scholarly journals Performance of Local Composition Models to Correlate the Aqueous Solubility of Naproxen in Some Choline Based Deep Eutectic Solvents at T = (298.15-313.15) K

2019 ◽  
Vol 25 (3) ◽  
pp. 244-253 ◽  
Author(s):  
Masumeh Mokhtarpour ◽  
Hemayat Shekaari ◽  
Fleming Martinez ◽  
Mohammed Taghi Zafarani-Moattar
Keyword(s):  
Oxalic Acid ◽  
Choline Chloride ◽  
Aqueous Solubility ◽  
Weight Fraction ◽  
Deep Eutectic Solvents ◽  
Solubility Data ◽  
Green Solvents ◽  
Local Composition ◽  
Molar Ratios ◽  
Different Temperatures

Background: To overcome low solubility of naproxen (NAP), deep eutectic solvents (DESs) based on choline chloride (ChCl) with glycerol (G) and oxalic acid (OA) as green solvents have been used up to 0.9 mole fraction of DES at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the two components with the molar ratios: ChCl/glycerol (1:2) and ChCl/oxalic acid (1:1). The solubility of NAP in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility in these solvents increased with increasing the weight fraction of DESs, especially in ChCl/OA. The solubility data were correlated by e-NRTL, Wilson and UNIQUAC models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were obtained. Conclusion: Oxalic acid based DES exhibits higher solubility than glycerol based DES. The thermodynamic models were successfully used to correlate solubility data. In addition, the results show that, the main contribution for NAP solubility in the aqueous DES solutions is the enthalpy.

scholarly journals Significant Increase in the Solubility of Celecoxib in Presence of Some Deep Eutectic Solvents as Novel Sustainable Solvents and the Thermodynamic Analysis of These Systems

2020 ◽  
Vol 26 (4) ◽  
pp. 423-433
Author(s):  
Hemayat Shekaari ◽  
Masomeh Mokhtarpour ◽  
Fereshteh Mokhtarpour ◽  
Saeid Faraji ◽  
Fleming Martinez ◽  
...  
Keyword(s):  
Choline Chloride ◽  
Aqueous Solubility ◽  
Weight Fraction ◽  
Deep Eutectic Solvents ◽  
Solubility Data ◽  
Driving Mechanism ◽  
Solvent Mixtures ◽  
Molar Ratios ◽  
Different Temperatures ◽  
B Vitamin

Background: Deep eutectic solvents (DESs) exist a wide variety of potential and existing applications. Based on the fact that the choline chloride (ChCl) is a complex B vitamin and widely used as food additive, the choline-based DESs are generically regarded as being harmless and non-toxic. In this regard, the low aqueous solubility of celecoxib (CLX) have been increased by use of DESs as neoteric class of solvents at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the ChCl/EG, U and G with the molar ratios: 1:2 and ChCl/MA with 1:1. The shake flask method was used to measure the solubility of CLX in the aqueous DESs solutions at different temperatures. Results: The solubility of the CLX increased with increasing the weight fraction of DESs. The observed solubility data was subjected to evaluate the relative performance of a number of models including Apelblat, Yalkowsky and Jouyban–Acree models for their correlation efficacy. Moreover, the apparent dissolution enthalpy, entropy and Gibbs free energy were obtained from the experimental solubility values. Conclusion: It was found that the solubility data was satisfactorily fitted using the mentioned models at different temperatures. The dissolution process of CLX in the studied solvent mixtures within investigated temperature range was endothermic, and the driving mechanism is the positive entropy.

scholarly journals Solubility Enhancement of Betamethasone, Meloxicam and Piroxicam by Use of Choline-Based Deep Eutectic Solvents

2020 ◽  
Vol 27 (1) ◽  
pp. 86-101
Author(s):  
Salva Golgoun ◽  
Masumeh Mokhtarpour ◽  
Hemayat Shekaari
Keyword(s):  
Choline Chloride ◽  
Aqueous Solubility ◽  
Weight Fraction ◽  
Deep Eutectic Solvents ◽  
Molar Ratios ◽  
New Class ◽  
Different Temperatures ◽  
Calculated Solubility ◽  
Experimental Values ◽  
Good Agreement

Background: The low aqueous solubility of three important drugs (betamethasone (BETA), meloxicam (MEL) and piroxicam (PIR)) have been increased by use of deep eutectic solvents (DESs) based choline chloride/urea (ChCl/U), choline chloride/ethylene glycol (ChCl/EG) and choline chloride/glycerol (ChCl/G) as new class of solvents at T = (298.15 to 313.15) K. Methods: DESs were prepared by combination of the ChCl/EG, U and G with the molar ratios: 1:2. The solubility of drugs in the aqueous DESs solutions was measured at different temperatures with shake flask method. Results: The solubility of the investigated drugs increased with increasing the weight fraction of DESs. The solubility data were correlated by e-NRTL and Wilson models. Also, the thermodynamic functions, Gibbs energy, enthalpy, and entropy of dissolution were calculated. Conclusion: At the same composition of co-solvents and temperature, the BETA, PIR and MEL solubility was highest in (ChCl/U + water), (ChCl/U + water) and (ChCl/EG + water) respectively. The calculated solubility based on these models was in good agreement with the experimental values. In addition, the results show that, the main contribution for drugs solubility in the aqueous DES solutions is the enthalpy.

Deep eutectic solvent delignification: Impact of initial lignin

BioResources ◽  
2017 ◽  
Vol 12 (4) ◽  
pp. 7301-7310
Author(s):  
Veronika Majová ◽  
Silvia Horanová ◽  
Andrea Škulcová ◽  
Jozef Šima ◽  
Michal Jablonský
Keyword(s):  
Lactic Acid ◽  
Oxalic Acid ◽  
Lignin Content ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Kappa Number ◽  
Kraft Pulps ◽  
Oxygen Delignification ◽  
Detailed Understanding

This study aimed to resolve the issue of the lack of detailed understanding of the effect of initial lignin content in hardwood kraft pulps on pulp delignification by deep eutectic solvents. The authors used Kappa number of the concerned pulp, intrinsic viscosity, and selectivity and efficiency of delignification as the parameters of the effect. The pulp (50 g oven dry pulp) was treated with four different DESs systems based on choline chloride with lactic acid (1:9), oxalic acid (1:1), malic acid (1:1), and system alanine:lactic acid (1:9); the results were compared to those reached by oxygen delignification. The results showed that the pulp with a higher initial lignin content had a greater fraction of easily removed lignin fragments.

scholarly journals Thermal Conductivities of Choline Chloride-Based Deep Eutectic Solvents and Their Mixtures with Water: Measurement and Estimation

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3816
Author(s):  
Taleb H. Ibrahim ◽  
Muhammad A. Sabri ◽  
Nabil Abdel Jabbar ◽  
Paul Nancarrow ◽  
Farouq S. Mjalli ◽  
...  
Keyword(s):  
Atmospheric Pressure ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Standard Uncertainty ◽  
Heat Transfer Fluids ◽  
Wide Range ◽  
Different Temperatures ◽  
Experimental Values ◽  
Water Measurement ◽  
Thermal Conductivities

The thermal conductivities of selected deep eutectic solvents (DESs) were determined using the modified transient plane source (MTPS) method over the temperature range from 295 K to 363 K at atmospheric pressure. The results were found to range from 0.198 W·m−1·K−1 to 0.250 W·m−1·K−1. Various empirical and thermodynamic correlations present in literature, including the group contribution method and mixing correlations, were used to model the thermal conductivities of these DES at different temperatures. The predictions of these correlations were compared and consolidated with the reported experimental values. In addition, the thermal conductivities of DES mixtures with water over a wide range of compositions at 298 K and atmospheric pressure were measured. The standard uncertainty in thermal conductivity was estimated to be less than ± 0.001 W·m−1·K−1 and ± 0.05 K in temperature. The results indicated that DES have significant potential for use as heat transfer fluids.

scholarly journals Extraction of Illegal Dyes from Red Chili Peppers with Cholinium-Based Deep Eutectic Solvents

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Shuqiang Zhu ◽  
Dongling Liu ◽  
Xinyue Zhu ◽  
Along Su ◽  
Haixia Zhang
Keyword(s):  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Raw Material ◽  
Extraction Time ◽  
Solvent Ratio ◽  
Extraction Temperature ◽  
Green Solvents ◽  
Hydrogen Bond Donor ◽  
Relative Standard ◽  
Orange G

Deep eutectic solvents (DESs) as a new kind of green solvents have been used to extract bioactive compounds but there are few applications in extracting chrysoidine dyes. In this study, we developed an ultrasonic-assisted extraction method with choline chloride/hydrogen bond donor (ChCl/HBD) DES for the extraction of chrysoidine G (COG), astrazon orange G (AOG), and astrazon orange R (AOR) in food samples. Some experimental parameters, such as extraction time, raw material/solvent ratio, and temperature, were evaluated and optimized as follows: the ratio of ChCl/HBD, 1 : 2 (v/v); the ratio of sample/DES, 1 : 10 (g/mL); extraction time, 20 min; extraction temperature, 50°C. Under the optimized conditions, the limits of detection (μg/mL) were 0.10 for COG and 0.06 for AOG and AOR. The relative standard deviations were in the range of 1.2–2.1%. The recoveries of the three dyes were in the range of 80.2–105.0%. By comparing with other commonly used solvents for extracting chrysoidine dyes, the advantages of DESs proved them to be potential extraction solvents for chrysoidine G, astrazon orange G, and astrazon orange R in foods.

Efficient extraction of major catechins in Camellia sinensis leaves using green choline chloride-based deep eutectic solvents

RSC Advances ◽  
2015 ◽  
Vol 5 (114) ◽  
pp. 93937-93944 ◽  
Author(s):  
Ji Li ◽  
Zhigang Han ◽  
Yongpeng Zou ◽  
Bo Yu
Keyword(s):  
Organic Acids ◽  
Camellia Sinensis ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Green Solvents ◽  
Efficient Extraction

Choline chloride-based deep eutectic solvents (DESs), composed of alcohols, organic acids and saccharides, were used as green solvents for extraction of major catechins inCamellia sinensisleaves.

scholarly journals Deep eutectic solvents aqueous two-phase system based ultrasonically assisted extraction of ursolic acid (UA) from Cynomorium songaricum Rupr.

2017 ◽  
Author(s):  
Xifeng Zhang ◽  
Ji Zhang
Keyword(s):  
Ursolic Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvent ◽  
Deep Eutectic Solvents ◽  
Selective Extraction ◽  
Phase System ◽  
Green Solvents ◽  
Active Components ◽  
Two Phase ◽  
Solid Ratio

Deep eutectic solvents (DESs) are new green solvents that have attracted the attention of the scientific community mainly due to their unique properties and special characteristics, which are different from those of traditional solvents.A method based on ultrasonically assisted deep eutectic solvent aqueous two-phase systems( UAE-DES-ATPS) was developed for extracting ursolic acid (UA) from Cynomorium songaricum Rupr. Four different types of choline chloride-based DESs were prepared.Choline chloride-glucose (ChCl-Glu) exhibited good selective extraction ability. An optimum DES-ATPS of 36% (w/w) ChCl-Glu and 25% (w/w) K2HPO4 was considered to be a satisfactory system for extracting UA. Response surface methodology (RSM) method was used to optimize the extraction of UA using UAE-DES-ATPS. The optimum ultrasound-assisted conditions were as follows: solvent to solid ratio of 15:1 (g/g), ultrasound power of 470 W, and extraction time of 54 min. Compared with the conventional UAE method, the yields were basically the same, but the presented method had higher purity. The structure of UA did not change between pure UA and UA in the upper phase by UV–vis and FT-IR. This approach using ChCl-based DES-ATPS as a novel extraction system and ultrasound as a source of energy provided better choice for the separation of active components from other natural products.

scholarly journals Delignification of unbleached pulp by ternary deep eutectic solvents

2021 ◽  
Vol 10 (1) ◽  
pp. 666-676
Author(s):  
Veronika Majová ◽  
Michal Jablonský ◽  
Marek Lelovský
Keyword(s):  
Hydrogen Bond ◽  
Lactic Acid ◽  
Lignin Content ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
Kappa Number ◽  
Molar Ratios ◽  
The Individual ◽  
Low Solubility ◽  
Unbleached Pulp

Abstract The processing of lignocellulosic materials is very limited because of their low solubility in water and some organic solvents. Fifteen ternary deep eutectic solvents (DESs) were prepared and tested as solvents suitable for delignification of unbleached pulp. The selected ternary DESs are composed of quaternary ammonium salts and amino acids as hydrogen-bond acceptors, and organic acids and polyvalent alcohols as hydrogen bond donors, with molar ratios varying for the individual components. The delignification efficiency is significantly influenced by the degree of penetration of the solvent into the pulp fibre structure. Therefore, the density and viscosity analysis of individual solvents was performed. Unbleached beech pulp with initial kappa number 13.9 was treated with the prepared DESs. The kappa number indicates the residual lignin content or the bleachability of pulp. The efficiency of the solvents ranged from 1.4% to 28.1%. The most suitable for the pretreatment of fibres, based on lignin removal efficiency, were found to be three DESs, in the following order: malonic acid/choline chloride/1,3-propanediol (1:1:3) > choline chloride/acetamide/lactic acid (1:2:3) > choline chloride/urea/lactic acid (1:2:3).

scholarly journals X-Ray structure and ionic conductivity studies of anhydrous and hydrated choline chloride and oxalic acid deep eutectic solvents

2018 ◽  
Vol 20 (48) ◽  
pp. 30120-30124 ◽  
Author(s):  
Lorenzo Gontrani ◽  
Matteo Bonomo ◽  
Natalia V. Plechkova ◽  
Danilo Dini ◽  
Ruggero Caminiti
Keyword(s):  
Molecular Dynamics ◽  
Ionic Conductivity ◽  
Oxalic Acid ◽  
Choline Chloride ◽  
Deep Eutectic Solvents ◽  
X Ray ◽  
Effect Of Water ◽  
Shed Light

X-Ray, conductivity and molecular dynamics studies shed light on the effect of water of crystallization on choline chloride–oxalic acid DESs

scholarly journals A Global Model for the Estimation of Speeds of Sound in Deep Eutectic Solvents

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1626
Author(s):  
Hamed Peyrovedin ◽  
Reza Haghbakhsh ◽  
Ana Rita C. Duarte ◽  
Sona Raeissi
Keyword(s):  
Experimental Data ◽  
Thermodynamic Properties ◽  
Speed Of Sound ◽  
Deep Eutectic Solvents ◽  
Green Solvents ◽  
Speeds Of Sound ◽  
Molar Ratios ◽  
Lack Of Information ◽  
Proposed Model ◽  
Group Contribution Methods

Deep eutectic solvents (DESs) are newly introduced green solvents that have attracted much attention regarding fundamentals and applications. Of the problems along the way of replacing a common solvent by a DES, is the lack of information on the thermophysical properties of DESs. This is even more accentuated by considering the dramatically growing number of DESs, being made by the combination of vast numbers of the constituting substances, and at their various molar ratios. The speed of sound is among the properties that can be used to estimate other important thermodynamic properties. In this work, a global and accurate model is proposed and used to estimate the speed of sound in 39 different DESs. This is the first general speed of sound model for DESs. The model does not require any thermodynamic properties other than the critical properties of the DESs, which are themselves calculated by group contribution methods, and in doing so, make the proposed method entirely independent of any experimental data as input. The results indicated that the average absolute relative deviation percentages (AARD%) of this model for 420 experimental data is only 5.4%. Accordingly, based on the achieved results, the proposed model can be used to predict the speeds of sound of DESs.

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