scholarly journals Original Article. Sensitization to Aeroallergens in Pediatric Patients with Allergic Rhinitis and Asthma

2016 ◽  
Vol 9 (2) ◽  
pp. 139-144
Author(s):  
Nikolay K. Balgaranov ◽  
Lachezar S. Nikolov ◽  
Nadia I. Kolarova-Yaneva ◽  
Vania N. Nedkova ◽  
Kristina Ts. Tabakova ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pediatric Patients ◽  
Dominant Role ◽  
Allergic Diseases ◽  
Indoor Allergens ◽  
Children With Asthma ◽  
Study Population ◽  
Skin Prick Tests ◽  
Allergen Extracts

Summary Asthma and allergic rhinitis are common in childhood. Establishing sensitization to aeroallergens is crucial to effectively prevent exacerbation of these respiratory allergic diseases. The study aimed to evaluate sensitization to the most common aeroallergens in children with asthma and allergic rhinitis.We establishedacorrelation between patients sensitized to indoor, outdoor and simultaneously to both allergens. The study population consisted of 276 patients (168 boys and 108 girls) ages 4 to 16 years with asthma (A) and allergic rhinitis (AR). Skin prick tests were performed with 21 commercial allergen extracts: pollens, mites, epithelia and insects, and molds. We found that 217 patients were sensitized to at least one aeroallergen: 117 patients hadapositive result to mites, 92 to pollens, 72 to epithelia and insects, and 63 - to mold allergens. Dermatophagoides pteronyssinus was the most prevalent aeroallergen. Sensitized only to indoor allergens were 104 patients, 60 - only to outdoor allergens, and 53 were sensitized to both. Mites were the most frequent aeroallergens in children with Aand AR. Lately there has been foundasignificant increase in rates of sensitization to mold allergens, especially to Alternaria alternata. Our study has confirmed the dominant role of indoor allergens in children with respiratory allergic diseases.

scholarly journals Does aeroallergen sensitivity and allergic rhinitis in children cause milder COVID-19 infection?

2021 ◽  
Vol 42 (6) ◽  
pp. 522-529 ◽  
Author(s):  
Emine Vezir ◽  
Mina Hizal ◽  
Burcu Cura Yayla ◽  
Kubra Aykac ◽  
Arzu Yilmaz ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pediatric Patients ◽  
Immunoglobulin E ◽  
Allergic Diseases ◽  
Clinical Severity ◽  
Patients Âgés ◽  
Skin Prick Tests ◽  
Novel Coronavirus ◽  
The Impact ◽  
The Relationship

Background: There are conflicting data with regard to the impact of respiratory and allergic comorbidities on the course of novel coronavirus disease 2019 (COVID-19) in children. Objective: This study aimed to investigate the relationship between allergic diseases and COVID-19 severity in pediatric patients. Methods: Seventy-five pediatric patients with COVID-19 were classified according to clinical severity and evaluated in the allergy/immunology and pulmonology departments 1 to 3 months after the infection resolved. Blood was collected from the patients for a complete blood cell count and assessment of immunoglobulin and total immunoglobulin E (IgE) levels, and skin-prick tests and spirometry tests were performed. Results: A total of 75 patients ages 5‐18 years were evaluated. COVID-19 was asymptomatic/mild in 44 patients and moderate/severe/critical in 31 patients. Based on allergy evaluation, allergic rhinitis was diagnosed in 19 patients (25.3%), asthma in 10 patients (13%), and atopic dermatitis in 3 patients (4%). Aeroallergen sensitivity was detected in 26 patients (34.7%). COVID-19 infection was asymptomatic/mild in 15 patients with allergic rhinitis (78.9%) and in 21 with aeroallergen sensitivity (80.8%) (p = 0.038 and p = 0.005, respectively). There was no difference in severity between the patients with and without asthma (p = 0.550). The median (interquartile range) total IgE level was significantly higher in the asymptomatic/mild group (71.8 [30.7‐211.2]) (p = 0.015). There were no differences in terms of spirometry parameters. Conclusion: Aeroallergen sensitization and allergic rhinitis in children may be associated with a milder course of COVID-19. The knowledge that atopy is associated with less-severe COVID-19 outcomes in children may guide clinical risk classification.

scholarly journals Role of innate lymphoid cells in allergic diseases

2019 ◽  
Vol 40 (3) ◽  
pp. 138-145 ◽  
Author(s):  
M. Asghar Pasha ◽  
Gargi Patel ◽  
Russell Hopp ◽  
Qi Yang
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Innate Lymphoid Cells ◽  
Lymphoid Cells ◽  
Food Allergies ◽  
Antigen Receptors ◽  
Medline Search ◽  
Allergic Disorders

Background: Over the past decade, there has been increasing interest and research into understanding the type 2 immune responses by the epithelium-derived cytokines interleukin (IL) 33, IL-25, and thymic stromal lymphopoietin. Innate lymphoid cells (ILC) are a unique family of effector immune cells that functionally resemble T cells but lack clonal distributed antigen receptors. Group 2 ILCs, ILC2s, are known for their capability to secrete proallergic cytokines, including IL-5 and IL-13. ILC2s are enriched at mucosal barriers in lung, gut, and skin, and their activation has been associated with a variety of allergic disorders. Objective: To study the role of ILC2 in different allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Methods: A MEDLINE search was performed for articles that reported on ILC2 in allergic disorders, including allergic rhinitis, asthma, atopic dermatitis, and food allergies. Results: A review of the literature revealed an important role of ILC2 in various allergic disorders. Conclusion: Identification of ILC2s in patients with allergic rhinitis, asthma, and atopic dermatitis indicates that these cells may represent a new therapeutic target. In this review, we discussed the current understanding of ILC2 biology and its function and regulation in various allergic diseases.

scholarly journals The Role of Interleukin-37 in the Pathogenesis of Allergic Diseases

Acta Naturae ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 54-64
Author(s):  
I. P. Shilovskiy ◽  
M. E. Dyneva ◽  
O. M. Kurbacheva ◽  
D. A. Kudlay ◽  
M. R. Khaitov
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Bronchial Asthma ◽  
Interleukin 1 ◽  
Allergic Diseases ◽  
Biological Properties ◽  
Negative Regulator ◽  
Cellular Mechanisms ◽  
Wide Range

Cytokines of the interleukin-1 (IL-1) family play an important role in the realization of the protective functions of innate immunity and are the key mediators involved in the pathogenesis of a wide range of diseases, including various manifestations of allergy. The IL-1 family includes more than 11 members. However, the functions of many of them remain to be elucidated. Recently, new members of the IL-1 family have been discovered. In 2000, several independent research groups reported the discovery of a new interleukin of this family, which was named IL-37, or IL-1F7 (according to the new nomenclature). IL-37 was assigned to the IL-1 family based on its structural similarity with other members of this family. The study of its biological properties showed that its activity changes in inflammatory diseases, such as rheumatoid arthritis, psoriasis, as well as allergic diseases (allergic rhinitis, bronchial asthma, and atopic dermatitis). However, unlike most members of the IL-1 family, IL-37 acts as a negative regulator of inflammation. Activation of IL-37 suppresses inflammation, resulting in the suppression of inflammatory cytokines and chemokines, which in turn prevents infiltration of pro-inflammatory cells, mainly eosinophils and neutrophils. The exact molecular and cellular mechanisms of the anti-inflammatory effect of IL-37 in the development of allergic diseases (AD) have not been fully studied. This review summarizes and analyzes the accumulated experimental data on the role of IL-37 in the pathogenesis of AD, such as allergic rhinitis, bronchial asthma, and atopic dermatitis.

scholarly journals Research on the improvement of allergic rhinitis in asthmatic children after reducing dust mite exposure: a randomized, double-blind, cross-placebo study protocol

2020 ◽  
Author(s):  
Ming Chen ◽  
YuFen Wu ◽  
Shuhua Yuan ◽  
Jiande Chen ◽  
Luanluan Li ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Allergic Diseases ◽  
House Dust Mites ◽  
Life Questionnaire ◽  
Dust Mites ◽  
Double Blind ◽  
Asthma Control Questionnaire ◽  
Asthmatic Children ◽  
Dust Mite ◽  
Children With Asthma

Abstract Background: Allergic rhinitis (AR) in children has become a major respiratory inflammatory disease with a high incidence that is increasing yearly. In China, 54.93% of children with asthma have AR, which often requires synchronous treatment. House dust mites (HDMs) are common allergens that often cause attacks of AR and asthma. Reducing allergen exposure is one of the most important measures to control and treat AR and asthma attacks. Hestelia Mite Bait, containing 0.1% emamectin, is a new tool for trapping and killing dust mites that can reduce the number of dust mites on mattresses, thereby may reduce stimulation by allergens and ultimately improve asthma and rhinitis symptoms. This single-centre, randomized double-blind cross-placebo trial will explore the improvement of allergic rhinitis in asthmatic children after reducing dust mite exposure.Methods: We will recruit 60 children (aged 3-12 years) who have been diagnosed with allergic rhinitis and asthma and are allergic to dust mites as confirmed by a serum allergen test. Participants will randomly receive the Hestelia Mite Bait intervention for 8 weeks and the placebo intervention for 8 weeks. There will be a 4-week washout period between the two interventions. The primary outcome is the v isual analogue scale (VAS) score of AR symptoms; the secondary outcomes include the Rhinitis Control Assessment Test (RCAT) score, Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) score , changes in the dust mite level, drug usage for asthma and AR , Asthma Control Questionnaire-5 (ACQ-5) score, frequency of acute asthma attacks and emergency visits, and frequency of hospitalization.Discussion: This study will scientifically and objectively evaluate the improvement effect on rhinitis and asthma after reducing dust mite exposure and provide a convenient means for the prevention and treatment of children's airway allergic diseases in the future.Trial registration : ChiCTR1900024688 (www.chictr.org.cn) registration date: July 21, 2019

scholarly journals The Role of Allergens in Atopic Dermatitis

2020 ◽  
Author(s):  
Suna Asilsoy ◽  
Serdar Al
Keyword(s):  
Allergic Rhinitis ◽  
Atopic Dermatitis ◽  
Allergic Diseases ◽  
Skin Lesions ◽  
Atopic Diseases ◽  
Chronic Skin ◽  
Genetic And Environmental Factors ◽  
Inhalant Allergens ◽  
Chronic Skin Disease

Atopic dermatitis (AD) is a chronic skin disease caused by genetic and environmental factors. Often it begins in early childhood. It is located at the first step of the process we refer to as atopic march. This feature is a precursor of the development of other allergic diseases such as asthma and allergic rhinitis. Especially in patients with atopy of food and inhalant allergens, the occurrence of other atopic diseases is more common. Although the role of these sensitivities in AD is controversial, it has been determined that some patients may trigger eczematous skin lesions. In this report, the role of allergens in atopic dermatitis are reviewed in the light of current literature.

scholarly journals Childhood CCL18, CXCL10 and CXCL11 levels differentially relate to and predict allergy development

2021 ◽  
Author(s):  
Johanna Huoman ◽  
Sadia Haider ◽  
Angela Simpson ◽  
Clare Murray ◽  
Adnan Custovic ◽  
...  
Keyword(s):  
Immune Cell ◽  
Allergic Diseases ◽  
Population Based ◽  
Longitudinal Models ◽  
Cross Sectional ◽  
Association Analyses ◽  
Allergic Sensitisation ◽  
Children With Asthma ◽  
Longitudinal Association ◽  
Study Population

Background: Chemokines are important mediators in immune cell recruitment, contributing to allergy development. However, extensive studies of chemokines in the circulation in relation to the presence and development of allergic diseases remain scarce. Our aim was to investigate associations of circulating allergy-related chemokines with development of asthma and sensitisation cross-sectionally and longitudinally in a population-based cohort. Methods: The chemokines CCL17, CCL22, CXCL10, CXCL11 and CCL18 were measured in plasma samples from children in the Manchester Asthma and Allergy Study. Samples were available from cord blood at birth (n=376), age 1 (n=195) and 8 years (n=334). Cross-sectional and longitudinal association analyses were performed in relation to asthma and allergic sensitisation, as well as allergic phenotype clusters previously derived using machine learning in the same study population. Results: In children with asthma and/or allergic sensitisation, CCL18 levels were consistently elevated at ages 1 and/or 8 years. In a longitudinal model including information on asthma from 4 time-points (ages 5, 8, 11 and 16 years), we observed a significant association between increasing CCL18 levels at age 1 and a higher risk of asthma from early school age to adolescence (OR=2.9, 95% CI 1.1-7.6, p=0.028). We observed similar associations in longitudinal models for allergic sensitisation. Asthma later in life was preceded by increased CXCL10 levels after birth, and decreased CXCL11 levels at birth. Conclusion: Elevated CCL18 levels throughout childhood precede the development of asthma and allergic sensitisation. The Th1-associated chemokines CXCL10 and CXCL11 also associated with development of both outcomes, with differential temporal effects.

Role of BAFF in pediatric patients with allergic rhinitis during sublingual immunotherapy

2014 ◽  
Vol 173 (8) ◽  
pp. 1033-1040 ◽  
Author(s):  
Renzhong Luo ◽  
Wenlong Liu ◽  
Jie Wang ◽  
Yanqiu Chen ◽  
Changzhi Sun ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Pediatric Patients ◽  
Sublingual Immunotherapy

scholarly journals Prevention and Management with Pro-, Pre and Synbiotics in Children with Asthma and Allergic Rhinitis: A Narrative Review

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 934
Author(s):  
Lien Meirlaen ◽  
Elvira Ingrid Levy ◽  
Yvan Vandenplas
Keyword(s):  
Allergic Rhinitis ◽  
Genetic Background ◽  
Animal Studies ◽  
Allergic Diseases ◽  
Confounding Factors ◽  
Substantial Evidence ◽  
Children With Asthma ◽  
Probiotic Strains ◽  
Asthma Outcomes ◽  
English Articles

Allergic diseases including allergic rhinitis and asthma are increasing in the developing world, related to a westernizing lifestyle, while the prevalence is stable and decreasing in the industrialized world. This paper aims to answer the question if prevention and/or treatment of allergic rhinitis and asthma can be achieved by administrating pro-, pre- and/or synbiotics that might contribute to stabilizing the disturbed microbiome that influences the immune system through the gut–lung axis. We searched for relevant English articles in PubMed and Google Scholar. Articles interesting for the topic were selected using subject heading and key words. Interesting references in included articles were also considered. While there is substantial evidence from animal studies in well controlled conditions that selected probiotic strains may offer benefits in the prevention of wheezing and asthma, outcomes from clinical studies in infants (including as well pre- and postnatal administration) are disappointing. The latter may be related to the multiple confounding factors such as environment, strain selection and dosage, moment of administration and genetic background. There is little evidence to recommend administration of pro, pre- or synbiotics in the prevention of asthma and allergic rhinitis in children.

scholarly journals Association between allergic rhinitis and sino-nasal polyposis

1970 ◽  
Vol 17 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Mohammad Shah Kamal ◽  
Khabir Uddin Ahmed ◽  
Parvez Humayun ◽  
Taufiq Atiq ◽  
Anwar Hossain ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Polyposis ◽  
Prospective Trial ◽  
Male Predominance ◽  
The People ◽  
Respiratory Allergies ◽  
Relevant Role ◽  
Skin Prick Tests ◽  
Airborne Allergens

Objective: To investigate the role of allergy in nasal polyposis. Methods: 60 patients of nasal polyposis were selected randomly in a multicentric prospective trial from July 2006 to July 2008. Data were collected from the patient by personal interview, clinical examination and laboratory tests in a prescribed protocol. Socio-demographic character and presentation of the samples were studied and according to the symptoms of allergy those were submitted to skin pick test with a large series of seasonal and perennial airborne allergens. Results were presented in a tabulated form. Results: The incidence of nasal polyposis was highest among the people of 5th decade (40%) with male predominance (53.33%). The majority of the patients came from rural area (76.67%) and most of them were farmer (50%) and came from relatively poor class (73.33%). All the patients presented with significant nasal obstruction (100%). Next common presentations were running nose 90%, headache 80%, sneezing 70% and nasal itching 40%. Severity of symptoms increased with the exposure of national allergens (20%), food allergens (30%) and drugs (3.33%). 10% of patients were suffering from bronchial asthma. 20% patients with nasal polyposis were positive on Skin prick tests(SPT) with airborne allergens. A review of the clinical histories of SPT-positive patients revealed the presence of obstructive rhinitis and chronic rhinorrhea in most cases, whereas acute symptoms, such as sneezing and itching, were reported by a minority of subjects. Conclusion: Clinically evident respiratory allergies, particularly to perennial airborne allergens, play a relevant role in the pathogenesis of nasal polyposis. Key words: Allergic rhinitis; nasal polyposis. DOI: http://dx.doi.org/10.3329/bjo.v17i2.8851 BJO 2011; 17(2): 117-120

scholarly journals Prevalence and comorbidity of asthma, allergic rhinitis and eczema among school children in Republic of Srpska: A cross-sectional study

2017 ◽  
Vol 145 (1-2) ◽  
pp. 9-13 ◽  
Author(s):  
Sanela Domuz ◽  
Adrijana Domuz ◽  
Slobodanka Petrovic
Keyword(s):  
Allergic Rhinitis ◽  
Primary Schools ◽  
Allergic Diseases ◽  
Cross Sectional Study ◽  
World Health ◽  
Sectional Study ◽  
Cross Sectional ◽  
Therapeutic Concept ◽  
Children With Asthma ◽  
The Republic

Introduction/Objective. The incidence of comorbidity of asthma and allergic rhinitis was one of the reasons for changing guidelines for the treatment of asthma and allergic rhinitis. The World Health Organization and Allergic Rhinitis and its Impact on Asthma group proposed the new diagnostic and therapeutic concept ??one airway, one disease.? Further, the presence of allergic rhinitis in children with asthma contributes significantly to low control of asthma; also, the treatment of allergic rhinitis in children with asthma has positive effects in terms of reducing the severity of asthma symptoms. The aim of this study was to determine the prevalence of allergic diseases among children in the Republic of Srpska, as well as to determine whether allergic rhinitis and eczema are more common in children with asthma. Methods. Our study was conducted as a cross-sectional study and included 3,000 children aged six to 15 years from 13 primary schools in the Republic of Srpska. The final data processing included 1,975 correctly completed questionnaires. Results. The prevalence of wheezing in the previous 12 months was 7.9%, of allergic rhinitis 12.7%, and of eczema 5%. Asthma was diagnosed by a doctor in 3.5% of the children, allergic rhinitis in 19.2%, and eczema was diagnosed in 14.5% of the children. Conclusion. Children with asthma had statistically significant higher prevalence of other alergic diseases compared to general population. Also, children with mild asthma had statistically significant risk to be undiagnosed. Undiagnosed asthma in comorbidity with other allergic diseases leads to poor asthma control in children.

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