scholarly journals Adrenocortical function in patients with macrometastases of the adrenal gland

2000 ◽  
pp. 91-97 ◽  
Author(s):  
A Lutz ◽  
M Stojkovic ◽  
M Schmidt ◽  
W Arlt ◽  
B Allolio ◽  
...  
Keyword(s):  
Adrenal Gland ◽  
Adrenal Insufficiency ◽  
Malignant Tumors ◽  
Cross Sectional Study ◽  
Adrenocortical Function ◽  
Adrenal Metastases ◽  
Cross Sectional ◽  
Study Population ◽  
The Impact ◽  
Bilateral Metastases

OBJECTIVE: Metastases of the adrenal gland are a frequent finding in patients with malignant tumors like bronchogenic carcinoma or breast cancer. Only limited and conflicting data on adrenocortical function in these patients are available. DESIGN: Cross-sectional study. METHODS: We investigated the impact of adrenal macrometastases on adrenocortical function in a series of 28 tumor patients using the ACTH(1-24) stimulation test and dexamethasone suppression test. Seven normal controls (Con), eleven patients without adrenal metastases (No Met), eight patients with unilateral (Uni Met) and nine patients with bilateral adrenal metastases (Bil Met) were investigated. RESULTS: The prevalence of adrenal insufficiency was low in our study population, with only two of nine patients with bilateral metastases having subclinical adrenocortical insufficiency. In the remaining patients with uni- or bilateral metastases, baseline and stimulated cortisol concentrations were higher than in controls and cancer patients without metastases (baseline cortisol (in nmol/l): Con: 307+/-33.2 vs Uni Met: 440+/-53.5, and Bil Met: 637.6+/-92.1, P=0.04 by ANOVA; cortisol 60 min after ACTH(1-24): Con: 794.6+/-41.2 vs Uni Met: 990.8+/-92.9, and Bil Met: 1151.4+/-155.5, P=0.03 by ANOVA). Simultaneously, baseline and stimulated serum aldosterone concentrations were significantly blunted in the tumor groups. CONCLUSIONS: Adrenal insufficiency is infrequent and develops only in patients with bilateral metastases. However, the majority of patients have activation of the hypothalamic-pituitary-adrenal axis despite adrenal metastases with strongly elevated cortisol concentrations.

scholarly journals Prevalence and quality of life in high school pupils with acne in Serbia

2013 ◽  
Vol 70 (10) ◽  
pp. 935-939 ◽  
Author(s):  
Jelena Peric ◽  
Natasa Maksimovic ◽  
Janko Jankovic ◽  
Biljana Mijovic ◽  
Vesna Reljic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
High School ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Demographic Questionnaire ◽  
Study Population ◽  
Serbian Version ◽  
The Impact ◽  
Spearman’S Correlation

Background/Aim. Acne is a common problem in adolescent children with considerable emotional and psychological effects. The aim of this study was to determine the self-reported prevalence of acne and to assess its impact on the quality of life in high school pupils in Serbia. Methods. The cross-sectional study was conducted in May 2011 in two medical high schools in Serbia. Only pupils who gave a written informed consent to participate in the study (n = 440) were asked to fill in two questionnaires: short demographic questionnaire and Cardiff Acne Disability Index (CADI), a disease-specific questionnaire measuring disability induced by acne. Internal consistency (tested by Cronbach?s alpha) and item-total score correlations (Spearman's correlation analysis) were used for reliability analyses. Results. The study population consisted of 440 pupils, 281 from Belgrade and 159 from Uzice. Among them 371 (84.3%) were girls and 69 (15.7%) boys, with similar sex distribution in Belgrade and Uzice. The total mean age of pupils was 16.48 years (SD = 0.55). Out of 440 pupils 228 (51.8%) self-reported their acne. The acne prevalence was significantly higher in pupils from Uzice (73.6%) than in those from Belgrade (39.6%). The overall mean CADI score for the whole sample was 2.87 ? 2.74, with the similar quality of life impairment in adolescents from Belgrade and from Uzice. The mean Cronbach?s alpha was 0.82. Conclusion. This study shows that the quality of life impairment due to acne is mild for the majority of the affected pupils. The Serbian version of the CADI is a reliable, valid, and valuable tool for assessing the impact of acne on the quality of life.

scholarly journals Contraception and Sexsual Activity as Factor Influenced Leucorrhea

2017 ◽  
Vol 5 (3) ◽  
pp. 371
Author(s):  
Sari Priyanti
Keyword(s):  
Hormonal Contraception ◽  
Cross Sectional Study ◽  
Childbearing Age ◽  
Cross Sectional ◽  
The Public ◽  
First Sexual Intercourse ◽  
Number Of Children ◽  
Study Population ◽  
The Impact ◽  
First Time

ABSTRACTCervical cancer was non communicable desease that worries the public and causes an increase mortality in women. One of the first sign causes of cervical cancer is occourrence of Leucorrhoe. The incidence of Leucorrhoe in women Indonesia by 90% of which >75% of women experience once of leucorrhoe and experience ≥ 2 times by 25%. Leucorrhoe should not be considered an ordinary thing because can be caused to itchy on genetalia, pain during sexsual, infection  can be caused odema on genetalia, hot like burned on vagina even the impact if not treated promptly will caused infertility and cancer. Aims of study was to analyze factors of influenced on Leucorrhoe incident. Design of study was cross sectional study. Population was women of childbearing age who use contraceptives in the karang jeruk village, Jatirejo sub district, Mojokerto district in March of 2017. Sample in this study was 33 people. Data analyze with logistic regresion. Result of study showed contraceptive and sexsual activity has significant influenced with leucorrhoe (PR = 10.000; 95% CI= 1,732-57,722 dan PR=8,750; 95% CI=1,466-52,232). Suggestion: should be married and have first sexual intercourse for the first time at the age of  ≥ 20 years, limit the number of children not more than 2 as the greater the number of children the greater the risk of Leucorrhoe, and not using hormonal contraception for a along time that more than 2 years. Keywords: contraceptive,sexsual activity, leucorrhoe

scholarly journals Assessment of the perceived burden associated with Malignant Melanoma with Pictorial Representation of Illness and Self Measure (PRISM) and Melanoma Concerns Questionnaire (MCQ-28)

2022 ◽  
Author(s):  
Alessandro Borghi ◽  
Maria Elena Flacco ◽  
Alberto Monti ◽  
Lucrezia Pacetti ◽  
Michela Tabanelli ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Well Being ◽  
Cross Sectional Study ◽  
Pictorial Representation ◽  
Cross Sectional ◽  
Prism Score ◽  
Related Data ◽  
Perceived Burden ◽  
Study Population ◽  
The Impact

Abstract Purpose The impact of malignant melanoma (MM) on patients’ psychophysical well-being has been poorly addressed. We aimed to assess the perceived burden in patients with a diagnosis of MM, using two different tools, one generic and one specific for MM, such as Pictorial Representation of Illness and Self Measure (PRISM) and Melanoma Concerns Questionnaire (MCQ-28), respectively. The correlation between PRISM and MCQ-28 subscales and the relevance of disease and patient-related variables were also investigated. Methods This single-centre, cross-sectional study included all adult consecutive MM patients who attended our Dermatology Unit from December 2020 to June 2021. Demographics and disease-related data were recorded. PRISM and MCQ-28 were administered. Results One hundred and seventy-one patients were included (mean age: 59.5 ±14.9 years.; 48.0% males). Median time from MM diagnosis to inclusion was 36 months. Nearly 80% of the patients had in situ or stage I MM. Overall, 22.2% of the patients reported a PRISM score <100mm and similar percentages provided scores indicating impaired quality of life, as assessed with MCQ-28 subscales. A weak, albeit significant, correlation was found between PRISM scores and ACP, CON and SOC2 subscales. The most relevant association found was that between lower PRISM scores and higher-stage MM. Conclusions In the study population, mostly affected with superficial MM, their perception of the burden associated with MM did not appear either particularly dramatic or disabling. PRISM seems a reliable system for capturing and quantifying the domains correlated with the emotive dimension of MM, especially MM-related concerns and willingness to face life

scholarly journals The Association between Obesity and Chronic Conditions: Results from a Large Electronic Health Records System in Saudi Arabia

2021 ◽  
Vol 18 (23) ◽  
pp. 12361
Author(s):  
Suliman Alghnam ◽  
Saleh A. Alessy ◽  
Mohamed Bosaad ◽  
Sarah Alzahrani ◽  
Ibrahim I. Al Alwan ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Chronic Conditions ◽  
National Guard ◽  
Cross Sectional Study ◽  
Primary Diagnosis ◽  
Cross Sectional ◽  
Prevalence Of Obesity ◽  
Associated Conditions ◽  
Study Population ◽  
The Impact

This cross-sectional study aimed to estimate the prevalence of obesity and its association with diabetes and hypertension among beneficiaries in the National Guard Health Affairs system of Saudi Arabia. We included individuals aged 17 years and older, and patients were classified as diabetic or hypertensive if they had any visit during the 4 years where the primary diagnosis was one of those conditions or they were taking diabetes or hypertension medications. The association between obesity (body mass index ≥30) and diabetes and hypertension were evaluated using a multiple logistic regression model, adjusting for age, gender, nationality, and region. A total of 616,092 individuals were included. The majority were Saudi nationals (93.1%). Approximately 68% of the population were either obese (38.9%) or overweight (29.30%). Obesity was more prevalent among Saudi nationals (39.8% vs. 26.7%, p < 0.01) and females (45.3% vs. 31.2%, p < 0.01). Obesity was independently associated with diabetes mellitus (OR = 2.24, p < 0.01) and hypertension (OR = 2.15, p < 0.01). The prevalence of obesity in the study population was alarming and more pronounced among women. Our findings call for efforts to intensify preventive measures to reduce obesity and associated conditions. Using electronic records to examine the impact of interventions to reduce obesity and chronic conditions may help monitor and improve population health.

scholarly journals ASSESSMENT ON IMPACT OF COVID 19 PANDEMIC ON FEAR AND SOCIOECONOMIC STATUS AMONG SOUTH INDIAN POPULATION

2020 ◽  
pp. 52-56
Author(s):  
SREEJA NYAYAKAR ◽  
MUTHUKUMAR M. ◽  
LATHA SREE MOOTHI
Keyword(s):  
Socioeconomic Status ◽  
Family Life ◽  
Indian Population ◽  
Cross Sectional Study ◽  
South Indian Population ◽  
Cross Sectional ◽  
South Indian ◽  
Study Population ◽  
General Populations ◽  
The Impact

Objective: To assess the impact of the COVID 19 pandemic on fear and socioeconomic status among the south Indian population. Methods: A prospective observational cross-sectional study was conducted on 18-year old and older people who are willing to fill the online form were included in the study. People who are not willing to fill the form and those who filled the forms incompletely were excluded from the study. Microsoft Excel was used for recording and analyzing the data of recruited subjects. Descriptive statistical analyses were used to calculate the average and standard deviation. Results: In total 476 respondents were included in the study to make the results. From the 476 respondents, 53.9% were males and 43.4% were females, 43.4% of individuals were satisfied with family life, 31.7% of individuals were satisfied with their salary, 37.3% of individuals were satisfied with their economic position, 55.2% of individuals were satisfied with their health and 50.4% of individuals were satisfied with their life in general. Conclusion: Our study concludes that young students are showing more interest in online surveys among other general populations and data concludes that fear about the infection was less among the study population. More than half of the participants are concerned about their salary and most of the participants are not feared about their family life and their health.

scholarly journals PREVALENSI GIGI IMPAKSI MOLAR TIGA PARTIAL ERUPTED PADA MASYARAKAT DESA TOTABUAN

e-GIGI ◽  
2015 ◽  
Vol 3 (2) ◽  
Author(s):  
Delsy T. Sahetapy ◽  
P. S. Anindita ◽  
Bernat S. P. Hutagalung
Keyword(s):  
Cross Sectional Study ◽  
Third Molars ◽  
Sectional Study ◽  
Cross Sectional ◽  
Impacted Teeth ◽  
Village Community ◽  
Lower Jaw ◽  
Tooth Impaction ◽  
Study Population ◽  
The Impact

Abstract: Dental tooth impaction is a state of latent or not erupted or partly erupted after a normal eruption time. The impact of impacted teeth, namely the absence of pain, inflammation, and cysts but the prevalence of impacted teeth in several countries including in Indonesia is quite high. Some areas in Indonesia yet has particularly impacted teeth, especially data on partial erupted. This study aims to determine the prevalence of impacted teeth partially erupted on Totabuan Village community. This research is a descriptive cross sectional study. The study population is villagers Totabuan, the study sample as many as 37 people are 13 men and 24 women aged 24-60 years. Results of studies have impacted teeth partially erupted third molars most women (60%), and more common in the age of 24-35 years (62%). Partially erupted tooth impaction occurs most often in the lower jaw (53%) with most gear position on mesioangular (48.4%).Keywords: dental impaction, partial erupted.Abstrak: Gigi impaksi merupakan suatua keadaan gigi terpendam atau tidak erupsi baik sebagian maupun seluruhnya setelah melewati waktu erupsi normal. Dampak dari gigi impaksi yaitu adanya rasa sakit, inflamasi, serta kista akan tetapi prevalensi gigi impaksi di beberapa negara termasuk di Indonesia cukup tinggi. Beberapa daerah di Indonesia belum meiliki data mengenai gigi impaksi khususnya partial erupted. Penelitian ini bertujuan untuk mengetahui prevalensi gigi impaksi partial erupted pada masyarakat Desa Totabuan. Penelitian ini merupakan penelitian deskriptif dengan rancangan cross sectional study. Populasi penelitian yaitu masyarakat Desa Totabuan, dengan sampel penelitian sebanyak 37 orang yaitu 13 orang laki-laki dan 24 orang perempuan dengan usia 24-60 tahun. Hasil penelitian ditemukan adanya gigi impaksi molar tiga partial erupted paling banyak pada perempuan (60%), dan banyak ditemukan pada usia 24-35 tahun (62%). Gigi impaksi partial erupted paling sering terjadi pada rahang bawah (53%) dengan posisi gigi paling banyak pada mesioangular (48,4%). Berdasarkan penelitian yang telah dilakukan dapat disimpulkan bahwa gigi impaksi molar tiga partial erupted yang paling banyak ditemukan pada perempuan, dan banyak ditemukan pada usia yaitu 24-35 tahun. Gigi impaksi molar tiga partial erupted paling banyak ditemukan pada rahang bawah, dengan posisi gigi paling banyak pada mesioangular.Kata kunci: gigi impaksi, partial erupted.

scholarly journals Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali

2018 ◽  
Vol 146 (3) ◽  
pp. 354-358
Author(s):  
B. Kone ◽  
Y. S. Sarro ◽  
M. Maiga ◽  
M. Sanogo ◽  
A. M. Somboro ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Disease Burden ◽  
Cross Sectional Study ◽  
Pulmonary Infections ◽  
Sectional Study ◽  
Cross Sectional ◽  
Global Spread ◽  
Study Population ◽  
The Impact ◽  
Culture Positive

AbstractThe global spread of non-tuberculous mycobacteria (NTM) may be due to HIV/AIDS and other environmental factors. The symptoms of NTM and tuberculosis (TB) disease are indistinguishable, but their treatments are different. Lack of research on the epidemiology of NTM infections has led to underestimation of its prevalence within TB endemic countries. This study was designed to determine the prevalence and clinical characteristics of pulmonary NTM in Bamako. A cross-sectional study which include 439 suspected cases of pulmonary TB. From 2006 to 2013 a total of 332 (76%) were confirmed to have sputum culture positive for mycobacteria. The prevalence of NTM infection was 9.3% of our study population and 12.3% of culture positive patients. The seroprevalence of HIV in NTM group was 17.1%. Patients who weighed <55 kg and had TB symptoms other than cough were also significantly more likely to have disease due to NTM as compared to those with TB disease who were significantly more likely to have cough and weigh more than 55 kg (OR 0.05 (CI 0.02–0.13) and OR 0.32 (CI 0.11–0.93) respectively). NTM disease burden in Bamako was substantial and diagnostic algorithms for pulmonary disease in TB endemic countries should consider the impact of NTM.

scholarly journals Dichromacy: Color Vision Impairment and Consanguinity in Heterogenous Population of Pakistan

2019 ◽  
Vol 3 (1) ◽  
pp. 41-56
Author(s):  
Muhammad Shoaib Akhtar ◽  
Muhammad Aslamkhan ◽  
Mian Sahib Zar ◽  
Asif Hanif ◽  
Abdul Rehman Haris
Keyword(s):  
Epidemiological Data ◽  
Population Based ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Population Prevalence ◽  
Ishihara Test ◽  
Study Population ◽  
Heterogenous Population ◽  
The Impact ◽  
Color Vision Impairment

Abstract: Background and Objectives: Dichromacy, an X-linked recessive disorder is identified worldwide, more in males than females. In European Caucasians, its incidence is 8% in males and 0.5% in females. In India, it is 8.73% in males and 1.69% in females, and in Iran, it is 8.18% in males and 0.43% in females. Population based epidemiological data about dichromacy in different ethnic groups in Pakistan is not available. The aim of this study was to find out the population prevalence of inherited red-green dichromacy in a heterogenous population of the district of Chiniot, Punjab, Pakistan, and to determine the impact of consanguinity and ethnicity. Methods: In this cross-sectional study, boys and girls of the higher secondary schools were examined in the three tehsils of district Chiniot. Pseudoisochromatic Ishihara Test has been employed for detection of dichromacy in the study population. The sample size was calculated statistically as 260, which was expanded to 705 and divided by population density of the three tehsils. Results: Screening of 359 males and 346 females revealed 19 (5.29%) dichromat males and only 2 (0.58%) females. The study population belonged to 23 castes / isonym groups. The consanguinity found in the district of Chiniot is 84.82% and in the dichromat families, it is 85.71%, of which 52.37% are first cousin. Interpretation & Conclusion: The study has shown that the incidence of dichromacy could be reduced through genetic counseling

Impact of Maternal age and Parity on Exclusive Breast Feeding Practices

2021 ◽  
Vol 15 (10) ◽  
pp. 2527-2529
Author(s):  
Muhammad Bilal Safdar ◽  
Muhammad Naveed ◽  
Mujahid Razzaq ◽  
Mahwish Ejaz ◽  
Anum Tahir ◽  
...  
Keyword(s):  
Breast Feeding ◽  
Maternal Age ◽  
Feeding Practices ◽  
Cross Sectional Study ◽  
P Value ◽  
Formula Milk ◽  
Cross Sectional ◽  
Exclusive Breast Feeding ◽  
Study Population ◽  
The Impact

Aim: To determine the impact of maternal age and parity on incidence of exclusive breast feeding practices in infants. Study Design: Cross sectional study Place and duration of study: Department of Pediatric medicine, University of Lahore Teaching Hospital Lahore from December 2020 till May 2021 Methodology: A Total of 231 mothers who were having children up till 1 year of age were registered for the study after ethical clearance. Verbal consent was taken from the mothers. Demographic details of the study population were recorded. The study population was interviewed with the help of predesigned questionnaire which included maternal age, parity and feeding practices. Confidentiality of data was ensured. All data was entered and analyzed using SPSS 23. Quantitative variables are presented as mean and standard deviation. Results: The study participants were between age range of 19 years to 37 years. Out of 231 mothers 145(62.8%) breastfed their babies of which 96(41.6%) were exclusively breastfeeding and 49 were either giving formula milk 28(4.8%) or fresh milk 11(4.8%). In addition, 86(37.2%) did not breastfed at all. There was no statistical difference in pattern of breast feeding with maternal age and parity, p-value more than 0.05 Conclusion: Importance of breastfeeding should be emphasized in antenatal and postnatal visits to mothers regardless of their age and parity Keywords: Breastfeeding, Maternal age, Parity

scholarly journals Quality of Life and Characterization of Patients With Atopic Dermatitis in Portugal: The QUADEP Study

2020 ◽  
Vol 30 (6) ◽  
pp. 430-438 ◽  
Author(s):  
D Carvalho ◽  
P Aguiar ◽  
P Mendes-Bastos ◽  
A Palma-Carlos ◽  
J Freitas ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Negative Impact ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Impact Scale ◽  
Study Population ◽  
The Impact

Objectives: To investigate the quality of life (QOL) of and to characterize patients with atopic dermatitis (AD) in Portugal. Methods: This was a cross-sectional study of patients with AD and other eczemas. Skindex-29, Skindex-teen, and the Childhood Atopic Dermatitis Impact Scale (CADIS) were the instruments used to assess QOL in adults, teenagers, and children, respectively. The SF-12 was also used, and disease severity was evaluated using the Patient-Oriented SCORAD (PO-SCORAD) instrument. Associations with QOL were assessed based on the odds ratio (OR). P values <.05 and 95%CIs were considered statistically significant. Results: The study population comprised 162 participants aged 0.5-74 years. We found that 37.3% of AD patients consider their disease disabling and that more than half of the patients feel stigmatized by society. The mean Skindex score for AD was 39.68, and the impact on QOL was severe in 44%. “Symptoms” was the most affected category in adults. AD was moderate to severe in 87% of the sample. One of the factors that most influenced poorer QOL in AD was age: with increasing age, the Skindex is likely to increase (OR, 1.03; 95%CI, 1.00-1.06). “Considering the disease a disability” was also associated (OR, 6.72; 95%CI, 2.56-17.63). QOL worsens with increasingly affected body area (OR, 1.07; 95%CI, 1.03-1.11) and the presence of edema (OR, 2.0; 95%CI, 1.23-3.40). Conclusions: This is the first study to provide data on QOL in patients with AD in Portugal. Our data show an expected negative impact. More awareness-raising activities are needed to increase knowledge, decrease stigmatization, and, consequently, address the factors involved in the QOL of patients with AD.

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