THE INCIDENCE OF CONGENITAL MALFORMATIONS: A STUDY OF 5,964 PREGNANCIES

PEDIATRICS ◽  
1954 ◽  
Vol 14 (5) ◽  
pp. 505-522
Author(s):  
RUSTIN MCINTOSH ◽  
KATHARINE K. MERRITT ◽  
MARY R. RICHARDS ◽  
MARY H. SAMUELS ◽  
MARJORIE T. BELLOWS
Keyword(s):  
Birth Order ◽  
Congenital Malformations ◽  
Maternal Age ◽  
Neonatal Period ◽  
Incidence Rates ◽  
Organ System ◽  
Neonatal Deaths ◽  
Products Of Conception ◽  
A Prospective Study ◽  
Relationship Of

I. The plan is described of a prospective study of the outcome of 5,964 pregnancies, with special emphasis on the relationship of factors in fetal environment to the incidence of abortions, stillbirths, neonatal mortality and congenital malformations. II. Data are presented on the overall incidence of congenital malformations according to sex, race, weight at delivery, maternal age and order of birth. A. The incidence of congenital malformations among 5,739 products of conception weighing over 500 grams was 7.5%. The rate was 7.0% among infants born alive and surviving the neonatal period, 13.6% among antepartum deaths, 23.3% among intrapartum deaths, 29.6% among neonatal deaths and 70.6% among deaths occurring between the ages of one and 12 months. B. The following relationships in incidence rates among live-born infants surviving the neonatal period were found. 1. The rate among males (8.4%) was half again as high as among females (5.5%). 2. Non-white infants had a higher rate (7.8%) than white infants (6.3%). 3. Infants weighing 2,500 grams or less had a higher proportion with defects (9.7%) than did those weighing over 2,500 grams (6.7%), although this difference occurred entirely among females. 4. Maternal age had no effect on the incidence of congenital malformations. 5. White infants of lower birth order had a lower rate (5.3%) than did those of higher birth orders (8.2%). No difference according to birth order was observed among non-white infants. III. A system of classification of malformations is described and discussed. Incidence rates by organ system groups are presented. A. Less than one-half of the malformations found among live-born infants were suspected or noted at birth. B. Malformations of musculo-skeletal system and skin were more frequent than malformations of other systems. Incidence rates by organ system groups are directly related to problems of diagnosis. C. Of the malformed live-born infants, 14.8% had more than one malformation and in 9.1% more than one system was involved. Of the malformed stillbirths and neonatal deaths, 66.0% had more than one malformation and in 51.1% more than one system was involved.

scholarly journals Analysis of factors associated with early neonatal deaths through linkage between SIM and SINASC, in Sergipe, Brazil

2021 ◽  
Vol 10 (16) ◽  
pp. e171101623676
Author(s):  
Thais Serafim Leite de Barros Silva ◽  
Sérgio de Brito Barbosa ◽  
Lara Benario de Lisboa Santos ◽  
Rayssa da Nóbrega Didou ◽  
Júlia Maria Gonçalves Dias ◽  
...  
Keyword(s):  
Information System ◽  
Congenital Malformations ◽  
Neonatal Period ◽  
Secondary Data ◽  
Single Women ◽  
Multiple Pregnancies ◽  
Neonatal Deaths ◽  
Factors Associated ◽  
Survivor Group ◽  
Early Neonatal Deaths

In Brazil, more than 70% of neonatal deaths are concentrated in the early neonatal period, with about 41.2% of them occurring in the first 24 hours of life. Thus, the objective of this study was to carry out an analysis of factors associated with early neonatal deaths that occurred in Sergipe, Brazil, through the linkage of records in the information systems: Live Birth Information System (SINASC) and Mortality Information System (SIM). This study was carried out in Sergipe, Brazil, in which an analysis was made of secondary data on children born and early neonatal deaths in Sergipe between 2006 and 2019 registered in the SINASC and in the SIM. A linkage was carried out between the databases, identifying 484,629 live births, 480,784 survivors and 3,845 who died with less than 7 days of life, with a low percentage of ignored data or absent. Maternal age was similar between groups. However, the newborns who died had lower weight, gestational age and Apgar in the first and fifth minutes than the survivor group. Regarding the newborn, there were more deaths in males and in congenital malformations. As for information about the mother and pregnancy, there were more deaths in single women, multiple pregnancies, lower gestational ages and vaginal delivery. There was an association between neonatal deaths and lower Apgar in the first and fifth minutes, lower weights, lower gestational ages, male gender, congenital malformations, women with multiple pregnancies, vaginal births and single mothers.

Maternal and Neonatal Variables in Twins: an Epidemiological Approach

1996 ◽  
Vol 45 (4) ◽  
pp. 461-469 ◽  
Author(s):  
M. A. Campana ◽  
M. M. Roubicek
Keyword(s):  
Congenital Malformations ◽  
Maternal Age ◽  
Public Hospital ◽  
Buenos Aires ◽  
Population Studies ◽  
Caucasian Population ◽  
Neonatal Deaths ◽  
Monozygotic Twinning ◽  
Increased Risk ◽  
Epidemiological Approach

AbstractPopulation studies on human twinning are scarce in Argentina. In order to analyze frequencies and certain maternal and neonatal variables related to twin births, we studied a series of 69.678 consecutive newborns with 500 g of weight and over, which occurred at a public hospital in the province Buenos Aires, during 14 years (1982-1995). The frequency of twin births (10 per 1000 deliveries) and sex ratio were similar to other studies reported in Caucasian population. Maternal age and order of gravity/parity were positively correlated with twinning rates, more markedly so in dissimilar sex-pairs. Stillbirths and neonatal deaths were more frequent in twins than in singletons, but less frequent when comparing groups of same weight. Congenital malformations were not found to be significantly more frequent in twins than in the total newborn population. However, their occurrence, predominantly in like-sexed pairs and the concordance for defect type in doubly affected same-sex pairs, suggests that monozygotic twinning carries an increased risk for malformation.

Perinatal Mortality in Twins, Australia, 1973-1980: II. Maternal Age, Lethal Congenital Malformations and Sex

1988 ◽  
Vol 37 (3-4) ◽  
pp. 321-329 ◽  
Author(s):  
John D.H. Doherty
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Sex Ratio ◽  
Perinatal Mortality ◽  
Congenital Malformations ◽  
Maternal Age ◽  
Teenage Mothers ◽  
Neonatal Deaths ◽  
Perinatal Mortality Rate

AbstractThe influence of maternal age and congenital malformations on perinatal mortality in twins in Australia from 1973 to 1980, is described. Stillbirths and neonatal deaths in twins fell with advancing maternal age. For teenage mothers, the twin perinatal mortality rate was 127.15/1,000. The sex ratio in twins is closer to unity than in singletons. Perinatal mortality due to malformation fell as maternal age increased up to 35 years. The role of zygosity and the distribution of birth weight with maternal age are discussed.

scholarly journals Stillbirths, Neonatal Morbidity, and Mortality in Health-Facility Deliveries in Urban Gambia

2021 ◽  
Vol 9 ◽  
Author(s):  
Bully Camara ◽  
Claire Oluwalana ◽  
Reiko Miyahara ◽  
Alyson Lush ◽  
Beate Kampmann ◽  
...  
Keyword(s):  
Birth Weight ◽  
Mortality Rate ◽  
Low Birth Weight ◽  
Health Facility ◽  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Neonatal Period ◽  
Birth Asphyxia ◽  
High Rate ◽  
Neonatal Deaths

Background: The Gambia Demographic and Health Survey 2013 data showed that up to 63% of deliveries in the country occur in health facilities. Despite such a high rate, there are few facility-based studies on delivery outcomes in the country. This analysis ancillary to a randomized control trial describes occurrence of poor pregnancy outcomes in a cohort of women and their infants delivering in a government health facility in urban Gambia.Methods: Using clinical information obtained during the trial, we calculated rates of poor pregnancy outcomes including stillbirths, hospitalization and neonatal deaths. Logistic regression was used to calculate odds ratio (OR) and 95% confidence interval (CI) in the risk factors analysis.Results: Between April 2013 and 2014, 829 mothers delivered 843 babies, including 13 stillbirths [15.4 (7.1–23.8)] per 1,000 births. Among 830 live born infants, 7.6% (n = 63) required hospitalization during the 8-week follow-up period. Most of these hospitalizations (74.6%) occurred during the early neonatal period (<7 days of life). Severe clinical infections (i.e., sepsis, meningitis and pneumonia) (n = 27) were the most common diagnoses, followed by birth asphyxia (n = 13), major congenital malformations (n = 10), jaundice (n = 6) and low birth weight (n = 5). There were sixteen neonatal deaths, most of which also occurred during the early neonatal period. Overall, neonatal mortality rate (NMR) and perinatal mortality rate (PMR) were 19.3 (CI: 9.9–28.7) per 1,000 live births and 26.1 (CI: 15.3–36.9) per 1,000 total births, respectively. Severe clinical infections and birth asphyxia accounted for 37 and 31% of neonatal deaths, respectively. The risk of hospitalization was higher among neonates with severe congenital malformations, low birth weight, twin deliveries, and those born by cesarean section. Risk of mortality was higher among neonates with severe congenital malformations and twin deliveries.Conclusion: Neonatal hospitalization and deaths in our cohort were high. Although vertical interventions may reduce specific causes of morbidity and mortality, data indicate the need for a holistic approach to significantly improve the rates of poor pregnancy outcomes. Critically, a focus on decreasing the high rate of stillbirths is warranted.Clinical Trial Registration:ClinicalTrials.gov Identifier: NCT01800942.

scholarly journals Congenital Malformations and Perinatal Deaths among the Children of Atomic Bomb Survivors: A Reappraisal

2021 ◽  
Author(s):  
Michiko Yamada ◽  
Kyoji Furukawa ◽  
Yoshimi Tatsukawa ◽  
Keiko Marumo ◽  
Sachiyo Funamoto ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Congenital Malformations ◽  
Radiation Effects ◽  
Atomic Bomb ◽  
Perinatal Deaths ◽  
Neonatal Deaths ◽  
Atomic Bomb Survivors ◽  
Parental Exposure ◽  
Increased Risk ◽  
Major Congenital Malformations

Abstract From 1948 to 1954, the Atomic Bomb Casualty Commission conducted a study of pregnancy outcomes of children of atomic bomb survivors who had received radiation doses from zero to near-lethal levels. Past reports (1956, 1981, and 1990) on the cohort did not identify significant associations of radiation exposure with untoward pregnancy outcomes such as major congenital malformations, stillbirths, or neonatal deaths, individually or in aggregate. We have re-examined the risk of major congenital malformations and perinatal deaths in the children of the atomic bomb survivors (N=71,603) using fully reconstructed data to minimize the potential for bias, with refined estimates of the gonadal dose from the Dosimetry System 2002 and refined analytical methods for characterizing dose-response relationships. The analyses show that parental exposure is associated with increased risk for major congenital malformations and perinatal deaths, but the estimates are imprecise for direct radiation effects and most are not statistically significant. Nonetheless, the uniformly positive estimates for untoward pregnancy outcomes among children of both maternal and paternal survivors are useful for risk assessment purposes, although extending them to circumstances other than atomic bomb survivors comes with uncertainty as to the generalizability of the Hiroshima and Nagasaki populations.

BIRTH ORDER, STAGE OF INFANCY AND INFANT MORTALITY IN INDIA

2017 ◽  
Vol 50 (5) ◽  
pp. 604-625 ◽  
Author(s):  
S. K. Mishra ◽  
Bali Ram ◽  
Abhishek Singh ◽  
Awdhesh Yadav
Keyword(s):  
Infant Mortality ◽  
Birth Order ◽  
Neonatal Period ◽  
Family Health ◽  
National Family Health Survey ◽  
Female Children ◽  
National Family ◽  
Urban Rural ◽  
Using Data ◽  
The Relationship

SummaryUsing data from India’s National Family Health Survey, 2005–06 (NFHS-3), this article examines the patterns of relationship between birth order and infant mortality. The analysis controls for a number of variables, including mother’s characteristics such as age at the time of survey, current place of residence (urban/rural), years of schooling, religion, caste, and child’s sex and birth weight. A modest J-shaped relationship between birth order of children and their risk of dying in the neonatal period is found, suggesting that although both first- and last-born children are at a significantly greater risk of dying compared with those in the middle, last-borns (i.e. fourth and higher order births) are at the worst risk. However, in the post-neonatal period first-borns are not as vulnerable, but the risk increases steadily with the addition of successive births and last-borns are at much greater risk, even worse than those in the neonatal period. Although the strength of relationship between birth order and mortality is attenuated after the potential confounders are taken into account, the relationship between the two variables remains curvilinear in the neonatal period and direct in the post-neonatal period. There are marked differences in these patterns by the child’s sex. While female children are less prone to the risk of dying in the neonatal period in comparison with male children, the converse is true in the post-neonatal period. Female children not only run higher risks of dying in the post-neonatal period, but also become progressively more vulnerable with an increase in birth order.

Relationship of Liking of First Names to Birth Order and Loneliness

1990 ◽  
Vol 66 (3_suppl) ◽  
pp. 1177-1178 ◽  
Author(s):  
Charles E. Joubert
Keyword(s):  
Birth Order ◽  
Relationship Of
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