THE USE OF SERIAL HEMAGGLUTINATION TESTS IN FOLLOWING THE COURSE OF TUBERCULOSIS IN CHILDREN

PEDIATRICS ◽  
1954 ◽  
Vol 14 (4) ◽  
pp. 340-345
Author(s):  
VIRGINIA H. PEDEN ◽  
KEITH E. VINCENT ◽  
EDITH RICH
Keyword(s):  
Prognostic Significance ◽  
Spinal Fluid ◽  
Older Children ◽  
X Ray ◽  
Hemagglutination Test ◽  
Tuberculous Disease ◽  
Absolute Height ◽  
Tuberculin Testing ◽  
Tuberculosis In Children ◽  
Meningeal Tuberculosis

1. In cases of known pulmonary (or meningeal) tuberculosis in which X-ray (or spinal fluid) findings have become stabilized, a rise or fall in a previously stable hemagglutinin titer is a reliable indication that X-ray (or spinal fluid) evidence of improvement of the disease will follow within a few weeks. 2. A change in hemagglutinin titer occurring simultaneously with improvement in X-ray (or spinal fluid) findings serves as reliable additional evidence of improvement of the disease. 3. The significance of a changing hemaglutinin titer must always be evaluated with reference to X-ray (or spinal fluid) findings. A changing titer can be considered evidence of impending or beginning improvement of the disease only if the X-ray (or spinal fluid) findings are either static or improving. 4. A changing hemagglutinin titer was useful in predicting or confirming improvement of tuberculous disease in 38% of the group of cases studied. In the remaining cases, a change in hemagglutinin titer either failed to occur at all, or did not occur until after definite X-ray (or spinal fluid) improvement had taken place. 5. The absolute height of the hemagglutinin titer, in itself, was of no prognostic significance in connection with the course of tuberculosis in children. 6. In following the course of tuberculosis, the hemagglutination test is of more value in older children and in children with relatively mild forms of the disease than in infants or in patients with severe forms of tuberculosis, because the former are more likely to develop positive tests. 7. Tuberculin testing did not interfere with the use of the hemagglutination test in following the course of tuberculous disease.

THE TRENDS OF TUBERCULOSIS IN CHILDREN AGED 1- 12 YEARS AND ITS MANAGEMENT FROM 2011 TO 2015 AT ARTHUR DAVISON CHILDRENS HOSPITAL IN NDOLA: Retrospective study (Preprint)

2019 ◽  
Author(s):  
Martin Greta
Keyword(s):  
The Body ◽  
Smear Microscopy ◽  
Newly Diagnosed ◽  
X Ray ◽  
Children's Hospital ◽  
Co Morbidity ◽  
Children’S Hospital ◽  
Childhood Tb ◽  
Tuberculosis In Children ◽  
Age Range

BACKGROUND Tuberculosis is a widespread and in many cases a fatal, infectious disease caused by many strains of mycobacterium complex usually mycobacterium tuberculosis. It can affect any part of the body but mainly the lungs hence called pulmonary tuberculosis. Tuberculosis in children has been less of a public health priority in the recent years despite the fact that TB has been a major cause of childhood morbidity and mortality worldwide with difficulties in diagnosis. Data on trends of childhood TB is rarely in published literature hence need for this research which will help in publishing OBJECTIVE To establish the trends in TB among children aged 1-12 years and its management over a period of five years from 2011- 2015 at Arthur Davison children’s hospital in Ndola and also to determine the proportion of TB in these children and to establish the age group most affected by TB over the period of five years and lastly to assess the proportion of TB and HIV as a co-morbidity METHODS The study reviewed all records that were registered in the MOH TB register at ADH from 2011 to 2015 coming up with a total number of 483 TB records and these records had satisfied the inclusion and exclusion criteria. The data capturing tool was used to collect the data. RESULTS : This study determined the trends of TB in children aged 1 to 12 over the five years period from a total of 483 reviewed paediatric TB cases , its proportion in these children, the age range most affected by TB and lastly assessed TB and HIV as a co-morbidity at Arthur Davison Children’s hospital. It revealed that the trends were decreasing and that out of 483 TB patient, the majority 157(32.5%) of the TB patients were seen in the year 2011, followed by 129(26.7%), 84(17.4%), 57(11.8%) and 56(11.6%) representing the year 2012, 2013, 2014 and 2015 respectively. Findings on the age range most affected are that the majority 282(58.4%) of the TB patients were aged (5-12) years old while 201(41.6%) were aged between (1-5) years old. Therefore, the age range most affected by TB was between (5-12) years. The TB proportion results showed that Out of 483, the majority 467(96.7%) of the TB patient type were newly diagnosed, followed by 13(2.7%), 2(.4%) and the rest 1(.2%) that were Relapse, Trans-in and Treatment resumed respectively. And that many 467(96.7%) of TB condition types were PTB while 16(3.3%) were EPTB. Furthermore, the majority of 463(95.9%) were diagnosed by X-ray while 20(4.1%) were diagnosed by smear microscopy. And lastly In terms of HIV as a co-morbidity, the majority 175(36.2%) of the TB patients were HIV positive, followed by 173(35.8%) that were HIV negative while the rest 135(28%) of the TB patients were not tested for HIV CONCLUSIONS This study reports that the trends of TB in children aged 1-12 years have been decreasing from 2015 to 2011 .And the age range most affected was found to have been 5-12 years and the proportion of TB cases were mostly newly diagnosed and the diagnosis was made by use x-ray and lastly the large proportion of TB patients had tested positive for HIV as a co-morbidity. Therefore efforts should be made to sustain this decreasing trend of childhood TB.

Przewlekły kaszel jako główna manifestacja chłoniaka Hodgkina – opis przypadku

2019 ◽  
Vol 23 (3) ◽  
Author(s):  
Katarzyna Wójcicka ◽  
Andrzej Pogorzelski
Keyword(s):  
Chronic Cough ◽  
Correct Diagnosis ◽  
Diagnostic Methods ◽  
Radiographic Examination ◽  
Older Children ◽  
X Ray ◽  
Volume Curve ◽  
Flow Volume Curve ◽  
Mediastinal Widening ◽  
Chest X Ray

A cough lasting longer than 4-8 weeks, defined as chronic cough, always requires thorough diagnostic evaluation. In addition to detailed history-taking and physical examination, simple and available diagnostic methods, such as chest x-ray and spirometry, should be performed. They may be helpful tool to establish the underlying cause of cough. Many younger children may have difficulties in performing the forced expiratory maneuvers and fulfilling repeatability criteria for spirometry. The disturbances resulting from insufficient cooperation should be considered in interpratation of the obtained results. The shape of the flow-volume curve, which suggests upper or central airways obstruction, can not be ignored and always requires further investigation for diagnosis of respiratory pathology. The chest x-ray is the most frequently performed radiographic examination in children. Accurate interpretation is essential in reaching a correct diagnosis. Mediastinal widening on the chest x-ray in children can occur due to a large variety of causes. The normal thymus can take on a variety of sizes and shapes and still be considered normal in the first few years of life. In older children mediastinal widening should be differentiated from mediastinal masses. Lymph node enlargement represents a frequent cause, usually as a result of infection or malignancy. The article reports a case of a 12-year-old boy with chronic cough, mediastinal widening on the chest X-ray and abnormal spirometry results, who was finally diagnosed with stage III Hodgkin’s lymphoma.

scholarly journals Foreign Body Aspiration in Infants and Older Children: A Comparative Study

2019 ◽  
Vol 99 (1) ◽  
pp. 47-51 ◽  
Author(s):  
Shorook Na’ara ◽  
Igor Vainer ◽  
Moran Amit ◽  
Arie Gordin
Keyword(s):  
Foreign Body ◽  
Medical Center ◽  
Age Groups ◽  
Signs And Symptoms ◽  
Foreign Body Aspiration ◽  
Preschool Age ◽  
Small Airways ◽  
Older Children ◽  
X Ray ◽  
Young Infants

Background: Foreign body aspiration (FBA) is a major cause of morbidity and mortality in children. It is a preventable event that predominates in preschool age. The signs and symptoms mimic respiratory diseases common in the same age-group. We compared FBA in infants to FBA in older children. Methods: Retrospective analysis of all the cases of suspected FBA of children under the age of 18 years hospitalized at one medical center during 2002 to 2016. We analyzed the data according to age: up to 1 year (infants) and 1 to 18 years. Results: One hundred seventy-five children with suspected FBA were admitted; of whom, 27 (15%) were infants and 148 (85%) were older children (age 1-18 years). For the 2 age groups, adults witnessed 85% and 73%, respectively, of the incidents ( P = .4). In the neonate group, 48% presented with normal X-ray findings compared to only 20% in the older group; 15% of the older group had a positive chest X-ray for a foreign body, while none had such in the infants’ group ( P = .01). For the 2 age groups, the majority of the FBs found were from organic origin. About half of the patients were diagnosed and managed within 24 hours of the aspiration event. In 10%, repeated bronchoscopy was performed due to a retained FB remnant. In a multivariate analysis, signs and symptoms ( P < .05), location of the FB ( P < .001), and witnessed aspiration ( P < .001) were independent prognostic factors for the length of hospitalization. Conclusion: Foreign body aspiration is not uncommon in young infants; the management is challenging due to small airways, the need to use smaller bronchoscopes, and the lack of working channel forces in pediatric bronchoscopes.

scholarly journals Radiographic aspects of acute community-acquired bacterial pneumonia and pulmonary tuberculosis in children

2021 ◽  
Author(s):  
Rivo Lova Herilanto Rakotomalala ◽  
Harimino Mireille Rakotondravelo ◽  
Andrianina Harivelo Ranivoson ◽  
Annick Lalaina Robinson
Keyword(s):  
Community Acquired Pneumonia ◽  
University Hospital ◽  
Radiographic Images ◽  
X Ray ◽  
Male Predominance ◽  
Mother And Child ◽  
Chest X Ray ◽  
The Right ◽  
The University ◽  
Tuberculosis In Children

Background: The etiological diagnosis of pneumonia is often difficult because of the impossibility of microbiological confirmation most of the time. Therefore, chest X-ray is still essential for a positive diagnosis and etiological orientation. The main objective of our study was to describe the radiographic aspects of acute community-acquired pneumonia and tubercular pneumonia in children.Methods: This was a descriptive retrospective study conducted at the university hospital mother and child of Tsaralalana from January 1st to July 31st, 2017.Results: Sixty-nine cases of pneumonia were included, including 13 cases of TB pneumonia and 46 cases of acute community-acquired pneumonia. The average age was 36.68 months with a male predominance. Clinically, respiratory functional signs predominated in both cases. Alteration in general condition was mainly observed in tubercular pneumonia (26.08%). Alveolar syndromes were present in 43.47% of TB pneumonias and 36.94% of acute community-acquired pneumonia. With regard to the radiographic images, alveolar involvement was common to both types of pneumonia; the nodular image was present in 8.69% of the tubercular pneumonias and 2.17% of the acute community-acquired pneumonia; the cavity image was present only in the tubercular pneumonia (p=0.04); the right-sided location predominated in both cases.Conclusions: X-ray images were common to both TB pneumonia and acute community-acquired pneumonia; some images were specific to TB pneumonia. However, the etiologic orientation of pneumonia is based on a combination of epidemiologic, clinical, and radiographic evidence.

DUODENAL ULCER IN CHILDHOOD

PEDIATRICS ◽  
1970 ◽  
Vol 45 (2) ◽  
pp. 283-286
Author(s):  
Mary Loretta Rosenlund ◽  
C. Everett Koop
Keyword(s):  
Duodenal Ulcer ◽  
Common Symptom ◽  
Peptic Ulcers ◽  
Older Children ◽  
Duodenal Ulcers ◽  
X Ray ◽  
Ulcer Disease ◽  
The Past ◽  
Younger Age ◽  
The Central Nervous System

There has been some disagreement concerning the admittedly rare incidence of duodenal ulcer disease in children. Because of conflicting reports from other pediatrics centers, we have reviewed the records of all patients admitted to The Children's Hospital of Philadelphia in the past 20 years (1948 through 1967) in whom duodenal ulcer was diagnosed by x-ray, at operation or on postmortem examination (Table I). There were 27 children between the ages of 15 days and 15½ years, with well established duodenal ulcers. Six of these were female (22%). The age at presentation was scattered, but the majority were between 2 and 11 years of age. Presenting complaints were varied: gastrointestinal bleeding was most common in the younger age group, while abdominal pain, usually persistent and intermittent, was the most common symptom in the older children. The diagnosis of duodenal ulcer was made by x-ray examination in 22 patients and at operation in 2; and the ulcers were discovered only at autopsy in 3 children. All the ulcers were duodenal; the precise location was not specified in 9, but 11 were bulbar and 7 were postbulbar. Complications of the ulcer were noted in 9 patients. Perforation occurred in 7 patients, leading to death in 4 (all had disease of the central nervous system) and repeated bleeding in 2. Etiology of the ulcer disease was determined in 15 of the children, but the cause was unknown in 12. Our series is concerned only with duodenal ulcers which, admittedly, comprise the greatest percentage of peptic ulcers.

PENICILLIN THERAPY OF LATE CONGENITAL SYPHILIS

PEDIATRICS ◽  
1948 ◽  
Vol 1 (5) ◽  
pp. 601-616
Author(s):  
RALPH V. PLATOU ◽  
JOHN T. KOMETANI
Keyword(s):  
Body Weight ◽  
Congenital Syphilis ◽  
Single Agent ◽  
Previous Treatment ◽  
Spinal Fluid ◽  
Older Children ◽  
Total Dosage ◽  
Intramuscular Injections ◽  
Interstitial Keratitis ◽  
Penicillin Therapy

Though no valid comparisons can be made until more patients have been treated and followed for a longer time, it seems to us that penicillin used alone is at least as effective as any other single agent for the treatment of late congenital syphilis. To what extent treatment or time alone contribute to improvements cannot yet be stated. Most of the clinical and serologic indications of healing developed rather slowly; in only a few patients with the most superficial lesions were there objective signs of improvement during therapy. The treatment schedules we employed are similar to those previously recommended for infants. At present we advise a total dosage comprising at least 100,000 units commercial penicillin per kilogram body weight, divided into 100 equal intramuscular injections and given at two to three hour intervals around the clock for eight or more days. Therapeutic reactions, entirely febrile in nature, have all been transient and benign. There were no deaths. We believe that the simplicity, safety and convenience of these plans make them preferable to the more costly, hazardous, and time-consuming older methods; further-more, they effectively curtail the appallingly high delinquency rates formerly prevailing. Results were significantly better for children treated under six years of age than they were for older children, and also for those who had normal spinal fluid before treatment; they were suggestively but not significantly better among those for whom the larger dosage schedules were used. Outcome was significantly worse in those who had received previous treatment of any sort. There were just three relapse—two defined only serologically, and one by a questionable recurrence of interstitial keratitis. About a quarter of those with latent congenital syphilis have become seronegative. The poorest results ensued for patients with clinical neurosyphilis; two children from this group continued to exhibit definite deterioration. For interstitial keratitis, results were most gratifying in two patients treated within a month of onset. Seventy-two per cent of all patients with late congenital syphilis so far treated with penicillin and followed for more than two months are clinically well and have negative serologic reactions or progressively declining titers.

Tracheobronchial foreign body aspiration in children: a 5-year retrospective study from Shanghai, China

2019 ◽  
Author(s):  
Guodong Ding ◽  
Beirong Wu ◽  
Angela Vinturache ◽  
Chen Cai ◽  
Min Lu ◽  
...  
Keyword(s):  
Foreign Body ◽  
Descriptive Analysis ◽  
Sudden Onset ◽  
Rigid Bronchoscopy ◽  
Flexible Bronchoscopy ◽  
Older Children ◽  
Female Ratio ◽  
X Ray ◽  
Presenting Symptoms ◽  
First Choice

Abstract Background Foreign body (FB) aspiration is a common and serious problem in childhood, but little information is available about this condition in Chinese context. We aimed to characterize the clinical and epidemiological features of airway FBs in a pediatric Chinese population. Methods A retrospective review of medical records of children aged 0-14 years who attended with a diagnosis of FB aspiration the Shanghai Children's Hospital between 2013 and 2017 was carried out. Descriptive analysis was used to assess patient's demographics, clinical, radiographic, bronchoscopic findings, time to presentation, and characteristics of the FBs. Results Among the 200 patients included in the study, 92% were under 3 years of age, with a peak incidence of FB aspiration occurring between 1 and 2 years. The male to female ratio was 2.6:1. Twenty-three percent of the patients were admitted within 24 hours of the event, 40% within 1 week, 30% within 1 month, and 7% more than 1 month after aspiration. Eleven percent were laryngotracheal FBs and 89% were bronchial FBs. The most common presenting symptoms of laryngotracheal FBs were cough, dyspnea, and wheezing; those of bronchial FBs were cough, decreased air entry, and wheezing. Chest X-ray was normal in four-fifths of the children with laryngotracheal FBs, whereas most common abnormal x-ray findings in children with bronchial FBs were mediastinal shift, obstructive emphysema, and pneumonia. In children younger than 2 years FBs were more frequently found in the left bronchus, whereas in older children FBs were more frequently found in the right bronchus. Ninety-three percent of the removed FBs were organic materials such as food items and the most frequently aspirated FBs were peanuts. Flexible bronchoscopy was successfully performed in 80.5% of the patients, while rigid bronchoscopy or direct laryngoscopy in 17.5% of the patients. Four patients were subjected to thoracic surgery and 1 died during bronchoscopy due to acute respiratory failure. Conclusions Tracheobronchial FBs should be suspected in children who have sudden onset of cough and wheezing episode, even when physical and radiographic evidence is absent. Flexible bronchoscopy has become the first choice in China used for FB removal from airways in children.

scholarly journals Latent tuberculosis infection and tuberculosis in children and adolescents

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Cassia Satsuki Ishikawa ◽  
Olivia Mari Matsuo ◽  
Flavio Sarno
Keyword(s):  
Computed Tomography ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculin Test ◽  
Tuberculosis Infection ◽  
Gastric Aspirate ◽  
X Ray ◽  
Qualitative Variables ◽  
Chest X Ray ◽  
Tuberculosis In Children

ABSTRACT Objective: To describe the characteristics of patients diagnosed with tuberculosis and latent tuberculosis infection. Methods: A retrospective study, between 2012 and 2015, with data from patients of Programa Einstein na Comunidade de Paraisópolis. To evaluate possible factors associated with patient's sex and diagnoses of tuberculosis and latent tuberculosis infection, χ2 or Fisher's exact tests were used for qualitative variables, and Mann-Whitney test for quantitative or ordinal qualitative variables. Results: A total of 77 patients were evaluated. Age ranged from 6 months to 13.4 years, with a majority of males (54.5%), aged zero to 4 years (54.5%), diagnosed with latent tuberculosis infection (64.9%), and classified as eutrophic (71.2%). The tuberculin test was positive in 92% and in most cases the values were above 10mm (68.0%). Approximately three-quarters of chest X-ray tests were normal (72.7%). After chest X-ray, computed tomography of thorax was the most ordered exam (29.9%), followed by smear and culture for Mycobacterium tuberculosis in the gastric aspirate (28.6%). The frequencies of altered chest X-ray (70.4% versus 4.0%), computed tomography of thorax requests (55.6% versus 16.0%) and other tests requested (81.5% versus 38.0%) were significantly higher in patients with a diagnosis of tuberculosis, relative to those with latent tuberculosis infection, respectively. Conclusion: In our sample, proportions of altered chest X-ray, and performing computed tomography of thorax and other tests in patients diagnosed with tuberculosis were higher than in those with latent tuberculosis infection.

The Prognostic Significance of Changes in X-Ray Attenuation on CT in Established Cerebral Infarcts

2003 ◽  
Vol 16 (2) ◽  
pp. 114-121 ◽  
Author(s):  
J. De Reuck ◽  
E. van de Velde ◽  
G. van Maele ◽  
W. Wissaert
Keyword(s):  
Prognostic Significance ◽  
Cerebral Infarcts ◽  
X Ray
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