Relationship between insulin-like growth factor-1, insulin resistance and metabolic profile with pre-obesity and obesity in children

2021 ◽  
Vol 34 (3) ◽  
pp. 301-309 ◽  
Author(s):  
Marina Jaksic ◽  
Milica Martinovic ◽  
Najdana Gligorovic-Barhanovic ◽  
Tanja Antunovic ◽  
Mirjana Nedovic-Vukovic
Keyword(s):  
Insulin Resistance ◽  
Growth Factor ◽  
Nutritional Status ◽  
Metabolic Profile ◽  
Density Lipoprotein ◽  
Obese Group ◽  
Lipoprotein Cholesterol ◽  
Insulin Like Growth Factor ◽  
Total Body ◽  
The Relationship

Abstract Objectives Childhood obesity is a serious medical condition with alarmingly high rates worldwide. There is controversy regarding the relationship between insulin-like growth factor-1 (IGF-1) and pediatric obesity. We investigated the relationship between IGF-1, insulin resistance and metabolic profile with childhood pre-obesity/obesity. Methods The study involved 201 children aged 7–15 years, divided in three groups according to their nutritional status (International Obesity Task Force criteria): normal-weight (n=84), pre-obese (n=82), obese (n=35). Laboratory IGF-1, insulin, fasting blood glucose (FBG), lipid profile, alanine-aminotransferase (ALT), uric acid (UA), anthropometric and body composition parameters were analyzed. Body mass index and IGF-1 standard deviation score (SDS), waist-to-height ratio (WtHR) and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) score were calculated. Results Pre-obese/obese children had significantly higher IGF-1 SDS, FBG, insulin, HOMA-IR, UA, ALT, triglycerides, and lower high-density lipoprotein cholesterol (HDL-c); obese group had higher WtHR and low-density lipoprotein cholesterol (LDL-c) compared to controls (p<0.05). In obese group, IGF-1 SDS was positively correlated with fat free/muscle mass, total body water (p<0.05) and negatively correlated with LDL-c (p<0.05). In pre-obese/obese HOMA-IR and insulin were positively correlated with age, total body fat (TBF) (p<0.05) and negatively correlated with HDL-c (pre-obese) (p<0.05). Multivariate ordinal logistic regression analyses showed that IGF-1 SDS (OR=1.94; 95%CI: 1.21–3.11), TBF (OR=1.37; 95%CI: 1.21–1.54) were predictors of nutritional status (p<0.001). FBG (OR=42.39; 95%CI: 2.31–77.2) and UA (OR=1.03; 95%CI: 1.01–1.05) were predictors of IR (p<0.001). Conclusions IGF-1 SDS and TBF were predictors of nutritional status. Further studies are required to clarify the role of IGF-1 in pathophysiology of obesity and its comorbidities.

scholarly journals The Correlation between Vitamin D and Clinical Implications for Obesity-Related Type 2 Diabetes Mellitus

2020 ◽  
Vol 14 (1) ◽  
pp. 39-45
Author(s):  
Noor Thair Tahir ◽  
Hind SH. Ahmed ◽  
Rasha K. Hashim ◽  
Teba D. Soluiman
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Density Lipoprotein ◽  
Obese Group ◽  
Lipoprotein Cholesterol ◽  
Diabetic Patients ◽  
Clinical Implications ◽  
Vitamin D Levels

Background: Obesity and type 2 diabetes have both rapidly raised during the last periods and are ongoing to increase at a disturbing rate universal. Several clinical and epidemiological researches demonstrated a reverse association between circulating vitamin D levels, central adiposity and the progress of insulin resistance and diabetes. Objective: The target of this work was to elucidate the complex role of vitamin D and the clinical implications of diabetes on metabolic defects related with obesity. Subjects and Methods: This study encompassed 90 diabetic patients (45 obese and 45 non obese) who were attending the National Diabetic Center/ Al-Mustansiriyah University during the period from June 2019 to January 2020; their age range was (35-60) years. All participant underwent clinical and biochemical examinations. Results: A substantial rise (p= 0.01) in waist/hip ratio, body mass index, fasting serum glucose, total cholesterol, triacylglycerol, and low density lipoprotein cholesterol in obese diabetic patients as paralleled to non-obese group. Moreover, there was an elevation in glycated hemoglobin, serum insulin, and homeostasis model assessment for insulin resistance in obese group, but it was not significant. A substantial decrease (p= 0.01) in serum high density lipoprotein cholesterol and vitamin D3 were detected in obese diabetic patients as paralleled to non-obese group.       Also, obese diabetic patients had the higher percent (61%) of D3 deficiency as paralleled to non-obese patients. Conclusions: In the present study, it is found that there is significant increase in blood sugar in the individuals with decreased vitamin D levels, which was related with insulin resistance, decreased β-cell function, and obesity.  

scholarly journals Association Between Insulin-like Growth Factor 1 and Insulin Resistance in Obese Prepubertal Boys: A Cross-sectional Study

2020 ◽  
Author(s):  
Jiangying Kuang ◽  
Li Zhang ◽  
Yueqin Xu ◽  
Jiang Xue ◽  
Shuang Liang
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Growth Factor ◽  
Cardiovascular Risk Factors ◽  
Whole Body ◽  
Sensitivity Index ◽  
Insulin Like Growth Factor ◽  
Prepubertal Boys ◽  
The Relationship

Abstract Background: As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1(IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversy with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys.Methods: We used whole body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in this study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants.Results: Among obese boys, the group of children with WBISI ≤1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than WBISI >1.285 group. The results of multivariate stepwise regression analysis show that WBISI was positively correlated with IGF-1 SDS (β =1.726, p = 0.002) after adjusting for traditional cardiovascular risk factors.Conclusion: IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers.

scholarly journals Association between insulin-like growth factor 1 and insulin resistance in obese prepubertal boys:a cross-sectional study

2020 ◽  
Author(s):  
Jiangying Kuang ◽  
Li Zhang ◽  
Yueqin Xu ◽  
Jiang Xue ◽  
Shuang Liang
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Growth Factor ◽  
Cardiovascular Risk Factors ◽  
Whole Body ◽  
Sensitivity Index ◽  
Insulin Like Growth Factor ◽  
Prepubertal Boys ◽  
The Relationship

Abstract Background As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1(IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversy with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys.Methods We used whole body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in this study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants.Results Among obese boys, the group of children with WBISI ≤ 1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than WBISI > 1.285 group. The results of multivariate stepwise regression analysis show that WBISI was positively correlated with IGF-1 SDS (β = 1.726, p = 0.002) after adjusting for traditional cardiovascular risk factors.Conclusion IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers.

scholarly journals Pediatric Loss-of-Control Eating and Anxiety in Relation to Components of Metabolic Syndrome

2018 ◽  
Vol 44 (2) ◽  
pp. 220-228 ◽  
Author(s):  
Meghan E Byrne ◽  
Marian Tanofsky-Kraff ◽  
Nichole R Kelly ◽  
Anne Claire Grammer ◽  
Manuela Jaramillo ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Treatment Seeking ◽  
Loss Of Control ◽  
Convenience Sample ◽  
Air Displacement Plethysmography ◽  
The Relationship

Abstract Objective Pediatric loss-of-control (LOC) eating is associated with, and predictive of, gains in adiposity and adverse metabolic outcomes. In addition, some preliminary data suggest that anxiety may exacerbate the relationship of LOC eating with weight and metabolic syndrome (MetS)-related measures. We therefore examined whether anxiety moderated the relationship between LOC eating and body mass index z (BMIz), adiposity, and MetS-related measures in youth. Methods A convenience sample of non-treatment-seeking boys and girls of varying weight strata were interviewed to determine the presence of LOC eating and completed a questionnaire assessing trait anxiety. BMIz and MetS-related measures (blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, glucose, and insulin) were measured after an overnight fast. Adiposity was assessed by air displacement plethysmography or dual-energy x-ray absorptiometry. Analyses adjusted for age, sex, race, height, fat mass, and depressive symptoms, as appropriate. Results In all, 379 youths (13.0 ± 2.8 years; 53% female; BMIz = 0.8 ± 1.1; 22% with LOC eating) were studied. Anxiety was not significantly related to BMIz, adiposity, or MetS-related measures. However, anxiety and LOC eating interacted such that only among youth with LOC eating, anxiety was positively associated with fasting insulin (p = .02) and insulin resistance (p = .01). The interaction of anxiety and LOC eating was not significantly related to BMIz, adiposity, or any other MetS-related measure (ps = ns). Conclusions Only among non-treatment-seeking youth with LOC eating, anxiety may be associated with increased insulin secretion and insulin resistance. Longitudinal studies are required to confirm these findings and explore mechanisms for these relationships.

Relationship between insulin-like growth factor-I and low-density lipoprotein cholesterol levels in primary hypothyroidism in women

1989 ◽  
Vol 123 (2) ◽  
pp. 341-345 ◽  
Author(s):  
N. Hoogerbrugge–v.d.Linden ◽  
H. Jansen ◽  
W. C. Hülsmann ◽  
J. C. Birkenhäger
Keyword(s):  
Growth Factor ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Primary Hypothyroidism ◽  
Lipoprotein Cholesterol ◽  
Low Density ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I

ABSTRACT The effect of insulin-like growth factor-I (IGF-I) on the disturbance of lipid metabolism during primary hypothyroidism was studied in 12 women with primary hypothyroidism. Significant increases in both low-density lipoprotein (LDL) cholesterol and intermediate-density lipoprotein cholesterol were seen. Lipoprotein concentrations reverted to normal after substitution with thyroxine (T4) until the euthyroid state was reached. A decrease in IGF-I of 65% (P<0·005) was seen in hypothyroid patients and this was inversely correlated (r=−0·75; P<0·01) with the concentration of LDL cholesterol. Multivariate regression analysis of LDL cholesterol against IGF-I and free T4 showed that IGF-I determines the concentration of LDL cholesterol instead of free T4. Our data suggest that in hypothyroidism, IGF-I is a determinant of the concentration of LDL cholesterol. In addition, hypothyroidism can influence plasma lipoprotein metabolism by lowering the activity of the salt-resistant lipase (liver lipase). Journal of Endocrinology (1989) 123, 341–345

scholarly journals Association between insulin-like growth factor 1 and insulin resistance in obese prepubertal boys: a cross-sectional study

2020 ◽  
Author(s):  
Jiangying Kuang ◽  
Li Zhang ◽  
Yueqin Xu ◽  
Jiang Xue ◽  
shuang liang
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Growth Factor ◽  
Cardiovascular Risk Factors ◽  
Whole Body ◽  
Sensitivity Index ◽  
Insulin Like Growth Factor ◽  
Prepubertal Boys ◽  
The Relationship

Abstract Background As one of the most common features of obesity, insulin resistance is central to the pathogenesis of the metabolic syndrome. Low insulin-like growth factor 1(IGF-1) levels have been proven to be associated with many traditional cardiovascular risk factors, but it still remains controversy with the relationship between IGF-1 and insulin resistance. Accordingly, the main purpose of this study is to investigate the relationship between IGF-1 and insulin resistance in obese prepubertal boys. Methods We used whole body insulin sensitivity index (WBISI) to represent insulin resistance. 70 obese prepubertal boys were included in this study, and the obese subjects were divided into two groups by using 1.285 as a threshold value for WBISI. Clinical examination and laboratory examinations were assessed for all participants. Results Among obese boys, the group of children with WBISI ≤ 1.285 had lower IGF-1 standard deviation scores (SDS) (p = 0.021) than WBISI > 1.285 group. The results of multivariate stepwise regression analysis show that WBISI was positively correlated with IGF-1 SDS (β = 1.726, p = 0.002) after adjusting for traditional cardiovascular risk factors. Conclusion IGF-1 SDS was negatively associated with insulin resistance in obese prepubertal boys, independent of other traditional cardiovascular disease risk markers.

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