scholarly journals EFFECT OF CHITOSAN AND LIPID LAYERS DEPOSITED ONTO POLYETHYLENE TEREPHTHALATE (PET) ON ITS WETTING PROPERTIES

2021 ◽  
Vol 26 ◽  
pp. 210-221
Author(s):  
Klaudia Szafran ◽  
◽  
Małgorzata Jurak ◽  
Agnieszka Ewa Wiącek
Keyword(s):  
Tissue Engineering ◽  
Polyethylene Terephthalate ◽  
Antimicrobial Properties ◽  
Air Plasma ◽  
Langmuir Blodgett ◽  
Wetting Properties ◽  
Theoretical Approaches ◽  
Building Components ◽  
Total Surface Free Energy ◽  
Lipid Layers

The wetting properties of chitosan (Ch) and single 1,2-dipalmitoylsn-glycero-3-phosphocholine (DPPC), cholesterol (Chol) and binary DPPC-Chol layers deposited onto polyethylene terephthalate activated by low-temperature air plasma (PETair) were examined. PET is widely used in tissue engineering, but its low hydrophilicity limits its integration with the surrounding tissues. Ch is a biocompatible polysaccharide, distinguished by its antimicrobial properties, widely distributed in medicine. DPPC and Chol are the major building components of cell membrane, so they can perfectly mimic membrane behaviour during contact with the Ch layer. Monolayers of lipids were deposited onto PETair with or without the Ch layer using the Langmuir-Blodgett technique. The total surface free energy (SFE)and its components changes were calculated from theoretical approaches. Wettability strongly depended on the monolayer composition as well as the Ch layer. The Ch film decreased the contact angle and increased SFE of the PET surface with the lipid monolayers due to specific organisation of molecules within the chitosan scaffold. The most promising combination of surface modification for tissue engineering applications seems to be the PETair/Ch/DPPC-Chol system.

scholarly journals WETTING PROPERTIES OF CHITOSAN-MODIFIED AND PLASMA-TREATED PEEK SURFACES

2018 ◽  
Vol XXIII ◽  
pp. 159-169 ◽  
Author(s):  
Kacper Przykaza ◽  
Małgorzata Jurak ◽  
Agnieszka E. Wiącek
Keyword(s):  
Free Energy ◽  
Surface Free Energy ◽  
Contact Angle Hysteresis ◽  
Chitosan Film ◽  
Film Surface ◽  
Contact Angles ◽  
Biologically Active ◽  
Air Plasma ◽  
Wetting Properties ◽  
Total Surface Free Energy

In this paper, the wettability of chitosan/phospholipid (1,2-dipalmitoyl-sn-glycero-3-phosphocholine – DPPC), chitosan/lipid (cholesterol – Chol) and chitosan/protein (cyclosporine A – CsA) films on air plasma activated polyetheretherketone (PEEK) plates was studied. The layers were prepared using the solution spreading technique and their surface wetting properties were determined based on the measurements of the advancing and receding contact angles of water, formamide and diiodomethane. Moreover, based on the contact angle hysteresis model of Chibowski, values of total surface free energy were estimated. Significant changes in PEEK polarity were observed after plasma activation and modifications with Ch/DPPC, Ch/Chol and Ch/CsA layers. These molecules modulate the chitosan film surface by changing the type and magnitude of interactions, which is revealed in the values of surface free energy. These results may be important for the development and implementation of highly biocompatible bone substitution polymers coated with chitosan film with anti-fungal and anti-bactericidal properties. Those systems based on chitosan may also carry and release biologically active substances which could be relevant in the new generation of drug delivery systems.

Utilization of air-plasma treated waste polyethylene terephthalate particles as a raw material for particleboard production

2016 ◽  
Vol 90 ◽  
pp. 188-194 ◽  
Author(s):  
Petr Klímek ◽  
Tomáš Morávek ◽  
Jozef Ráhel ◽  
Monika Stupavská ◽  
David Děcký ◽  
...  
Keyword(s):  
Polyethylene Terephthalate ◽  
Raw Material ◽  
Air Plasma ◽  
Waste Polyethylene

scholarly journals Anticoagulant Polyethylene Terephthalate Surface by Plasma-Mediated Fucoidan Immobilization

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 750 ◽  
Author(s):  
Kadir Ozaltin ◽  
Marian Lehocky ◽  
Petr Humpolicek ◽  
Jana Pelkova ◽  
Antonio Di Martino ◽  
...  
Keyword(s):  
Polyethylene Terephthalate ◽  
Photoelectron Spectroscopy ◽  
Anticoagulant Activity ◽  
Blood Clot ◽  
Clot Formation ◽  
Thrombin Time ◽  
Air Plasma ◽  
Water Contact ◽  
Polymeric Biomaterials ◽  
Performance Surface

Biomaterial-based blood clot formation is one of the biggest drawbacks of blood-contacting devices. To avoid blood clot formation, their surface must be tailored to increase hemocompatibility. Most synthetic polymeric biomaterials are inert and lack bonding sites for chemical agents to bond or tailor to the surface. In this study, polyethylene terephthalate was subjected to direct current air plasma treatment to enhance its surface energy and to bring oxidative functional binding sites. Marine-sourced anticoagulant sulphated polysaccharide fucoidan from Fucus vesiculosus was then immobilized onto the treated polyethylene terephthalate (PET) surface at different pH values to optimize chemical bonding behavior and therefore anticoagulant performance. Surface properties of samples were monitored using the water contact angle; chemical analyses were performed by FTIR and X-ray photoelectron spectroscopy (XPS) and their anticoagulant activity was tested by means of prothrombin time, activated partial thromboplastin time and thrombin time. On each of the fucoidan-immobilized surfaces, anticoagulation activity was performed by extending the thrombin time threshold and their pH 5 counterpart performed the best result compared to others.

scholarly journals Vascular Tissue Engineering: Recent Advances in Small Diameter Blood Vessel Regeneration

2014 ◽  
Vol 2014 ◽  
pp. 1-27 ◽  
Author(s):  
Valentina Catto ◽  
Silvia Farè ◽  
Giuliano Freddi ◽  
Maria Cristina Tanzi
Keyword(s):  
Tissue Engineering ◽  
Cardiovascular Diseases ◽  
Blood Vessel ◽  
Polyethylene Terephthalate ◽  
Vascular Tissue ◽  
Vascular Grafts ◽  
Small Diameter ◽  
Synthetic Polymers ◽  
Vascular Tissue Engineering ◽  
Vessel Regeneration

Cardiovascular diseases are the leading cause of mortality around the globe. The development of a functional and appropriate substitute for small diameter blood vessel replacement is still a challenge to overcome the main drawbacks of autografts and the inadequate performances of synthetic prostheses made of polyethylene terephthalate (PET, Dacron) and expanded polytetrafluoroethylene (ePTFE, Goretex). Therefore, vascular tissue engineering has become a promising approach for small diameter blood vessel regeneration as demonstrated by the increasing interest dedicated to this field. This review is focused on the most relevant and recent studies concerning vascular tissue engineering for small diameter blood vessel applications. Specifically, the present work reviews research on the development of tissue-engineered vascular grafts made of decellularized matrices and natural and/or biodegradable synthetic polymers and their realization without scaffold.

Surface modification of a biomedical polyethylene terephthalate (PET) by air plasma

2009 ◽  
Vol 255 (8) ◽  
pp. 4446-4451 ◽  
Author(s):  
Liqing Yang ◽  
Jierong Chen ◽  
Yafei Guo ◽  
Zheng Zhang
Keyword(s):  
Surface Modification ◽  
Polyethylene Terephthalate ◽  
Air Plasma

scholarly journals Generation of a novel human dermal substitute functionalized with antibiotic-loaded nanostructured lipid carriers (NLCs) with antimicrobial properties for tissue engineering

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Jesús Chato-Astrain ◽  
Isabel Chato-Astrain ◽  
David Sánchez-Porras ◽  
Óscar-Darío García-García ◽  
Fabiola Bermejo-Casares ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antimicrobial Properties ◽  
Study Groups ◽  
Biomechanical Properties ◽  
Nanostructured Lipid Carriers ◽  
Dermal Substitute ◽  
The Novel ◽  
Severe Burns ◽  
Caspase 7 ◽  
Human Dermis

Abstract Background Treatment of patients affected by severe burns is challenging, especially due to the high risk of Pseudomonas infection. In the present work, we have generated a novel model of bioartificial human dermis substitute by tissue engineering to treat infected wounds using fibrin-agarose biomaterials functionalized with nanostructured lipid carriers (NLCs) loaded with two anti-Pseudomonas antibiotics: sodium colistimethate (SCM) and amikacin (AMK). Results Results show that the novel tissue-like substitutes have strong antibacterial effect on Pseudomonas cultures, directly proportional to the NLC concentration. Free DNA quantification, WST-1 and Caspase 7 immunohistochemical assays in the functionalized dermis substitute demonstrated that neither cell viability nor cell proliferation were affected by functionalization in most study groups. Furthermore, immunohistochemistry for PCNA and KI67 and histochemistry for collagen and proteoglycans revealed that cells proliferated and were metabolically active in the functionalized tissue with no differences with controls. When functionalized tissues were biomechanically characterized, we found that NLCs were able to improve some of the major biomechanical properties of these artificial tissues, although this strongly depended on the type and concentration of NLCs. Conclusions These results suggest that functionalization of fibrin-agarose human dermal substitutes with antibiotic-loaded NLCs is able to improve the antibacterial and biomechanical properties of these substitutes with no detectable side effects. This opens the door to future clinical use of functionalized tissues.

Poly(ester amide) derived from municipal polyethylene terephthalate waste guided stem cells for osteogenesis

2019 ◽  
Vol 43 (35) ◽  
pp. 14166-14178 ◽  
Author(s):  
Krishanu Ghosal ◽  
Kishor Sarkar
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Soybean Oil ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Polyethylene Terephthalate ◽  
Renewable Resources ◽  
Ethylene Terephthalate ◽  
Poly Ethylene Terephthalate ◽  
Poly Ethylene

A novel poly(ester amide) was synthesized by using recycled poly(ethylene terephthalate) waste and soybean oil and other renewable resources for bone tissue engineering applications.

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