Two New Aromatic Constituents from Stocksia brahuica

1999 ◽  
Vol 54 (7) ◽  
pp. 940-942 ◽  
Author(s):  
Viqar Uddin Ahmad ◽  
Zulfiqar Ali ◽  
Muhammad Shaiq Ali ◽  
Fazila Iqbal ◽  
Muhammad Zahid ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Diphenylacetic Acid

The methanolic extract of Stocksia brahuica yielded two new aromatic constituents: diphenylacetic acid and brahene (2',4'-dihydroxy-7-methoxy-4,5-methylenedioxyisoflavene). Their structures were characterized with the help of modern spectroscopic techniques including 2D-NMR.

scholarly journals DOLABRANE-TYPE DITERPENOID AND LIGNAN CONSTITUENTS FROM THE STEM BARKS OF CERIOPS DECANDRA (GRIFF.) W. THEOB.

2020 ◽  
Vol 58 (4) ◽  
pp. 419
Author(s):  
Kieu Thi Phuong Linh ◽  
Nguyen Van Chien ◽  
Nguyen Quoc Trung ◽  
Vu Huy Thong ◽  
Nguyen Van Tuyen ◽  
...  
Keyword(s):  
Detailed Analysis ◽  
Methanolic Extract ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Chromatographic Separations ◽  
First Report ◽  
Esi Ms ◽  
Ceriops Decandra

Three dolabrane-type diterpenoids (1‒3) and a lignan derivative (4) were isolated from a methanolic extract of C. decandra stem barks using various chromatographic separations. Their structures were elucidated to be tagalsine X (1), tagalsin P (2), ent-5α,2-oxodolabr-3-ene-3,15,16-triol (3), and (+)-pinoresinol (4) by detailed analysis via spectroscopic techniques (1D, 2D NMR, and ESI-MS data) as well as comparison with those reported. This is the first report of compound 4 from the Ceriops genus.

scholarly journals SECONDARY METABOLITES FROM THE STEM BARKS OF RHIZOPHORA MUCRONATA LAMK

2020 ◽  
Vol 58 (6) ◽  
pp. 653
Author(s):  
Nguyen Phuong Thao
Keyword(s):  
Secondary Metabolites ◽  
Detailed Analysis ◽  
Methanolic Extract ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Rhizophora Mucronata ◽  
Chromatographic Separations ◽  
First Report ◽  
Esi Ms ◽  
Phenolic Derivatives

Using various chromatographic separations, three phenolic derivatives (1‒3) and three phytosteryl glycosides (4‒6) were isolated from a methanolic extract of R. mucronata stem barks. Their structures were elucidated to be cinchonain Ia (1), breynioside B (2), polystachyol (3), β-sitosterol 3-O-β-D-glucopyranoside (4), β-sitosterol 3-O-β-D-(6'-O-palmitoyl) glucopyran-oside (5), and β-sitosterol 3-O-β-D-(6'-O-stearoyl)glucopyranoside (6) by detailed analysis via spectroscopic techniques (1D, 2D NMR, and ESI-MS data) as well as comparison with those reported. This is the first report of compounds 1‒6 from the Rhizophora genus.

scholarly journals Flavonoid Glycoside Constituents from the Leaves of Hibiscus Tiliaceus 

2021 ◽  
Vol 31 (3) ◽  
pp. 7-11
Keyword(s):  
Detailed Analysis ◽  
Methanolic Extract ◽  
Chemical Constituents ◽  
Folk Medicine ◽  
2D Nmr ◽  
Tropical Climate ◽  
Flavonoid Glycoside ◽  
Spectroscopic Techniques ◽  
Chromatographic Separations

Hibiscus tiliaceus L. is a typical plant of tropical climate and found in the regions of mangroves in Vietnam. Although all part of this plant are used in folk medicine, there are little studies of its chemical constituents. Four flavonoids (1‒4) were isolated from a methanolic extract of H. tiliaceus leaves (Malvaceae) using various chromatographic separations. Their structures were elucidated to be astragalin (1), isoquercitrin (2), rutin (3), and trans-tiliroside (4) by detailed analysis via spectroscopic techniques (1D and 2D NMR) as well as comparison with those reported.

scholarly journals PHENOLIC CONSTITUENTS FROM THE STEM BARKS OF RHIZOPHORA APICULATA BLUME

2020 ◽  
Vol 58 (5) ◽  
pp. 517
Author(s):  
Nguyen Phuong Thao
Keyword(s):  
Detailed Analysis ◽  
Methanolic Extract ◽  
2D Nmr ◽  
Spectroscopic Techniques ◽  
Chromatographic Separations ◽  
First Report ◽  
Esi Ms ◽  
Rhizophora Apiculata ◽  
Phenolic Constituents ◽  
Phenolic Derivatives

Using various chromatographic separations, seven phenolic derivatives (1‒7) were isolated from a methanolic extract of R. apiculata stem barks. Their structures were elucidated to be dunnianoside E (1), (+)-dihydroquercetin (2), 2,6-dimethoxy-[1,4]benzoquinone (3), 2,4,6-trimethoxyphenol (4), 3,4,5-trimethoxybenzyl alcohol (5), hydroxytyrosol (6), and methyl 3,4-dihydroxycinnamate (7) by detailed analysis via spectroscopic techniques (1D, 2D NMR and ESI-MS data) as well as comparison with those reported. This is the first report of compounds 1 and 4‒7 from Rhizophora genus.

scholarly journals Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity

Biomolecules ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 862
Author(s):  
Iryna Stepanenko ◽  
Maria V Babak ◽  
Gabriella Spengler ◽  
Marta Hammerstad ◽  
Ana Popovic-Bijelic ◽  
...  
Keyword(s):  
Cell Lines ◽  
2D Nmr ◽  
Multidrug Resistant ◽  
Lung Fibroblasts ◽  
Spectroscopic Techniques ◽  
Tyrosyl Radical ◽  
X Ray Diffraction ◽  
Healthy Human ◽  
12 Steps ◽  
Esi Mass Spectrometry

A series of thiosemicarbazone-coumarin hybrids (HL1-HL3 and H2L4) has been synthesised in 12 steps and used for the preparation of mono- and dinuclear copper(II) complexes, namely Cu(HL1)Cl2 (1), Cu(HL2)Cl2 (2), Cu(HL3)Cl2 (3) and Cu2(H2L4)Cl4 (4), isolated in hydrated or solvated forms. Both the organic hybrids and their copper(II) and dicopper(II) complexes were comprehensively characterised by analytical and spectroscopic techniques, i.e., elemental analysis, ESI mass spectrometry, 1D and 2D NMR, IR and UV–vis spectroscopies, cyclic voltammetry (CV) and spectroelectrochemistry (SEC). Re-crystallisation of 1 from methanol afforded single crystals of copper(II) complex with monoanionic ligand Cu(L1)Cl, which could be studied by single crystal X-ray diffraction (SC-XRD). The prepared copper(II) complexes and their metal-free ligands revealed antiproliferative activity against highly resistant cancer cell lines, including triple negative breast cancer cells MDA-MB-231, sensitive COLO-205 and multidrug resistant COLO-320 colorectal adenocarcinoma cell lines, as well as in healthy human lung fibroblasts MRC-5 and compared to those for triapine and doxorubicin. In addition, their ability to reduce the tyrosyl radical in mouse R2 protein of ribonucleotide reductase has been ascertained by EPR spectroscopy and the results were compared with those for triapine.

Flavon- and Flavonolglycosides from Achillea pannonica Scheele

2001 ◽  
Vol 56 (7-8) ◽  
pp. 521-525 ◽  
Author(s):  
Denata Kasaj ◽  
Liselotte Krenn ◽  
Sonja Prinz ◽  
Antje Hüfner ◽  
Shi Shan Yuc ◽  
...  
Keyword(s):  
Methanolic Extract ◽  
2D Nmr ◽  
Flavonoid Glycosides ◽  
Spectroscopic Methods ◽  
Esi Ms ◽  
Aerial Parts ◽  
Nmr Techniques ◽  
Chemotaxonomic Study ◽  
First Time ◽  
C Nmr

The detailed investigation of a methanolic extract of aerial parts of Achillea pannonica SCHEELE. within a chemotaxonomic study led to the isolation of 6 flavonoid glycosides. Besides rutin, apigenin-7-O-glucopyranoside, luteolin-7-O-glucopyranoside, apigenin-7-O-rutinoside and acacetin-7-O-rutinoside, an unusual flavondiglucoside was isolated. Its structure was established by UV, 1HNMR and 13C NMR spectroscopic methods including 2D-NMR techniques and ESI-MS as luteolin-7,4′-O-β-diglucoside. This substance is reported for the first time in the genus Achillea. Chemotaxonomic aspects are discussed briefly

scholarly journals Exploration of Hepatoprotective Potential and Phytochemicals of Ziziphus oxyphylla Edgew

2020 ◽  
Vol 40 (04) ◽  
pp. 431-436
Author(s):  
Abdullah .
Keyword(s):  
Superoxide Dismutase ◽  
Methanolic Extract ◽  
Histopathological Examination ◽  
Liver Weight ◽  
2D Nmr ◽  
Chloroform Fraction ◽  
Hypotonic Solution ◽  
2D Nmr Spectroscopy ◽  
Hepatic Diseases ◽  
Antihepatotoxic Activity

Ziziphus oxyphylla Edgew (ZO) has been traditionally used for the treatment of hepatic diseases in Pakistan. The current study was carried out to investigate the effectiveness and mechanism underlying hepatoprotective effect of ZO. Hepatoprotective potential of root extracts (crude methanolic extract and subsequent fractions) was investigated against carbon tetrachloride (CCl4) induced hepatotoxicity in BALB/c mice via determination of serum biomarkers, antioxidant enzymes (catalase, superoxide dismutase), lipid peroxidation and histopathology. Membrane stabilizing activity was determined via inhibition of hypotonic solution and heat-induced hemolysis. Crude methanolic extract and chloroform fraction ameliorated CCl4 induced elevated levels of alanine transaminase (ALT), alkaline phosphatase (ALP), total proteins (TP), total bilirubin (TB) and reversed the antioxidants imbalance in terms of catalase (CAT), superoxide dismutase (SOD) and reduced malondialdehyde (MDA) level. Crude methanol extract inhibited hemolysis induced by hypotonic solution and heat. Histopathological examination of liver specimens of extracts administered mice exhibited recovery from CCl4 induced pathological changes. Moreover, CCl4 induced alteration in body and liver weight was countered by the administration of ZO. Compounds betulinic acid (AZO1), ceanothic acid (AZO2) and zizybrenalic acid (AZO3) were isolated from chloroform fraction of the plant. The structures of compounds were deduced using 1D-and 2D-NMR spectroscopy techniques. The results show that Ziziphus oxyphylla roots extract possess antihepatotoxic activity mediated by the protection of anti-oxidant defense system and membrane-stabilizing activity, probably due to the presence of pentacyclic triterpenes

scholarly journals Stereoselective synthesis and transformation of pinane-based 2-amino-1,3-diols

2021 ◽  
Vol 17 ◽  
pp. 983-990
Author(s):  
Ákos Bajtel ◽  
Mounir Raji ◽  
Matti Haukka ◽  
Ferenc Fülöp ◽  
Zsolt Szakonyi
Keyword(s):  
Alkaline Hydrolysis ◽  
Stereoselective Synthesis ◽  
2D Nmr ◽  
Ring Closure ◽  
Spectroscopic Techniques ◽  
Reductive Alkylation ◽  
X Ray ◽  
Relative Stereochemistry ◽  
Hydrolysis Of

A library of pinane-based 2-amino-1,3-diols was synthesised in a stereoselective manner. Isopinocarveol prepared from (−)-α-pinene was converted into condensed oxazolidin-2-one in two steps by carbamate formation followed by a stereoselective aminohydroxylation process. The relative stereochemistry of the pinane-fused oxazolidin-2-one was determined by 2D NMR and X-ray spectroscopic techniques. The regioisomeric spiro-oxazolidin-2-one was prepared in a similar way starting from the commercially available (1R)-(−)-myrtenol (10). The reduction or alkaline hydrolysis of the oxazolidines, followed by reductive alkylation resulted in primary and secondary 2-amino-1,3-diols, which underwent a regioselective ring closure with formaldehyde or benzaldehyde delivering pinane-condensed oxazolidines. During the preparation of 2-phenyliminooxazolidine, an interesting ring–ring tautomerism was observed in CDCl3.

scholarly journals Secondary Metabolites from Leaves of Polyalthia lateriflora and Their Antimicrobial Activity

2020 ◽  
Vol 11 (3) ◽  
pp. 4353-4358
Author(s):  
Saripah Salbiah Syed Abdul Azziz ◽  
Ahmed Kareem Obaid Aldulaimi ◽  
Saadon Abdulla Aowda ◽  
Yuhanis Mhd Bakri ◽  
Ali Arkan Majhool ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Antimicrobial Activity ◽  
Secondary Metabolites ◽  
Betulinic Acid ◽  
2D Nmr ◽  
Significant Inhibition ◽  
Spectroscopic Techniques ◽  
E Coli ◽  
Phytochemical Components ◽  
Antibacterial Potential

The study aimed to isolate and identify the phytochemical components of Polyalthia lateriflora leaves and evaluate the antimicrobial activity. Six well-known compounds, including three triterpene lupeol (1) betulinic acid (2), β-Sitosterol-β-D-glucoside (3) and three oxoaporphine alkaloids O-methylmoschotaline (4), liriodenine (5) and atherosperminine (6). Structural elucidation of compounds were established through spectroscopic techniques such as 1D and 2D NMR (1H and 13C, DEPT, COSY, NOESY, HMBC, HMQC), IR and LC-MS. The isolated compounds and crude extracted were tested for their antibacterial potential against several microorganisms including P. aeruginosa, E. coli, s, S. aureus, B. subtilis and Saccharomyces cerevisiae and its showed significant inhibition toward the organisms species with different concentration range.

scholarly journals Flavonoids and Triterpenoid Saponins from Pimenta dioica (Merr.) L

2007 ◽  
Vol 2 (9) ◽  
pp. 1934578X0700200
Author(s):  
Fatma A. Moharram ◽  
Mona A Mohamed ◽  
Mohamed SA Marzouk ◽  
Elsayed A Aboutabl
Keyword(s):  
Methanolic Extract ◽  
2D Nmr ◽  
Physicochemical Analysis ◽  
Triterpenoid Saponins ◽  
Pimenta Dioica ◽  
First Time

The defatted and desalted 80% methanolic extract of the leaves of Pimenta dioica (Mirr.) L. resulted in the isolation of three triterpenoid saponins, 23-hydroxy-3α-[( O-α-L-rhamnopyranosyl-(1→2)- O-α-L-arabinopyranosyl) oxy] olean-12-en-28-oic acid O-α-L-rhamnopyranosyl-(1→4)- O-β-D-galactopyranosyl-(1→6)- O-β-D-galactopyranosyl ester (1), 2α,3α,23-trihydroxyolean-12-en-28-oic acid O-β-D-glucopyranosyl ester (2), and 2α,3α,23-trihydroxyolean-13(18)-en-28-oic acid O-β-D-glucopyranosyl ester (3), along with a novel dihydrokaempferol glucoside, namely, 3-carboxy-6,8-di- C-methyl-dihydrokaempferol 3- O-β-D-glucopyranoside (4), together with three known flavonoids, quercetin 3- O-β-D-glucuronopyranoside (5), quercitrin (6) and mernesitin (7), all for the first time from the genus Pimenta. The structures were identified on the basis of chemical and physicochemical analysis (UV, HRESI-MS, 1 and 2D NMR).

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