ACTIVITY OF GLUTAMIC-OXALOACETIC TRANSAMINASE IN THE SERUM IN THE NEONATAL PERIOD

PEDIATRICS ◽  
1957 ◽  
Vol 20 (4) ◽  
pp. 584-589
Author(s):  
Simon Kove ◽  
Stanley Goldstein ◽  
Felix Wróblewski
Keyword(s):  
Neonatal Period ◽  
Newborn Infants ◽  
Normal Range ◽  
Glutamic Oxaloacetic Transaminase ◽  
Newborn Period ◽  
Method Of Determination ◽  
Normal Term ◽  
Pathologic State ◽  
Normal Adults

The activity of glutamic oxaloacetic transaminase (GOT) in the serum was determined by the spectrophotometric method in 63 normal term newborn infants, varying from birth to 11 days of age. The normal range of activity in the newborn period varied from 13 to 105 units (with the exception of one infant in whom the level was 160 units). This is a considerably wider range than that of 5 to 45 units found in normal adults. Allowing for an error of about ±10% inherent in the method of determination of GOT, activity as great as approximately 120 units, which in adults would be indicative of some pathologic state, must be considered physiologic in the newborn infant. The activity of GOT was not related to the age of the infant within the neonatal period studied, and varied widely in different infants for each day of age, without any distinctive pattern. Variations of the activity of GOT in specimens of cord blood studied ranged below 59 units, which was lower than for any other day of the neonatal period adequately investigated. No infants were studied repeatedly. No relation was found between the concentration of bilirubin and the activity of GOT in the serum.

Salivary Immunoglobulins: Absence of γA in Saliva Following Exchange Transfusions in Neonatal Period

PEDIATRICS ◽  
1967 ◽  
Vol 40 (3) ◽  
pp. 452-454
Author(s):  
JOHN C. SELNER ◽  
DEBORAH A. MERRILL ◽  
HENRY N. CLAMAN
Keyword(s):  
Neonatal Period ◽  
Newborn Infants ◽  
Newborn Period ◽  
Data Support ◽  
Serial Samples

The possible transport of serum γA into saliva was studied in the newborn period. Five infants with erythroblastosis fetalis and undetectable γA in serum or saliva had two-volume exchange transfusions. Serum γA rose to "adult" levels after transfusion, but no detectable γA appeared in serial samples of saliva, as measured by electroimmunodiffusion (EID). The data support the thesis that salivary γA is not transported from the serum and tends to confirm the findings of Haworth and Dilling who previously described the absence of salivary γA following exchange transfusions in newborn infants.

Determination of Blood Sugar in Newborn Infants

PEDIATRICS ◽  
1961 ◽  
Vol 28 (5) ◽  
pp. 850-851
Author(s):  
GLORIA S. BAENS ◽  
WILLIAM OH ◽  
EVELYN LUNDEEN ◽  
MARVIN CORNBLATH
Keyword(s):  
Blood Sugar ◽  
Newborn Infants ◽  
Newborn Period ◽  
Claude Bernard

To the Editor: Recently, there has been a renewed interest in the level of blood sugar in the newborn period, with very low or zero blood sugars being reported1, 2 In some of these reports there is no mention of how the blood was collected, how long it was permitted to stand, how it was precipitated, or analyzed. As reviewed by Peters and Van Slyke,3 the disappearance of sugar from blood in vitro has been well documented since the time of Claude Bernard.

Determination of Anterior Displacement of the Anus in Newborn Infants and Children

PEDIATRICS ◽  
1984 ◽  
Vol 73 (2) ◽  
pp. 216-217
Author(s):  
Salomon H. Reisner ◽  
Yaakov Sivan ◽  
Menachem Nitzan ◽  
Paul Merlob
Keyword(s):  
Simple Technique ◽  
Neonatal Period ◽  
Normal Values ◽  
Newborn Infants ◽  
Common Cause ◽  
Anterior Displacement ◽  
Position Index ◽  
Infancy And Early Childhood ◽  
Made In

Anterior displacement of the anus is a common cause of constipation in infancy and early childhood. However, normal values are not available for defining anal displacement. Using a simple technique, an anal position index of less than 0.34 in girls and less than 0.46 in boys was indicative of anterior displacement. The diagnosis can be made in the neonatal period.

CORTISOL METABOLISM IN THE NEWBORN

1964 ◽  
Vol 45 (2) ◽  
pp. 286-296 ◽  
Author(s):  
D. Aarskog ◽  
K. F. Stoa ◽  
T. Thorsen
Keyword(s):  
Ethyl Acetate ◽  
Serum Bilirubin ◽  
Neonatal Period ◽  
Newborn Infants ◽  
Total Radioactivity ◽  
Serum Bilirubin Level ◽  
Maximum Serum ◽  
Cortisol Metabolism ◽  
Methylene Dichloride ◽  
Normal Adults

ABSTRACT Following intravenous administration of cortisol-4-14C to seven full-term and five premature newborn infants, the urinary excretion of free and conjugated substances was measured in different fractions. Three normal adult subjects served as controls. The study comprised the following fractions: a) Free »lowpolar« fraction, extractable with methylene dichloride. b) Free »high-polar« fraction, extractable with ethyl acetate. c) »Low-polar« glucuronoside fraction, extractable with methylene dichloride following β-glucuronidase hydrolysis. d) »High-polar« glucuronoside fraction, extractable with ethyl acetate following β-glucuronidase hydrolysis. e) Solvolysis fraction, extractable with ethyl acetate after previous removal of the free and glucuronoside conjugated fractions and subsequent solvolysis. The excretion of total radioactivity in the group of normal newborns was found to be delayed as compared with the adult subjects. The unconjugated fractions were found to be somewhat higher in the newborn than in the adult subjects. On the other hand, the »low-polar« glucuronosides were essentially lower. These deviations from the findings in normal adults were still more pronounced in the group of premature newborns. An inverse relationship was demonstrated between the percentage excreted as glucoronosides and the maximum serum bilirubin level in the neonatal period.

A modified radioimmunoassay for 1,25-dihydroxycholecalciferol.

1981 ◽  
Vol 27 (3) ◽  
pp. 458-463 ◽  
Author(s):  
T K Gray ◽  
T McAdoo ◽  
D Pool ◽  
G E Lester ◽  
M E Williams ◽  
...  
Keyword(s):  
Radioligand Binding ◽  
Normal Range ◽  
High Affinity ◽  
Organic Extraction ◽  
The Mean ◽  
The Stability ◽  
Mean Concentration ◽  
Chromatographic Isolation ◽  
Normal Adults

Abstract A radioimmunoassay for 1,25-dihydroxycholecalciferol which did not cross react with 1,25-dihydroxyergocalciferol is described. IgG fractions were prepared from the serum of rabbits that had been immunized with 1,25-dihydroxycholecalciferol-3-hemisuccinate coupled to bovine albumin. Radioligand binding by the IgG fractions was time-, temperature-, and pH-dependent. The IgG fractions had a high affinity for 1,25-dihydroxycholecalciferol but cross reacted with 25-hydroxycholecalciferol and 24,25-dihydroxycholecalciferol. Vitamin D2 metabolites did not cross react in the assay when amounts up to 9 ng per tube were tested. The determination of 1,25-dihydroxycholecalciferol in human serum required an organic extraction and chromatographic isolation of the metabolite. Radioligand binding was influenced by the presence and concentration of the proteins in the phosphate buffer. The mean concentration of 1,25-dihydroxycholecalciferol in serum from normal adults was 56 (SEM 5.7) ng/L. 1,25-Dihydroxycholecalciferol was not detectable in serum from a nephrectomized subject and the concentration in serum was lower than normal in hypoparathyroid patients. Ingestion of 1,25-dihydroxycholecalciferol by nephrectomized or hypoparathyroid patients restored the concentration of 1,25-dihydroxycholecalciferol in serum to the normal range. The stability of the IgG fraction, the relatively short incubation interval, and the ability to measure 1,25-dihydroxycholecalciferol without interference from 1,25-dihydroxyergocalciferol are unique aspects of this radioimmunoassay.

scholarly journals Studies on the Mechanical Fragility of Erythrocytes

Blood ◽  
1953 ◽  
Vol 8 (2) ◽  
pp. 165-169 ◽  
Author(s):  
RICHARD B. GOLDBLOOM ◽  
ENID FISCHER ◽  
JOHN REINHOLD ◽  
DAVID YI-YUNG HSIA
Keyword(s):  
Neonatal Period ◽  
Newborn Infants ◽  
The Mean ◽  
Relationship Of

Abstract 1. The mechanical fragilities of incubated and nonincubated erythrocytes of normal newborn infants, children and adults have been determined through the use of a simplified rotator. 2. The mean mechanical fragility of nonincubated erythrocytes was 7.1 per cent for newborns, 4.0 per cent for children and adults; the mean mechanical fragility of incubated erythrocytes was 13.4 per cent for newborns, 10.5 per cent for children and 10.8 per cent for adults. 3. The possible relationship of increased mechanical fragility of erythrocytes in the newborn to increased hemolysis in the neonatal period is suggested. 4. Possible causes of variation in the determination of mechanical fragility of incubated erythrocytes are discussed.

Newborn Platelet Dysfunction: a Storage Pool and Release Defect

1976 ◽  
Vol 36 (01) ◽  
pp. 200-207 ◽  
Author(s):  
Donald G. Corby ◽  
Thomas F. Zuck
Keyword(s):  
Specific Activity ◽  
Platelet Rich Plasma ◽  
Adenine Nucleotides ◽  
Blood Platelets ◽  
Newborn Infants ◽  
Specific Radioactivity ◽  
High Dose ◽  
Platelet Dysfunction ◽  
Paired Samples ◽  
Normal Adults

SummaryPer cent aggregation, release and content of adenine nucleotides, and specific radioactivity were evaluated in citrated platelet-rich plasma (PRP) prepared from paired samples of maternal and cord blood. Platelets of newborn infants aggregated normally in response to high dose ADP (20 μM), strong collagen suspensions, and thrombin; however, when compared with PRP from the mothers or from normal adults, per cent aggregation in response to lower concentrations of ADP (2 μM), weak collagen, and part particularly epinephrine was markedly reduced. Nucleotide release after stimulation of the newborns’ PRP with the latter two inducers was also impaired. ATP and ADP content of the newborns’ platelets was also significantly less than that of their mothers or of normal adults, but specific activity was normal. The data suggest that the impairment of ADP release in the platelets of newborn infants is due to decreased sensitivity to external stimuli. Since metabolic ATP is necessary for the platelet release reaction, it is postulated that the platelet dysfunction results from a lack of metabolic ATP.

Profil Penyakit Malaria Di Rumah Sakit Islam Siti Rahmah Padang Tahun 2018

2020 ◽  
Vol 2 (2) ◽  
pp. 08-15
Author(s):  
Rahma Triyana ◽  
Salmi Salmi
Keyword(s):  
Observational Study ◽  
Frequency Distribution ◽  
Cross Section ◽  
Laboratory Tests ◽  
Age Group ◽  
Normal Range ◽  
Cross Sectional ◽  
West Sumatra ◽  
Severity Of The Disease

Malaria is one of the health problems in Indonesia, especially West Sumatra. Determination of the description of Malaria disease in an area is needed to determine the spread and severity of the disease. This study aims to determine the frequency distribution according to age, sex and place of residence, description of the types of Plasmodium causes of Malaria and hematological features in Malaria patients at Siti Rahmah Padang Hospital in 2018. This type of research is a descriptive observational study with an approach or design cross section (cross sectional). The frequency distribution of Malaria sufferers in Siti Rahmah Padang Hospital in 2018 according to the highest age was in the age group 21-30 years as many as 28 cases (36.8%), the highest sex among men was 46 (60.5%) and the highest number of residences was found in Koto Tangah sub-district there were 31 cases (40.8%). The type of Plasmodium found in Malaria cases in Siti Rahmah Padang Hospital in 2018 was P. vivax (73 cases (96.05%)) and P. falciparum (3 cases (3.95%)). The results of laboratory tests on Hb, hematocrit, platelet and leukocyte levels in Malaria positive patients in Siti Rahmah Padang Hospital in 2018 were in the normal range.

Profil Penyakit Malaria di Rumah Sakit Islam Siti Rahmah Padang Tahun 2018

2020 ◽  
Vol 2 (2) ◽  
pp. 08-15
Author(s):  
Rahma Triyana Y ◽  
Salmi Salmi
Keyword(s):  
Observational Study ◽  
Frequency Distribution ◽  
Cross Section ◽  
Laboratory Tests ◽  
Age Group ◽  
Normal Range ◽  
Cross Sectional ◽  
West Sumatra ◽  
Severity Of The Disease

Malaria is one of the health problems in Indonesia, especially West Sumatra. Determination of the description of Malaria disease in an area is needed to determine the spread and severity of the disease. This study aims to determine the frequency distribution according to age, sex and place of residence, description of the types of Plasmodium causes of Malaria and hematological features in Malaria patients at Siti Rahmah Padang Hospital in 2018. This type of research is a descriptive observational study with an approach or design cross section (cross sectional). The frequency distribution of Malaria sufferers in Siti Rahmah Padang Hospital in 2018 according to the highest age was in the age group 21-30 years as many as 28 cases (36.8%), the highest sex among men was 46 (60.5%) and the highest number of residences was found in Koto Tangah sub-district there were 31 cases (40.8%). The type of Plasmodium found in Malaria cases in Siti Rahmah Padang Hospital in 2018 was P. vivax (73 cases (96.05%)) and P. falciparum (3 cases (3.95%)). The results of laboratory tests on Hb, hematocrit, platelet and leukocyte levels in Malaria positive patients in Siti Rahmah Padang Hospital in 2018 were in the normal range.

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