Thyroid-stimulating antibody and thyrotropin-binding inhibitory immunoglobulin activity in hypothyroid patients who subsequently developed thyrotoxicosis

1990 ◽  
Vol 122 (4) ◽  
pp. 499-504 ◽  
Author(s):  
Hajime Tamai ◽  
Kanji Kasagi ◽  
Osamu Mizuno ◽  
Nobuyuki Kobayashi ◽  
Gen Komaki ◽  
...  
Keyword(s):  
Hypothyroid Patient ◽  
Blocking Antibody ◽  
Autoimmune Thyroid ◽  
Thyroid Stimulating Antibody ◽  
The Third ◽  
Thyroid Stimulating Antibodies ◽  
Antibody Levels ◽  
Blocking Antibodies ◽  
Immunoglobulin Levels ◽  
Hypothyroid Patients

Abstract. Although abnormal thyroid-stimulating and -blocking antibodies have been demonstrated in hyperthyroid and hypothyroid patients with autoimmune thyroid disorders, a direct correlation is not always observed. Thyroid-stimulating antibody, thyrotropinbinding inhibitory immunoglobulin, and thyroid-stimulating blocking antibody levels were determined in three hypothyroid patients who subsequently developed hyperthyroidism. Thyroid-stimulating antibodies levels were normal in one, elevated in another, and unmeasured in the third hypothyroid patient, but became elevated in all patients with the onset of hyperthyroidism. There was discordance, however, in one patient who had markedly elevated thyroid-stimulating antibodies and TSH-binding inhibitory immunoglobulin levels when she was hypothyroid. The data indicate that thyroidal responses to the abnormal stimulating antibodies may differ among patients with autoimmune thyroid disease.

scholarly journals Comparison of the Immunogenicity of five COVID-19 vaccines in Sri Lanka

2021 ◽  
Author(s):  
Chandima Jeewandara ◽  
Inoka Aberathna ◽  
Saubhagya Danasekara ◽  
Laksiri Gomes ◽  
Suranga Fernando ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Clinical Outcomes ◽  
Antibody Responses ◽  
Blocking Antibody ◽  
Post Vaccination ◽  
Positive Threshold ◽  
Reported Data ◽  
Antibody Levels ◽  
Blocking Antibodies

We assessed antibody responses 3 months post-vaccination in those who received mRNA-1273 (n=225), Sputnik V (n=128) or the first dose of Gam-COVID-Vac (n=184) and compared the results with previously reported data of Sinopharm and AZD1222 vaccinees. 99.5% of Moderna >94% of AZD1222 or Sputnik V, 72% to 76% of Gam-COVID-Vac (first dose) and 38.1% to 68.3% of Sinopharm vaccinees had ACE2 blocking antibodies above the positive threshold. The ACE2 blocking antibody levels were highest to lowest was Moderna > Sputnik V/ AZD1222 (had equal levels)> first dose of Gam-COVID-Vac > Sinopharm. All Moderna recipients had antibodies above the positive threshold to the ancestral (WT), B.1.1.7, B.1.351.1 and 80% positivity rate for B.1.617.2. Positivity rates of Sputnik V vaccinees for WT and variants, were higher than AZD1222 vaccinees, while Sinopharm vaccinees had the lowest positivity rates (<16.7%). These findings highlight the need for further studies to understand the effects on clinical outcomes.

scholarly journals Seasonality of month of birth of patients with Graves’ and Hashimoto’s diseases differ from that in the general population

2007 ◽  
Vol 156 (6) ◽  
pp. 631-636 ◽  
Author(s):  
Gerasimos E Krassas ◽  
Konstantinos Tziomalos ◽  
Nikolaos Pontikides ◽  
Hadas Lewy ◽  
Zvi Laron
Keyword(s):  
General Population ◽  
Perinatal Period ◽  
Thyroid Peroxidase ◽  
Month Of Birth ◽  
Autoimmune Thyroid ◽  
Common Etiology ◽  
Antibody Titers ◽  
Low Levels ◽  
Antibody Levels

Objective: We aimed to test the viral hypothesis in the pathogenesis of autoimmune thyroid disease (AITD). Design: We determined the pattern of month of birth (MOB) distribution in patients with AITD and in the general population and searched for differences between them. Methods: A total of 1023 patients were included in this study; 359 patients had Graves’ hyperthyroidism (GrH) and 664 had Hashimoto’s hypothyroidism (HH). We divided the patients with HH into three subgroups according to their thyroid peroxidase (TPO) antibody titers at diagnosis: low levels (<500 IU/ml), high levels (500–1000 IU/ml), and extremely high levels (>1000 IU/ml). We used cosinor analysis to analyze the data. Results: Overall, patients with GrH and HH had a different pattern of MOB distribution when compared with the general population and between groups. Furthermore, among both patients with GrH and HH, both genders had a different pattern of MOB distribution when compared with the general population and this pattern was also different between genders. Finally, only women with extremely high titers of TPO antibodies at diagnosis and men with low or extremely high TPO antibody levels showed rhythmicity in MOB, with a pattern of MOB distribution different from that in controls. Conclusions: The different MOB seasonality in both GrH and HH points towards a similar maybe even common etiology with type 1 diabetes mellitus and multiple sclerosis, namely a seasonal viral infection as the initial trigger in the perinatal period, the clinical disease resulting from further specific damage over time.

scholarly journals Incidence of Psychiatric Morbidities in Drug Naive Hypothyroid Patients: A Case Control Study

2017 ◽  
Vol 4 (2) ◽  
Author(s):  
Syed Ummar I ◽  
Shree Aarthi R ◽  
Thirunavukarasu M
Keyword(s):  
Statistical Difference ◽  
Case Control Study ◽  
Psychiatric Morbidity ◽  
Case Control ◽  
Symptom Duration ◽  
Hypothyroid Patient ◽  
Drug Naïve ◽  
Thyroid Profile ◽  
Hypothyroid Patients ◽  
Control Study

Background: Hypothyroidism is one the etiology of emerging psychiatric illness. The present study is an attempt to find out the incidence of psychiatric morbidity in drug-naïve hypothyroid patients and to find the correlation between patient’s sociodemographic variable, symptom duration, varying thyroid profile, subtype of hypothyroidism and psychiatric morbidity. Materials and Methods: This is a case-control study. The sample in this study consists of 75 hypothyroid patient and 75 euthyroid patients from Endocrinology out-patient department, matched for age and sex, after obtaining informed consent. Results: There was no statistical difference between cases and controls, with regard to sociodemographic variables. The psychiatric morbidity in hypothyroid patients is higher than euthyroid population (χ2 =32.9, p=0.001). The incidence and severity of depression (I – χ2=7.29, p=0.004), (severity- χ2 =10.42, p=0.02), anxiety (I- χ2 =3.84, p=0.05), (severity- χ2 =4.81, p=0.03) and cognitive impairment (I- χ2 =10..9, p=0.001), (severity- χ2 =13.04, p=0.001) are higher in hypothyroid patient when compared with controls. But the incidence of Psychosis is not statistically significant between groups. Among hypothyroid patients various parameters like symptom duration, varying thyroid profile and subtype of hypothyroidism did not reveal any significant statistical difference between patients with and without psychiatric morbidity. Conclusion: Incidence and severity of psychiatric morbidity in hypothyroid patients is higher than euthyroid population in our study. Hypothyroidism is one of the reversible etiologies of psychiatry disorder which is most often overlooked. Early diagnosis and treatment of hypothyroidism may alter the course of psychiatric illness and reduce the morbidity of these illnesses among patients.

scholarly journals THE PLACENTAL TRANSMISSION OF ANTIBODIES IN THE SKIN SENSITIVE TYPE OF HUMAN ALLERGY

1940 ◽  
Vol 72 (5) ◽  
pp. 611-621 ◽  
Author(s):  
William B. Sherman ◽  
Stanley F. Hampton ◽  
Robert A. Cooke
Keyword(s):  
Human Placenta ◽  
Passive Transfer ◽  
Skin Tests ◽  
Pollen Extract ◽  
Human Beings ◽  
Typhoid Vaccine ◽  
Blocking Antibody ◽  
Quantitative Studies ◽  
Blocking Antibodies ◽  
Immune Antibody

1. Quantitative studies of the skin-sensitizing antibodies, blocking antibodies, and hemagglutinins in sera of allergic human beings have been made. 2. A comparison of 12 maternal and the 12 corresponding cord sera by the method of passive transfer showed the human placenta to be impermeable to skin-sensitizing antibodies. 3. Direct skin tests and passive transfer studies of 6 infants at the ages of 3 to 6 months showed negative reactions to the antigens to which their mothers were sensitive. 4. The blocking antibody present in the sera of hay fever patients after treatment with pollen extract injections was also demonstrated in the cord sera. The apparent placental transmission of this antibody gave further evidence that it was distinct from the skin-sensitizing antibody. Infant sera obtained at the ages of 3 to 6 months showed no evidence of this immune antibody. 5. The cord sera from 4 of these cases were shown to contain the same isoagglutinins as the maternal sera, showing that the placentas were permeable to these antibodies. The mothers and their offspring reacted alike to Schick testing. 6. Typhoid agglutinins were demonstrated in maternal and cord sera of an adult who previously received injections of triple typhoid vaccine, whereas the serum of the corresponding infant at the age of 3 months failed to show agglutinins.

Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy

2020 ◽  
Vol 12 (534) ◽  
pp. eaav7431 ◽  
Author(s):  
Maud Mayoux ◽  
Andreas Roller ◽  
Vesna Pulko ◽  
Stefano Sammicheli ◽  
Stanford Chen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Function ◽  
Gene Signature ◽  
Blocking Antibody ◽  
Patients With Cancer ◽  
Cell Immunity ◽  
Number Of Patients ◽  
Blocking Antibodies ◽  
In Cis

PD-L1/PD-1 blocking antibodies have demonstrated therapeutic efficacy across a range of human cancers. Extending this benefit to a greater number of patients, however, will require a better understanding of how these therapies instigate anticancer immunity. Although the PD-L1/PD-1 axis is typically associated with T cell function, we demonstrate here that dendritic cells (DCs) are an important target of PD-L1 blocking antibody. PD-L1 binds two receptors, PD-1 and B7.1 (CD80). PD-L1 is expressed much more abundantly than B7.1 on peripheral and tumor-associated DCs in patients with cancer. Blocking PD-L1 on DCs relieves B7.1 sequestration in cis by PD-L1, which allows the B7.1/CD28 interaction to enhance T cell priming. In line with this, in patients with renal cell carcinoma or non–small cell lung cancer treated with atezolizumab (PD-L1 blockade), a DC gene signature is strongly associated with improved overall survival. These data suggest that PD-L1 blockade reinvigorates DC function to generate potent anticancer T cell immunity.

scholarly journals Autoimmune thyroiditis: clinical presentation in a Nepalese population

2014 ◽  
Vol 3 (1) ◽  
pp. 44-47
Author(s):  
K Paudel ◽  
B Paudel
Keyword(s):  
Clinical Presentation ◽  
Clinical Signs ◽  
Clinical Manifestations ◽  
Primary Hypothyroidism ◽  
Cold Intolerance ◽  
Wide Range ◽  
Tingling Sensation ◽  
Pedal Edema ◽  
Antibody Levels ◽  
Hypothyroid Patients

Background: Hypothyroidism has a wide range of clinical presentations. This study was conducted to describe the clinical manifestations of chronic Hashimoto`s thyroiditis (HT) in a Nepalese population. We also tried to identify symptoms or signs characteristic for HT. Methods: During the study period, all newly diagnosed patients with hypothyroidism were interviewed about symptoms, and clinical signs were assessed. The data of hypothyroid patients were divided in two groups: TPO antibody positive and TPO antibody negative. The symptoms and signs of the two groups were analyzed and compared. Results: Among the 88 hypothyroid patients, 33 (37.5%) had positive TPO antibody levels. Female patients were more likely to be TPO antibody positive (41.3% among female and 15.4% among male). The most frequent symptoms were lethargy, cold intolerance, constipation, tingling sensation and weight gain, and the most frequent signs were facial puffiness and non-pitting pedal edema, in both groups. Statistical analysis revealed, that cold intolerance, decreased appetite and insomnia were significantly more prevalent symptoms in the TPO antibody positive group (p<0.05). Conclusion: Hashimoto`s thyroiditis is a common cause of primary hypothyroidism. It is not possible to differentiate it from the clinical presentation. Nepal Journal of Medical Sciences | Volume 03 | Number 01 | January-June 2014 | Page 68-71 DOI: http://dx.doi.org/10.3126/njms.v3i1.10362

IgG Levels after Treatment with Antigen Vials Based on the Scratch Testing, Intradermal Testing, Modified RAST Testing

1986 ◽  
Vol 95 (3_part_1) ◽  
pp. 307-311 ◽  
Author(s):  
Richard J. Trevino
Keyword(s):  
Scratch Testing ◽  
Igg Antibody ◽  
Intradermal Testing ◽  
Blocking Antibody ◽  
Multiple Treatment ◽  
End Point ◽  
Specific Igg ◽  
Inhalant Allergens ◽  
Inhalant Allergy ◽  
Antibody Levels

In this study, there were three groups of patients—each group consisting of four patients. The first group had been skin tested by the scratch method, the second group was skin tested by the end point titration intradermal method, and the third group had been tested for inhalant allergy by the modified RAST technique. All of them had multiple treatment vials made, dependent on the type of testing they had, and the vials all included the ten inhalants that were tested for. All patients had been treated for a year with weekly immunotherapy injections. Specific IgG levels, blocking antibody levels to the ten inhalant allergens, were determined. The results were that the patients who had been scratch tested had the lowest levels of specific IgG blocking antibody—while both intradermal end point titration and modified RAST testing had much higher elevations of blocking IgG antibody, with the RAST having the highest. It is concluded that, since the treatment vials prepared after scratch testing of all the antigens are at the same concentration, there are many antigens that are not given in adequate amounts to cause a good IgG response whereas, by calibrating the concentrations of antigens in the intradermal titration and the modified RAST testing, all the antigens are being injected in sufficient quantities to get a good blocking antibody response.

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