scholarly journals Adjustment of the Number of Ride-Sharing Vehicles by Introducing the predeclaration on the expected time period of use

2021 ◽  
Vol 36 (6) ◽  
pp. AG21-K_1-9
Author(s):  
Masato Ota ◽  
Yuko Sakurai ◽  
Takeshi Okadome ◽  
Itsuki Noda
1995 ◽  
Vol 268 (4) ◽  
pp. R919-R923 ◽  
Author(s):  
S. M. Martin ◽  
T. J. Malkinson ◽  
W. L. Veale ◽  
Q. J. Pittman

Conscious virgin, pregnant, or lactating rats were given intravenous Escherichia coli endotoxin while their temperatures were monitored telemetrically. Virgin females responded to 10-50 micrograms/kg endotoxin with a slight hypothermia, followed by a fever of nearly 2 degrees C magnitude. In pregnant rats given 25 micrograms/kg of the endotoxin, fevers were reduced between 96 h before and 24 h after parturition compared with those seen in virgins or in lactating rats > 24 h postpartum. In the 24-h period before expected time of parturition, no rat developed a fever and the majority of animals became hypothermic; furthermore, in 80% of such animals given 25 micrograms/kg endotoxin, the hypothermia was accompanied by death within 3-15 h. Some mortality and hypothermia were also seen up to 48 h before birth and up to 24 h after birth. No mortality was observed in virgin, pregnant, or lactating rats outside of this time period. We conclude that, around the time of delivery, there is a suppression of fever in the rat and occasional toxic responses to endotoxin.


eLife ◽  
2013 ◽  
Vol 2 ◽  
Author(s):  
Antonio Scialdone ◽  
Sam T Mugford ◽  
Doreen Feike ◽  
Alastair Skeffington ◽  
Philippa Borrill ◽  
...  

Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find that the rate of decrease is adjusted to accommodate variation in the time of onset of darkness and starch content, such that reserves last almost precisely until dawn. Generation of these dynamics therefore requires an arithmetic division computation between the starch content and expected time to dawn. We introduce two novel chemical kinetic models capable of implementing analog arithmetic division. Predictions from the models are successfully tested in plants perturbed by a night-time light period or by mutations in starch degradation pathways. Our experiments indicate which components of the starch degradation apparatus may be important for appropriate arithmetic division. Our results are potentially relevant for any biological system dependent on a food reserve for survival over a predictable time period.


Author(s):  
Peter Anderson ◽  
Eva Jané Llopis ◽  
Amy O’Donnell ◽  
Eileen Kaner

Abstract Aims To investigate if COVID-19 confinement led to excess alcohol purchases by British households. Methods We undertake controlled interrupted time series analysis of the impact of COVID-19 confinement introduced on 26 March 2020, using purchase data from Kantar Worldpanel’s of 23,833 British households during January to early July 2020, compared with 53,428 British households for the same time period during 2015–2018. Results Excess purchases due to confinement during 2020 were 178 g of alcohol per 100 households per day (adjusted for numbers of adults in each household) above an expected base of 438 g based on averaged 2015–2018 data, representing a 40.6% increase. However, when adjusting for expected normal purchases from on-licenced premises (i.e. bars, restaurants, etc.), there was evidence for no excess purchases of grams of alcohol (a 0.7% increase). With these adjustments, beer purchases dropped by 40%, wine purchases increased by 15% and spirits purchases by 22%. Excess purchases increased the richer the household and the lower the age of the main shopper. Confinement was associated with a shift in purchases from lower to higher strength beers. Conclusion During the COVID-19 confinement, the evidence suggests that households did not buy more alcohol for the expected time of the year, when adjusting for what they normally would have purchased from on-licenced premises.


Author(s):  
Laura E. Peterson ◽  
Denise H. Daudelin ◽  
Lisa C. Welch ◽  
Anshu Parajulee ◽  
Harry P. Selker

Abstract The Common Metrics Initiative aims to develop and field metrics to improve research processes within the national Clinical and Translational Science Award (CTSA) Consortium. A Median Accrual Ratio (MAR) common metric was developed to assess the results of efforts to increase subject accrual into a set of clinical trials within the expected time period. A pilot test of the MAR was undertaken at Tufts Clinical and Translational Science Institute (CTSI) with eight CTSA Consortium hubs. Post-pilot interviews were conducted with 9 CTSA Principal Investigators (PIs) and 23 pilot team members. Over three-quarters (78%) of respondents reported that the MAR could be useful for performance improvement, but also described limitations or concerns. The most commonly cited barrier to MAR use for performance improvement was difficulty in interpreting the single value that is produced. Most respondents were interested in using the MAR to assess recruitment at an individual trial level. Majority of respondents (63%) had mixed opinions about aggregating metric results across the CTSA Consortium for comparison or benchmarking. Collecting data about additional contextual factors, and comparing accrual between subgroups, were cited as potentially helping address concerns about aggregation. Significant challenges remain in ensuring that the MAR can be sufficiently useful for collaborative process improvement. We offer recommendations to potentially improve metric usefulness.


Author(s):  
Fitri Nugraheni ◽  
Vendie Abma ◽  
Sigit Yasien

The permit process must comply with laws and regulations. The permit functions as controlling and supervising tool from the government of activities in certain cases based on the guidelines that must be implemented. The permit also functions as a disciplinarian and regulator in accordance with the law in the administration of government. In the process, several constrains or obstacles often occur in terms of the period of the process as well as technical and non-technical constrains. In this research, an analysis of the scheduling of the site plan permit approval process is based on field data related to the site plan permit approval process with the PERT method. The data used are primary data in the form of interviews and filling in the form of questions and secondary data in the form of a site plan approval process flow. The data that has been collected is then processed and analyzed in several stages. First, calculate the expected time period (te) using interview data and the results of filling in the expected time period (te), so that the expected time period for each activity will be found in accordance with the site plan approval process flow. Second, determine the dependency relationship between activities. In this stage, the relationship between each activity is determined. Third, create a network by changing the existing site authorization process flow into a form of network planning. The results of the schedule using the PERT method are a period of 38 days with alternatives that can be done to reach the time (Tx) of 18 working days in accordance with the Regent Regulations. In addition, the probability of the overall activity being completed is 0.8531 or 85.31%.


2020 ◽  
Author(s):  
Barbara Pietragalla ◽  
Linda Füzér

<p>The Swiss phenology network operated by MeteoSwiss counts approximately 160 stations where up to 69 phenological events are observed by private persons. Currently, 68% of the observer transmit their data online by a recently developed tool called Phenotool. In order to reduce typing errors during the entry of the data, the values are instantly checked by Phenotool. The observer receives a visual warning if the data exceeds defined limits of an expected time-period giving him the opportunity to verify the date entered. The defined limits need to be as suitable as possible for each station and phenological event as numerous false warnings reduce the sensitivity of the observers and cause them to ignore the warning. <br>Until June 2019, limits had been used for five altitudinal layers and for each phenological event resulting from the mean ± 2 SD (standard deviation) rounded to the nearest 10. However, for some stations these limits were not appropriate, therefore, we decided to calculate station specific limits as follows: The median and SD was calculated for each phenological series consisting of at least 10 observations. In a second step, the mean of all SDs < 20 days was calculated and 2.5 times SD added/subtracted from the median. This approach leads to the same range of the limits for each phenological event, while the start of the limits is specific for each stations depending on the previously calculated median. If we would have used a station-specific standard deviation, stations with high variability and often less accurate data, would have been “awarded” with a large range. <br>For new stations, data-series consisting of less than 10 observations or deviant data-series, we calculated the limits with the mean standard deviations as described above and a predicted median from a linear regression model showing the relationship between the medians of a specific phenological event and the station heights. Deviant data-series were recognized by a difference larger than 30 days between modelled and calculated median.<br>The comparison of the old and new limits revealed that the newly calculated limits have an average range which is 8.52 days smaller. 55 out of the 69 phenological events have a smaller range, two has the same, and the remaining 12 have a larger range. Using the previous limits, in average 8.12% of the data from 1985-2019 was outside the defined ranges, however, applying the new limits results in 3.98% of the observations not fitting the limits. Considering the fact that the new limits have in average a smaller range, this improvement becomes even more significant. To conclude, we can say that the new limits produce clearly less warnings and more appropriate warnings in Phenotool enhancing data quality.</p>


2005 ◽  
Vol 119 (3) ◽  
pp. 184-188 ◽  
Author(s):  
A Alaani ◽  
R Hogg ◽  
N Saravanappa ◽  
R M Irving

Bell’s palsy or idiopathic facial palsy is the commonest cause of unilateral lower motor neuron facial palsy. Misdiagnosis of facial nerve palsy as Bell’s palsy is still seen in clinical practice. The clinician should always consider the possibility of a potentially serious underlying pathology before making the diagnosis of Bell’s palsy.We present a series of 13 patients referred to our ENT department with an initial diagnosis of Bell’s palsy. Further clinical examination and investigation revealed the underlying cause. Many had additional symptoms and signs related to the ear.In all patients with unilateral facial palsy a detailed history should be taken and thorough clinical examination carried out. Where no recovery occurs within the expected time period further radiological investigations such as computerized axial tomography (CT) and magnetic resonance imaging (MRI) should be performed. Current scanning techniques provide good quality images, which can show occult lesions of the temporal bone, internal acoustic canal and/or cerebellopontine angle. Radiologists with a special interest and experience in otoneurological radiology should ideally report these images, and a close co-operation between ENT surgeon and radiologist is essential in arriving at a proper diagnosis.


1997 ◽  
Vol 161 ◽  
pp. 419-429 ◽  
Author(s):  
Antonio Lazcano

AbstractDifferent current ideas on the origin of life are critically examined. Comparison of the now fashionable FeS/H2S pyrite-based autotrophic theory of the origin of life with the heterotrophic viewpoint suggest that the later is still the most fertile explanation for the emergence of life. However, the theory of chemical evolution and heterotrophic origins of life requires major updating, which should include the abandonment of the idea that the appearance of life was a slow process involving billions of years. Stability of organic compounds and the genetics of bacteria suggest that the origin and early diversification of life took place in a time period of the order of 10 million years. Current evidence suggest that the abiotic synthesis of organic compounds may be a widespread phenomenon in the Galaxy and may have a deterministic nature. However, the history of the biosphere does not exhibits any obvious trend towards greater complexity or «higher» forms of life. Therefore, the role of contingency in biological evolution should not be understimated in the discussions of the possibilities of life in the Universe.


Author(s):  
Itaru Watanabe ◽  
Dante G. Scarpelli

Acute thiamine deficiency was produced in mice by the administration of oxythiamine, a thiamine analogue, superimposed upon a thiamine deficient diet. Adult male Swiss mice (30 gm. B.W.) were fed with a thiamine deficient diet ad libitumand were injected with oxythiamine (170 mg/Kg B.W.) subcutaneously on days 4 and 10. On day 11, severe lassitude and anorexia developed, followed by death within 48 hours. The animals treated daily with subcutaneous injections of thiamine (300 μg/Kg B.W.) from day 11 through 15 were kept alive. Similarly, feeding with a diet containing thiamine (600 μg/Kg B.W./day) from day 9 through 17 reversed the condition. During this time period, no fatal illness occurred in the controls which were pair-fed with a thiamine deficient diet.The oxythiamine-treated mice showed a significant enlargement of the liver, which weighed approximately 1.5 times as much as that of the pair-fed controls. By light and electron microscopy, the hepatocytes were markedly swollen due to severe fatty change and swelling of the mitochondria.


Author(s):  
Robert E. Ogilvie

The search for an empirical absorption equation begins with the work of Siegbahn (1) in 1914. At that time Siegbahn showed that the value of (μ/ρ) for a given element could be expressed as a function of the wavelength (λ) of the x-ray photon by the following equationwhere C is a constant for a given material, which will have sudden jumps in value at critial absorption limits. Siegbahn found that n varied from 2.66 to 2.71 for various solids, and from 2.66 to 2.94 for various gases.Bragg and Pierce (2) , at this same time period, showed that their results on materials ranging from Al(13) to Au(79) could be represented by the followingwhere μa is the atomic absorption coefficient, Z the atomic number. Today equation (2) is known as the “Bragg-Pierce” Law. The exponent of 5/2(n) was questioned by many investigators, and that n should be closer to 3. The work of Wingardh (3) showed that the exponent of Z should be much lower, p = 2.95, however, this is much lower than that found by most investigators.


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