scholarly journals Safety of glucosamine, examined on ants as models

2018 ◽  
Vol 3 (3) ◽  
pp. 132-142
Author(s):  
Marie-Claire Cammaerts ◽  
Roger Cammaerts
Keyword(s):  
Adverse Effect ◽  
Beneficial Effect ◽  
Learning And Memory ◽  
Social Relationship ◽  
Severe Adverse Effect ◽  
Physiological Effects ◽  
Body Movements ◽  
Relationship Cognition ◽  
Cells Death

Arthritis is one of the most spread illnesses and is treated using essentially glucosamine. Since some years, the efficiency and even the safety of this drug is debated. Indeed, a placebo has often an effect similar to that of glucosamine, and in some cases, this drug appeared to induce cells’ death. In the present work, we examined the ethological and physiological effects of glucosamine using ants as models. No severe adverse effect was found: the ants’ sensitive perception, social relationship, cognition, learning and memory were not impacted by glucosamine consumption. Moreover, this drug leaded to no dependence, and its effect slowly vanished in about 14hours after weaning. Glucosamine only increased the ants’ activity and locomotion. Body movements are known as being beneficial to patients suffering from arthritis. Therefore, we cautiously hypothesize that one potential beneficial effect of glucosamine may result from an increase of activity and locomotion it induces.

scholarly journals Risk Factors of Daptomycin-Induced Eosinophilic Pneumonia in a Population with Osteoarticular Infection

Antibiotics ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 446
Author(s):  
Laura Soldevila-Boixader ◽  
Bernat Villanueva ◽  
Marta Ulldemolins ◽  
Eva Benavent ◽  
Ariadna Padulles ◽  
...  
Keyword(s):  
Risk Factors ◽  
Adverse Effect ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Older Patients ◽  
Retrospective Cohort ◽  
Joint Infection ◽  
Eosinophilic Pneumonia ◽  
Severe Adverse Effect ◽  
Osteoarticular Infection

Background: Daptomycin-induced eosinophilic pneumonia (DEP) is a rare but severe adverse effect and the risk factors are unknown. The aim of this study was to determine risk factors for DEP. Methods: A retrospective cohort study was performed at the Bone and Joint Infection Unit of the Hospital Universitari Bellvitge (January 2014–December 2018). To identify risk factors for DEP, cases were divided into two groups: those who developed DEP and those without DEP. Results: Among the whole cohort (n = 229) we identified 11 DEP cases (4.8%) and this percentage almost doubled in the subgroup of patients ≥70 years (8.1%). The risk factors for DEP were age ≥70 years (HR 10.19, 95%CI 1.28–80.93), therapy >14 days (7.71, 1.98–30.09) and total cumulative dose of daptomycin ≥10 g (5.30, 1.14–24.66). Conclusions: Clinicians should monitor cumulative daptomycin dosage to minimize DEP risk, and be cautious particularly in older patients when the total dose of daptomycin exceeds 10 g.

Pulmonary artery catheter during cardiac surgery: A rare but severe adverse effect

1998 ◽  
Vol 12 (1) ◽  
pp. 125-126
Author(s):  
Georges Daccache ◽  
Jean-Paul Depoix ◽  
Sophie Provenchere ◽  
Ivan Philip ◽  
Daniel Enguerand ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Cardiac Surgery ◽  
Pulmonary Artery ◽  
Pulmonary Artery Catheter ◽  
Severe Adverse Effect

scholarly journals Search and Selection of Probiotics That Improve Mucositis Symptoms in Oncologic Patients. A Systematic Review

Nutrients ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 2322 ◽  
Author(s):  
José Antonio Picó-Monllor ◽  
José Manuel Mingot-Ascencao
Keyword(s):  
Adverse Effect ◽  
Latin American ◽  
Bifidobacterium Longum ◽  
Caribbean Literature ◽  
Saccharomyces Boulardii ◽  
Cochrane Library ◽  
Bibliographic Databases ◽  
Severe Adverse Effect ◽  
Oncologic Patients ◽  
Search And Selection

Mucositis is a common and severe adverse effect of radiotherapy and/or chemotherapy treatments applied to oncologic patients. The development of effective therapies and adjuvant treatments to increase their efficacy and reduce adverse effect is a priority in cancer therapy. Probiotics are non-pathogenic live microorganisms that when ingested in adequate amounts can colonize the intestinal tract promoting the restoration of a healthy gut microbiota and contributing to all its functions including the maintenance of the integrity of the mucosa and the modulation of the immune system. In order to check the possible efficacy and safety of these microorganisms to prevent or ameliorate mucositis′ symptoms, we have systematically searched the bibliographic databases MEDLINE (via Pubmed), EMBASE, The Cochrane library, Scopus, Web of science, and Latin American and Caribbean Literature in Health of Sciences (LILACS) using the descriptors “Mucositis”, “Probiotics”, “Neoplasms”, “Humans”, and “Clinical Trials”. After applying our inclusion and exclusion criteria, 15 studies were accepted for review and critical analysis. Our analysis suggests that a combination of Bifidobacterium longum, Lactobacillus acidophilus, Bifidobacterium breve, Bifidobacterium infantis, and Saccharomyces boulardii could be a good combination of probiotics to reduce incident rates of mucositis or ameliorate its symptoms in chemo or radiotherapy treated patients.

scholarly journals Seizure: An Adverse Effect of Regadenoson in Myocardial Perfusion Imaging

2019 ◽  
Vol 2019 ◽  
pp. 1-3 ◽  
Author(s):  
Sohab S. Radwan ◽  
Owen G. Schwartz
Keyword(s):  
Adverse Effect ◽  
Stress Testing ◽  
Seizure Threshold ◽  
Severe Adverse Effect ◽  
Cardiac Stress ◽  
A2a Receptor ◽  
Patients At Risk ◽  
The Central Nervous System ◽  
Artery Disease ◽  
Modern Era

Regadenoson is a selective adenosine 2a (A2a) receptor agonist that is used in cardiac stress testing to evaluate for ischemic heart disease and has largely replaced adenosine in the modern era. Since adenosine receptors are involved in synaptic transmission between neurons throughout the central nervous system (CNS) including the cerebral cortex, hippocampus, and other structures as well, regadenoson can lower the seizure threshold in susceptible individuals. Epileptogenic activity is an uncommon yet potentially severe adverse effect of regadenoson use, and therefore, more awareness is required in screening patients at risk and evaluating alternate ways to investigate coronary artery disease (CAD) in susceptible individuals.

A Severe Adverse Effect of Atomoxetine

2020 ◽  
Vol 43 (2) ◽  
pp. 50-51
Author(s):  
Gokce Guldiken ◽  
Ali Karayagmurlu
Keyword(s):  
Adverse Effect ◽  
Severe Adverse Effect

scholarly journals Drug-Induced Autoimmune Hepatitis in a Patient Treated with Minocycline: A Rare Adverse Effect

2018 ◽  
Vol 12 (2) ◽  
pp. 447-452 ◽  
Author(s):  
Jamil Shah ◽  
Abul Shahidullah ◽  
Yingxian Liu
Keyword(s):  
Adverse Effect ◽  
Autoimmune Hepatitis ◽  
Antinuclear Antibody ◽  
Acne Vulgaris ◽  
Young Female ◽  
Interesting Case ◽  
Severe Adverse Effect ◽  
Drug Induced ◽  
Smooth Muscle Antibodies

Drug-induced autoimmune hepatitis is an acute and potentially severe adverse effect, which has been reported following the long-term use of minocycline. The condition’s typical biochemical findings include an elevated antinuclear antibody titer, hypergammaglobulinemia with elevated levels of serum immunoglobulin G, and, sometimes, positive anti-smooth muscle antibodies. Characteristically, transaminase levels are very elevated, while markers of cholestasis and bilirubin levels are mildly increased, and histological features are very similar to those observed in sporadic autoimmune hepatitis. Here, we describe an interesting case of a young female who developed drug-induced autoimmune hepatitis after taking minocycline for the treatment of acne vulgaris.

scholarly journals Dapsone induced hypersensitivity syndrome: a case report

2020 ◽  
Vol 9 (10) ◽  
pp. 1609
Author(s):  
Sarika Kolli ◽  
Priyanka Suhagiya
Keyword(s):  
Adverse Effect ◽  
Case Report ◽  
Hypersensitivity Syndrome ◽  
Organ Involvement ◽  
Severe Adverse Effect

Dapsone is an anti-leprotic drug. It may cause a severe adverse effect known as dapsone hypersensitivity syndrome which involves fever, chills, rash, and internal organ involvement. We report a case of a patient who is 30 years old male presented with fever, skin desquamation, and hepatitis. The case is being reported to emphasize the need to diagnose and manage dapsone hypersensitivity syndrome.

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