scholarly journals Iron and Iron Regulatory Proteins in Amoeboid Microglial Cells Are Linked to Oligodendrocyte Death in Hypoxic Neonatal Rat Periventricular White Matter through Production of Proinflammatory Cytokines and Reactive Oxygen/Nitrogen Species

2011 ◽  
Vol 31 (49) ◽  
pp. 17982-17995 ◽  
Author(s):  
G. Rathnasamy ◽  
E.-A. Ling ◽  
C. Kaur
Keyword(s):  
White Matter ◽  
Proinflammatory Cytokines ◽  
Reactive Oxygen ◽  
Regulatory Proteins ◽  
Neonatal Rat ◽  
Microglial Cells ◽  
Periventricular White Matter ◽  
Nitrogen Species ◽  
Iron Regulatory Proteins

Expression of SIRT3 in various glial cell types in the periventricular white matter in the neonatal rat brain after hypoxia

2018 ◽  
Vol 52 ◽  
pp. 1-8 ◽  
Author(s):  
Xiu-Hua Li ◽  
Shun-Jin Liu ◽  
Xiao-Yu Liu ◽  
Hai-Yu Zhao ◽  
Mao-Geng Yang ◽  
...  
Keyword(s):  
White Matter ◽  
Rat Brain ◽  
Glial Cell ◽  
Cell Types ◽  
Neonatal Rat ◽  
Periventricular White Matter ◽  
Neonatal Rat Brain

Expression of ephrinB2 and EphB4 in a neonatal rat model of periventricular white matter damage

2015 ◽  
Vol 43 (3) ◽  
Author(s):  
Lihua Zhu ◽  
Lijuan Qian ◽  
Shiyu Wang ◽  
Ting Wang ◽  
Li Jiang
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Vascular System ◽  
Periventricular Leukomalacia ◽  
Vascular Supply ◽  
Neonatal Rat ◽  
Cerebral White Matter ◽  
Periventricular White Matter ◽  
White Matter Damage ◽  
Hypoxia Ischemia

AbstractPeriventricular white matter damage (PWMD), also termed periventricular leukomalacia, is the predominant neurologic lesion in preterm infants. It appears to relate in part to the development of the vascular supply to the cerebral white matter. We investigated whether, in case of severe hypoxia-ischemia, the vascular system would be subject to severe damage or remodeled.To evaluate microvessel density (MVD) and the use of ephrinB2 and its receptor EphB4 to mark arterioles and venules to establish the correct anatomic assignment of the remodeled vessels in a hypoxia-induced PWMD rat model.Postnatal day 3 rats underwent permanent ligation of the right common carotid artery followed by 6% OCompared with sham rats, MVD, ephrinB2 and EphB4 levels were higher in the brains of hypoxic-ischemic rats. Similar percentages of vessels expressed ephrinB2 and EphB4 in sham rats, but expression of ephrinB2 was greater in brains injured by hypoxia-ischemia.Following hypoxic-ischemic injury to the rat brain, microvessels were remodeled and more arterioles than venules were acquired.

Sign in / Sign up

Export Citation Format

Share Document