scholarly journals Age-Related Changes in Peripheral Nerves of the Dog. II. A Morphologic and Morphometric Study of Cross-Sectional Nerve

1982 ◽  
Vol 19 (4) ◽  
pp. 379-398 ◽  
Author(s):  
K. G. Braund ◽  
J. A. McGuire ◽  
C. E. Lincoln
Keyword(s):  
Fold Increase ◽  
Morphometric Study ◽  
First Year ◽  
Fiber Density ◽  
Cross Sectional ◽  
Quantitative Measurements ◽  
Age Related ◽  
Large Fiber ◽  
One Year ◽  
First Year Of Life

Qualitative histologic studies and quantitative measurements were made on cross-sectional preparations of common peroneal and ulnar nerves of 32 neuromuscular disease-free dogs from birth to 15 years of age, to provide normative data not available previously. Minimal lesions were seen in nerves of dogs from birth to seven years; however, in older dogs, the incidence of axonal degeneration and segmental demyelination and remyelination increased. Total fiber density of both nerves was over 40,000 fibers/mm2 at birth and declined rapidly during the first six to nine months to level off at about 10,000 fibers/mm2 by one year of age. Density of small (< 5 μm) and large (≥ 5 μm) diameter fibers attained adult values by one year of age. The frequency distribution of the myelinated fibers was unimodal at birth and became bimodal between three and six months of age. The peaks of the small and large fiber groups occurred at 3 μm and 6 μm, respectively. Larger diameter fibers (10 μm to 12 μm) reached adult values between nine months and one year of age. A 2.5 fold increase in mean fiber diameter occurred during the first year of life. There was no statistically significant change in any histometric parameter after maturity (approximately one year of age).

scholarly journals Anogenital Distance in Healthy Infants: Method-, Age- and Sex-related Reference Ranges

2020 ◽  
Vol 105 (9) ◽  
pp. 2996-3004 ◽  
Author(s):  
Margit Bistrup Fischer ◽  
Marie Lindhardt Ljubicic ◽  
Casper P Hagen ◽  
Ajay Thankamony ◽  
Ken Ong ◽  
...  
Keyword(s):  
Population Based ◽  
Specific Reference ◽  
First Year ◽  
Reference Ranges ◽  
Cross Sectional ◽  
Anogenital Distance ◽  
Sex Development ◽  
Age Related ◽  
Healthy Infants ◽  
First Year Of Life

Abstract Context The use of anogenital distance (AGD) in clinical and epidemiological settings is increasing; however, sex-specific reference data on AGD and data on longitudinal changes in AGD in children is scarce. Objective To create age-, sex-, and method-related reference ranges of AGD in healthy boys and girls aged 0–24 months, to assess the age-related changes in AGD and to evaluate the 2 predominantly used methods of AGD measurement. Design The International AGD consortium comprising 4 centers compiled data from 1 cross-sectional and 3 longitudinal cohort studies (clinicaltrials.gov [NCT02497209]). Setting All data were collected from population-based studies, recruiting from 4 maternity or obstetric centers (United States, Cambridge [United Kingdom], Odense, and Copenhagen [Denmark]). Subjects This study included a total of 3705 healthy, mainly Caucasian children aged 0–24 months on whom 7295 measurements were recorded. Main Outcome Measures AGDAS (ano-scrotal), AGDAF (ano-fourchette), AGDAP (ano-penile), AGDAC (ano-clitoral), AGD body size indices (weight, body mass index [BMI], body surface area, and length), and intra- and interobserver biases. Results We created age-specific reference ranges by centers. We found that AGD increased from birth to 6 months of age and thereafter reached a plateau. Changes in AGD/BMI during the first year of life were minor (0–6% and 0–11% in boys and girls, respectively). Conclusions Reference ranges for AGD can be used in future epidemiological research and may be utilized clinically to evaluate prenatal androgen action in differences-in-sex-development patients. The increase in AGD during the first year of life was age-related, while AGD/BMI was fairly stable. The TIDES and Cambridge methods were equally reproducible.

scholarly journals FEEDING PRACTICES IN THE FIRST YEAR OF LIFE: CHALLENGES TO FOOD AND NUTRITION POLICIES

2020 ◽  
Vol 38 ◽  
Author(s):  
Lorena dos Santos Tinôco ◽  
Clélia de Oliveira Lyra ◽  
Tamires Carneiro de Oliveira Mendes ◽  
Yan Nogueira Leite de Freitas ◽  
Adriana Souza da Silva ◽  
...  
Keyword(s):  
Fruits And Vegetables ◽  
Feeding Practices ◽  
Probit Analysis ◽  
Dietary Quality ◽  
First Year ◽  
Cross Sectional ◽  
Nutrition Policies ◽  
Food And Nutrition ◽  
One Year ◽  
First Year Of Life

ABSTRACT Objective: To evaluate the feeding practices for infants under one year of age, according to food and nutrition policies. Methods: This is a descriptive cross-sectional study based on secondary data from the Chamada Neonatal project (research on prenatal, childbirth, and infant care) in the state of Rio Grande do Norte. The sample analyzed comprised 837 mother/child (under one year of age) pairs. We found a prevalence of data on exclusive breastfeeding (EBF) in the first hour of life - partial and total -, as well as on food consumed by children 24 hours prior to the interview. We estimated the probability of consumption according to the child’s age in days using the probit analysis. Results: Among the interviewed mothers, 64.8% (95%CI 62.4-70.8) declared breastfeeding in the first hour of life, and 60% (95%CI 56.41-63.07) of the children were still breastfed at the end of their first year of life. The median duration of EBF was 63 days (95%CI 60-67). Water or tea, dairy products, fruits, and vegetables were introduced early, with medians lower than 180 days. The probit analysis revealed that the consumption of breast milk tended to decrease and food intake to increase as the child gets older, with exponential growth in the “unhealthy food” group. Conclusions: Although most children were breastfed up to one year of life, few did so exclusively. Foods were introduced early, with increased consumption of unhealthy ones, resulting in inadequate dietary quality according to recommendations from food and nutrition public policies.

scholarly journals Fatal Drowning in Brazilian Toddlers and Preschoolers in the City of Campina Grande

2018 ◽  
Vol 35 (2) ◽  
pp. 125-131
Author(s):  
Alessandro Leite Cavalcanti ◽  
Thaisy Sarmento Batista de Oliveira ◽  
Thaisy Sarmento Batista de Oliveira ◽  
Kívia Gabriella Gomes Muniz ◽  
Christiane Leite Cavalcanti ◽  
...  
Keyword(s):  
Secondary Data ◽  
Cross Sectional Study ◽  
Time Of Day ◽  
First Year ◽  
Sectional Study ◽  
Cross Sectional ◽  
Gender And Age ◽  
One Year ◽  
First Year Of Life ◽  
The City

Abstract Drowning is one of the accidents with the greatest impact on health. The objective of this paper was to analyze drowning deaths involving children up to four years of age in Campina Grande, Brazil. A cross-sectional study was developed using secondary data, carried out at the Forensic Medicine Unit. All autopsy reports of children 0-4 years of age, victims of drowning in the period from 2008 to 2011 were evaluated. Data referring to the year of occurrence, victims’ gender and age, time of day, day of week and place of occurrence were collected. Data analysis involved descriptive statistics (frequency distribution). Ninety-three cases of fatal drowning were identified, of which 20 (21.5%) involved children under four years of age. Most victims were male (80%), aged one year (35%). The accidents occurred predominantly during the day (85%), mostly at home (75%). The drowning victims were mostly boys in the first year of life and most cases of drowning occurred at their homes.

Social inequality in parent–infant relations: Epidemiological study of community nurse records

2021 ◽  
pp. 140349482098313
Author(s):  
Bjørn E. Holstein ◽  
Sofie Weber Pant ◽  
Janni Ammitzbøll ◽  
Trine Pagh Pedersen
Keyword(s):  
Community Sample ◽  
Occupational Status ◽  
Home Visits ◽  
Cross Sectional Study ◽  
Outcome Variable ◽  
Immigrant Parents ◽  
First Year ◽  
Cross Sectional ◽  
Parents And Children ◽  
First Year Of Life

Background: Some studies suggest that favourable socioeconomic circumstances are associated with better parent–child relations but the documentation of such an association is limited and inconsistent. Few studies focused on infancy, few studies relied on objective measurement of parent–infant relations, and few studies included more than one measurement of parent–infant relations in the first year of life. Aims: To report the prevalence of objectively measured problems in parent–infant relations during the first year of life and to examine the association between socioeconomic circumstances and parent–infant relations in an unselected community sample of infants. Methods: Cross-sectional study of a community sample of children from birth to 10 months in 15 municipalities in Denmark, n = 11,765. The exposure variables were population register data about socioeconomic circumstances: (a) parents’ education, (b) family composition, (c) parents’ origin, and (d) parents’ occupational status. The outcome variable was the health visitor’s concerns about the parent–infant relation assessed at four home visits from birth to 10 months after delivery. Results: The proportion of children with concerns about the parent–infant relation was 10.5%, 7.8% at one home visit and 2.8% at two or more home visits. Logistic regression analyses showed that all four indicators of socioeconomic circumstances were associated with concerns about the parent–infant relation in the first year of life. Conclusions: The risk of problematic parent–infant relations were significantly elevated among, children of immigrant parents, and children of parents with shorter education and not in education or work.

Teething Symptoms in the First Year of Life and Associated Factors: A Cohort Study

2010 ◽  
Vol 34 (3) ◽  
pp. 201-206 ◽  
Author(s):  
Carlos Alberto Feldens ◽  
Italo Medeiros Faraco Junior ◽  
Andréia Bertani Ottoni ◽  
Eliane Gerson Feldens ◽  
Márcia Regina Vítolo
Keyword(s):  
Associated Factors ◽  
Primary Outcome ◽  
First Year ◽  
Structured Interviews ◽  
Self Medication ◽  
Nuclear Families ◽  
Dental Examination ◽  
Pediatric Dentists ◽  
One Year ◽  
First Year Of Life

Objective: To investigate the occurrence and management of teething symptoms during the first year of life and associated factors. Study design: 500 children were recruited at birth. Research assessments including structured interviews, anthropometric measurements and dental examination were carried out after birth, at 6 months and at one-year of age. The primary outcome of this study was defined as the occurrence of one or more teething symptoms within the first year of life, as reported by the mother. Results: Teething symptoms were reported in 73% of the children analyzed (273/375). The symptoms most frequently reported were irritability (40.5%), fever (38.9%), diarrhoea (36.0%) and itching (33.6%). Dentists had little influence on the management of symptoms and self-medication to relieve them was a common practice. The risk of reporting teething symptoms was higher for children from nuclear families (p=0.040) and for children from families with higher income (p=0.040). Conclusions: Teething symptoms were highly reported in this population. Pediatric dentists should be accessible and provide adequate orientation when symptoms can be managed at home or immediate referral to health services when more serious diseases are suspected.

scholarly journals Developmental Trajectory of Audiovisual Speech Integration in Early Infancy. A Review of Studies Using the McGurk Paradigm

2015 ◽  
Vol 19 (2) ◽  
pp. 77-100 ◽  
Author(s):  
Przemysław Tomalski
Keyword(s):  
Speech Processing ◽  
Language Production ◽  
Developmental Trajectory ◽  
First Year ◽  
Audiovisual Speech ◽  
Perceptual Development ◽  
Phonological Knowledge ◽  
Young Infants ◽  
Age Related ◽  
First Year Of Life

Abstract Apart from their remarkable phonological skills young infants prior to their first birthday show ability to match the mouth articulation they see with the speech sounds they hear. They are able to detect the audiovisual conflict of speech and to selectively attend to articulating mouth depending on audiovisual congruency. Early audiovisual speech processing is an important aspect of language development, related not only to phonological knowledge, but also to language production during subsequent years. Th is article reviews recent experimental work delineating the complex developmental trajectory of audiovisual mismatch detection. Th e central issue is the role of age-related changes in visual scanning of audiovisual speech and the corresponding changes in neural signatures of audiovisual speech processing in the second half of the first year of life. Th is phenomenon is discussed in the context of recent theories of perceptual development and existing data on the neural organisation of the infant ‘social brain’.

Breast-feeding promotion in hospitals and prospective breast-feeding rates during the first year of life in two national surveys 1997–1998 and 2017–2019 in Germany

2021 ◽  
pp. 1-13
Author(s):  
Nele Hockamp ◽  
Constanze Burak ◽  
Erika Sievers ◽  
Silvia Rudloff ◽  
Anja Burmann ◽  
...  
Keyword(s):  
Breast Feeding ◽  
Infant Nutrition ◽  
Feeding Habits ◽  
First Year ◽  
Feeding Rates ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Web Based ◽  
Phone Calls ◽  
First Year Of Life

Abstract Objectives: The present study aimed to assess the current state of breast-feeding promotion in hospitals and the prevalence of breast-feeding during the first year of life in Germany and to compare the results with a study 20 years earlier. Design: In the studies on ‘breast-feeding and infant nutrition in Germany’ named ‘SuSe’, a cross-sectional survey in hospitals was combined with a subsequent prospective survey of breast-feeding and infant nutrition during the first year of life (0·5, 2, 4, 6 and 12 months after birth) in mother–infant pairs who were recruited in the hospitals. Written questionnaires and phone calls were used in SuSe I and web-based questionnaires in SuSe II. Breast-feeding promotion and prevalence were evaluated using recommendations from the WHO and the UNICEF. Setting: Two nationwide surveys SuSe I (1997–1998) and SuSe II (2017–2019). Participants: In SuSe I, 177 hospitals and 1717 mother–infant pairs and in SuSe II 109 hospitals and 962 mother–infant pairs were included. Results: In SuSe II, hospitals implemented seven of the WHO ‘Ten Steps to Successful Breastfeeding’ to a greater extent than the hospitals in SuSe I. More mothers exclusively breastfed for 4 months (57 % v. 33 %) and continued breast-feeding until 6 (78 % v. 48 %) and 12 months (41 % v. 13 %). In both studies, exclusive breast-feeding decreased between 4 and 6 months of age due to the introduction of complementary feeding. Conclusions: In Germany, breast-feeding habits have come closer to the recommendations over the last 20 years.

AGE-RELATED CHANGES IN THICKNESS OF CORTEX AND ITS LAYERS IN THE PARAMEDIAN LOBULE OF THE CEREBELLUM IN CHILDREN

2020 ◽  
pp. 14-18
Author(s):  
Татьяна Александровна Цехмистренко ◽  
Аслан Батразович Мазлоев ◽  
Дмитрий Константинович Обухов
Keyword(s):  
Right Hemisphere ◽  
Molecular Layer ◽  
First Year ◽  
Age Related ◽  
Average Group ◽  
Computer Morphometry ◽  
The Right ◽  
First Year Of Life ◽  
Granular Layers ◽  
Age Related Changes

Цель - изучение возрастных изменений толщины коры и ее слоев в парамедианной дольке мозжечка у детей. Материал и методы. Работа выполнена на постмортальном материале (62 мозжечка), полученном от детей в возрасте от рождения до 12 лет, умерших в результате травм без повреждений головного мозга. С помощью компьютерной морфометрии на окрашенных методом Ниссля фронтальных гистологических срезах коры, взятой билатерально в области парамедианной (тонкой) дольки (HVIIB) на вершине листков мозжечка, измеряли толщину коры, а также толщину ее молекулярного и зернистого слоев. Анализ количественных данных проводили в годовых интервалах. Результаты. В парамедианной дольке мозжечка увеличение толщины коры происходит в четыре этапа: в правом полушарии - от рождения к 1, 3, 5 и 9 годам, в левом полушарии - к 1, 5, 7 и 9 годам. Левосторонняя асимметрия толщины коры мозжечка отмечается у детей 1 и 2 лет, толщины молекулярного слоя - у детей 3 лет жизни. Правосторонняя асимметрия характерна для толщины зернистого слоя у детей 3 лет и поперечника коры, в целом, у детей 6 лет. Толщина коры и слоев в области парамедианной дольки мозжечка по среднегрупповым показателям достигает уровня взрослых людей к 9 годам. Выводы. Толщина коры мозжечка и ее слоев в области дольки H VII B увеличивается гетерохронно и гетеродинамически в правом и левом полушариях мозжечка у детей на первом году жизни, а также в периоды раннего, первого и второго детства. Уменьшения поперечника коры и слоев в парамедианной дольке мозжечка у детей от рождения до 12 лет не обнаружено. Objective - to study the age-related changes in the thickness of the cortex and its layers in the paramedian lobule of the cerebellum in children. Material and methods. The work was performed on postmortem material (62 cerebellums) obtained from children aged from birth to 12 years who died from injuries but without brain damage. The thickness of the cortex, as well as the thickness of its molecular and granular layers, were measured using computer morphometry on the Nissl-stained frontal histological sections of the cortex taken bilaterally in the region of the paramedian (gracile) lobule (HVIIB) at the top of the folia of cerebellum. Analysis of quantitative data was performed at annual intervals. Results. In the paramedian lobule of the cerebellum, the increase in the thickness of the cortex occured in four stages: in the right hemisphere - from birth to 1, 3, 5 and 9 years, in the left hemisphere - to 1, 5, 7 and 9 years. Left-sided asymmetry of the cortical thickness of the cerebellum was observed in 1 and 2-year old children, the thickness of the molecular layer - in 3-year old children. Right-sided asymmetry was characteristic for the thickness of the granular layer in 3-year old children and a cross-section of the cortex in 6-year old children. The thickness of the cortex and layers in the area of the paramedian lobule of the cerebellum on the average group indicators reached the level of adults by 9 years. Conclusions. The thickness of the cerebellar cortex and its layers in the area of the lobule HVIIB increased heterochronically and heterogeneously in the right and left hemispheres of the cerebellum in children of the first year of life, and in the periods of early, first and second childhood. No reduction in the diameter of the cortex and layers in the paramedian lobule of the cerebellum of children from birth to 12 years was found.

ADENOVIRUS COMPLEMENT-FIXING ANTIBODY TITERS FROM BIRTH THROUGH THE FIRST YEAR OF LIFE

PEDIATRICS ◽  
1963 ◽  
Vol 32 (4) ◽  
pp. 497-500
Author(s):  
Rosa Lee Nemir ◽  
Donna O'Hare ◽  
Stanley Goldstein ◽  
Charles B. Hilton
Keyword(s):  
Cytopathic Effect ◽  
Gradual Increase ◽  
Newborn Infants ◽  
First Year ◽  
Placental Barrier ◽  
Culture Studies ◽  
Antibody Titers ◽  
Level 1 ◽  
One Year ◽  
First Year Of Life

Complement fixing antibody titers to the adenoviruses were determined in 251 newborn infants, using cord blood. Approximately 95% of these were found to have CF titers of 1:16 or over, the majority (75%) were 1:32 or more. Material from the pharyngeal and rectal swabs of these infants on tissue culture studies (542) on HeLa and amnion cells showed no cytopathic effect in oven 96% of these infants. A longitudinal study of 114 of these infants was made at 3 months intervals; 67 have been observed for one year. At 3 months, only 12% still showed CF antibody titers, and these were chiefly at a low level, 1:16. At the subsequent 3-month interval observations, a gradual rise in CF antibodies were found. At one year of age, approximately 37% had titers of 1:32 on over. The findings of this report support the statement that CF antibodies to adenovirus pass the placental barrier. There is a gradual increase in the percentage of infants with positive CF antibodies after 3 months.

scholarly journals In congenital hypothyroidism bone maturation at birth may be a predictive factor of psychomotor development during the first Year of life irrespective of other variables related to treatment

2003 ◽  
pp. 1-6 ◽  
Author(s):  
M Wasniewska ◽  
F De Luca ◽  
A Cassio ◽  
N Oggiaro ◽  
P Gianino ◽  
...  
Keyword(s):  
Congenital Hypothyroidism ◽  
Psychomotor Development ◽  
First Year ◽  
X Rays ◽  
Bone Maturation ◽  
Gestation Age ◽  
Group A ◽  
One Year ◽  
First Year Of Life ◽  
Tsh Levels

OBJECTIVE: To evaluate in a cohort of infants with congenital hypothyroidism (CH): (a) the frequency of bone maturation (BM) retardation at birth and (b) whether BM delay at birth may be considered as a tool to make a prognosis of psychomotor status at the age of 1 Year, irrespective of other variables related to treatment. DESIGN: BM at birth, CH severity and developmental quotient (DQ) at the age of 1 Year were retrospectively evaluated in 192 CH infants selected by the following inclusion criteria: (a) gestation age ranging between 38 and 42 weeks; (b) onset of therapy within the first Month of life; (c) initial thyroxine (l-T(4)) dosage ranging from 10 to 12 microg/kg/day; (d) normalization of serum thyrotropin (TSH) levels before the age of 3 Months; (e) Monthly adjustments of l-T(4) dose during the first Year of life with serum TSH levels ranging from 0.5 to 4 mIU/l; (f) no major diseases and/or physical handicaps associated with CH; (g) availability of both thyroid scanning and knee X-rays at the time of treatment initiation; (h) availability of DQ assessment at an average age of 12 Months. METHODS: BM was considered normal if the distal femur bony nucleus diameter exceeded 3 mm (group A) or retarded if either this nucleus was absent (subgroup B1) or its diameter was <3 mm (subgroup B2). DQ was evaluated with the Brunet-Lezine test. RESULTS: In 44.3% of cases BM was either delayed (23.5%) or severely delayed (20.8%). The risk of BM retardation was higher in the patients with athyreosis than in the remaining patients (41/57 vs 44/135, chi(2)=25.13, P<0.005). BM-retarded infants showed a more severe biochemical picture of CH at birth and a lower DQ at the age of one Year compared with the group A patients. If compared with infants of subgroup B2 those of subgroup B1 exhibited significantly lower T(4) levels at birth and a more frequent association with athyreosis (70.0 vs 30.0%; chi(2)=7.49, P<0.01), whereas DQ was superimposable in both subgroups. CONCLUSIONS: (a) BM at birth is delayed in almost half of CH patients and (b) CH severity per se can affect DQ at the age of 1 Year irrespective of other variables related to therapy.

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