DENTISTRY IN CHILDREN

PEDIATRICS ◽  
1958 ◽  
Vol 21 (1) ◽  
pp. 148-154
Author(s):  
Paul K. Losch ◽  
Charles L. Boyers
Keyword(s):  
Dental Caries ◽  
Complex Disease ◽  
Disease Process ◽  
Stomach Tube ◽  
Dental Decay ◽  
Early Theory ◽  
Germ Free ◽  
The Past ◽  
Great Health ◽  
Free Environment

IT SEEMS only proper to begin this discussion with a few words about dental decay. Certainly in view of the prevalence of this disease, it deserves recognition as one of the great health problems. The study of dental caries as a disease process has received a striking amount of attention in the past few years, yet we are forced to go back to an early theory of the etiology of this disease in order to discuss it intelligently. Many years ago a theory was proposed in which it was stated that bacteria, with their enzyme systems working on a substrate of fermentable carbohydrate found primarily in plaques upon the smooth surfaces of teeth, lead to the decalcification of the mineral portion of the tooth. The theory also stated that the organic material is then destroyed by proteolysis. Much of the work which has been done in the field of caries since the time of this proposal has borne out the soundness of the original theory. But certainly we cannot regard dental caries as such a simple and straightforward disease. As a matter of fact, we know that dental caries is an extremely complex disease and each new area of research merely emphasizes this point. For instance, we know that dental caries cannot arise without bacteria being present. This has been demonstrated in the experiments with animals raised in a germ-free environment in which it has been shown conclusively that no caries occurs. To further elucidate the picture, we also know from the experiments of Shaw and Kite that animals fed by stomach tube will not develop dental decay.

Biological factors in dental caries: role of saliva and dental plaque in the dynamic process of demineralization and remineralization (part 1)

2004 ◽  
Vol 28 (1) ◽  
pp. 47-52 ◽  
Author(s):  
John Hicks ◽  
Franklin Garcia-Godoy ◽  
Catherine Flaitz
Keyword(s):  
Dental Caries ◽  
Low Socioeconomic Status ◽  
Dental Plaque ◽  
Complex Disease ◽  
Immune Surveillance ◽  
Disease Process ◽  
Tooth Surface ◽  
Biological Factors ◽  
Phosphate Binding ◽  
Carbohydrate Ingestion

Dental caries is a complex disease process that afflicts a large proportion of the world's population, regardless of gender, age and ethnicity, although it does tend to affect more indivduals with a low socioeconomic status to a greater extent. The process of dental caries is dependent upon biological factors that are present within the saliva and dental plaque. There are many different agents within saliva and plaque that serve to protect the tooth surface against caries development. Salivary flow rate, buffering capacity, antimicrobial activity, microorganism aggregation and clearance from the oral cavity, immune surveillance, and calcium phosphate binding proteins all interact to inhibit or reverse demineralization of exposed tooth surfaces. Cariogenic bacteria levels within the saliva and plaque determine whether caries will occur or not, and the concentration in saliva and plaque are intimately related to the type of carbohydrate ingestion and the frequency of ingestion, as well as the oral hygiene practiced by the individual.

Biological factors in dental caries enamel structure and the caries process in the dynamic process of demineralization and remineralization (part 2)

2005 ◽  
Vol 28 (2) ◽  
pp. 119-124 ◽  
Author(s):  
John Hicks ◽  
Franklin Garcia-Godoy ◽  
Catherine Flaitz
Keyword(s):  
Dental Caries ◽  
Low Socioeconomic Status ◽  
Complex Disease ◽  
Disease Process ◽  
Tooth Surface ◽  
Low Socioeconomic ◽  
Enamel Structure ◽  
Acidic Conditions ◽  
Root Surfaces ◽  
Critical Ph

Dental caries is a complex disease process that afflicts a large proportion of the world's population, regardless of gender, age and ethnicity, although it does tend to affect more indivduals with a low socioeconomic status to a greater extent.The physicochemical properties of the mineral comprising the tooth surface and subsurface modulate the development, arrestment and remineralization of dental caries. Post-eruption maturation of enamel surfaces and exposed root surfaces is important in order for more susceptible mineral phases to be modified by incorporation of soluble fluoride from the plaque into dental hydroxyapatite. The chemical reactions that occur during acidic conditions when tooth mineral dissolves (critical pH) are determined by the supersaturation of calcium and phosphate within plaque and saliva, as well as if fluoride is present.

Biological factors in dental caries: role of remineralization and fluoride in the dynamic process of demineralization and remineralization (part 3)

2004 ◽  
Vol 28 (3) ◽  
pp. 203-214 ◽  
Author(s):  
John Hicks ◽  
Franklin Garcia-Godoy ◽  
Catherine Flaitz
Keyword(s):  
Dental Caries ◽  
Low Socioeconomic Status ◽  
Complex Disease ◽  
Disease Process ◽  
Reaction Rates ◽  
Caries Experience ◽  
Great Promise ◽  
Tooth Structure ◽  
Low Levels

Dental caries is a complex disease process that afflicts a large proportion of the world, regardless of gender, age and ethnicity, although it does tend to affect more with a low socioeconomic status to a greater extent. Remineralization may be enhanced by providing low levels of calcium and phosphate, in conjunction with minimal amounts of fluoride. It is truly remarkable the difference that a very small amount of fluoride (<1ppm) has upon demineralization and remineralization. This is because fluoride acts as a catalyst and influences reaction rates with dissolution and transformation of various calcium phosphate mineral phases within tooth structure and resident within plaque adjacent to tooth surfaces. The incorporation of minimal amounts of fluoride into HAP yields FHAP that resists demineralization to similar level as FAP. New and emerging methods have been and are in the process of being developed. These hold great promise for preventing and reversing caries, especially in the one-fifth of the population that accounts for two-thirds of the caries experience. Still, the mainstay in caries prevention and remineralization is frequent exposure to low levels of fluoride. This may be accomplished with fluoridated toothpastes, supplemented with fluoride mouthrinses,CPP-ACP containing chewing gum and application of fluoride varnishes.The role of systemic fluorides appears to be limited and primarily has a topical effect.

Organophotoredox-Catalyzed C–H Alkylation of Imidazoheterocycles with Malonates: Total Synthesis of Zolpidem

Synthesis ◽  
2020 ◽  
Author(s):  
Narendra R. Chaubey ◽  
Anant R. Kapdi ◽  
Biswanath Maity
Keyword(s):  
Total Synthesis ◽  
Room Temperature ◽  
Drug Molecule ◽  
Bond Functionalization ◽  
First Report ◽  
Mild Conditions ◽  
The Past ◽  
Hypnotic Drug ◽  
Free Environment

AbstractOrganophotocatalytic C–H bond functionalization has attracted a lot of attention in the past several years due to the possibility of catalyzing reactions in a metal- and peroxide-free environment. Continuing on these lines, an organophotoredox-catalyzed C–H functionalization of imidazo[1,2-a]pyridines and related heterocycles with bromomalonates under mild conditions is reported, providing excellent yields of the products at room temperature. This is the first report involving malonates as coupling partners leading to the synthesis of a range of functionalized products including total synthesis of zolpidem, a sedative­-hypnotic drug molecule.

Metastasectomy for Stage IVA Colon Cancer: Does the Type of Treating Institution Make a Difference?

2021 ◽  
pp. 000313482110233
Author(s):  
Shinho T. Kang ◽  
Ryan Moran ◽  
Lala Hussain ◽  
Hamza Guend ◽  
Erik M. Dunki-Jacobs ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Complex Disease ◽  
Academic Research ◽  
Disease Process ◽  
Tumor Location ◽  
Colon Resection ◽  
Academic Community ◽  
Metastatic Colon Cancer ◽  
Isolated Liver

Treatment of metastatic colon cancer has evolved over time. More evidence has been emerging in recent years supporting metastasectomy in selected patients. We sought to elucidate whether the type of institution—community, comprehensive community, academic/research, and integrated cancer network—would have an effect on patient outcome, specifically those colon cancer patients with isolated liver metastasis. This retrospective cohort study queried the National Cancer Database (NCDB) from 2010 to 2014 for patients who were 18 years of age or older with stage IVA colon cancer with isolated liver metastasis. We then performed uni- and multivariate analyses comparing patients based on such factors as age, tumor characteristics, primary tumor location, rate of chemotherapy, and type of treating institution. Patients who came from regions of higher income, receiving chemotherapy, and presenting to an academic/research hospital were more likely to undergo metastasectomy. Median survival was longest at academic/community hospitals at 22.4 months, 6 to 7 months longer than the other three types of institutions. Factors positively affecting survival included receiving chemotherapy, presenting to an academic/research institution, and undergoing metastasectomy, all at P < .05. In our study, the rate of metastasectomy was more than double at academic/research institutions for those with stage IVA colon cancer with isolated liver metastasis. Prior studies have quoted a mere 4.1% synchronous colon resection and metastasectomy. Our findings suggest that we should maintain multidisciplinary approach to this complex disease process and that perhaps it is time for us to consider regionalization of care in treating metastatic colon cancer.

Chiari Malformation Presenting in Adults: A Surgical Experience in 127 Cases

Neurosurgery ◽  
1983 ◽  
Vol 12 (4) ◽  
pp. 377-390 ◽  
Author(s):  
Walter Joseph Levy ◽  
Laura Mason ◽  
Joseph F. Hahn
Keyword(s):  
Chiari Malformation ◽  
Complex Disease ◽  
Pathological Condition ◽  
Disease Process ◽  
Central Canal ◽  
Surgical Anatomy ◽  
Long Run ◽  
Long Term Follow Up ◽  
History Of

Abstract We reviewed 127 patients who were operated upon for adult presentation Chiari malformation and made six conclusions: (a) The clinical examination remains crucial in the diagnosis. (b) The surgical anatomy is highly varied. (c) Syrinxes can be missed on preoperative contrast studies. (d By a conservative grading system, we determined that 46%; of the patients improved during long term follow-up. One-quarter deteriorated over the long run in spite of any treatment. (e) The overall results did not differ whether the treatment was plugging of the central canal plus decompression or decompression alone. (f) In patients with progression, plugging of the central canal obtained superior results. A review of the literature shows that the natural history of this complex disease process has not been established. This history is needed to identify the course of what may be several important factors that lead to the pathological condition in this disease.

scholarly journals Beyond Natriuretic Peptides for Diagnosis and Management of Heart Failure

2017 ◽  
Vol 63 (1) ◽  
pp. 211-222 ◽  
Author(s):  
Nasrien E Ibrahim ◽  
James L Januzzi
Keyword(s):  
Heart Failure ◽  
Renal Dysfunction ◽  
Complex Disease ◽  
Disease Process ◽  
Clinical Information ◽  
Matrix Remodeling ◽  
Injury Death ◽  
Societal Burden ◽  
Myocardial Stretch ◽  
Novel Biomarkers

Abstract BACKGROUND Heart failure (HF) is a complex syndrome with an enormous societal burden in terms of cost and morbidity and mortality. Natriuretic peptide (NP) testing is now widely used to support diagnosis, prognostication, and management of patients with HF, but NPs come with limitations, including vulnerability to the presence of obesity, atrial fibrillation, and renal dysfunction, for example. Beyond the NPs, novel biomarkers may supplement traditional clinical and laboratory testing to improve understanding of the complex disease process of HF, and possibly to personalize care for those affected through better individual phenotyping. CONTENT In this review we discuss novel biomarkers by dividing them into categories based on major pathophysiologic pathways they represent including myocardial stretch/stress, cardiac extracellular matrix remodeling, cardiomyocyte injury/death, oxidative stress, inflammation, neurohumoral activation, and renal dysfunction. SUMMARY Given the limitations of NPs, along with the complex physiology in HF, it is logical to consider utilization of novel biomarkers providing orthogonal biological and clinical information. Several novel HF biomarkers have shown promise but have substantial expectations to meet before being used clinically. Nonetheless, it is reasonable to expect the future lies in the application of multibiomarker panels for the improvement in management of HF and the personalization of care.

Questioning Role of Hypochloremia in Bronchopulmonary Dysplasia

PEDIATRICS ◽  
1986 ◽  
Vol 78 (6) ◽  
pp. 1173-1173
Author(s):  
JEFFREY M. PERLMAN ◽  
JEFF DAWSON
Keyword(s):  
Bronchopulmonary Dysplasia ◽  
Metabolic Alkalosis ◽  
Complex Disease ◽  
Disease Process ◽  
Control Group ◽  
Study Group

In Reply.— We appreciate the interest in our report published in Pediatrics (1986;77:212-216). The three letters raise similar questions, and in response we would like to make three points. First, including the two infants in the control group who died with the infants in the study group still resulted in significant differences between the two groups regarding duration of furosemide (Lasix) therapy, hypochloremia, or metabolic alkalosis (P &gt; .001). Second (as noted in our discussion), bronchopulmonary dysplasia is a complex disease process.

scholarly journals Prevalence of Dental Caries Among Costa Rican Male Students Aged 12-22 Years Using ICDAS-II

2021 ◽  
pp. 378-392
Author(s):  
Sylvia Gudiño-Fernández ◽  
Adrián Gómez-Fernández ◽  
Katherine Molina-Chaves ◽  
Juan Barahona-Cubillo ◽  
Romain Fantin ◽  
...  
Keyword(s):  
Public Health ◽  
Dental Caries ◽  
Young People ◽  
Costa Rican ◽  
Assessment System ◽  
Male Students ◽  
Caries Experience ◽  
Dental Decay ◽  
Icdas Ii ◽  
Decayed Tooth

Objective: Dental decay is a public health challenge in Low- and Middle-Income Countries, particularly for young people, often confronted to healthcare access barriers. The aim of this study was to determine the prevalence and severity of dental caries among young male students in Costa Rica. Study design: A cross-sectional study was performed in 428 Costa Rican male students aged 12-22 years, who attended a nonprofit social welfare boarding school in 2019. A clinical examination was ran by three calibrated examiners following the International Caries Detection and Assessment System (ICDAS-II). Results: Caries prevalence was estimated at 83%, 15% have lost a tooth due to dental decay, 61% have at least one filled tooth, 36% have at least one filled and decayed tooth. The most frequent caries lesions were codes 2-Inactive (46.7%), and code 1-Inactive (23.8%). DMFT indicated a mean index using ICDAS-II 1-6>0 codes of 7.89. Using ICDAS-II 3-6>0 as threshold, the index decreases to 3.94. Finally, the lower and upper first permanent molars were found to be the most affected teeth. Conclusions: Dental caries experience represents a significant public health burden in young people, requiring better access to public dental healthcare.

scholarly journals Glucose modulates Drosophila longevity and immunity independent of the microbiota.

2015 ◽  
Author(s):  
Anthony Galenza ◽  
Jaclyn Hutchinson ◽  
Bart Hazes ◽  
Shelagh Campbell ◽  
Edan Foley
Keyword(s):  
Metabolic Disorders ◽  
Animal Health ◽  
Critical Factor ◽  
Longitudinal Survey ◽  
Enteric Infection ◽  
Survival Times ◽  
Germ Free ◽  
Free Environment ◽  
Nutritional Imbalance ◽  
Adult Drosophila

The acquisition of nutrients is essential for maintenance of metabolic processes in all organisms. Nutritional imbalance contributes to myriad metabolic disorders that include malnutrition, diabetes, and even cancer. Recently, the importance of macronutrient ratio of food has emerged as a critical factor to determine health outcomes. Here we show that individual modifications to a completely defined diet markedly impact multiple aspects of organism wellbeing in Drosophila melanogaster. Through a longitudinal survey of several diets we demonstrate that increased levels of dietary glucose significantly improve longevity and immunity in adult Drosophila. Our metagenomic studies, show that relative macronutrient levels not only influence the host, but also have a profound impact on microbiota composition. However, we found that elevated dietary glucose extended the lifespan of adult flies even when raised in a germ-free environment. Furthermore, when challenged with a chronic enteric infection, flies fed a diet with added glucose had increased survival times even in the absence of an intact microbiota. Thus, in contrast to known links between the microbiota and animal health, our findings uncover a novel microbiota-independent response to diet that impacts host wellbeing. As dietary responses are highly conserved in animals, we believe our results offer a general understanding of the association between glucose metabolism and animal health.

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