PLASMA TESTOSTERONE IN MALE PUBERTY

1974 ◽  
Vol 75 (1) ◽  
pp. 181-194 ◽  
Author(s):  
D. Knorr ◽  
F. Bidlingmaier ◽  
O. Butenandt ◽  
H. Fendel ◽  
R. Ehrt-Wehle
Keyword(s):  
Bone Age ◽  
Pubic Hair ◽  
Cross Sectional Study ◽  
Growth Spurt ◽  
Plasma Testosterone ◽  
Gas Liquid Chromatography ◽  
Cross Sectional ◽  
Sexual Characteristics ◽  
Testicular Size ◽  
Axillary Hair

ABSTRACT Plasma testosterone was investigated by gas-liquid chromatography with an electron capture detector in a cross-sectional study in childhood and during puberty in 214 boys. The testosterone values were correlated with sexual characteristics such as axillary hair, pubic hair, testicular size and bone age. In 22 individuals during puberty a longitudinal study was started, indicating a very steep increase of plasma testosterone between 40 and 240 ng/100 ml. This stage is mostly passed through very rapidly within 10 months. Plasma testosterone, growth velocity and weight gain were correlated in two boys during puberty. The peak of growth spurt occurs between 50 and 170 ng of plasma testosterone.

PLASMA LH AND FSH RESPONSE TO LRH AND PLASMA TESTOSTERONE LEVELS IN BOYS WITH IRREGULAR PUBERTY

1977 ◽  
Vol 85 (3) ◽  
pp. 456-464 ◽  
Author(s):  
Zvi Dickerman ◽  
Yehuda Bar-Haim ◽  
Ruth Prager-Lewin ◽  
Haiuta Kaufman ◽  
Zvi Laron
Keyword(s):  
Bone Age ◽  
Pubic Hair ◽  
Growth Spurt ◽  
Plasma Testosterone ◽  
Control Group ◽  
Testicular Development ◽  
Pubertal Stage ◽  
Testosterone Levels ◽  
Basal Plasma ◽  
Pubertal Stages

ABSTRACT Nineteen boys with irregular puberty (IP), defined as a discrepancy of two or more pubertal stages between the criteria for genitalia and that for pubic hair, were subjected to a standard LRH test (50 μg/m2, iv) and the response of gonadotrophins as well as the basal levels of plasma testosterone, LH and FSH were compared to those of boys with normal, regular puberty. When the results were plotted against the pubertal stage for genitalia (Pg), it was found that in the boys with IP the basal plasma testosterone levels were lower and the response of plasma LH to LRH stimulation lesser than in the controls. However, when these parameters were plotted against the pubertal stage for pubic hair (Ph) it was found, that in the boys with IP the plasma testosterone levels were significantly higher and the response of both LH and FSH stimulation greater than in the control group. It was concluded that irregular puberty in boys may be regarded as a normal variation. The delayed development of sexual hair and penile length, and retarded pubertal growth spurt and bone age maturation seen in these boys, with normal testicular development, may be explained by a temporary reduced peripheral sensitivity to androgens and a compensatory effort by the pituitary, manifested in increased secretion of LH and testosterone, relatively to their pubertal stage for pubic hair.

REPLACEMENT ORAL ETHINYLOESTRADIOL THERAPY FOR GONADAL DYSGENESIS: GROWTH AND ADRENAL ANDROGEN STUDIES

1979 ◽  
Vol 91 (3) ◽  
pp. 519-528 ◽  
Author(s):  
Anne W. Lucky ◽  
Samuel P. Marynick ◽  
Robert W. Rebar ◽  
Gordon B. Cutler ◽  
Michael Glen ◽  
...  
Keyword(s):  
Gonadal Dysgenesis ◽  
Bone Age ◽  
Pubic Hair ◽  
Height Velocity ◽  
First Year ◽  
Adrenal Androgen ◽  
Secondary Sexual Characteristics ◽  
Sexual Characteristics ◽  
Second Year ◽  
Pre Treatment

ABSTRACT We have studied growth and adrenal dehydroepiandrosterone (DHA) responses to iv synthetic adrenocorticotrophic hormone (ACTH, Cortrosyn) in 6 girls with gonadal dysgenesis before and during treatment with lowdose ethinyloestradiol (EOe2). In all patients there was a statisfactory induction of secondary sexual characteristics including increase in breasts and pubic hair and onset of withdrawal bleeding within 6 months of therapy. Height velocity increased from 2.8 ± 0.9 cm/year pre-treatment to 5.3 ± 1.5 cm/year (P < 0.02) in the first year. There was deceleration to 1.9 ± 1.1 cm/year in the second year. There was no disproportionate advancement in bone age and thus, presumably, no loss of ultimate height. We could demonstrate no change in basal or ACTH-stimulated levels of DHA, a specific adrenal androgen, to account for the increased pubic hair and growth in these patients.

scholarly journals Prevalence of nutritional deficiencies among school going adolescents of Vadodara, Gujarat, India: a cross sectional study

2019 ◽  
Vol 6 (6) ◽  
pp. 1767
Author(s):  
Ashish Shamjibhai Bhalsod ◽  
Nisarg N. Dave ◽  
Nilesh Thakor
Keyword(s):  
Vitamin A Deficiency ◽  
Protein Energy Malnutrition ◽  
Cross Sectional Study ◽  
Nutritional Deficiencies ◽  
Growth Spurt ◽  
Cross Sectional ◽  
Male Adolescents ◽  
Protein Energy ◽  
Complex Deficiency ◽  
Fatty Acid Deficiency

Background: Adolescent constitutes over 23% of the population in India. Critical development occurs during adolescence period. Growth spurt and increase in physical activity during adolescent period increases the nutrition and health needs of the adolescent. Objective was to study prevalence of nutritional deficiencies among school going adolescents of Vadodara city, Gujarat.Methods: The study was carried during period from September 2018 to August 2019. After taking the permission of principals of 3 schools and consent of the parents of adolescents, 511 adolescents from 3 schools of Vadodara city were examined for signs of various nutritional deficiencies. The data was collected by predesign, pretested proforma and analyzed using SPSS 17.0 (Trial Version).Results: Out of total 511 adolescents 253(49.5%) were female. Mean age of the study adolescents was 15.6±1.81 years. Maximum numbers of the adolescents were in the age group of 10-14 years (60.3%). Mean age of female and male adolescents was 15.2±1.71 years and 15.6±2.01 years respectively. The study revealed that vitamin A deficiency was present in 38(7.4%) adolescents. Vitamin B complex deficiency signs were seen in 112(21.9%) adolescents. Vitamin C deficiency signs were seen in 43(8.4%) adolescents. Protein Energy Malnutrition was observed in 52(10.1%) adolescents. Essential fatty acid deficiency was observed in 56(10.9%) adolescents.Conclusions: High prevalence of nutritional deficiencies among these adolescents needs great attention and health education.

scholarly journals Parceria sexual entre pessoas vivendo com HIV: gerenciando as diferenças sorológicas

2020 ◽  
Vol 19 (2) ◽  
pp. 494-530
Author(s):  
Layze Braz de Oliveira ◽  
Christefany Régia Braz Costa ◽  
Priscila Silva Pontes ◽  
Rosilane de Lima Brito Magalhães ◽  
Elucir Gir ◽  
...  
Keyword(s):  
Care Service ◽  
Scientific Evidence ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Hiv Diagnosis ◽  
Cross Sectional ◽  
Number Of Children ◽  
Study Results ◽  
Sexual Characteristics ◽  
Vaginal Sex

Objetivo: Analizar si existen diferencias entre las características sociodemográficas, clínicas y afectivas sexuales en las diferentes asociaciones sexuales entre personas viviendo con VIH / sida. Métodos: Se trata de un estudio transversal realizado en un servicio de asistencia especializada en el tratamiento de personas con el Virus de la Inmunodeficiencia Humana, con 173 participantes. Los datos fueron recolectados por medio de entrevistas con cuestionarios construidos para el estudio. Resultados: Se verificaron evidencias estadísticas entre la serología del compañero y el sexo, estado civil, hijo, número de hijos. La serología del compañero sexual también presentó evidencias científicas entre las variables tipo de asociación, uso del preservativo masculino, práctica sexual vaginal insertiva, divulgación del diagnóstico del VIH para la asociación sexual y considera importante la divulgación del VIH para el socio. Conclusión: La serología del compañero fue influenciada por las variables sociodemográficas y afectivo-sexuales. Objective: To analyze whether there are differences between socio-demographic, clinical and affective-sexual characteristics in the different sexual partnerships between people living with HIV/AIDS. Methods: This is a cross-sectional study carried out in a care service specialized in the treatment of people with Human Immunodeficiency Virus, with 173 participants. Data were collected through interviews with a questionnaire built for the study. Results: Statistical evidences were verified between the serology of the partner and the sex, marital status, child, number of children. The serology of the sexual partner also presented scientific evidence among the type variables of partnership, use of the male condom, insertive vaginal sex, dissemination of the HIV diagnosis to the sexual partnership and the importance of spreading HIV to the partner. Conclusion: The serology of the partner was influenced by sociodemographic and affective-sexual variables.

SEXUAL MATURATION OF CHINESE BOYS IN HONG KONG

PEDIATRICS ◽  
1966 ◽  
Vol 37 (5) ◽  
pp. 804-811
Author(s):  
K. S. Francis Chang ◽  
P. H. Ng ◽  
Marjorie M. M. C. Lee ◽  
S. J. Chan
Keyword(s):  
Sexual Maturation ◽  
Developmental Stages ◽  
Total Sample ◽  
Pubic Hair ◽  
Socioeconomic Background ◽  
Cross Sectional ◽  
Socioeconomic Groups ◽  
End Point ◽  
Axillary Hair ◽  
Probit Method

Sexual maturation of 3,658 Chinese school boys from 6 to 18 years of age was assessed by investigating four attributes associated with puberty, namely, growth of genitalia (penis), pubic hair, axillary hair, and change of voice. The first two attributes were rated on a 5-point scale (5 stages), and the last two attributes were just noted as having occurred or not. The children were divided into three socioeconomic groups based on multiple criteria comprising family educational level, occupation, income, and housing conditions. The probit method of biological assay with weighting scheme was employed to estimate the 30%, 50% (median age), and 70% end points and fiducial limits of the onset of development of the above-mentioned four attributes of boys in the three socioeconomic groups and of the total sample. In the case of genitalia and pubic hair, the same was done for the completion of development. The median ages (50% end point) of onset of development for genitalia, pubic hair, voice, and axillary hair of the total sample were 13.19 ± 0.19, 13.31 ± 0.21, 13.67 ± 0.43, and 14.57 ± 0.10 respectively. The median ages (50% end point) for the completion of genitalia and pubic hair development were the same, 16.47 ± 0.10. The estimated duration between the successive developmental stages of genitalia and pubic hair show the period between Stages 2 and 3 to be the shortest (genitalia, 0.55 year, pubic hair, 0.39), and longest in the period between Stage 4 and 5 (genitalia and pubic hair, 1.87). The estimated whole duration of pubescence from onset to completion was about 3.28 years. In temporal sequence of maturation, the development of genitalia and pubic hair was the first and practically simultaneous, followed by the change of voice (0.48 year after genitalia), and the last to develop was the axillary hair (0.9 year after change of voice). The effect of socioeconomic background was shown to be evident, the boys from well-circumstanced homes being significantly more advanced in development than those from poor homes. Comparison of our results with those of similar cross-sectional investigations on American and British boys show little difference in spite of race and clime.

Letters to the Editor

PEDIATRICS ◽  
1973 ◽  
Vol 52 (1) ◽  
pp. 150-150
Author(s):  
Gertrude Costin ◽  
Maurice D. Kogut
Keyword(s):  
Thyroid Hormone ◽  
Clinical Data ◽  
Pubic Hair ◽  
Breast Development ◽  
Letters To The Editor ◽  
Female Patients ◽  
Secondary Sexual Characteristics ◽  
Adequate Therapy ◽  
Sexual Characteristics ◽  
Axillary Hair

Drs. Costin and Kogut comment as follows: We were pleased to read Dr. Comas' letter in which he describes a 12-4/12-year-old girl whose clinical data suggest that she may be an example of the syndrome that we reported. The evidence for this was the occurrence of menstruation, pubic hair, and breast development when the patient was hypothyroid and disappearance of menstruation following treatment with thyroid hormone. It is not clear why Dr. Comas' patient had an increase in pubic hair and appearance of axillary hair following treatment at a time when her menstrual periods ceased; in all the reported female patients regression of the secondary sexual characteristics was noted following adequate therapy.

Treatment of anorchia with oral testosterone undecanoate: pharmacodynamics and clinical effectiveness

1980 ◽  
Vol 95 (2) ◽  
pp. 244-250 ◽  
Author(s):  
J. Weil ◽  
F. Bidlingmaier ◽  
O. Butenandt ◽  
W. G. Sippell ◽  
W. Baumgartner ◽  
...  
Keyword(s):  
Single Dose ◽  
Oral Administration ◽  
Sexual Maturation ◽  
Peak Level ◽  
Clinical Effectiveness ◽  
Bone Age ◽  
Plasma Testosterone ◽  
Testosterone Undecanoate ◽  
Axillary Hair ◽  
Specific Radio

Abstract. The pharmacodynamics of plasma testosterone (T) and androstenedione (A) levels were studied in ten hypogonadal boys after oral administration of testosterone undecanoate (TU). Plasma T and A levels were measured by specific radio-immunoassays. Six hours after a single dose of 120 mg TU, there was a significant increase (P < 0.005) in plasma T and A with a median T peak level of 940 ng/100 ml. Furthermore, twelve agonadal boys treated with a mean dose of 60 mg TU/day were examined over a period of 18–24 months. During this therapy, plasma T and A levels were significantly higher than before (P < 0.005), whereas plasma levels of LH and FSH did not decrease significantly. With the exception of one anorchic boy, all patients showed signs of sexual maturation, such as growth of pubic and axillary hair, and steady development of bone age during oral TU treatment.

scholarly journals Nutritional status of adolescent girls in a rural area of Bangladesh: A cross sectional study

2017 ◽  
Vol 52 (3) ◽  
pp. 221-228 ◽  
Author(s):  
A Begum ◽  
KN Sharmin ◽  
MA Hossain ◽  
N Yeasmin ◽  
T Ahmed
Keyword(s):  
Nutritional Status ◽  
Nutrition Education ◽  
Adolescent Girls ◽  
Rural Areas ◽  
Adolescent Girl ◽  
Cross Sectional Study ◽  
Growth Spurt ◽  
Measuring Instruments ◽  
Sectional Study ◽  
Cross Sectional

The improvement of adolescent nutritional status may help address the reduction of all forms of malnutrition in Bangladesh. This is because at this stage, they experience a growth spurt thus increasing the need for most nutrients, needed for growth and reproductive health. The objective of this research was to assess the nutritional status of adolescent girls in rural areas of Bangladesh and find out the associated factors that affects nutritional status. A cross sectional study was carried out among 106 adolescent girls of Nobabpur village in Comilla district. A questionnaire was developed to obtain demographic information, food intake pattern and anthropometric measures such as weight, height with measuring instruments. About 80% were found normal according to BMI where about 13% adolescent girls were malnourished, below the cut off value 18.5. Place of residence, education of adolescent girls, their family expenditure to food and improper knowledge on food and nutrition were identified as underlying causes. Nutritional profiles of adolescent girl can be improved by implementing effective nutrition education program, providing supplementary food, facilitating primary health care program and creating awareness about nutritional knowledge. Severely malnourished adolescent girl in the selected area should be identified as early as possible and brought under supplementary feeding program.Bangladesh J. Sci. Ind. Res. 52(3), 221-228, 2017

Comparison of Tanner staging of HIV-infected and uninfected girls at the University of Nigeria Teaching Hospital, Ituku/Ozalla, Enugu, Nigeria

2017 ◽  
Vol 30 (7) ◽  
Author(s):  
Ogochukwu N. Iloh ◽  
Kenechukwu K. Iloh ◽  
Agozie C. Ubesie ◽  
Ifeoma J. Emodi ◽  
Anthony N. Ikefuna ◽  
...  
Keyword(s):  
Sexual Maturation ◽  
Developmental Stages ◽  
Pubic Hair ◽  
Cross Sectional Study ◽  
Breast Development ◽  
Cross Sectional ◽  
Tanner Staging ◽  
Perinatal Hiv ◽  
Number Of Factors ◽  
Nigeria Teaching Hospital

AbstractBackground:A number of factors influence sexual maturation in adolescents, including chronic illnesses like HIV. Marshall and Tanner devised a method of classifying the adolescent based on the level of sexual maturation into five stages. This study compared the Tanner staging of HIV-infected and uninfected girls.Methods:This was a cross-sectional study of 100 HIV-infected girls aged 8–18 years and 100 uninfected counterparts matched for age and social class. Using standard photographs as a guide, stages of sexual maturation were determined according to the method proposed by Marshall and Tanner. Data analysis was done with SPSS version 20. p-values <0.05 were regarded as significant.Results:The study participants were aged 8–17 years. Fifty-five subjects compared to 39 controls were still in pre-pubertal breast developmental stages while 45 subjects (45%) compared to 61 controls (61%) have commenced breast development (p=0.024). Similarly, 52 subjects compared to 31 controls were in the pre-pubertal pubic hair developmental stages, while 48 subjects (48%) compared to 69 controls (69%) had commenced pubic hair development (p=0.003).Conclusions:Perinatal HIV infection affected the onset of pubic hair and breast development but did not significantly affect the attainment of sexual maturation.

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