Free and conjugated plasma catecholamines in pheochromocytoma patients with and without sustained hypertension

Abstract. Ten pheochromocytoma patients, five with paroxysmal hypertension (Group 1), five with sustained hypertension (Group 2) and 15 normals were studied to determine the relationship between differential secretion of the catecholamines (CA) or differences in their sulphoconjugation and the hypertension patterns in these patients. Group 1 patients were studied in the normotensive period. A consistent finding in this study is that permanent hypertensive patients showed the highest free and conjugated norepinephrine (NE) levels while paroxysmal patients studied during the normotensive period showed the highest conjugated epinephrine (E) levels. Although no significant difference was found in levels of free plasma epinephrine in the Group 1 patients, in the ratio of total plasma E/NE, E was clearly predominant. No significant differences could be found in the degree of the per cent conjugation of individual catecholamines between both groups of patients. Group 1 showed a higher (P < 0.05) E and a lower dopamine (DA) per cent conjugation than controls. In conclusion, although the dominant type of CA secreted seems to be the main factor in determining the hypertension pattern, sulphoconjugation ability may also play an important role.

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The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients

Blood Purification ◽

10.1159/000515639 ◽

2021 ◽

pp. 1-7

Author(s):

Emre Erdem ◽

Ahmet Karatas ◽

Tevfik Ecder

Keyword(s):

Serum Ferritin ◽

Hemodialysis Patients ◽

Rank Test ◽

Significant Difference ◽

All Cause Mortality ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. Methods: A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: serum ferritin <800 ng/mL, group 2: serum ferritin 800–1,500 ng/mL, and group 3: serum ferritin >1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. Results: Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5–60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, p = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05–0.49]; p = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12–0.88]; p = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23–1.04]; p = 0.063). Conclusion: Time-averaged serum ferritin levels >1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.

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Interaction Between Age and Change in Velocity During a Baseball Training Program

Orthopaedic Journal of Sports Medicine ◽

10.1177/2325967120927939 ◽

2020 ◽

Vol 8 (6) ◽

pp. 232596712092793

Author(s):

Christopher Antonacci ◽

Thomas R. Atlee ◽

Peter N. Chalmers ◽

Christopher Hadley ◽

Meghan E. Bishop ◽

...

Keyword(s):

Training Program ◽

Age Groups ◽

Maximum Velocity ◽

Age Group ◽

Significant Difference ◽

Group 3 ◽

Baseball Pitchers ◽

Group 2 ◽

The Relationship ◽

Group 1

Background: Pitching velocity is one of the most important metrics used to evaluate a baseball pitcher’s effectiveness. The relationship between age and pitching velocity after a lighter ball baseball training program has not been determined. Purpose/Hypothesis: The purpose of this study was to examine the relationship between age and pitching velocity after a lighter ball baseball training program. We hypothesized that pitching velocity would significantly increase in all adolescent age groups after a lighter baseball training program, without a significant difference in magnitude of increase based on age. Study Design: Cohort study; Level of evidence, 2. Methods: Baseball pitchers aged 10 to 17 years who completed a 15-week training program focused on pitching mechanics and velocity improvement were included in this study. Pitchers were split into 3 groups based on age (group 1, 10-12 years; group 2, 13-14 years; group 3, 15-17 years), and each group trained independently. Pitch velocity was assessed at 4 time points (sessions 3, 10, 17, and 25). Mean, maximum, and mean change in pitch velocity between sessions were compared by age group. Results: A total of 32 male baseball pitchers were included in the analysis. Mean/maximum velocity increased in all 3 age groups: 3.4/4.8 mph in group 1, 5.3/5.5 mph in group 2, and 5.3/5.2 mph in group 3. While mean percentage change in pitch velocity increased in all 3 age groups (group 1, 6.5%; group 2, 8.3%; group 3, 7.6%), the magnitude of change was not significantly different among age groups. Program session number had a significant effect on mean and maximum velocity, with higher mean and maximum velocity seen at later sessions in the training program ( P = .018). There was no interaction between age and program session within either mean or maximum velocity ( P = .316 and .572, respectively). Conclusion: Age had no significant effect on the magnitude of increase in maximum or mean baseball pitch velocity during a velocity and mechanics training program in adolescent males.

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Expression of Sigma-Class Glutathione-S-Transferase in Fetal and Pediatric Filum Terminale Samples: A Comparative Study

Medicina ◽

10.3390/medicina55050133 ◽

2019 ◽

Vol 55 (5) ◽

pp. 133

Author(s):

Cahit Kural ◽

Serpil Oguztuzun ◽

Gülçin Güler Şimşek ◽

Servet Guresci ◽

Pınar Kaygın ◽

...

Keyword(s):

Tethered Cord ◽

Filum Terminale ◽

Glutathione S Transferase ◽

Chi Square ◽

Significant Difference ◽

Chi Square Test ◽

Normal Human ◽

Group 2 ◽

The Relationship ◽

Group 1

Background and objectives: The pathophysiology of tethered cord syndrome (TCS) in children is not well elucidated. An inelastic filum terminale (FT) is the main factor underlying the stretching of the spinal cord in TCS. Our study aimed to investigate the expression of glutathione-S-transferase (GST) in children and fetal FT samples in order to understand the relationship between this enzyme expression and the development of TCS. Materials and Methods: FT samples were obtained from ten children with TCS (Group 1) and histological and immunohistochemical examinations were performed. For comparison, FT samples from fifteen normal human fetuses (Group 2) were also analyzed using the same techniques. Statistical comparison was made using a Chi-square test. Results: Positive GST-sigma expression was detected in eight (80%) of 10 samples in Group 1. The positive GST-sigma expression was less frequent in nine (60%) of 15 samples from Group 2. No statistically significant difference was detected between the two groups (p = 0.197). Conclusions: Decreased FT elasticity in TCS may be associated with increased GST expression in FT. More prospective studies are needed to clarify the mechanism of the GST–TCS relationship in children.

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COVID-19-associated healthcare worker depression: An increasingly common condition

Praxis of Otorhinolaryngology ◽

10.5606/kbbu.2021.23855 ◽

2021 ◽

Vol 9 (3) ◽

pp. 93-97

Author(s):

Kemal Koray Bal

Keyword(s):

Healthcare Workers ◽

Depressive Mood ◽

Clinical Psychologist ◽

Sufficient Information ◽

Increased Risk ◽

Significant Difference ◽

Group 2 ◽

Work Done ◽

The Relationship ◽

Group 1

OBJECTIVE: This study aimed to evaluate the mood of the employees of the ear-nose-throat (ENT) department with the Beck Depression Inventory (BDI) during the coronavirus disease 2019 (COVID-19) pandemic and determine the relationship between the mood and the quality and quantity of the work done. METHODS: A total of 62 healthcare workers (24 males, 38 females; mean age: 34.3±1.1 years; range 24 to 52 years) of our ENT clinic, who have been actively managing COVID-19 patients since April 2020, were included in the study. Those in the study were classified into two groups as nurses (Group 1) and doctors (Group 2). Group 1 consisted of 33 (53.2%) nurses, and Group 2 consisted of 29 (46.8%) doctors. The participants were assessed with a questionnaire by a clinical psychologist, and BDI was conducted to evaluate depressive mood in these individuals. RESULTS: A statistically significant difference was found between the groups in thinking they have sufficient knowledge on COVID-19, and the employees in Group 2 were more of the opinion that they did not have sufficient information (p=0.002). A statistically significant difference was found between the groups in terms of their viewpoint on the precautions against COVID-19 (p=0.001). Group 2 was more inclined to think that the precautions taken were inadequate (p=0.001). There was no statistically significant difference between the groups in terms of BDI severity, age, and BDI score (p=0.252, p=0.137, p=0.053, respectively). CONCLUSION: Employees of high-risk departments such as ENT may be more prone to a depressed mood. The increased risk of contamination in correlation with the work done can lead to increased BDI scores and depressive mood disorder.

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The Effects of Leukocyte- and Platelet-Rich Plasma (L-Prp) and Pure Platelet-Rich Plasma (P-Prp) an a Rat Endometriosis Model

10.1101/802421 ◽

2019 ◽

Author(s):

Ali Doğukan Anğın ◽

İsmet Gün ◽

Önder Sakin ◽

Muzaffer Seyhan Çıkman ◽

Zehra Meltem Pirioğlu ◽

...

Keyword(s):

Platelet Rich Plasma ◽

Saline Group ◽

Group 4 ◽

Vascular Congestion ◽

Significant Difference ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Volume Difference ◽

Group 1

AbstractOur aim was to investigate the effect of platelet-rich plasma (PRP) derivatives, which can be produced from the patient’s own blood and have minimal side effects, on endometriosis. To the best of our knowledge, this is the first study in the literature that studies the relationship between PRP and endometriosis. Endometriosis foci were created in the first operation. In the second operation (30th day) groups were formed. Group 1 (n= 8) was administered saline, group 2 (n= 7) leukocyte- and platelet-rich plasma (L-PRP), and group 3 (n= 8) pure platelet-rich plasma (P-PRP). Group 4 (n= 10) was used to obtain PRP. In the last operation (60th day), the endometriotic foci were measured, and then excised. There was no statistically significant difference between the pre and post volumes of the endometriotic foci, between their volume differences and volume difference rates (p > .05). However, it was observed that existing implant volumes in all groups decreased statistically significantly within their own groups by the end of the experiment compared to the previous volumes (p < .05). When the implants were assessed through histopathological scoring in terms of edema, vascular congestion, inflammatory cell infiltration, hemorrhage, epithelial line, and hemosiderin accumulation and immunohistochemical staining in terms of VEGF, there was no significant difference in the comparison between the groups. Although L-PRP and P-PRP generated more reduction in the endometriosis foci, they did not create any statistical differences.

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The relationship between digital ultrasonographic image echotexture parameters of the uterus and preovulatory follicle development and ovulation in purebred Arabian mares

Veterinarski arhiv ◽

10.24099/vet.arhiv.0921 ◽

2021 ◽

Vol 91 (3) ◽

pp. 261-268

Author(s):

Ömer Korkmaz ◽

◽

Tuğra Akkuş ◽

Birten Emre ◽

Abuzer K. Zonturlu

Keyword(s):

Ovarian Follicle ◽

Objective Assessment ◽

Computer Assisted ◽

Follicle Development ◽

Preovulatory Follicle ◽

Significant Difference ◽

The Difference ◽

Group 2 ◽

The Relationship ◽

Group 1

Objective assessment of ultrasonographic images is only possible using computer-assisted echotexture analysis. This study investigated the relationship between cyclic digital echotexture analysis of ultrasonographic uterine images, and preovulatory follicle development and ovulation in 48 cyclic purebred Arabian mares during the breeding season. When the mares’ ovarian follicle diameters exceeded 30 mm, ultrasonographic examinations were performed and ultrasonographic images recorded with uterine endometrial edema degrees following follicle development until ovulation day. Echotexture measurements, including mean grayness value (MGV), heterogeneity (HET) and contrast (CON) parameters, were performed on the days when ovarian follicle diameters reached 30 mm (Group 1, n = 12), 35 mm (Group 2, n = 12), 40 mm (Group 3, n = 12) and 45 mm (Group 4, n = 12) in images recorded the day before ovulation and on the day of ovulation. MGV was the lowest in Group 2 and the difference from the other groups was statistically significant (P<0.001). CON was significantly higher in Group 2 than Groups 3 and 4 (P<0.01). However, there was no significant difference compared to Group 1 (P>0.05). Variations in HOM (P<0.05), contrast (P<0.05) and MGV (P<0.01) were statistically significant on the day before ovulation and ovulation day. Thus, uterine ultrasonographic echotexture parameters are associated with preovulatory follicle development in mares, which suggests that these parameters can indicate the day of ovulation in purebred Arabian mares.

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Life Satisfaction and Resilience among Divorced Women in India

International Journal of Indian Psychology ◽

10.25215/0301.135 ◽

2015 ◽

Vol 3 (1) ◽

Author(s):

Gautami Kapila ◽

Dr Arun Kumar

Keyword(s):

Life Satisfaction ◽

Statistical Analysis ◽

Satisfaction Scale ◽

Resilience Scale ◽

Significant Difference ◽

Group 2 ◽

The Relationship ◽

Women In India ◽

Life Satisfaction Scale ◽

Group 1

Aim: The purpose of the study was to identify the level of Life Satisfaction and Resilience among the divorced women in India. Method: This study aims to identify the relationship between Life satisfaction and resilience. Standardized questionnaires (LIFE SATISFACTION SCALE & CONNOR DAVIDSON RESILIENCE SCALE) were employed to measure Life satisfaction and Resilience, among 60 divorced women (Group1: women divorced for less than 5 years & Group 2: women divorced for more than 5 years), all aged between 30-50 years. The results were analysed using T-test and Pearson r. The score were tabulated. Results: The statistical analysis suggested a positive correlation between Life satisfaction and Resilience. The results also indicated that there is no significant difference between the level of life satisfaction and resilience among the Group 1 and Group 2.

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Graves Hastalığı ile Tnf- α, Galektin-3 ve Fibronektin Düzeylerinin İlişkisi

The Journal of Tepecik Education and Research Hospital ◽

10.5222/terh.2020.86719 ◽

2020 ◽

Author(s):

Ayşe İrem Yasin ◽

Mahmut Muzaffer İlhan ◽

Saime Turan ◽

İlhan Yaylim ◽

Özcan Karaman ◽

...

Keyword(s):

Inflammatory Process ◽

Tnf Alpha ◽

Enzyme Linked Immunosorbent Assay ◽

Control Group ◽

Healthy Controls ◽

Significant Difference ◽

Galectin 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

INTRODUCTION: In the pathogenesis of Graves' disease (GD), which is the most common cause of hyperthyroidism, cellular and humoral immune systems are thought to play a role together. TNF-alpha, fibronectin and galectin-3 known to play an active role in inflammatory processes. The aim of this study was to investigate the relationship between galectin-3, fibronectin and TNF-alpha molecules with hyperthyroidism and GD. METHODS: The study included 108 volunteers, 50 Graves, 19 non-Graves hyperthyroid patients and 39 healthy controls. Galectin-3, fibronectin and TNF-alpha levels measured by enzyme-linked immunosorbent assay (ELISA). In the Graves group (Group 1) 32 women, 18 men; in the non-Graves hyperthyroidism group (Group 2) 13 women, 6 men; and there were age- and sex-matched 26 females and 13 males in the control group (Group 3). RESULTS: TNF-alpha levels were 22.7 ± 1.97 pg / ml in Group 1, 19.8 ± 2.56 pg / ml in Group 2, and 16.6 ± 2.29 pg / ml in the control group. TNF-alpha levels were significantly higher in GD group compared to healthy controls (p <0.009). There was no significant difference between the three groups in terms of galectin-3 and fibronectin levels. DISCUSSION AND CONCLUSION: In this study, the relationship between GD and galectin-3 investigated for the first time in the literature and TNF-alpha levels shown in addition to the inflammatory markers known in GD. This finding supports the previous studies and shows the presence of the inflammatory process in GD. Unlike the other causes of hyperthyroidism, the lightening of this inflammatory process in GD, with inflammatory comorbidities such as ophthalmopathy, orbitopathy and dermopathy, will contribute to the development of new treatment options both for the disease itself and for these comorbidities.

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Quality of Life According to Duration of Disease in Women With Low Disability in Multiple Sclerosis

International Journal of MS Care ◽

10.7224/1537-2073-10.3.77 ◽

2008 ◽

Vol 10 (3) ◽

pp. 77-80 ◽

Cited By ~ 1

Author(s):

Cecilie Fjeldstad ◽

Gabriel Pardo ◽

Michael Bemben

Keyword(s):

Quality Of Life ◽

Multiple Sclerosis ◽

Significant Difference ◽

Duration Of Disease ◽

Established Relationship ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

The primary aim of this study was to investigate the relationship between Expanded Disability Status Scale (EDSS) scores and quality of life (QOL) in women with multiple sclerosis (MS) and low disability and whether duration of disease influenced the established relationship. Sixty-six women diagnosed with MS (44.0 ± 1.2 [standard error] years) had EDSS scores of <5.0 as determined by their neurologist. Duration of disease from time of diagnosis ranged from 2 months to 28 years, and subjects were arbitrarily divided into three groups (group 1: 0.1–10.0 years; group 2: 10.1–20.0 years; group 3: 20.1–33.0 years). After giving informed consent, all subjects completed the MS Quality of Life-54 questionnaire (MSQOL-54). Mean EDSS was 1.4 for group 1, 2.0 for group 2, and 2.1 for group 3. Group 3 had the highest score for both the physical and mental components of MSQOL-54. In general, the relationship between the functional systems (FS) of EDSS and subcomponents of MSQOL-54 were negative and low to moderate in strength (r = −0.25 to −0.61; P < .01 or < .05), with cerebral FS having the most significant relationship with QOL variables. When duration of disease was considered, sensory FS was the only one that showed a significant difference between groups 1 and 2. In women with low disability caused by MS, the longer the duration of disease, the better the QOL, as reported by MSQOL-54.

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Morphokinetic parameters comparison between euploid and aneuploid blastocysts

Biomedical Research and Therapy ◽

10.15419/bmrat.v8i5.671 ◽

2021 ◽

Vol 8 (5) ◽

pp. 4325-4332

Author(s):

Phuong Thi Bich Le ◽

Anh Hoang Le ◽

Loc Minh Tai Nguyen ◽

Vinh Quang Dang

Keyword(s):

Recurrent Miscarriage ◽

Time Lapse ◽

Advanced Maternal Age ◽

Morphokinetic Parameters ◽

Alternative Approach ◽

Significant Difference ◽

Invasive Method ◽

Group 2 ◽

The Relationship ◽

Group 1

Background: Pre-implantation genetic testing for aneuploidy (PGT-A) has been using for years in embryoselection. However, this is an invasive method and may cause harm to the embryos. Therefore, time-lapse monitoring has been thought to be an alternative approach for embryo selection due to its efficiency. Up to now, several studies were investigating the relationship between the morphokinetic parameters and the embryo ploidy. However, the results are not consistent. This study aims to evaluate the correlation between morphokinetic parameters and PGT-A results. Methods: This retrospective cohort study was conducted at IVFMD Phu Nhuan, My Duc Phu Nhuan Hospital, between September 2018 and June 2019. Patients undergoing PGT-A due to advanced maternal age, repeated implantation failure or recurrent miscarriage and having embryo cultured under time-lapse monitoring were included. Patients with the re-thawing embryo for PGT-A were not eligible. The time from insemination to the pronuclear appearing (tPN), the onset of two to eight-cell divisions (t2 to t8) and the duration of the second cell cycle (cc2, t3-t2) were observed. Results: There were 39 patients included in the study, with mean age of 36.4 +/- 5.7 years. A total of 110 blastocysts were biopsied. Amongst them, 63 embryos (57.3%) were euploidy (group 1), and 47 embryos (42.7%) were aneuploidy (group 2). There was no significant difference between euploid, and aneuploid embryos regarding all morphokinetic parameters, including tPN, t2, t3, t4, t5, cc2, and t8 (7.2 +/- 1.5 hours vs. 7.4 +/- 1.6 hours; 25.0 +/- 2.8 hours vs. 25.6 +/- 3.2 hours; 35.8 +/- 3.6 hours vs. 36.9 +/- 3.3 hours; 37.5 +/- 4.4 hours vs. 38.3 +/- 4.3 hours; 49.2 +/- 5.52 hours vs. 49.9 +/- 6.2 hours; 10.7 +/- 2.6 hours vs. 11.2 +/- 1.7 hours; and 55.7 +/- 6.4 hours vs. 58.1 +/- 7.4 hours, respectively). Conclusion: In this study, we found no difference in the morphokinetic parameters between euploid and aneuploid embryos.

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