Measles seroprevalence of an adolescent population vaccinated with a single dose of measles vaccine before their first birthday

Gamma interferon (IFN-?) plays an important role in the immune response to live measles virus vaccination. To study the immune response to measles vaccination, IFN-? level was estimated in 30 children. Of these, 24 children vaccinated with a single dose of measles vaccine at nine months of age and 06 children vaccinated with a second dose during the Measles Catch-up Immunization campaign. Measles vaccine strain was cultured in Vero cell line and the Tissue Culture Infective Dose (TCID)50 was used as standard live virus. Peripheral blood Mononuclear cells (PBMCs) was separated by Ficoll- Hypaque density gradient centrifugation and stimulated with measles virus antigens and mitogens (lectin), cultured in CO2 and IFN-? level was measured from culture supernatant by ELISA. On stimulation with measles antigen and lectin respectively, IFN-? level was highest (105 pg/ml and 226.54 pg/ml) in the 109-120 months age group while it was lowest (12.97±8.16 pg/ml and 13.16±8.0 pg/ml) in the 61-72 months age group. No significant difference was observed in IFN-? level after stimulation with either measles antigen or lectin among well-nourished (p<0.8) and mal-nourished (p<0.7) children suggesting that nutritional status did not have any effect on IFN-? level. However, IFN-? level was higher in children who received two dose of measles vaccine than those who received a single dose (p<0.001).Bangladesh Med Res Counc Bull 2014; 40 (3): 118-121

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Positive Effect of Single-Dose Measles Vaccination in Reducing the Incidence of Pneumonia in Children with Measles

Journal of Tropical Pediatrics ◽

10.1093/tropej/fmaa085 ◽

2020 ◽

Author(s):

Zafer Bağcı ◽

Yunis Yusuf Daki

Keyword(s):

Single Dose ◽

Length Of Hospital Stay ◽

Vaccination Rate ◽

Hospitalization Rate ◽

High Morbidity ◽

Measles Vaccine ◽

Hospitalization Rates ◽

Training And Research ◽

Measles Vaccination ◽

Positive Effect

Abstract Aim Measles is a worldwide common, highly infectious and vaccine-preventable contagious disease with high morbidity and mortality rates. We investigated the effects of administering single-dose measles vaccination in children with measles on the incidence of pneumonia and hospitalization. Materials and methods We retrospectively analysed the hospital records of children aged 0–18 years who were diagnosed with measles within a year before the study in a training and research hospital in Mogadishu, Somalia. We compared the measles vaccine ratios, hospitalization rates, hospitalization duration and pneumonia development rates. Results We found that 34 (15.6%) patients had received measles vaccination, while 184 (84.4%) did not receive the vaccination. All the vaccinated patients received only a single dose of the vaccine. The proportion of those who had received pneumonia vaccine (14/34, 41.2%) was significantly lower than that of those who had never received a dose of measles containing vaccine (179/184, 97.3%) (p = 0.001). Moreover, patients who were immunized [n = 3 (3.1%)] had a significantly lower hospitalization rate than those who were not immunized [n = 94 (96.9%)] (p = 0.001). Conclusion The risk of pneumonia in children with measles vaccination, rate of hospitalization and length of hospital stay was significantly lower in children who had received even a single dose of the vaccine when compared with that in those who had not vaccinated. The results of this study reiterate the need for more effective global measles vaccination.

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ERRATA

PEDIATRICS ◽

10.1542/peds.76.2.298a ◽

1985 ◽

Vol 76 (2) ◽

pp. 298-298

Keyword(s):

Single Dose ◽

Urinary Tract ◽

Response To Therapy ◽

Female Adolescents ◽

Specific Response ◽

Adolescent Population ◽

Therapeutic Trials ◽

Tract Infections ◽

Current Guidelines ◽

Single Dose Treatment

In the article, "Single-Dose Versus Conventional Therapy of Urinary Tract Infections in Female Adolescents" by Fine and Jacobson (Pediatrics 1985;75:916-920), the last sentence of the first paragraph should read: Although adolescents have been included in the study samples of many therapeutic trials, their age-specific response to therapy has never been isolated, and no current guidelines exist regarding single-dose treatment in the adolescent population.

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Stabilized Measles Vaccine in a Novel Single-Dose Delivery System: A Practical Reality for Worldwide Elimination of Measles

Clinical Infectious Diseases ◽

10.1093/clinids/5.3.511 ◽

1983 ◽

Vol 5 (3) ◽

pp. 511-513

Author(s):

M. R. Hilleman ◽

W. J. McAleer ◽

A. A. McLean ◽

E. B. Buynak ◽

H. Z. Markus

Keyword(s):

Single Dose ◽

Delivery System ◽

Measles Vaccine ◽

Dose Delivery ◽

System A ◽

Practical Reality

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Preclinical Safety and Biodistribution of Sindbis Virus Measles DNA Vaccines Administered as a Single Dose or Followed by Live Attenuated Measles Vaccine in a Heterologous Prime–Boost Regimen

Human Gene Therapy ◽

10.1089/hum.2007.172 ◽

2008 ◽

Vol 19 (5) ◽

pp. 522-531 ◽

Cited By ~ 9

Author(s):

Karina Ramirez ◽

Eileen M. Barry ◽

Jeffrey Ulmer ◽

Richard Stout ◽

James Szabo ◽

...

Keyword(s):

Single Dose ◽

Sindbis Virus ◽

Dna Vaccines ◽

Measles Vaccine ◽

Boost Regimen ◽

Preclinical Safety

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SAFE ADMINISTRATION OF THE MEASLES VACCINE TO CHILDREN ALLERGIC TO EGGS

PEDIATRICS ◽

10.1542/peds.98.2.321b ◽

1996 ◽

Vol 98 (2) ◽

pp. 321-322

Author(s):

Robert A. Wood

Keyword(s):

Single Dose ◽

Measles Vaccine ◽

Mmr Vaccine ◽

History Of

The MMR vaccine can be safely administered in a single dose to children with allergy to eggs, even those with a history of anaphylaxis.

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Immunogenicity of a single dose of reduced-antigen acellular pertussis vaccine in a non-vaccinated adolescent population

Vaccine ◽

10.1016/j.vaccine.2005.11.024 ◽

2006 ◽

Vol 24 (12) ◽

pp. 2043-2048 ◽

Cited By ~ 28

Author(s):

Markus Knuf ◽

Fred Zepp ◽

Claudius Meyer ◽

Edith Grzegowski ◽

Joanne Wolter ◽

...

Keyword(s):

Single Dose ◽

Pertussis Vaccine ◽

Acellular Pertussis Vaccine ◽

Adolescent Population

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The Response of Testes Cells to Low Level, Single dose Helium Particle Irradiation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053929 ◽

1982 ◽

Vol 40 ◽

pp. 252-253

Author(s):

D.E. Philpott ◽

W. Sapp ◽

C. Williams ◽

J. Stevenson ◽

S. Black ◽

...

Keyword(s):

Stem Cell ◽

Single Dose ◽

B Cell ◽

Cell Survival ◽

Spermatogonial Stem Cell ◽

Low Doses ◽

Particle Irradiation ◽

Stem Cell Survival ◽

Irradiation Injury ◽

Radio Sensitivity

Spermatogonial stem-cell survival after irradiation injury has been studied in rodents by histological counts of surviving cells. Many studies, including previous work from our laboratory, show that the spermatogonial population demonstrates a heterogeneous response to irradiation. The spermatogonia increase in radio-sensitivity as differentiation proceeds through the sequence As - Apr - A1 - A2 - A3 - A4 - In - B. The stem (As) cell is the most resistant and the B cell is the most sensitive. The purpose of this work is to investigate the response of spermatogonial cell to low doses (less than 10 0 rads) of helium particle irradiation.

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Gastric Ulcers Produced by Cisplatin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100099337 ◽

1981 ◽

Vol 39 ◽

pp. 582-583

Author(s):

S.K. Aggarwal ◽

J. San Antonio

Keyword(s):

Electron Microscopy ◽

Single Dose ◽

Side Effects ◽

Antitumor Agent ◽

Gastric Ulcers ◽

Enzyme Cytochemistry ◽

Intestinal Toxicity ◽

Ovarian Cancers ◽

Inner Surface

Cisplatin (cis-dichlorodiammineplatinum(II)) a potent antitumor agent is now available for the treatment of testicular and ovarian cancers. It is however, not free from its serious side effects including nephrotoxicity, gastro intestinal toxicity, myelosuppression, and ototoxicity. Here we now report that the drug produces peculiar bloating of the stomach in rats and induces acute ulceration.Wistar-derived rats weighing 200-250 g were administered cisplatin(9 mg/kg) ip as a single dose in 0.15 M NaCl. After 3 days the animals were sacrificed by decapitation. The stomachs were removed, the contents analyzed for pepsin and acidity. The inner surface was examined with a dissecting microscope after a moderate stretching for ulcers. Affected areas were fixed and processed for routine electron microscopy and enzyme cytochemistry.The drug treated animals kept on food and water consistently showed bloating and lesions (Fig. 1) with a frequency of 6-70 ulcers in the rumen section of the stomachs.

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