Topical Nasal Decongestant Oxymetazoline: Safety Considerations for Perioperative Pediatric Use

Two lead removal water filters were developed to lower lead levels in drinking water below 10 μg.L-1 in order to meet the new regulation given by the European Directive 98-83, applicable in December 2013. An appropriate adsorbent was selected through a stringent research program among a wide range of media, and is composed of a synthetic zeolite and an activated carbon. Two prototypes were developed: the first is a faucet-mounted filter which contains a fixed bed of the adsorbent and a hollow fiber bundle, while the second is an under-sink cartridge made of a porous extruded block of carbon and adsorbent. Both are able to treat at least 1,000 litres of any water containing on average 100 to 150 μg Pb.L-1, by lowering the lead concentration below 10 μg.L-1. Once their safety considerations were addressed by an independent laboratory according to the French Ministry of Health recommendations, 20 prototypes were installed at consumers' taps in northeastern France. Their performance in terms of lead removal, HPC control and bad taste and odor reduction was followed for 6 months. This field testing program resulted in the validation of both prototypes which meet the new French Ministry of Health recommendations and assures that the filtered water is fully ED 98-83 compliant. Their commercialization will be launched first in France in middle 2002.

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Safety Considerations in the Use of Ketorolac for Postoperative Pain

Current Drug Safety ◽

10.2174/1574886311666160719154420 ◽

2017 ◽

Vol 12 (1) ◽

pp. 67-73 ◽

Cited By ~ 10

Author(s):

Benjamin Maslin ◽

Lawrence Lipana ◽

Brandon Roth ◽

Gopal Kodumudi ◽

Nalini Vadivelu

Keyword(s):

Postoperative Pain ◽

Safety Considerations

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Sentinel lymph node biopsy and neoadjuvant chemotherapy in the management of early breast cancer: Safety considerations and timing

South African Medical Journal ◽

10.7196/samj.2017.v107i6.12239 ◽

2017 ◽

Vol 107 (6) ◽

pp. 497 ◽

Cited By ~ 1

Author(s):

Jenny Edge ◽

Sarah Nietz

Keyword(s):

Breast Cancer ◽

Lymph Node ◽

Sentinel Lymph Node ◽

Sentinel Lymph Node Biopsy ◽

Neoadjuvant Chemotherapy ◽

Early Breast Cancer ◽

Lymph Node Biopsy ◽

Node Biopsy ◽

Safety Considerations

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3D Printing of Mini Tablets for Pediatric Use

Pharmaceuticals ◽

10.3390/ph14020143 ◽

2021 ◽

Vol 14 (2) ◽

pp. 143

Author(s):

Julius Krause ◽

Laura Müller ◽

Dorota Sarwinska ◽

Anne Seidlitz ◽

Malgorzata Sznitowska ◽

...

Keyword(s):

3D Printing ◽

Fused Deposition Modeling ◽

Dosage Forms ◽

Small Scale ◽

Fused Deposition ◽

On Demand ◽

Pediatric Diseases ◽

Deposition Modeling ◽

Manufacturing Techniques ◽

Pediatric Use

In the treatment of pediatric diseases, suitable dosages and dosage forms are often not available for an adequate therapy. The use of innovative additive manufacturing techniques offers the possibility of producing pediatric dosage forms. In this study, the production of mini tablets using fused deposition modeling (FDM)-based 3D printing was investigated. Two pediatric drugs, caffeine and propranolol hydrochloride, were successfully processed into filaments using hyprolose and hypromellose as polymers. Subsequently, mini tablets with diameters between 1.5 and 4.0 mm were printed and characterized using optical and thermal analysis methods. By varying the number of mini tablets applied and by varying the diameter, we were able to achieve different release behaviors. This work highlights the potential value of FDM 3D printing for the on-demand production of patient individualized, small-scale batches of pediatric dosage forms.

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Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment

Pharmaceutics ◽

10.3390/pharmaceutics13081135 ◽

2021 ◽

Vol 13 (8) ◽

pp. 1135

Author(s):

Kristin Entzian ◽

Achim Aigner

Keyword(s):

Drug Delivery ◽

Biological Effects ◽

Invasive Technique ◽

Stimuli Responsive ◽

Comprehensive Overview ◽

Drug Concentrations ◽

Therapeutic Outcomes ◽

Cost Efficient ◽

Safety Considerations

Conventional cancer chemotherapies often exhibit insufficient therapeutic outcomes and dose-limiting toxicity. Therefore, there is a need for novel therapeutics and formulations with higher efficacy, improved safety, and more favorable toxicological profiles. This has promoted the development of nanomedicines, including systems for drug delivery, but also for imaging and diagnostics. Nanoparticles loaded with drugs can be designed to overcome several biological barriers to improving efficiency and reducing toxicity. In addition, stimuli-responsive nanocarriers are able to release their payload on demand at the tumor tissue site, preventing premature drug loss. This review focuses on ultrasound-triggered drug delivery by nanocarriers as a versatile, cost-efficient, non-invasive technique for improving tissue specificity and tissue penetration, and for achieving high drug concentrations at their intended site of action. It highlights aspects relevant for ultrasound-mediated drug delivery, including ultrasound parameters and resulting biological effects. Then, concepts in ultrasound-mediated drug delivery are introduced and a comprehensive overview of several types of nanoparticles used for this purpose is given. This includes an in-depth compilation of the literature on the various in vivo ultrasound-responsive drug delivery systems. Finally, toxicological and safety considerations regarding ultrasound-mediated drug delivery with nanocarriers are discussed.

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