A mechanism-based pharmacological evaluation of efficacy of Flacourtia indica in management of dyslipidemia and oxidative stress in hyperlipidemic rats

2016 ◽  
Vol 27 (2) ◽  
Author(s):  
Shiv Vardan Singh ◽  
Atul Shrivastava ◽  
Jyotshna ◽  
Upma Chaturvedi ◽  
Subhash Chandra Singh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Plasma Lipid ◽  
Antioxidant Potential ◽  
Lipid Levels ◽  
Pharmacological Evaluation ◽  
Triton Wr 1339 ◽  
Intraperitoneal Dose ◽  
And Oxidative Stress

AbstractHyperlipidemia was induced by a single intraperitoneal dose of Triton WR-1339 in Charles Foster rats. The plasma lipid levels were estimated in control and treated groups. The antioxidant potential ofTheThese finding suggest that

Pharmacological Evaluation of Novel Flavone from Morus alba in Pentylenetetrazole-Induced Kindling and Oxidative Stress

2018 ◽  
Vol 37 (1) ◽  
pp. 43-52 ◽  
Author(s):  
Bin Wang ◽  
Gaurav Gupta ◽  
Mahaveer Singh ◽  
Kasturi Vishwanatha Setty Veerabhadrappa ◽  
Anurag Mishra ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Morus Alba ◽  
Pharmacological Evaluation ◽  
And Oxidative Stress

scholarly journals Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats

2015 ◽  
Vol 8 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Saeed Samarghandian ◽  
Mohsen Azimi-Nezhad ◽  
Mahmoud M. Shabestari ◽  
Farahzad Jabbari Azad ◽  
Tahereh Farkhondeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Chronic Exposure ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Serum Triglycerides ◽  
Stress Indices ◽  
And Oxidative Stress

Abstract Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents. The results of the present study indicated that Cd administration significantly increased the serum levels of TG, TC, LDL-C, MDA and Cd with reduction in the HDL-C and GSH levels. In conclusion, evidence is presented that chronic exposure to low Cd concentration can adversely affect the lipid and lipoprotein profile via lipid peroxidation.

The Effects of Yellow Soybean, Black Soybean, and Sword Bean on Lipid Levels and Oxidative Stress in Ovariectomized Rats

2010 ◽  
Vol 80 (2) ◽  
pp. 97-106 ◽  
Author(s):  
Jae Soon Byun ◽  
Young Sun Han ◽  
Sang Sun Lee
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Women ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Thiobarbituric Acid ◽  
Female Rats ◽  
Ovariectomized Rats ◽  
Lipid Levels ◽  
Black Soybean ◽  
And Oxidative Stress

Soy isoflavones have been reported to decrease the risk of atherosclerosis in postmenopausal women. However, the effects of dietary consumption of soybean have not been explored. In this study, we evaluated the effects of consuming yellow soybeans, black soybeans (Glycine max), or sword beans (Canavalia gladiate) on lipid and oxidative stress levels in an ovariectomized rat model. Forty-seven nine-week-old female rats were ovariectomized, randomly divided into four groups, and fed one of the following diets for 10 weeks: a diet supplemented with casein (NC, n = 12), a diet supplemented with yellow soybean (YS, n = 12), a diet supplemented with black soybean (BS, n = 12), or a diet supplemented with sword bean (SB, n = 11). Plasma triglyceride (TG) levels in the BS and SB groups were significantly lower than that in the NC group. Notably, the BS group had significantly lower plasma total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) levels than the other groups. Hepatic total lipid levels were significantly lower in the YS and SB groups, and cholesterol levels were significantly lower in the SB group than in the NC group. Superoxide dismutase (SOD) and catalase (CAT) activities were significantly higher in the groups fed beans compared to the NC group. Hepatic thiobarbituric acid reactive substances (TBARS) levels were also significantly lower in the BS and SB groups than the NC group. In conclusion, our results suggest that consumption of various types of beans may inhibit oxidative stress in postmenopausal women by increasing antioxidant activity and improving lipid profiles. Notably, intake of black soybean resulted in the greatest improvement in risk factors associated with cardiovascular disease.

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

2014 ◽  
Vol 17 (3) ◽  
pp. 493-499 ◽  
Author(s):  
O. Yilmaz ◽  
M. Korkmaz ◽  
J. J. Jaroszewski ◽  
E. Yazici ◽  
E. Ulutas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Cortisol Level ◽  
Serum Cortisol ◽  
The Other ◽  
Antioxidant Potential ◽  
Blood Samples ◽  
Flunixin Meglumine ◽  
Postoperative Stress ◽  
And Oxidative Stress

Abstract The aim of this study was to compare the effect of flunixin meglumine (FM) and meloxicam (M) on postoperative and oxidative stress in ovariohysterectomized bitches. Twenty four bitches were divided into three groups (n=8 in each) and treated during premedication as follows: FM (2.2 mg/kg, iv, Fluvil, Vilsan, Turkey), M (0.2 mg/kg, sc, Maxicam, Sanovel, Turkey) or 0.9% saline (1 ml, iv, IE, Turkey) - control (C) group. The concentrations of serum cortisol, nitric oxide (NO), malondialdehyde (MDA), antioxidant potential (AOP) and glutation (GSH) were measured in blood samples collected during incision (0 h), closure of incision line (0.5 h) and 1, 2.5, 12 and 24 hours after incision. It was observed that cortisol level was higher at 0.5, 1 and 2.5 h in group C (p < 0.05), 0.5 h in group FM (p < 0.001), and 1 and 2.5 h in group M (p < 0.01), as compared to that determine at 0 h. Group C showed higher cortisol level during 0.5 h (p < 0.05) than that found in the other groups. Group FM displayed lower levels during 1 h (p < 0.01) and 2.5 h (p < 0.05) as compared to those observed in other groups. Concentrations of MDA, AOP and GSH between all the groups did not show any significant differences. MDA level was higher at 0.5 and 1 h in groupM (p < 0.05) than that found in group C and it was the lowest at 2.5 h in group C (p < 0.05). AOP was higher at 2.5 h in group FM and M (p < 0.05) than that observed in group C, and at 12 and 24 h in group M than that found in group C and FM. GSH did not show any significant differences between the groups. NO level in group FM after 12 h was higher (p < 0.05) than that at 0.5, 1 and 24 h. Moreover, NO level was lower at 0.5 (p < 0.01), 1 (p < 0.05) and 24 h (p < 0.05) in group FM than that observed in group C and M. In conclusion, flunixin meglumine decreases cortisol and NO levels more efficiently than meloxicam. Therefore, it is suggested that postoperative stress following ovariohysterectomy may be prevented by flunixin meglumine in bitches.

scholarly journals The Effects of Isoflavone Supplementation Plus Combined Exercise on Lipid Levels, and Inflammatory and Oxidative Stress Markers in Postmenopausal Women

Nutrients ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 424 ◽  
Author(s):  
Jéssica Giolo ◽  
Juliene Costa ◽  
Jair da Cunha-Junior ◽  
Ana Pajuaba ◽  
Ernesto Taketomi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Postmenopausal Women ◽  
Oxidative Stress Markers ◽  
Lipid Levels ◽  
Combined Exercise ◽  
Stress Markers ◽  
And Oxidative Stress

scholarly journals Prenylcysteine oxidase 1, an emerging player in atherosclerosis

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
C. Banfi ◽  
R. Baetta ◽  
S. S. Barbieri ◽  
M. Brioschi ◽  
A. Guarino ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Arterial Wall ◽  
Platelet Adhesion ◽  
Plasma Lipid ◽  
Lipid Levels ◽  
Multiple Functions ◽  
Atherosclerotic Lesions

AbstractThe research into the pathophysiology of atherosclerosis has considerably increased our understanding of the disease complexity, but still many questions remain unanswered, both mechanistically and pharmacologically. Here, we provided evidence that the pro-oxidant enzyme Prenylcysteine Oxidase 1 (PCYOX1), in the human atherosclerotic lesions, is both synthesized locally and transported within the subintimal space by proatherogenic lipoproteins accumulating in the arterial wall during atherogenesis. Further, Pcyox1 deficiency in Apoe-/- mice retards atheroprogression, is associated with decreased features of lesion vulnerability and lower levels of lipid peroxidation, reduces plasma lipid levels and inflammation. PCYOX1 silencing in vitro affects the cellular proteome by influencing multiple functions related to inflammation, oxidative stress, and platelet adhesion. Collectively, these findings identify the pro-oxidant enzyme PCYOX1 as an emerging player in atherogenesis and, therefore, understanding the biology and mechanisms of all functions of this unique enzyme is likely to provide additional therapeutic opportunities in addressing atherosclerosis.

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