scholarly journals In active acromegaly, IGF1 bioactivity is related to soluble Klotho levels and quality of life

2014 ◽  
Vol 3 (2) ◽  
pp. 85-92 ◽  
Author(s):  
A J Varewijck ◽  
A J van der Lely ◽  
S J C M M Neggers ◽  
S W J Lamberts ◽  
L J Hofland ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Reference Range ◽  
Short Form ◽  
Receptor Activation ◽  
Oral Glucose ◽  
Cross Sectional ◽  
Sf 36 ◽  
Activation Assay ◽  
Active Acromegaly

The value of measuring IGF1 bioactivity in active acromegaly is unknown. Soluble Klotho (S-Klotho) level is elevated in active acromegaly and it has been suggested that S-Klotho can inhibit activation of the IGF1 receptor (IGF1R). A cross-sectional study was carried out in 15 patients with active acromegaly based on clinical presentation, unsuppressed GH during an oral glucose tolerance test, and elevated total IGF1 levels (>+2 s.d.). Total IGF1 was measured by immunoassay, IGF1 bioactivity by the IGF1R kinase receptor activation assay and S-Klotho by an ELISA. Quality of Life (QoL) was assessed by Acromegaly QoL (AcroQoL) Questionnaire and Short-Form-36 Health Survey Questionnaire (SF-36). Out of 15 patients, nine had IGF1 bioactivity values within the reference range. S-Klotho was higher in active acromegaly compared with controls. Age-adjusted S-Klotho was significantly related to IGF1 bioactivity (r=0.75, P=0.002) and to total IGF1 (r=0.62, P=0.02). IGF1 bioactivity and total IGF1 were inversely related to the physical component summary of the SF-36 (r=−0.78, P=0.002 vs r=−0.60, P=0.03). Moreover, IGF1 bioactivity, but not total IGF1, was significantly inversely related to the physical dimension of the AcroQoL Questionnaire (r=−0.60, P=0.02 vs r=−0.37, P=0.19). In contrast to total IGF1, IGF1 bioactivity was within the reference range in a considerable number of subjects with active acromegaly. Elevated S-Klotho levels may have reduced IGF1 bioactivity. Moreover, IGF1 bioactivity was more strongly related to physical measures of QoL than total IGF1, suggesting that IGF1 bioactivity may better reflect physical limitations perceived in active acromegaly.

scholarly journals Predictors of quality of life among patients on dialysis in southern Brazil

2008 ◽  
Vol 126 (5) ◽  
pp. 252-256 ◽  
Author(s):  
Maristela Bohlke ◽  
Diego Leite Nunes ◽  
Stela Scaglioni Marini ◽  
Cleison Kitamura ◽  
Marcia Andrade ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Peritoneal Dialysis ◽  
Short Form ◽  
Outcome Measurement ◽  
Cross Sectional Study ◽  
Southern Brazil ◽  
Cross Sectional ◽  
Sf 36 ◽  
Dialysis Facilities

CONTEXT AND OBJECTIVE: Quality of life (QoL) is considered important as an outcome measurement, especially for long-term diseases such as chronic renal failure. The present study searched for predictors of QoL in a sample of patients undergoing dialysis in southern Brazil. DESIGN AND SETTING: This was a cross-sectional study developed in three southern Brazilian dialysis facilities. METHODS: Health-related QoL of patients on hemodialysis or peritoneal dialysis was measured using the generic Short Form-36 (SF-36) health survey questionnaire. The results were correlated with sociodemographic, clinical and laboratory variables. The analysis was adjusted through multiple linear regression. RESULTS: A total of 140 patients were assessed: 94 on hemodialysis and 46 on peritoneal dialysis. The mean age was 54.2 ± 15.4 years, 48% were men and 76% were white. The predictors of higher (better) physical component summary in SF-36 were: younger age (β-0.16; 95% confidence interval, CI: -0.27 to -0.05), shorter time on dialysis (β-0.06; 95% CI: -0.09 to -0.02) and lower Khan comorbidity-age index (β 5.16; 95% CI: 1.7-8.6). The predictors of higher mental component summary were: being employed (β 8.4; 95% CI: 1.7-15.1), being married or having a marriage-like relationship (β 4.56; 95% CI: 0.9-8.2), being on peritoneal dialysis (β 4.9; 95% CI: 0.9-8.8) and not having high blood pressure (β 3.9; 95% CI: 0.3-7.6). CONCLUSIONS: Age, comorbidity and length of time on dialysis were the main predictors of physical QoL, whereas socioeconomic issues especially determined mental QoL.

scholarly journals Childhood mouth-breathing consequences at adult age: ventilatory function and quality of life

2014 ◽  
Vol 27 (2) ◽  
pp. 211-218 ◽  
Author(s):  
Jovana de Moura Milanesi ◽  
Priscila Weber ◽  
Luana Cristina Berwig ◽  
Rodrigo Agne Ritzel ◽  
Ana Maria Toniolo da Silva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Mouth Breathing ◽  
Walk Test ◽  
Ventilatory Function ◽  
Nasal Breathing ◽  
Cross Sectional ◽  
Adult Age ◽  
Sf 36

Introduction Mouth breathing can affect the functions of the respiratory systems and quality of life. For this reason, children who grow up with this stimulus may have implications on physical and psychological aspects at adult age.Objective To evaluate childhood mouth-breathing consequences for the ventilatory function and quality of life at adult age.Materials and methods Prospective, observational and cross-sectional study with 24 adults, between 18 and 30 years old, mouth breathers during childhood, comprised the childhood mouth-breathing group (CMB). The childhood nasal-breathing (CNB) group was composed of 20 adults of the same age, without history of respiratory disease during all their lives. Measurements of maximal respiratory pressures, peak expiratory flow and 6-minute walk test were assessed. In addition, all the volunteers answered the Short Form-36 questionnaire (SF-36).Results The maximal inspiratory (p = 0.001) and expiratory (p = 0.000) pressures as well as the distance in the walk test (p = 0.003) were lower in the COB. The COB also presented lower score in the General Health domain of the SF-36 Questionnaire (p = 0.002).Conclusion Childhood mouth-breathing yields consequences for the ventilatory function at adult age, with lower respiratory muscle strength and functional exercise capacity. Conversely, the quality of life was little affected by the mouth breathing in this study.

scholarly journals Urinary incontinence and quality of life: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Damiano Pizzol ◽  
Jacopo Demurtas ◽  
Stefano Celotto ◽  
Stefania Maggi ◽  
Lee Smith ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Urinary Incontinence ◽  
Short Form ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Cross Sectional ◽  
Sf 36

Abstract Background Urinary incontinence (UI) and low quality of life (QoL) are two common conditions. Some recent literature proposed that these two entities can be associated. However, no attempt was made to collate this literature. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of existing data to estimate the strength of the association between UI and QoL. Methods An electronic search of major databases up to 18th April 2020 was carried out. Meta-analysis of cross-sectional and case–control studies comparing mean values in QoL between patients with UI and controls was performed, reporting random-effects standardized mean differences (SMDs) ± 95% confidence intervals (CIs) as the effect size. Heterogeneity was assessed with the I2. Results Out of 8279 articles initially screened, 23 were finally included for a total of 24,983 participants, mainly women. The mean age was ≥ 50 years in 12/23 studies. UI was significantly associated with poor QoL as assessed by the short-form 36 (SF-36) total score (n = 6 studies; UI: 473 vs. 2971 controls; SMD = − 0.89; 95% CI − 1.3 to − 0.42; I2 = 93.5) and by the sub-scales of SF-36 and 5/8 of the domains included in the SF-36. Similar results were found using other QoL tools. The risk of bias of the studies included was generally high. Conclusions UI is associated with a poor QoL, with a strong level of certainty. This work, however, mainly based on cross-sectional and case–control studies, highlights the necessity of future longitudinal studies for better understanding the importance of UI on QoL.

scholarly journals Assessment of quality of life of stroke survivors in a rural area of North Kerala, India

2017 ◽  
Vol 4 (3) ◽  
pp. 841 ◽  
Author(s):  
Priya Chandran ◽  
Dhanya Shenoy ◽  
Jayakrishnan Thavody ◽  
Lilabi M. P.
Keyword(s):  
Quality Of Life ◽  
Rural Area ◽  
Short Form ◽  
Significant Proportion ◽  
Population Based ◽  
Stroke Survivors ◽  
Cross Sectional ◽  
Sf 36 ◽  
Role Limitation

Background: With increase in prevalence of stroke and life expectancy the quality of life of stroke survivors assumes importance. Despite advances in diagnosis and treatment of cerebrovascular accidents the survivors continue to experience low Quality of life (QoL) especially in developing countries. The objective of this study was to assess the quality of life among stroke survivors and the prevalence of depression among them.  Methods: Cross-sectional population based study was conducted in a rural area of North Kerala. Stoke survivors were interviewed at home to assess the quality of life and depression status. QOL was assessed using the Medical Outcomes 36-Item Short-Form Health Survey (SF-36), functional status using the modified barthel index (MBI), and mood using the Beck’s Depression Inventory (BDI).Results: A total of 40 patients (65.5% men, mean age 70.58±10.7 years) were interviewed.  The mean MBI was 55.25±2.79, and the prevalence of unrecognized depression was 90%. 95 percent of patients needed varying degrees of care for their activities of daily living. The SF-36 scores of the patients were considerably lower than that to that of the general population especially in the areas of role limitation and physical functioning. Depression was more among older subjects and Depressed patients had lower MBI scoresConclusions: A significant proportion of stroke survivors continue to face limitations in their physical activities. In addition, majority have unrecognised depression that affects their QOL adversely.

scholarly journals IMPACT OF DIFFERENT LEVELS OF DISEASE ACTIVITY IN PAINFUL PROFILE AND QUALITY OF LIFE IN PEOPLE WITH RHEUMATOID ARTHRITIS

2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Selena Márcia Dubois Mendes ◽  
Bárbara Liliane Lôbo Queiroz ◽  
Larissa Vieira Santana ◽  
Abrahão Fontes Baptista ◽  
Mittermayer Barreto Santiago ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Pain Perception ◽  
Short Form ◽  
Care Service ◽  
Cross Sectional ◽  
Sf 36 ◽  
Different Levels

Rheumatoid arthritis (RA) is a systemic inflammatory autoimmune disease with impact on increasing the morbidity and mortality rates. Different levels of disease activity (LDA) have been established, however, its impact on pain and quality of life have yet to be been evidenced. The aim of this study was to evaluate the relationship of different levels of disease activity on the painful profile and quality of life (QOL) of patients diagnosed with RA. This was a cross-sectional study, conducted in RA patients attending an Educational Outpatient Care Service in Salvador, Bahia, Brazil. The LDA was defined according to values of Erythrocyte Sedimentation Rate (ESR), Visual Analog Scale (VAS), and number of swollen and sore joints, according to the Disease Activity Score in 28 joints (DAS28). Types of pain were assessed using the Douleur Neuropathique en 4 questions (DN4). To evaluate QOL, the Short Form (36) Health Survey (SF-36) and Health Assessment Questionnaire (HAQ) were applied. The association between LDA, QOL and painful profile was verified using One Way-ANOVA and Bonferroni correction post-test. A high LAD was observed in 67.7% of the 96 patients  evaluated in this study. Pain sensation was reported by 94.8 % of participants with 40.6 % reporting it as nociceptive and 80.2% as intense. It was also observed that the higher LAD found the higher was the pain intensity reported (p=0.001) and lower QOL scores (p<0.001). Although the LDA did not correlate with the type of pain (p=0.611), it was correlated with the total score obtained in the QOL from the HAQ (p=0.001). The greatest impact on QOL evaluated through the SF-36 were physical (p<0.001) and functional capacity (p<0.001). In conclusion, RA patients who had high LDA reported more severe pain perception and obtained the lowest scores in the assessment of quality of life.

scholarly journals Assessment of Sleep among Patients with Chronic Liver Disease: Association with Quality of Life

2021 ◽  
Vol 11 (12) ◽  
pp. 1387
Author(s):  
Oana-Mihaela Plotogea ◽  
Gina Gheorghe ◽  
Madalina Stan-Ilie ◽  
Gabriel Constantinescu ◽  
Nicolae Bacalbasa ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Liver Disease ◽  
Chronic Liver Disease ◽  
Sleep Disturbances ◽  
Short Form ◽  
Chronic Liver ◽  
Poor Sleep ◽  
Cross Sectional ◽  
Sf 36

The present study aims to assess the sleep characteristics and health-related quality of life (HRQOL) among patients with chronic liver diseases (CLDs), as well as the relationship between them. We conducted a prospective cross-sectional study, over a period of eight months, on patients with CLDs. Sleep was assessed by subjective tools (self-reported validated questionnaires), semi-objective methods (actigraphy), and HRQOL by using the 36-Item Short Form Survey (SF-36) and Chronic Liver Disease Questionnaire (CLDQ). The results indicated that 48.21% of patients with CLDs had a mean Pittsburgh Sleep Quality Index (PSQI) score higher than five, suggestive of poor sleep; 39.29% of patients had a mean Epworth Sleepiness Scale (ESS) score ≥11, indicative of daytime sleepiness. Actigraphy monitoring showed that patients with cirrhosis had significantly more delayed bedtime hours and get-up hours, more awakenings, and more reduced sleep efficacy when compared to pre-cirrhotics. The CLDQ and SF-36 questionnaire scores were significantly lower in cirrhotics compared to pre-cirrhotics within each domain. Moreover, we identified significant correlations between the variables from each questionnaire, referring to HRQOL and sleep parameters. In conclusion, sleep disturbances are commonly encountered among patients with CLDs and are associated with impaired HRQOL. This is the first study in Romania that assesses sleep by actigraphy in a cohort of patients with different stages of CLD.

Quality of Life and Depression in Caregivers of Patients with Cancer

2017 ◽  
Vol 41 (S1) ◽  
pp. S653-S653
Author(s):  
I. Feki ◽  
S. Hentati ◽  
R. Sallemi ◽  
M. Moala ◽  
J. Masmoudi
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Short Form ◽  
University Hospital ◽  
Related Factors ◽  
Cross Sectional ◽  
Old Patients ◽  
Patients With Cancer ◽  
Sf 36

BackgroundMost elderly patients, with cancer are cared for, by a family member who may be affected by various stressors that can influence their health and quality of life (QOL).ObjectivesTo explore depression, quality of life and its related factors among caregivers of elderly patients with cancer.MethodologyThis is a descriptive and analytical cross-sectional study including 40 primary caregivers of old patients aged 65 or older, with cancer in oncologic radiotherapy service in university hospital Habib Bourguibain Sfax, Tunisia. The short form health survey (SF-36) and Beck inventory (13 items) were used to assess respectively QOL and depression.ResultsThe average age of caregivers was 44.62 years. The sex ratio (M/F) was 0.9. Most of caregivers (75%) had impaired QOL (score ˂ 66.7). The two main components of SF-36 were altered with a standard score of 45 for the physical component and 41.1 for mental component. According to Beck inventory, Depression was present in 67.6% of cases. Impaired QOL of life was significantly correlated with somatic illnesses in the caregiver (P = 0.016), advanced stage of cancer (P = 0.01), financial difficulties (P = 0.04), the non-cohabitation with the patient before the disease (P = 0.031) and depression (P = 0.00).ConclusionAccording to our study, caregiving can have a negative effect on the caregiver's mental and physical health. Assistance and information from healthcare professionals are the key to improving the ability of caregivers to cope with caring for older patients with cancer.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Oral health-related quality of life in patients with heart failure and left ventricular assist devices—results of a cross-sectional study

2021 ◽  
Author(s):  
Gerhard Schmalz ◽  
Christian Binner ◽  
Mirjam Eisner ◽  
Justus Wagner ◽  
Josephine Rast ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oral Health ◽  
Short Form ◽  
Left Ventricular ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

Abstract Objectives The aim of this cross-sectional study was to compare oral health-related quality of life (OHRQoL) of patients with left ventricular assist device (LVAD) and heart failure (HF). Material and methods Seventy-four patients with LVAD were recruited from University Department for Cardiac Surgery, Leipzig Heart Center, Germany. A group of 72 patients with HF was composed by matching (age, gender, smoking). The German short form of oral health impact profile (OHIP G14) was applied. Health-related quality of life (HRQoL) was measured by short form 36 survey (SF-36). Dental conditions (decayed-, missing- and filled-teeth [DMF-T]), remaining teeth and periodontal findings were assessed. Statistics: t-test, Mann-Whitney U test, Kruskal-Wallis test, chi-square or Fisher test, linear regression. Results Age, gender, smoking, underlying disease, co-morbidities and oral findings were comparable between groups (p > 0.05). OHIP G14 sum score was 3.53 ± 6.82 (LVAD) and 2.92 ± 5.35 (HF; p = 0.70), respectively. The scales SF-36 physical functioning (p = 0.05) and SF-36 social functioning (p < 0.01) were worse in LVAD. In the LVAD group, the DMF-T and remaining teeth negatively correlated with OHIP G14 sum score (p < 0.01). In HF patients, positive correlations were found between OHIP G14 and D-T (p < 0.01) and remaining teeth (p = 0.04). Moreover, DMF-T (p = 0.03) and remaining molars/premolars (p = 0.02) were negatively correlated with SF-36 scales in HF. Conclusions Oral health and OHRQoL was comparable between LVAD and HF; thereby, OHRQoL reflected the clinical oral status. Clinical relevance Dental care, with beginning in early stage of HF, should be fostered to preserve teeth and support quality of life before and after LVAD implantation.

scholarly journals Quality of Life among Patients with Glaucoma in Gaza Governorates

2020 ◽  
Vol 28 (1) ◽  
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Bodily Pain ◽  
Cross Sectional Study ◽  
Negative Effects ◽  
Cross Sectional ◽  
Sf 36 ◽  
Medium Level ◽  
Ophthalmic Hospital

Background: Glaucoma is the second leading cause of blindness worldwide. Quality of Life (QOL) has emerged as an important parameter for assessing the quality of health care of patients with Glaucoma disease. This study assessed QOL among Glaucoma patients in Gaza Governorates and the factors influencing their life conditions. Methods: This is a descriptive, analytical, cross-sectional study included 265 eligible glaucoma patients from Al Nasser Ophthalmic Hospital and European Gaza Hospital. Socio-demographic and disease-related characteristics in addition to QOL data were collected using the Glaucoma Quality of Life-15 (GQL-15) and Short-Form 36 Health Survey (SF-36) questionnaires. Results: Study participants had a medium level of QOL scores. The mean score for GQL-15 was 59.2 ± 17.6. The greatest difficulty was in activities involving glare and dark adaptation (48.5±18.0), while least difficulty for outdoor mobility (66.6±25.4). The overall mean percentage of SF-36 domain scores was 61.7±13.5. The bodily pain domain got the highest score (79.4); the social function domain was (72.22); and the lowest domain was General Health (48.58). Findings also showed that participants without ocular diseases and comorbidities had better QOL. Moreover, patients with higher educational level, higher income and disease duration less than 5 years had better QOL scores. Conclusion: Glaucoma has moderately negative effects on people’s ability to function independently in every field of their lives. Glaucoma patients should be educated to understand the prognosis of the disease and importance of the adherence to the daily treatment to improve their QOL.

scholarly journals QUALIDADE DE VIDA RELACIONADA À SAÚDE (HRQL) DE ADULTOS ENTRE 50 E 80 ANOS PRATICANTES DE ATIVIDADE FÍSICA REGULAR: APLICAÇÃO DO SF-36

2011 ◽  
Vol 16 (esp) ◽  
Author(s):  
Andréa Kruger Gonçalves ◽  
Adriane Ribeiro Teixeira ◽  
Cíntia De la Rocha Freitas ◽  
Eliane Jost Blessmann ◽  
Laysla Roedel ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Short Form ◽  
Well Being ◽  
Health Related Quality ◽  
Cross Sectional ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

A qualidade de vida relacionada à saúde-HRQL possui um caráter multidimensional com integração da saúde física, do bem-estar psicológico e da satisfação social. O objetivo foi avaliar a qualidade de vida relacionada à saúde (HRQL) de participantes de meia-idade e de idosos de um projeto de atividade física regular. O tipo de estudo foi descritivo, com corte transversal, sendo que a amostra foi composta por 40 adultos com idade entre 50 e 80 anos, integrantes do CELARI da ESEF/UFRGS. O instrumento utilizado foi o SF-36 e a análise empregada utilizou a estatística descritiva e o teste de correlação de Pearson. A pontuação dos domínios por ordem decrescente foi: AS, AF, AE, EGS, CF, SM, VIT, DOR. Houve correlação positiva significativa entre a maioria dos domínios do SF-36. As correlações não significativas ocorreram entre EGS x AS, SM x AF. A idade apenas correlacionou-se com o domínio EGS. A HRQL da amostra mostrou-se com valores superiores, ao ser comparada com a de outros estudos. Os valores atingiram no mínimo 70% de pontuação, na média dos domínios. Os resultados indicaram um nível satisfatório de HRQL e relação entre os domínios do SF-36. palavras-chave Envelhecimento. Qualidade de Vida. Atividade Física. Saúde. abstract The health-related quality of life – HRQOL is a multidimensional issue with integration of physical health, psychological well-being and social satisfaction factors. The aim of this study was to evaluate the health-related quality of life – HRQOL in ageing people who practice regular physical activity. This study was a descriptive cross-sectional and  the sample included 40 adults, aged between 50 and 80 years, attending a University Extension Program. The instrument used was the Brazilian version of Short Form-36. Descriptive statistical analysis was used to summarize HRQL data and Pearson’s correlation for comparison between domains. The score of the domains in descending order were: AS, AF, AE, EGS, CF, SM, VIT, DOR. There was a significant positive correlation between the majority of SF-36. The correlations were not significant between EGS x AS, SM x AF. The age was correlated only with the EGS field. The HRQL of the sample proved to be higher, when compared with other studies. The values ​​reached a minimum score of 70% in average scores. The results indicated a satisfactory level of HRQOL and a significant relationship between different aspects of health-related quality of life. keywords Aging. Quality of Life. Physical Activity. Health.

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