absent in the three family members with clear corneas. This study is the first report of a Vietnamese family affected with MECD, associated with an atypical peripheral corneal epithelial phenotype in the proband and a novel mutation in KRT12.


Blood ◽  
2000 ◽  
Vol 96 (3) ◽  
pp. 1191-1193 ◽  
Author(s):  
Takashi Tarumi ◽  
Danko Martincic ◽  
Anne Thomas ◽  
Robert Janco ◽  
Mary Hudson ◽  
...  

Abstract We report on a family with a history of venous thromboembolism associated with fibrinogen Paris V (fibrinogen A-Arg554→Cys). Ten members experienced thrombotic events, including 4 with fatal pulmonary emboli. Pulmonary embolism was the presenting feature in 4. Those with the mutation and a history of thrombosis had somewhat higher fibrinogen concentrations than those with the mutation and no thrombosis (294 ± 70 mg/dL vs 217 ± 37 mg/dL, respectively). The Paris V mutation consistently caused a prolongation of the reptilase time, and fibrin clots containing the abnormal fibrinogen were more translucent than normal clots. Given the early onset of symptoms and the initial presentation with pulmonary embolism in some family members, it was justifiable to offer prophylactic anticoagulation with warfarin to carriers of the mutation. Fibrinogen Paris V has now been reported in 4 apparently unrelated families, indicating that it is a relatively common cause of dysfibrinogenemia-associated thrombosis.


2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Uzair Abbas ◽  
Bushra Imdad ◽  
Sikander Adil Mughal ◽  
Israr Ahmed Baloch ◽  
Afshan Mehboob Khan ◽  
...  

Abstract Objective MicroRNAs are known to regulate 60% of genes at post translational level. MicroRNAs including Micro RNA-29 family play a vital role in cellular activities and have validate role in numerous metabolic disorders inclusive of diabetes mellitus and its complications. While micro RNA profile changes years before the occurrence of disease. This cross-sectional study was conducted in non-diabetic adults of diabetic and non-diabetic parents to explore the early changes in expression of micro RNA-29 family as it can be served as early biomarker of type 2 diabetes in non-diabetic adults. This study was conducted from January 2019 to January 2021. Micro RNA was extracted from plasma of 50 participants and expression was compared through qPCR. While data was analyzed through SPSS version 21.0. Results 29a and 29b had lower expression in participants with family history of DM compared to those having no family history of DM (P < 0.0001). While micro RNA 29c was found to be significantly higher in participants with positive family history of type 2 diabetes as compared to those without family history of diabetes (P = 0.001).


World Affairs ◽  
2021 ◽  
pp. 004382002110247
Author(s):  
James Alexander Foley

This article describes and analyzes the desperate situation of Korean first-generation divided family members who are still separated from their relatives nearly 70 years since the end of the Korean War (1950–1953). I aim to provide the reader with a reasonable quantification of the problem and make projections as to this first generation's likely future survival. The elements of the approach adopted to resolve the issue of family separation by the humanitarian bodies charged with addressing the problem, the Red Cross Societies of the two Koreas are described, and suggestions are made for improvement. The reunion program's successes and failures are critically assessed as is the key role played by the Red Cross Talks in the history of inter-Korean relations. Finally, conclusions are drawn as to the practical measures which may contribute to a resolution to the problem before the final disappearance of Korea's first generation of aged, separated family members.


Author(s):  
Е.В. Косинцева

В истории хантыйской литературы к жанру послания обратился только Матвей Иванович Новьюхов. В данной статье анализу подвергаются послания, вошедшие в книгу М.И. Новьюхова «С надеждой на счастье» (2012). Хантыйским поэтом представлены дружеские, любовные послания и послания-письма родным. Диалогическая природа жанра сильнее всего проявилась в дружеских и любовных посланиях хантыйского стихотворца. Диалог с мансийским поэтом Юваном Шесталовым позволил автору размышлять о месте и роли поэта в обществе. М.И. Новьюхов подчеркивает высокое предназначение поэта в жизни общества, не случайно в одном из посланий к основоположнику мансийской литературы он ставит рядом два понятия «поэт» и «гражданин». Частная жизнь и биографические реалии ярче представлены в любовных посланиях и посланиях-письмах к родным. Послания к членам семьи (брату, дочери) носят характер личной беседы. Образцы любовного послания содержит трогательные признания, адресованные возлюбленной. In the history of Khanty literature, only Matvey Ivanovich Novlukhov addressed to the genre of the epistle. The article analyzes the epistles included in the book of M. I. Novjukhov "With Hope For Happiness" (2012). The Khanty poet presents the friendly, love epistles and letters to relatives. The dialogic nature of the genre was most strongly manifested in the friendly and love epistles. The dialogue with the Mansi poet Yuvan Shestalov allowed the author to reflect on the place and role of a poet in society. Novjukhov emphasizes the high purpose of a poet in the life of society. It is no coincidence that in one of the epistles to the founder of Mansi literature, he puts the two concepts of "poet" and "citizen" side by side. Private life and biographical realities are more vividly represented in love epistles and letters to relatives. The epistles to family members (brother, daughter) are in the nature of a personal conversation. Samples of love epistles contain heartwarming declarations of love addressed to his beloved.


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