scholarly journals Activity of coagulation processes with comorbid hypertension and coronary heart disease

2021 ◽  
pp. 35-38
Author(s):  
A. I. Pastushyna
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Protein C ◽  
Stage Ii ◽  
Stage Iii ◽  
Control Group ◽  
Disease Group ◽  
Hypertensive Patients ◽  
Coronary Heart Disease Group ◽  
The Difference

Purpose – determine the characteristics of changes of procoagulant, anticoagulant and fibrinolytic links of the hemostatic system in patients with hypertension in combination with coronary heart disease. Materials and methods. 127 people were examined - 14 healthy (control), 61 patients with stage II hypertension with concomitant coronary heart disease (group 2), 52 hypertensive patients with stage III with concomitant coronary heart disease (group 3). There were evaluated indicators of hemostasis system: thrombin time, activated partial thromboplastin time, prothrombin index, soluble fibrin monomer complex, fibrinogen, protein C, antithrombin III of, and the time of XII-dependent fibrinolysis. Results. Patients on both study groups SFMC content significantly higher than the control group. SFMC content in patients with stage II hypertension with concomitant coronary heart disease exceed normative value of 3 times, and in the group of hypertensive patients with stage III with with concomitant coronary heart disease of 3.65 times. The content of fibrinogen in the third group of patients exceeded the indicators of the control group by 27.6%, the difference was significant (p<0,001). Also valid was the difference between the two comparable groups (p<0,001). The content of protein C in hypertensive patients stage III was lower than the control values at 28,7% (p<0,001). The difference between comparable groups also were significantly (p<0,001). At the same time, and XII-dependent fibrinolysis in patients with stage II hypertension in combination with coronary heart disease was 3.54 times longer than the standard values (p<0,001), and the combination of hypertension III stage with CAD - 4.7 times longer than the norm (p< 0.001). Conclusions. Patients with hypertension stage II and III with concomitant coronary heart disease characterized by increased blood clotting activity in the background suppression of the anticoagulant and fibrinolytic components of hemostasis. The largest contribution to the formation of thrombophilic changes in patients of both treatment groups belongs to inhibition of fibrinolysis, which is more pronounced when hypertension stage III combined with coronary heart disease.

scholarly journals Effect of a 36-month Pharmaceutical Care Program on the Coronary Heart Disease Risk in Elderly Diabetic and Hypertensive Patients

2011 ◽  
Vol 14 (2) ◽  
pp. 249 ◽  
Author(s):  
Paulo Roque Obreli Neto ◽  
Srecko Marusic ◽  
Divaldo Pereira De Lyra Júnior ◽  
Diogo Pilger ◽  
Joice Mara Cruciol-Souza ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pharmaceutical Care ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Intervention Group ◽  
Care Program ◽  
Control Group ◽  
Hypertensive Patients ◽  
Heart Disease Risk

Purpose. To examine the effect of a pharmaceutical care program on the coronary heart disease risk in elderly diabetic and hypertensive patients. Methods. A total of 200 elderly (> 60 years) diabetic and/or hypertensive patients were recruited into a randomized, controlled, prospective clinical trial with a 36-month follow-up, developed in a public primary health care unit in a municipality in the Brazilian State of Sao Paulo. A range of clinical measurements were evaluated at the baseline and up to 36 months afterwards. The intervention group patients received pharmaceutical care from a clinical pharmacist, whereas the control group patients received their usual care from the medical and nursing staff. The Framingham scoring method was used to estimate changes in the 10-year coronary heart disease risk scores of all the patients. Results. A total of 194 patients completed the study. Significant reductions (p < 0.05) in the mean values (baseline vs. 36 months) for the systolic blood pressure [156.7mmHg vs 133.7mmHg; p

Correlation Analysis of CPN, Hp, HCMV Pathogenic Microorganism Infection Status and Serum Inflammation Marker Level in Patients with Coronary Heart Disease

2021 ◽  
Vol 7 (5) ◽  
pp. 3251-3255
Author(s):  
Zhifeng Yao ◽  
Hong Shen ◽  
Minna Tang ◽  
Junbo Ge
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Inflammation Markers ◽  
Double Positive ◽  
Reactive Protein ◽  
Positive Rate ◽  
Single Positive ◽  
The Difference ◽  
Necrosis Factor

Objective: To investigate the correlation between CPN, Hp, HCMV pathogenic microorganism infection status and serum inflammation marker levels in patients with coronary heart disease. Methods: The subjects of this study were all patients with coronary heart disease who came to our hospital from December 2018 to December 2019. A total of 70 patients were selected as the observation group, and non-coronary heart disease patients who came to our hospital for physical examination at the same time 70 cases were used as a control group to detect the IgG antibodies of CPN, Hp and HCMV microorganisms of the two groups, as well as the serum inflammation markers interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-a. Results: The CPN-IgG single positive rate, Hp-IgG single positive rate, HCMV-IgG single positive rate, double positive rate and triple positive rate in the observation group were 10.0%, 14.3%, 18.6%, 41.4% and 11.4%, respectively., Are significantly higher than the control group, and the difference between the groups is statistically significant (P<0.05); interleukin-6, hypersensitive C-reactive protein and tumor necrosis factor-a in three positive patients are (37.4±8.9) pg/ml, (15.1 ±3.2) mg/L and (36.2±8.6) ng/L, significantly higher than the levels of serum inflammation markers corresponding to double-positive, single-positive and full-negative patients, the difference is statistically significant Significance (P<0.05); serum inflammatory markers of double-positive patients were significantly higher than those of single-positive patients, the difference was statistically significant (P<0.05); serum inflammatory markers of single-positive patients The level of substance was significantly higher than that of serum inflammation markers corresponding to all negative patients, and the difference was statistically significant (P<0.05). Conclusion: The infection load of CPN, Hp and HCMV pathogenic microorganisms in patients with coronary heart disease is positively correlated with the level of serum inflammation markers, which is closely related to the incidence of coronary heart disease. The mixed infection of three pathogenic microorganisms can enhance the inflammatory response of patients by inducing inflammation The reaction causes the occurrence and development of the disease, and the more complicated the pathogenic microbial infection of the patient, the higher the level of inflammation markers of the patient.

scholarly journals The Difference of ACE and ACE2 Gene Expression in Patients With Acute Aortic Dissection and Coronary Heart Disease

2021 ◽  
Author(s):  
Yang Li ◽  
Long Mao ◽  
Zongwei Xiao ◽  
Sandeep Bhushan
Keyword(s):  
Gene Expression ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Arterial Wall ◽  
Acute Aortic Dissection ◽  
Venous Blood ◽  
Control Group ◽  
The Difference ◽  
Group 2 ◽  
Ace2 Gene

Abstract BackgroundTo explore whether there is a difference in the expression of ACE and ACE2 genes in patients with acute AD and CHD. MethodsBlood samples from 68 patients, including 34 cases of acute AD (including Stanford type A and B), 21 cases of CHD, and 13 cases of control group. 2 ml of venous blood is submitted for plasma ACE concentration. The arterial wall tissue was taken during the operation for mRNA detection. ResultsThe ACE concentration in the AD group was (17.9 ± 7. 9) U / L, in the CHD group was (33.5 ± 8.1) U / L, and the ACE concentration in the control group was (38.4) ±4.8) U/L, statistically significant (P<0.05). The expression of ACE gene in the AD group was (0.2265 ± 0.3783); the expression in the CHD group was (7.085 7 ± 7.692 9), with significant (P < 0. 05). The expression of ACE2 gene in the AD group was (0.766 2 ± 0.858 6); in the CHD group was (9.612 7 ± 11.542 6), and the difference was significant (P < 0. 05). The expression of the ratio of ACE / ACE2 in the AD group was (0.413 8 ± 0.448); the expression in the CHD group was (0.811 1 ± 0.256 3), the difference was statistically significant (P <0. 001). ConclusionPlasma ACE concentration, ACE and ACE2 gene expression are significantly reduced in acute AD. The imbalance of ACE and ACE2 expression may be involved in the pathogenesis of AD.

scholarly journals The relationship between arterial stiffness index and coronary heart disease and its severity

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Longjian Gao ◽  
Dasheng Lu ◽  
Guangwei Xia ◽  
Hao Zhang
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Arterial Stiffness ◽  
Roc Analysis ◽  
Stiffness Index ◽  
Control Group ◽  
Disease Group ◽  
Vessel Disease ◽  
Arterial Stiffness Index

Abstract Background Arterial stiffness index (ASI) is closely related to coronary atherosclerosis. This study aims to explore whether ASI can predict coronary heart disease (CHD) and its severity. Methods In this study, a total of 726 patients with suspected CHD were recruited. Based on coronary angiography results, the subjects were assigned into three groups: the control group (without obvious coronary artery disease), single-vessel disease group, and multi-vessel disease group (the number of vessels diseased ≥ 2). At the same time, according to the results of angiography, myocardial enzyme spectrum, electrocardiogram, color Doppler echocardiography and clinical manifestations, these patients were divided into four groups: the control group, stable angina (SA) Group, unstable angina (UA) group, and acute myocardial infarction (AMI) group. We have compared whether there were differences in ASI and related baseline data between groups. Receiver operating curve (ROC) analysis was conducted to determine whether ASI could predict CHD and evaluate the severity. Results ASI was positively correlated with the number of diseased branches of coronary artery. The value of ASI was increased as the number of the diseased branches increased. The ASI value in the SA group was significantly higher compared with the control group. Furthermore, the ASI value in the UA and AMI groups was remarkably increased compared with the control and SA groups. The results of ROC analysis indicated that the sensitivity and specificity of ASI was 71.0% and 85.4% in diagnosing CHD, respectively. While ASI was used in predicting the severity of CHD, the sensitivity was 72.1% and specificity 57.9%. Conclusion ASI is of great value in the diagnosis of coronary heart disease and the prediction of its severity.

scholarly journals Ultrasound Detection of Epicardial Adipose Tissue Combined With Ischemic Modified Albumin in the Diagnosis of Coronary Heart Disease

2020 ◽  
Vol 23 (4) ◽  
pp. E461-E464
Author(s):  
Jiandong Xiao ◽  
Yuli Lu ◽  
Xinchun Yang
Keyword(s):  
Coronary Heart Disease ◽  
Adipose Tissue ◽  
Heart Disease ◽  
Epicardial Adipose Tissue ◽  
Reference Value ◽  
Control Group ◽  
Case Group ◽  
Disease Group ◽  
Vessel Disease ◽  
Single Vessel

Objective: To evaluate the value of epicardial adipose tissue (EAT) thickness combined with serum ischemic modified albumin (IMA) concentration in the diagnosis of coronary heart disease. Methods: A total of 180 patients with coronary heart disease from May 2017 to December 2018 were selected as the case group. After the examination of Judkins coronary angiography, they were grouped according to the results of angiography, including 60 patients in a single-vessel group, 60 patients in a double-vessel group, and 60 patients in a multi-vessel group. Sixty healthy people with physical examinations at our hospital at the same time were selected as the control group. All selected participants were tested for epicardial adipose tissue thickness by echocardiography and serum IMA concentration by albumin cobalt ion binding test. Results: The EAT thickness and IMA concentration in the single-vessel disease group, double-vessel disease group, and multi-vessel disease group significantly were higher than those in the control group (P < .01). The ROC curve shows that the sensitivity is 53.33% and the specificity is 87.6%, when the EAT thickness is 6.12 mm. The sensitivity is 76.0% and the specificity is 72.3%, when the serum IMA concentration is 72 U/L. When the two were combined, the sensitivity was 40.15% and the specificity was 96.89%. In the parallel test, the sensitivity was 88.3% and the specificity was 65.44%. Conclusion: Ultrasound detection of EAT thickness and serum IMA concentration has certain reference value for the diagnosis of coronary heart disease. Combined diagnosis can significantly improve the diagnosis rate and accuracy of coronary heart disease.

scholarly journals Effect of Smartphone-Based Telemonitored Exercise Rehabilitation among Patients with Coronary Heart Disease

2019 ◽  
Vol 13 (4) ◽  
pp. 659-667
Author(s):  
Yanxin Song ◽  
Chuan Ren ◽  
Ping Liu ◽  
Liyuan Tao ◽  
Wei Zhao ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiopulmonary Exercise Testing ◽  
Blood Lipid ◽  
Control Group ◽  
Exercise Rehabilitation ◽  
Echocardiographic Parameters ◽  
Exercise Compliance ◽  
The Difference

AbstractThe aim of this study was to investigate the effects of telemonitored exercise rehabilitation on patients with coronary heart disease (CHD) in China. Ninety-six patients with stable CHD were included and analyzed (48 in telemonitored group and 48 in control group). All patients received routine follow-up, and patients in telemonitored group participated in smartphone-based telemonitored cardiac rehabilitation. Patients’ demographic information, medical history, diagnosis and treatment of CHD, and laboratory results were collected. The difference of cardiopulmonary exercise testing (CPET), blood test, and echocardiographic parameters; exercise habits; control rate of blood lipid and blood glucose; and incidence of adverse events between the two groups during 6 months of follow-up was analyzed. After intervention, the subjects in the telemonitored group performed significantly better in VO2peak, exercise compliance, and some other parameters than those in the control group. Telemonitored exercise rehabilitation is an effective rehabilitation mode for CHD patients in China.

scholarly journals Detection of serum biochemical markers in elderly patients with type 2 diabetes mellitus and its relationship with coronary heart disease

2020 ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Coronary Heart Disease ◽  
Type 2 Diabetes Mellitus ◽  
Heart Disease ◽  
Elderly Patients ◽  
Control Group ◽  
Disease Group ◽  
And Control

Background and Aims: Coronary heart disease (CHD) is myocardial ischemia caused by coronary atherosclerosis and stenosis. This study aimed to investigate the relationship of CHD with glycated albumin (GA), glycosylated hemoglobin (HbA 1c), glucose (Glu), homocysteine (Hcy), triglyceride (TG), and apolipop protein A (apoA) levels in elderly patients with type 2 diabetes mellitus (T2DM). Moreover, it was attempted to predict which changes had a significant correlation with the occurrence of CHD in these biochemical indicators. Materials and Methods: This clinical cohort study included a total of 472 patients admitted to our hospital from June 2018 to June 2019. They were then divided into three groups of concurrent (n=168, T2DM complicated with CHD), DM (n=148, T2DM alone), and control (n=156, healthy individuals). Results: There were significant differences between the disease group (i.e., DM and concurrent groups) and control group in terms of GA (P=0.013, 28.58±8.01 vs. 15.77±1.44), HbA 1c (P=0.022, 9.5±1.5 vs. 5.5±0.5), Glu (P=0.012, 8.54±2.23 vs. 4.12±0.39), Hcy (P=0.031, 11.16±3.28 vs. 5.03±2.87), TG (P=0.021, 1.83±0.49 vs. 0.84±0.18), and apoA (P=0.031, 1.10±0.12 vs. 1.30±0.18). Moreover, GA (P=0.025, 27.14±6.34 vs. 28.58±8.01; concurrent group vs. DM group), HbA 1c (P=0.033, 8.3±1.2 vs. 9.5±1.5; concurrent group vs. DM group), Glu (P=0.019, 8.62±3.56 vs. 8.54±2.23; concurrent group vs. DM group), Hcy (P=0.031, 17.56±6.36 vs. 11.16±3.28; concurrent group vs. DM group), total cholesterol ([TC]; P=0.022, 3.06±0.20 vs. 3.69±0.29; concurrent group vs. DM group), and low-density lipoprotein ([LDL]; P=0.037, 2.57±1.02 vs. 3.40±1.17; concurrent group vs. DM group) in disease group (DM group and concurrent group) were higher than those in the control group; however, apoA (P=0.023, 0.95±0.12 vs. 1.10±0.12; concurrent group vs. DM group) in disease group was lower than that in the control group. Furthermore, there were significant differences between the disease and control groups in terms of GA, HbA 1c, Glu, Hcy, TC, LDL, and apoA (P<0.05). Pearson correlation analysis between DM and concurrent groups was performed on the clinical parameters with statistical differences, and GA was highly correlated with HbA 1c and Glu (P<0.01). Conclusion: High-risk patient screening with high levels of GA, Hcy, and apoA in elderly patients with T2DM can not only improve the symptoms of patients with targeted treatment but also reduce the incidence of CHD by timely intervention, which is of great significance to improve the quality of life of patients.

Possibilities for treating aspirin-i lesions of the stomach and duodenum in patients with chronic coronary heart disease

2020 ◽  
Vol 98 (3) ◽  
pp. 231-235
Author(s):  
N. Yu. Borovkova ◽  
M. V. Buyanova ◽  
T. E. Bakka ◽  
M. P. Nistratova ◽  
T. V. Vlasova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Proton Pump Inhibitor ◽  
Blood Serum ◽  
Proton Pump ◽  
The Body ◽  
Control Group ◽  
Pge2 Level ◽  
Endogenous Prostaglandins ◽  
Chronic Coronary Heart Disease

To evaluate possibilities of aspirin-induced gastroduodenopathy treatment in the patients with chronic ischemic heart disease by means of applying the internal endogenous prostaglandins stimulant.  Material and methods. 340 patients suffering from chronic coronary heart disease and receiving a long-term acetylsalicylic acid (ASA) therapy were examined on the base of the cardiovascular care unit of The Nizhny Novgorod Regional Clinical Hospital named after N.A. Semaschko. There were evaluated frequency, nature and severity of the aspirin-induced gastroduodenopathy. The patients with coronary heart disease and aspirin-induced gastroduodenopathy were divided in two groups. In the first group of patients there was applied rebamipide therapy (in a single daily dose 300 mg) in combination with the proton pump inhibitor (PPI) — pantoprazole. In the second group there was applied only pantoprazole therapy. For the purpose of specification of AIG pathogenetic mechanisms development, all the examined chronic coronary heart disease cases were tested on the prostaglandin E2 (PGE2) level in blood serum before the therapy beginning and after the treatment. The control group was formed of chronic coronary heart disease patients showing no AIG evidence. Statistical processing of the received data was fulfilled with the program «Statistika 10.0». Results. AIG was registered in 15% out of 340 chronic coronary heart disease patients. According to the endoscopic examination erosive disease of the body and antrum prevailed among the patients. The PGE2 level in the blood serum was significantly lower (р = 0,00087) in these patients in comparison with the control group. In association with PPI and rebamipide mixed therapy, esophagogastroduodenoscopy results showed no pathological findings in gastrointestinal mucosa and statistically significant (р = 0,00067) blood serum PGE2 level growing in all the treated patients. As a result of exclusive PPI therapy there was marked positive dynamics in endoscopic view in 19 out of 25 patients and a tendency to normalization of PGE2 level in the blood serum. However, PGE2 level growing was insignificant. Conclusion. The presented research demonstrates the possibility of AIG treatment with the use of internal endogenous prostaglandins stimulant — rebamipide in complex with proton pump inhibitor PPI therapy.

Effects of Teaching Resourcefulness in Patients with Coronary Heart Disease

2021 ◽  
pp. 019394592110207
Author(s):  
Min Wen ◽  
Yaqin Liang ◽  
Qianqian Shen ◽  
Juping Yu ◽  
Pingping He ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Health Education ◽  
Controlled Trial ◽  
Coping Styles ◽  
Intervention Group ◽  
Control Group ◽  
Convenience Sample ◽  
Cluster Randomized ◽  
And Coping

This cluster randomized controlled trial aimed to investigate the effects of an intervention to teach resourcefulness on depression and coping style of patients with coronary heart disease (CHD). A convenience sample of 72 patients in community settings took part. Participants in the intervention group (n = 36) received an 8-week intervention based on the concept of resourcefulness, plus routine health education. Participants in the control group (n = 36) received routine health education only. After the intervention, participants in the intervention group had significantly higher scores on resourcefulness and coping styles, and lower scores on depression than those in the control group (both ps < .001). The findings suggest that a well-developed intervention to teach resourcefulness could help patients with CHD to be more resourceful, improve their level of depression, and choose more effective strategies to cope with stress.

Abstract P276: Differential Association of D-dimer with Stroke and Coronary Heart Disease: The REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Neil A Zakai ◽  
George Howard ◽  
Leslie A McClure ◽  
Suzanne E Judd ◽  
Brett M Kissela ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Vascular Disease ◽  
Racial Differences ◽  
Statistical Significance ◽  
Female Gender ◽  
Cox Models ◽  
The Difference ◽  
Chd Risk Factors ◽  
D Dimer

Introduction: D-dimer, a marker of coagulation activation, has higher levels in blacks than whites and has been variably associated with stroke and coronary heart disease (CHD). Methods: REGARDS recruited 30,239 participants in their homes across the continental US between 2003-07; by design 55% were female, 41% black, and 56% lived in the southeast. In a case-cohort study, D-dimer was measured in 646 participants with incident stroke, 515 with incident CHD, and 1104 in a cohort random sample. D-dimer was log transformed and modeled per 1-unit increase. Cox models were used to determine the HR for vascular disease for D-dimer and the difference in HR (95% CI) by race and vascular disease calculated by bootstrapping with 1000 replicate samples and using the 2.5 and 97.5 percentiles of the distribution (see Table for model variables). Results: Median D-dimer was higher in blacks (0.45 mcg/mL; IQR 0.26, 0.85) than whites (0.38 mcg/mL; IQR 0.23, 0.69); p <0.001. D-dimer was higher with increasing age, female gender, diabetes, hypertension and prebaseline cardiovascular disease (all p <0.05). The table shows the HR of stroke and CHD by baseline D-dimer. In minimally-adjusted models, D-dimer was associated with both stroke and CHD. Accounting for Framingham stroke and CHD risk factors, D-dimer remained associated with CHD (HR 1.45; 95% CI 1.18, 1.79), but was marginally associated with stroke (HR 1.20; 95% CI 0.99, 1.45). The difference in the HR of D-dimer between CHD and stroke was 0.22 in the basic model and 0.25 in the Framingham model, but this difference was of marginal statistical significance (Table). There was no difference in the HRs for stroke or CHD for D-dimer in blacks compared to whites (Table). Discussion: The association of D-dimer with stroke appeared smaller than for CHD with similar associations by race. Findings suggest that hemostasis activation may play a greater role in pathogenesis of CHD than stroke. Further study is needed to confirm these findings and evaluate the association of D-dimer with different stroke subtypes.

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