Improving Physicochemical Properties of Repaglinide Through Pharmaceutical Adduct Formation

Background: Many formulation strategies are presently in development in pharmaceutical industry. However, the formation of pharmaceutical adducts is considered to be the most appropriate technique for improving the drug solubility and dissolution as no chemical bond changes are involved in this technique.Purpose: This technique is highly used for compounds which are not able to give viable formulation products with standard techniques such as salt formation and polymorph generation. In the present study, this method is applied to repaglinide, which is an hypoglycemic agent, with compromised solubility. Methods: The adducts were prepared by slow evaporation method and characterized using DSC, FTIR and PXRD studies. The solubility and dissolution studies were carried out to determine the increased solubility of drug in adducts. The drug amount interacted with coformers has also been determined. Results: The present study demonstrates the improvement in solubility and thus dissolution of repaglinide in adducts.Conclusion: The adducts formed in the present study can be further exploited to prepare formulation of repaglinide adducts with better physicochemical characteristics.

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Pharmaceutical Co-Crystals - Design, Development and Applications

Drug Delivery Letters ◽

10.2174/2210303109666191211145144 ◽

2020 ◽

Vol 10 (3) ◽

pp. 169-184

Author(s):

Rachna Anand ◽

Arun Kumar ◽

Arun Nanda

Keyword(s):

Physicochemical Properties ◽

Crystal Engineering ◽

Pharmacological Action ◽

Physicochemical Characteristics ◽

Research Area ◽

Dissolution Profile ◽

Design Development ◽

Drug Molecule ◽

Wide Range ◽

Major Factors

Background: Solubility and dissolution profile are the major factors which directly affect the biological activity of a drug and these factors are governed by the physicochemical properties of the drug. Crystal engineering is a newer and promising approach to improve physicochemical characteristics of a drug without any change in its pharmacological action through a selection of a wide range of easily available crystal formers. Objective: The goal of this review is to summarize the importance of crystal engineering in improving the physicochemical properties of a drug, methods of design, development, and applications of cocrystals along with future trends in research of pharmaceutical co-crystals. Co-crystallization can also be carried out for the molecules which lack ionizable functional groups, unlike salts which require ionizable groups. Conclusion: Co-crystals is an interesting and promising research area amongst pharmaceutical scientists to fine-tune the physicochemical properties of drug materials. Co-crystallization can be a tool to increase the lifecycle of an older drug molecule. Crystal engineering carries the potential of being an advantageous technique than any other approach used in the pharmaceutical industry. Crystal engineering offers a plethora of biopharmaceutical and physicochemical enhancements to a drug molecule without the need of any pharmacological change in the drug.

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ANTIMICROBIAL AND POWDER CHARACTERIZATION OF HERBAL DENTIFRICES

INDIAN DRUGS ◽

10.53879/id.50.11.p0039 ◽

2013 ◽

Vol 50 (11) ◽

pp. 39-47

Author(s):

V. K Sharma ◽

◽

B. Mazumder ◽

P. P. Sharma

Keyword(s):

Oral Cavity ◽

Physicochemical Properties ◽

Antimicrobial Effect ◽

Physicochemical Characteristics ◽

Water Soluble ◽

Particle Rearrangement ◽

Bulk Volume ◽

The Impact ◽

Tapped Density

The consumption of edible products strongly recommends the regular hygiene of oral cavity. Various dental products of allopathic and herbal origin are used as dentifrices. The dentifrices are considered safe and effective in terms of cleansing effect of oral cavity and antimicrobial effect against microbes causing bad smell and diseases such as gingivitis, pyorrhea etc. These characteristics of preparations are basically related to physicochemical properties of ingredients present in their composition and some how on directions of their use. In the present study, the marketed allopathic dentifrices coded as Brand I and II and herbal tooth powders coded as Brand III and IV were selected to analyze the impact of physicochemical properties of incorporated ingredients on their cleansing efficiency. The physicochemical characteristics studied were pH, bulk volume, tapped volume, tapped density, bulk density, true density, porosity, flowability, compressibility, compactability, cohesiveness, dispersability, Carr’s index, Hausner’s ratio, water soluble content, alcohol soluble content, foaming index, particle rearrangement behaviour and particle rearrangement constant. The antimicrobial effect of these powders was studied against Staphylococcus sorbinus, Staphylococcus salivarius and Lactobacillus acidophilus. It was observed that some of the physicochemical properties of all powders were different from each other. Marked antimicrobial effect of tooth powders was observed against pathogens. In all preparations, remarkable foaming index was analyzed that was generally considered responsible for cleansing effect.

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Preliminary Studies Regarding the Physicochemical Characteristics of Some Balsamic Vinegars

Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca Agriculture ◽

10.15835/buasvmcn-agr:4065 ◽

1970 ◽

Vol 66 (2) ◽

Author(s):

Delia Mihaela TRUTA ◽

Maria TOFANA ◽

Sonia Ancuţa SOCACI ◽

Rowena CHELEMAN

Keyword(s):

Physicochemical Properties ◽

Physical Properties ◽

Quality Evaluation ◽

Physicochemical Characteristics ◽

Production Method ◽

Chemical Information ◽

Grape Must ◽

The Third ◽

The Future ◽

Balsamic Vinegar

The aim of this work is to analyze the chemical and physical properties of balsamic vinegar, in order to improve the chemical information about this product, useful for its authentication and quality evaluation. Using three balsamic vinegars purchased in local markets as samples, this study investigated the labeling and the physicochemical properties of commercial concentrated balsamic vinegar in order to understand their production method and quality. Two of the samples were balsamic vinegars from Modena (BVM) and the third was a balsamic vinegar from Kalamata (BVK). According to the labels, all the balsamic vinegars samples were made of grape must and had an acidity of 6%. The appearance of the samples of vinegar differed significantly, but the acidity from the label was the same for all. Since people are paying much more attention to health, the number of concentrated vinegar products is expected to increase in the future. Thus, appropriate rules and physicochemical properties are required to regulate vinegar production and quality.

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Basic Review: Solubility Enhancement by Using Various Approaches

International Journal of Pharmaceutical Sciences Review and Research ◽

10.47583/ijpsrr.2021.v68i02.026 ◽

2021 ◽

Vol 68 (2) ◽

Author(s):

Baldha Krunal ◽

Sanjay Savaliya ◽

Payal N Vaja ◽

Dr. Chetan H Borkhtaria

Keyword(s):

Pharmaceutical Industry ◽

Water Solubility ◽

Development Stage ◽

Solubility Enhancement ◽

Therapeutic Action ◽

Drug Solubility ◽

Formulation Development ◽

Bioavailability Enhancement ◽

Screening Programs ◽

New Chemical Entities

The solubility enhancement process of drugs plays a key role in the formulation development to achieve the bioavailability and therapeutic action of the drug at the target site. About 40% of the new chemical entities identified by pharmaceutical industry screening programs face numerous problems in the formulation and development stage because of poor water solubility and low bioavailability. Drug solubility and bioavailability enhancement are the important challenges in the field of formulation of pharmaceuticals.

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Dragonflies (Odonata) of coastal sand-dune fresh waters of South-eastren Queensland and North-eastern New South Wales

Marine and Freshwater Research ◽

10.1071/mf9820077 ◽

1982 ◽

Vol 33 (1) ◽

pp. 77 ◽

Cited By ~ 7

Author(s):

AH Arthington ◽

JAL Watson

Keyword(s):

Physicochemical Properties ◽

Sand Dune ◽

New South ◽

New South Wales ◽

Physicochemical Characteristics ◽

Coastal Sand Dune ◽

Freshwater Streams ◽

South Wales ◽

North Eastern ◽

Coastal Sand

The Odonata and physicochemical properties of freshwater streams, lakes, ponds and bogs in the sand-dune systems of Fraser, Moreton and North Stradbroke Islands and Cooloola, Queensland: and Wooli, New South Wales, are described. The odonate faunas of these dune masses show some differences from those of nearby areas, and there are close associations between some species and particular types of dune fresh water. Although no physicochemical characteristics were identified that might limit these dune dragonflies to their specific habitats, the lake-dwellers in particular may be useful indicators of environmental change.

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Exploration on the Drug Solubility Enhancement in Aqueous Medium with the Help of Endo-Functionalized Molecular Tubes: A Computational Approach

Physical Chemistry Chemical Physics ◽

10.1039/d1cp01187a ◽

2021 ◽

Author(s):

Rabindranath Paul ◽

Sandip Paul

Keyword(s):

Pharmaceutical Industry ◽

Aqueous Medium ◽

Aqueous Solubility ◽

Solubility Enhancement ◽

Computational Approach ◽

Drug Solubility ◽

Drug Candidates ◽

Drug Molecules ◽

Molecular Tubes

One major problem in the pharmaceutical industry is the aqueous solubility of newly developed orally administered drug candidates. More than 50 % of the newly developed drug molecules suffer from...

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Structure and Physicochemical Properties of Water Treated under Methane with Low-Temperature Glow Plasma of Low Frequency

Water ◽

10.3390/w12061638 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1638 ◽

Cited By ~ 7

Author(s):

Aleksandra Ciesielska ◽

Wojciech Ciesielski ◽

Karen Khachatryan ◽

Henryk Koloczek ◽

Damian Kulawik ◽

...

Keyword(s):

Low Temperature ◽

Physicochemical Properties ◽

Treatment Time ◽

Low Frequency ◽

Aqueous Solubility ◽

Physicochemical Characteristics ◽

Scanning Calorimetry ◽

Spin Resonance ◽

Reflectance Ftir ◽

Glow Plasma

Our former studies delivered a strong evidence that water indirectly treated with low-temperature, low-pressure glow plasma of low frequency (GP) changed its structure depending on the atmosphere in which such treatment was performed (air, ammonia, and nitrogen) and on the time of the treatment (0 to 120 min). In every case, water of different physicochemical characteristics and interesting biological functions was produced. Therefore, the relevant studies were extended to treating deionized water with GP under methane. The resulting samples were characterized by means of ultraviolet/visible (UV/VIS), Fourier transformation infrared-attenuated total reflectance (FTIR-ATR), electron spin resonance (ESR) and Raman spectroscopies, differential scanning calorimetry (DSC), thermogravimetry, pH, conductivity, and refractive index. The generated samples of water had entirely different physicochemical properties from those recorded for water treated with GP in the air and under both ammonia and nitrogen. The treatment of water with GP under methane did not produce clathrates hosting methane molecules. Thermogravimetry delivered an evidence that the treatment with GP increased the aqueous solubility of methane. That solubility non-linearly changed against the treatment time.

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Salt Formation to Improve Drug Solubility

ChemInform ◽

10.1002/chin.200752235 ◽

2007 ◽

Vol 38 (52) ◽

Author(s):

Abu T. M. Serajuddin

Keyword(s):

Drug Solubility ◽

Salt Formation

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Review of Pharmaceutical Applications of N-Methyl-2-Pyrrolidone

Journal of Pharmacy & Pharmaceutical Sciences ◽

10.18433/j3p306 ◽

2010 ◽

Vol 13 (4) ◽

pp. 524 ◽

Cited By ~ 86

Author(s):

Abolghasem Jouyban ◽

Mohammad Amin Abolghasemi Fakhree ◽

Ali Shayanfar

Keyword(s):

Side Effects ◽

Adverse Effects ◽

Physicochemical Properties ◽

Physicochemical Characteristics ◽

Pharmaceutical Sciences ◽

Pharmaceutical Applications ◽

Pharmaceutical Industries

N-Methyl-2-pyrrolidone (NMP) or Pharmasolve is very strong solubilizing agent and it has important applications in different fields of industry. This review presents NMP physicochemical characteristics, application especially in pharmaceutical sciences, pharmacokinetic and toxicity. Characteristics of NMP such as physicochemical properties, solubilization efficacy, toxicity and adverse effects were compared with other common solvents used in the pharmaceutical industries. This review reveals that NMP is an acceptable pharmaceutical solvent and its efficacy, toxicity, and side effects are comparable with other common solvent.

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