PNIPAAM/SA pH-responsive microcapsules based on chemical and non-covalent crosslinking

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Zhengdong Fei ◽  
Dong Zheng ◽  
Ping Fan ◽  
Feng Chen ◽  
Mingqiang Zhong
Keyword(s):  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Doxorubicin Hydrochloride ◽  
Ph Responsive ◽  
Covalent Crosslinking ◽  
Stomach Acid ◽  
Accurate Treatment ◽  
Polymerization Method

AbstractA triple interpenetrating polymer network (IPN) with dual responses to temperature and pH was constructed based on chemical crosslinking and electrostatic interaction. In this IPN, CaCO3 microspheres were used as the kernel and PNIPAAM/sodium alginate microcapsules were prepared by the inverse emulsion polymerization method. Research results demonstrated that CaCO3 kernels were decomposed into Ca2+ and CO2 at pH 1.2. Such decomposition facilitated the formation of triple IPN of Ca2+ crosslinking. Moreover, microcapsules were expanded by tension of CO2 and the volume increased to 3.55 × 105 times that of the original microcapsules, with capsules remaining an intact morphology. These microcapsules loading doxorubicin hydrochloride (DOX) stability and responses to environment were investigated. No drug overflow was observed at pH 7.4, indicating the high stability of microcapsules. However, DOX was released gradually in the simulated human stomach acid with a weak solution of hydrochloric acid (pH 1.2, 37 °C). This showed that the prepared microcapsules were feasible for drug-loaded capsules and the controlled drug release behavior could relieve side effects of drugs to human body. Moreover, it will help to increase the drug utilization and realize accurate treatment.

scholarly journals pH-Responsive Succinoglycan-Carboxymethyl Cellulose Hydrogels with Highly Improved Mechanical Strength for Controlled Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3197
Author(s):  
Younghyun Shin ◽  
Dajung Kim ◽  
Yiluo Hu ◽  
Yohan Kim ◽  
In Ki Hong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mechanical Strength ◽  
Carboxymethyl Cellulose ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Hek 293 ◽  
Natural Polysaccharide ◽  
293 Cells

Carboxymethyl cellulose (CMC)-based hydrogels are generally superabsorbent and biocompatible, but their low mechanical strength limits their application. To overcome these drawbacks, we used bacterial succinoglycan (SG), a biocompatible natural polysaccharide, as a double crosslinking strategy to produce novel interpenetrating polymer network (IPN) hydrogels in a non-bead form. These new SG/CMC-based IPN hydrogels significantly increased the mechanical strength while maintaining the characteristic superabsorbent property of CMC-based hydrogels. The SG/CMC gels exhibited an 8.5-fold improvement in compressive stress and up to a 6.5-fold higher storage modulus (G′) at the same strain compared to the CMC alone gels. Furthermore, SG/CMC gels not only showed pH-controlled drug release for 5-fluorouracil but also did not show any cytotoxicity to HEK-293 cells. This suggests that SG/CMC hydrogels could be used as future biomedical biomaterials for drug delivery.

scholarly journals ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

2019 ◽  
pp. 98-103
Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Lateral Diffusion ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Ph Responsive ◽  
Gum Tragacanth ◽  
Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release

2013 ◽  
Vol 97 (2) ◽  
pp. 565-570 ◽  
Author(s):  
Qi Xu ◽  
Weijuan Huang ◽  
Linbin Jiang ◽  
Zhanjun Lei ◽  
Xueyong Li ◽  
...  
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network

Temperature and pH-Responsive Polyacrylamide/Poly(Acrylic Acid) Interpenetrating Polymer Network Nanoparticles

2016 ◽  
Vol 55 (11) ◽  
pp. 1086-1098 ◽  
Author(s):  
Abraham G. Alvarado ◽  
Jorge Cortés ◽  
Lourdes A. Pérez-Carrillo ◽  
Martin Rabelero ◽  
Jesús Arellano ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Ph Responsive ◽  
Poly Acrylic Acid

Host–Guest Assembly of pH-Responsive Degradable Microcapsules with Controlled Drug Release Behavior

2011 ◽  
Vol 115 (36) ◽  
pp. 17651-17659 ◽  
Author(s):  
Cao Li ◽  
Guo-Feng Luo ◽  
Hui-Yuan Wang ◽  
Jing Zhang ◽  
Yu-Hui Gong ◽  
...  
Keyword(s):  
Drug Release ◽  
Controlled Drug Release ◽  
Release Behavior ◽  
Ph Responsive ◽  
Drug Release Behavior

scholarly journals Formulation and In-Vitro Characterization of pH-Responsive Semi-Interpenetrating Polymer Network Hydrogels for Controlled Release of Ketorolac Tromethamine

Gels ◽  
2021 ◽  
Vol 7 (4) ◽  
pp. 167
Author(s):  
Muhammad Suhail ◽  
Yi-Han Hsieh ◽  
Yu-Fang Shao ◽  
Muhammad Usman Minhas ◽  
Pao-Chu Wu
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
Polymer Network ◽  
In Vitro Release ◽  
Interpenetrating Polymer Network ◽  
Sodium Polystyrene Sulfonate ◽  
Ketorolac Tromethamine ◽  
Polystyrene Sulfonate ◽  
Ph Responsive

Ketorolac tromethamine is a non-steroidal anti-inflammatory drug used in the management of severe pain. The half-life of Ketorolac tromethamine is within the range of 2.5–4 h. Hence, repeated doses of Ketorolac tromethamine are needed in a day to maintain the therapeutic level. However, taking several doses of Ketorolac tromethamine in a day generates certain complications, such as acute renal failure and gastrointestinal ulceration. Therefore, a polymeric-controlled drug delivery system is needed that could prolong the release of Ketorolac tromethamine. Therefore, in the current study, pH-responsive carbopol 934/sodium polystyrene sulfonate-co-poly(acrylic acid) (CP/SpScPAA) hydrogels were developed by the free radical polymerization technique for the controlled release of Ketorolac tromethamine. Monomer acrylic acid was crosslinked with the polymers carbopol 934 and sodium polystyrene sulfonate by the cross-linker N′,N′-methylene bisacrylamide. Various studies were conducted to evaluate and assess the various parameters of the fabricated hydrogels. The compatibility of the constituents used in the preparation of hydrogels was confirmed by FTIR analysis, whereas the thermal stability of the unreacted polymers and developed hydrogels was analyzed by TGA and DSC, respectively. A smooth and porous surface was indicated by SEM. The crystallinity of carbopol 934, sodium polystyrene sulfonate, and the prepared hydrogels was evaluated by PXRD, which revealed a reduction in the crystallinity of reactants for the developed hydrogels. The pH sensitivity of the polymeric hydrogel networks was confirmed by dynamic swelling and in vitro release studies with two different pH media i.e., pH 1.2 and 7.4, respectively. Maximum swelling was exhibited at pH 7.4 compared to pH 1.2 and, likewise, a greater percent drug release was perceived at pH 7.4. Conclusively, we can demonstrate that the developed pH-sensitive hydrogel network could be employed as a suitable carrier for the controlled delivery of Ketorolac tromethamine.

Synthesis and Properties of Thermo- and pH-Responsive PVA/P(DEA-co-MAA) Intelligent Semi-IPN Hydrogels

2012 ◽  
Vol 466-467 ◽  
pp. 229-233
Author(s):  
Nai Yan Zhang ◽  
Jiang Yu ◽  
Shou Jun Cai
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Biomedical Applications ◽  
Polymer Network ◽  
Radical Copolymerization ◽  
Unique Property ◽  
Interpenetrating Polymer Network ◽  
Poly Vinyl Alcohol ◽  
Ph Responsive ◽  
Free Radical Copolymerization

A series of temperature- and pH-responsive poly(vinyl alcohol)/poly(N, N-diethylacrylamide-co-methacrylic acid) PVA/P(DEA-co-MAA) intelligent semi-IPN hydrogels were synthesized by free-radical copolymerization techniques and semi-interpenetrating polymer network techniques. The effects of the feed components, temperature and pH on the swelling behavior of the hydrogels were studied in detail. This unique property makes them very useful for biomedical applications such as on-off switches for modulated drug delivery and tissue engineering. With the increase of PVA content, the thermo- and pH-responsive of the semi-IPN hydrogel improved.

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