scholarly journals Plasmapheresis: Is it a potential alternative treatment for chronic urticaria?

Open Medicine ◽  
2021 ◽  
Vol 17 (1) ◽  
pp. 113-118
Author(s):  
Laima Aleksandraviciute ◽  
Laura Malinauskiene ◽  
Kestutis Cerniauskas ◽  
Anzelika Chomiciene
Keyword(s):  
Retrospective Analysis ◽  
Chronic Urticaria ◽  
Alternative Treatment ◽  
Clinical Judgment ◽  
Common Disease ◽  
Traditional Treatment ◽  
Disease Remission ◽  
2Nd Generation ◽  
Temporary Relief ◽  
Potential Alternative

Abstract Background Chronic urticaria is a common disease. Plasmapheresis is an alternative treatment that can be appropriate for patients who are resistant to treatment with 2nd generation antihistamines or for whom treatment with omalizumab is unsuitable. Objective To investigate the effect of plasmapheresis treatment in chronic urticaria. Methods A retrospective analysis was performed based on the data of 98 patients suffering from refractory chronic urticaria who received plasmapheresis as an alternative treatment in Vilnius University’s Hospital Santaros Clinics from 2000 to 2020. The efficiency of the treatment was evaluated by clinical judgment. Results 58.2% of the patients exhibited a complete or significant response; of these, 37.8% had temporary relief of symptoms and 20.4% achieved disease remission; 41.8% showed no response to the plasmapheresis. Men (34.8%) had a tendency to achieve disease remission more often than women (16%) (p < 0.05). One patient did not finish the plasmapheresis treatment due to the symptoms’ exacerbation and treatment with omalizumab was initiated. Conclusion Plasmapheresis is a safe and effective alternative treatment when traditional treatment is unavailable or does not relieve symptoms completely. Our data showed that plasmapheresis was effective in more than half of our patients.

Narrow-band ultraviolet B as a potential alternative treatment for resistant psychogenic excoriation: an open-label study

2010 ◽  
Vol 26 (3) ◽  
pp. 162-164 ◽  
Author(s):  
Müge Güler Özden ◽  
Fatma Aydın ◽  
Nilgün Şentürk ◽  
Yüksel Bek ◽  
Tayyar Cantürk ◽  
...  
Keyword(s):  
Alternative Treatment ◽  
Narrow Band ◽  
Ultraviolet B ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
Potential Alternative

scholarly journals A 29-year retrospective analysis of koala rescues in New South Wales, Australia

2020 ◽  
Author(s):  
Renae Charalambous ◽  
Edward J. Narayan
Keyword(s):  
Retrospective Analysis ◽  
Cultural Differences ◽  
New South ◽  
New South Wales ◽  
Management Team ◽  
Common Disease ◽  
Induce Stress ◽  
South Wales ◽  
Government Legislation ◽  
Port Stephens

AbstractThe koala (Phascolactos cinereus) is currently listed by both the IUCN and the Australian Governments’ Threatened Species Scientific Committee as vulnerable to extinction with a decreasing population trend. This listing can be attributed to climate change and its impact on ecosystems, and anthropomorphic environmental change due to extensive land clearing and habitat fragmentation. These have both been proven to induce stress, which influences the onset of disease. This novel study performed a retrospective analysis whereby records for 12,543 wild, rescued koalas in New South Wales (NSW), Australia were studied in order to determine trends in koala sightings, clinical admissions and injury diagnoses over a period of 29 years (1989-2018). Results indicated that between all three study locations (Port Stephens, Port Macquarie and Lismore), the most common reason koalas were admitted into care was because of disease, the most common disease diagnosed was signs of chlamydia, and the most common outcome for koalas admitted into care was released. At Port Stephens, mature and female koalas were diagnosed with a disease more than any other age or sex, while juvenile and male koalas were released (back into the wild) more than any other age or sex. Additionally, there were fewer koalas with a disease and fewer koalas released in Port Stephens as each year progressed. At Port Macquarie, mature and male koalas were diagnosed with a disease more than any other age or sex, while juvenile and female koalas were released more than any other age or sex. Additionally, there were more koalas with a disease and fewer koalas released in Port Macquarie as each year progressed. At Lismore, adult and female koalas were diagnosed with a disease more than any other age or sex, while joey and male koalas were released more than any other age or sex. Additionally, there were more koalas with a disease and fewer koalas released in Lismore as each year progressed. Determining trends in clinical admissions and diagnosis over such a substantial period of time is an important factor in preventing the continuing decline of koalas throughout Australia, and in particular NSW. It is important to note that there are cultural differences between koala rescue groups in the three study locations (Port Stephens, Port Macquarie and Lismore). These differences may be reflected in the outcomes of koala patients as each group are driven by their own management team. It is essential that any further decline of koala populations is prevented, however this can only be achieved through informed recommendations through research studies such as these. These recommendations should lead to government legislation which can provide stronger protection to koala habitat.

scholarly journals New treatment options of chronic urticaria

2021 ◽  
Vol 97 (5) ◽  
pp. 266-272
Author(s):  
Bernadett Hidvégi ◽  
◽  
Lilla Mihályi
Keyword(s):  
Quality Of Life ◽  
Chronic Urticaria ◽  
Treatment Options ◽  
Multifactorial Disease ◽  
2Nd Generation ◽  
New Treatment

Chronic urticaria is a multifactorial disease with increasing prevalence, that significantly deteriorates the quality of life of patients. Authors describe the pathomechanism of the disease, and they present the currently available treatment options and the promising future therapies as well. The therapeutic basis of chronic urticaria is the modern, 2nd generation antihistamines in a dosage of even four times higher than the regular one. In therapy resistant cases omalizumab or cyclosporin is advised. There is a growing demand for new medications because the number of those patients , who are non-responders or do not respond adequately to these therapies, is definitely increasing.

Finite Element Study of Conformity of Flow Diverter With Intracranial Aneurysmal Vasculatures

2011 ◽  
Author(s):  
Ding Ma ◽  
Jianping Xiang ◽  
Adnan Siddiqui ◽  
Sabareesh Natarajan ◽  
Hui Meng
Keyword(s):  
Finite Element ◽  
Clinical Importance ◽  
Flow Diverter ◽  
Patient Specific ◽  
Endovascular Stents ◽  
Traditional Treatment ◽  
Flow Diverter Stent ◽  
Potential Alternative ◽  
Stenting Procedure ◽  
Lower Morbidity

Endovascular stents in the last decade have been extensively used in intracranial aneurysm (IA) management. Stenting procedure is normally performed with the placement of spring coils inside the aneurysm, where stent will serve as a mechanical scaffold to help anchor the packed coils. Although coiling holds relatively lower morbidity and mortality rate than traditional treatment, its applications to wide-necked IAs, IAs with large fusiform shapes, and thin-walled IAs are still problematic due to the difficulty of securing the coils in the first two scenarios and the vascular susceptibility to coil damage in the last situation. Recent flow diverter concept however offers a potential alternative to address these challenging cases with only stent (flow diverter) being implanted. A flow diverter stent usually has relatively high metal surface coverage rate (∼80%) so that it can significantly divert blood flow from going inside the aneurysm, causing the decreased flow in IA and subsequently the thrombogenic cascade in favor of occluding the lesion. Meanwhile, a new flow conduit across IA orifice is expected to form based on endothelial cell re-pavement on the inner surface of the stent. It is thus of academic and clinical importance to further examine the mechanisms involved with flow diverter to better understand the procedure and improve the treatment outcome. Since the straightening of vessel by stent and incomplete apposition between stent filaments and arterial wall could both induce complications, current study applies a developed finite element method (FEM) workflow to evaluate the conformity of a CoCr alloy flow diverter (Pipeline™ Embolization Device as PED by ev3, MN, USA) to patient specific IA geometries.

Il trattamento tradizionale dell'IPB nell'anziano: The traditional treatment of BPH in the elderly

1998 ◽  
Vol 65 (2) ◽  
pp. 222-225
Author(s):  
G. Fiaccavento ◽  
P. Scialpi ◽  
R. Zucconelli ◽  
P. Belmonte
Keyword(s):  
Life Expectancy ◽  
Elderly Patients ◽  
Retrospective Analysis ◽  
Open Surgery ◽  
Benign Prostatic Hypertrophy ◽  
The Elderly ◽  
Prostatic Hypertrophy ◽  
Traditional Treatment ◽  
Endoscopic Procedures ◽  
Made In

Longer life expectancy and the progress made in anaesthesiology have led to an increase over the last few years in the request for treatment of symptomatic benign prostatic hypertrophy (BPH) in elderly patients. A retrospective analysis on 270 patients aged 75 years who underwent surgery on the cervico-prostatic district between 1989 and 1997 showed a rate of complications (10% overall) comparable with that in patients of any age undergoing the same operation. This reinforces the conviction that both open surgery and endoscopic procedures for treating symptomatic BPH are safe and reliable even in the elderly.

scholarly journals Efficacy of Omalizumab in Indolent Systemic Mastocytosis

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
Calum Slapnicar ◽  
Martina Trinkaus ◽  
Lisa Hicks ◽  
Peter Vadas
Keyword(s):  
Mast Cells ◽  
Allergic Asthma ◽  
Retrospective Analysis ◽  
Chronic Urticaria ◽  
Systemic Mastocytosis ◽  
Heterogeneous Group ◽  
Internal Organs ◽  
Indolent Systemic Mastocytosis

Background. Systemic mastocytosis (SM) comprises a heterogeneous group of disorders characterized by the proliferation of clonal mast cells in skin and various internal organs. Omalizumab is an established, labelled therapy for allergic asthma and chronic urticaria, but its experience in the efficacy of SM is limited. Methods. A retrospective analysis of 6 patients diagnosed with indolent SM treated with omalizumab at St. Michael’s Hospital between 2009 and 2018 is described. Reported frequency of anaphylaxis, baseline and follow-up tryptase levels, and SM-related symptoms were captured to measure the control of the disease. Results. Of the 5 patients who had experienced unprovoked anaphylaxis prior to treatment with omalizumab, 3 had no further episodes of anaphylaxis following initiation of omalizumab, while the remaining 2 patients had milder multisystem reactions. Significant improvement in cutaneous symptoms was also observed. Conclusion. These data suggest that omalizumab provides benefit to patients with SM who remain highly symptomatic in spite of treatment with conventional therapies.

Admission of Whole Families

1982 ◽  
Vol 27 (8) ◽  
pp. 640-643 ◽  
Author(s):  
Barbara Dydyk ◽  
Glenn French ◽  
Cynthia Gertsman ◽  
Noreen Morrison
Keyword(s):  
Mental Health ◽  
Family Systems ◽  
Alternative Treatment ◽  
Mental Health Problems ◽  
Health Problems ◽  
Short Term ◽  
Traditional Treatment ◽  
Residential Unit ◽  
Program Description ◽  
Clinical Problems

This is a program description of a short-term residential unit in which whole families are assessed and treated. This unit provides an alternative treatment format for exploring situations where removal of the child appears to be the only remaining option. It also provides an in-depth consultation for agencies who are “stuck” in their treatment of family systems and allows for the teaching of family systems intervention techniques in a non-threatening way. It also allows an opportunity for an external system to reframe, what are, to the involved clinician, impasses with clinical problems. The program, because of its structure, introduces anxiety and tension into systems with chronic mental health problems. It, therefore, serves as, not a panacea, but as an adjunct to more traditional treatment for rigid and resistant systems.

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