THE VALUE OF HYPOSENSITIZATION THERAPY FOR BRONCHIAL ASTHMA IN CHILDREN—A 14-YEAR STUDY

PEDIATRICS ◽  
1968 ◽  
Vol 42 (5) ◽  
pp. 793-802
Author(s):  
Douglas E. Johnstone ◽  
Arthur Dutton
Keyword(s):  
Bronchial Asthma ◽  
Dose Group ◽  
Clinical Course ◽  
Age Of Onset ◽  
Previous History ◽  
Treated Group ◽  
Controlled Study ◽  
History Of ◽  
Asthma In Children ◽  
Prospective Controlled Study

The clinical course of 210 children with perennial bronchial asthma was followed in a prospective controlled study in which one half of the children received placebo injections while the other half received conventional hyposensitization therapy. Of the 130 children still under observation at the time of their sixteenth birthday, 22% of the placebo-treated children were free of asthma compared to 72% of the treated children. In the treated group the rate of loss of asthma may be related to the dose of antigen received in hyposensitization therapy. Whereas 66% of the "1/5,000" group were free of asthma at the end of the study, 78% of the "highest tolerated dose" group were symptom free in their sixteenth year. The likelihood of a child outgrowing asthma was not significantly influenced by his sex, age of onset, or severity of his symptoms when first seen. A previous history of hay fever increased the likelihood of a child's asthma persisting into adolescence.

Peculiarities of the clinical course bronchial asthma in children

1998 ◽  
Vol 79 (5) ◽  
pp. 346-348
Author(s):  
V. N. Tsybulkina ◽  
G. M. Zainetdinova ◽  
G. A. Shamsutdinova ◽  
A. N. Salikhova
Keyword(s):  
Effective Treatment ◽  
Bronchial Asthma ◽  
Specific Immunotherapy ◽  
Clinical Course ◽  
Treatment Method ◽  
Young Age ◽  
Age Group ◽  
Atopic Bronchial Asthma ◽  
Increased Sensitivity ◽  
Asthma In Children

It is established that in most of patients the course of atopic bronchial asthma occurs as clinical attacks of expiratory asphyxia repeated both by day and at night. In children aged 1 to 6 the course of this disease is principally slight, medium and grave. In elder age group (715 years) the share ef graver forms of bronchial asthma increases. The disease is determined by increased sensitivity to domestic allergens. Atypical forms are found only in young age group and obviously are not connected with hypersensitivity. The specific immunotherapy is an effective treatment method of the classical atopic bronchial asthma in children aged 7 to 15.

scholarly journals ANALYSIS OF THE ASSOCIATION OF BRONCHIAL ASTHMA CLINICAL COURSE WITH Arg16Gly POLYMORPHIC VARIANT IN THE β2-ADRENOCEPTOR GENE

2021 ◽  
Vol 17 (2) ◽  
pp. 70-76
Author(s):  
V.V. Kachkovska ◽  
L.N. Prystupa
Keyword(s):  
Bronchial Asthma ◽  
Early Onset ◽  
Clinical Course ◽  
Age Of Onset ◽  
Late Onset ◽  
Asthma Severity ◽  
Polymorphic Variant ◽  
Genotype Distribution ◽  
Significant Difference ◽  
Arg16gly Polymorphism

Relevance. The relevance of the study of Arg16Gly polymorphism of the β2-adrenoceptor (β2-AR) gene is due to the fact that a number of studies have proven its role in the development of bronchial asthma (BA), bronchial hyperactivity, the effectiveness of basic treatment. However, these associations show low reproducibility in various studies, so the question of the possibility of clinical application of the results of genetic testing for Arg16Gly polymorphic variant of the β2-AR gene remains unanswered. The main reasons why the clinical significance of this polymorphism is not confirmed in various studies are - population heterogeneity, insufficient sample size, improper characterization of comparison groups. Objective: to study the association of Arg16Gly polymorphism in the β2-adrenoceptor gene with BA clinical course taking into account the age of onset. Materials and methods. We examined 553 BA patients (group I included 282 patients with late-onset asthma and group II included 271 patients with early-onset asthma) and 95 apparently healthy individuals. The study has been approved by the Bioethics Committee of Medical Institute of Sumy State University. Arg16Gly polymorphism in the β2-АR gene (rs1042713) was determined using polymerase chain reaction-restriction fragment length polymorphism analysis. Statistical analysis of obtained results was performed using SPSS–17 program. Results. There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the β2-AR gene depending on asthma severity with no regard for the age of onset (χ2 = 5.14; p = 0.27). With regard for the age of onset, we found out that early-onset BA was linked to a difference in genotype distribution for this polymorphic variant in patients with severe and non-severe course (χ2 = 14.76; р = 0.001). The frequency of Gly/Gly genotype was higher in patients with severe course (41.4%) as compared to patients with mild course (16.4%), while the frequency of Arg/Arg (32.9%) and Arg/Gly (50.7%) genotypes was higher in patients with mild asthma as compared to patients with severe course (24.3% and 34.3%). There was no significant difference in the distribution of genotypes in patients with late-onset asthma with regard to course severity (χ2 = 4.94; p = 0.084). The relative risk of severe course for early-onset asthma was 3.84 times higher (95% CI 2.11–7.36; p = 0.001) in the recessive model, 2.58 times higher (95% CI 1.53–4,37, p = 0.001) in the dominant model, and 2.16 times (95% CI 1.56–3.04) higher in the additive model. In patients with late-onset asthma, no association was found in all models. Conclusions. There was no significant difference in the distribution of genotypes for Arg16Gly polymorphism in the β2-AR gene depending on asthma severity with no regard for the age of onset. When adjusted for the age of onset, the analysis revealed a difference in genotype distribution for this polymorphic variant in patients with severe and non-severe course having early-onset BA (р = 0.001). The frequency of Gly/Gly genotype was higher in patients with severe course as compared to patients with mild course. For patients with late-onset asthma, no differences were found (p = 0.084). Heterozygous and homozygous Gly allele carriers have a higher risk of early-onset asthma only.

scholarly journals Histologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagonist

2016 ◽  
Vol 36 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Leonardo R. de Lima ◽  
Heloisa M.F. Mendes ◽  
Frederico M. Soriani ◽  
Danielle G. de Souza ◽  
Geraldo Eleno S. Alves ◽  
...  
Keyword(s):  
Chemokine Receptors ◽  
Periodic Acid ◽  
Previous History ◽  
Basal Membrane ◽  
Treated Group ◽  
Periodic Acid Schiff ◽  
Chemokine Signaling ◽  
Mixed Breed ◽  
History Of ◽  
Membrane Changes

Abstract: With the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1β, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1β and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis.

scholarly journals Association between bronchial asthma in atopic children and their number of siblings

2014 ◽  
Vol 54 (5) ◽  
pp. 289
Author(s):  
Johan El Hakim Siregar ◽  
Lily Irsa ◽  
Supriatmo Supriatmo ◽  
Sjabaroeddin Loebis ◽  
Rita Evalina
Keyword(s):  
Elementary Schools ◽  
Bronchial Asthma ◽  
Inverse Relationship ◽  
International Study ◽  
Clinical History ◽  
Asthma Prevalence ◽  
Chi Square ◽  
Chi Square Test ◽  
History Of ◽  
Asthma In Children

Background The prevalence of asthma in children has increased in many countries. Environmental factors are believed to play an important role and an inverse relationship between number of siblings and atopic disorders has been observed.Objective To assess for an association between bronchial asthma in atopic children and their number of siblings.Methods A cross-secrional study was conducted from June to November 2010 in three elementary schools in Medan, North Sumatera. Trace cards from the Allergy-Immunology Indonesian Pediatric Association (IDAI) Working Group and questionnaires on the clinical history of atopy were used to screen children with the risk of atopy. The International Study of .Asthma and Allergies in Childhood (ISAAC) questionnaire to screen for bronchial asthma was distributed to children aged 7-10 years with a history of asthma, allergic rhinitis or atopic dermatitis. Subjects were divided into two groups, those with <3 siblings and those with 2:3 siblings. Chi-square test was used to analyze differences in bronchial asthma prevalence between the two groups.Results Ninety-six subjects enrolled in the study, with 48 subjects per group. The prevalence of bronchial asthma was significantly higher in atopic children who had <3 siblings than in children with 2:3 siblings (73.5% and 26.5%, respectively; P=0.04).Conclusion Bronchial asthma was significantly more frequent in children with less than 3 siblings compared to those with 3 or more siblings.

Hemicrania Continua Evolving from Episodic Paroxysmal Hemicrania

Cephalalgia ◽  
2006 ◽  
Vol 26 (9) ◽  
pp. 1143-1145 ◽  
Author(s):  
F Castellanos-Pinedo ◽  
M Zurdo ◽  
E Martínez-Acebes
Keyword(s):  
Family History ◽  
Migraine Without Aura ◽  
Clinical Course ◽  
Previous History ◽  
Primary Headache ◽  
Complete Response ◽  
Hemicrania Continua ◽  
Paroxysmal Hemicrania ◽  
History Of ◽  
Probable Migraine

A 45-year-old woman, who had been diagnosed in our unit with episodic paroxysmal hemicrania, was seen 2 years later for ipsilateral hemicrania continua in remitting form. Both types of headache had a complete response to indomethacin and did not occur simultaneously. The patient had a previous history of episodic moderate headaches that met criteria for probable migraine without aura and also had a family history of headache. The clinical course in this case suggests a pathogenic relationship between both types of primary headache.

Vocal Quality, Articulation and Audiological Characteristics of Children and Young Adults with Diagnosed Allergies

1982 ◽  
Vol 91 (3) ◽  
pp. 277-280 ◽  
Author(s):  
Barbara M. Baker ◽  
Claude D. Baker ◽  
Ha Thanh Le
Keyword(s):  
Allergic Rhinitis ◽  
Young Adults ◽  
Bronchial Asthma ◽  
Speech Sound ◽  
Previous History ◽  
Hearing Disorders ◽  
History Of ◽  
Children And Young Adults ◽  
Vocal Quality ◽  
Fluctuating Hearing Loss

This study details vocal quality, articulation errors, and hearing disorders in 80 children and young adults with diagnosed allergies. Results indicated that almost 50 % had abnormalities in vocal quality and/or articulation and 13% had reduced auditory acuity. Vocal quality disorders showed a significant relationship to bronchial asthma in association with other allergic reactions. All subjects with diminished hearing had allergic rhinitis either singly or in combination with another disorder. Findings suggest that bronchial asthma and allergic rhinitis are related to the development of vocal quality disorders and that allergic rhinitis is associated with misarticulations and diminished hearing. The presence of speech sound omissions in allergic rhinitis patients above age 8 may predict the presence or previous history of fluctuating hearing loss.

Natural History of Migraine in Childhood

Cephalalgia ◽  
2000 ◽  
Vol 20 (6) ◽  
pp. 573-579 ◽  
Author(s):  
MA Hernandez-Latorre ◽  
M Roig
Keyword(s):  
Natural History ◽  
Prophylactic Treatment ◽  
Clinical Course ◽  
Age Of Onset ◽  
Statistical Significance ◽  
Positive Family History ◽  
Phenotypic Expression ◽  
Clinical Evolution ◽  
History Of ◽  
Prospective Longitudinal

Epidemiological studies have shown that 3–7% of the paediatric population suffer from migraine. Despite this high prevalence little has been published about the natural history of migraine or of its prognosis. The objectives of this study were: (i) to outline the natural history of migraine in childhood; and (ii) to identify early predictors of an unfavourable clinical evolution. A prospective, longitudinal, 10-year follow-up study was conducted of the clinical evolution of 181 paediatric patients with migraine. Data analysis was performed by statistical significance and logistic regression tests. In our study 24.3% of children with migraine had their onset before age 6 years and another 57% between 6 and 10 years of age. A positive family history of migraine was recorded in 77.5%. Eighty-eight percent of patients followed a favourable clinical course. The remaining 12% of patients had to be placed on prophylactic treatment owing to the increasing of their headache. Of all parameters investigated, the age of onset was the only statistically significant predictor of an unfavourable clinical evolution. We conclude: (i) most patients with migraine headache starting in childhood do not require prophylactic treatment; (ii) the earlier the disease begins the more likely is an unfavourable clinical course; (iii) genetic factors play an important role in the phenotypic expression of the disease; (iv) our study suggests the existence, at least, of two different populations among childhood migraine patients.

scholarly journals PROFILE OF THE PATIENTS WHO UNDERWENT PROLENE HERNIA SYSTEM EXTENDED FOR INGUINAL HERNIA IN A TEACHING INSTITUTE IN SUBHIMALAYAN REGION

2020 ◽  
pp. 1-2
Author(s):  
Rohit Kumar ◽  
Arvind Bhatia ◽  
Shelja Rawat ◽  
Ritu Rawat ◽  
Shikha Rawat ◽  
...  
Keyword(s):  
Inguinal Hernia ◽  
Surgical Repair ◽  
Previous History ◽  
Controlled Study ◽  
History Of Surgery ◽  
Indirect Hernia ◽  
Prolene Hernia System ◽  
Direct Hernia ◽  
History Of ◽  
Scrotal Swelling

Introduction: Worldwide, inguinal hernia repair is probably the most commonly performed general surgical procedure. Hence, a slight refinement of surgical repair of inguinal hernia would mean a substantial benefit to the patient. Aim: The study aimed to study profile of the patients who underwent Prolene Hernia System Extended (PHSE) for Inguinal Hernia in a teaching institute in Sub-Himalayan region. Materials and Methods: This was a controlled study conducted over 30 adult patients of both genders admitted at Dr RPGMC Tanda at Kangra from September 2016 to September 2017. Patients clinically diagnosed with inguinal hernias both direct and indirect on examination were enrolled in the trial after their informed consent. Results: Mean age of the patients was 54.9±13.66 years (range 30 to 80 years). 33% of the patients were elderly. All the patients were males. 43% of the patients were smokers and 53% were consuming alcohol. 20% of the patients had associated co-morbidities. 7% patients had previous history of surgery. Fifty percent of the patients had direct hernia while 33% had indirect hernia. Among 10% patients, it was bubonocele type. Seven patients had complications. Scrotal swelling was the most common welling (n=3) followed by inguinodynia (n=2), and seroma formation and urinary retention in one patient each. Conclusion: PHSE for management of inguinal hernia is associated with better outcomes.

scholarly journals CHARACTERIZATION OF VEGETATIVE CHANGES IN BRONCHIAL ASTHMA OF VARIOUS SEVERITIES IN CHILDREN

2015 ◽  
Vol 8 (1) ◽  
Author(s):  
Hurmatoy Khankeldieva ◽  
Ibrohim Alimjanov ◽  
Habiba Negmatshaeva ◽  
Mavjuda Abdullaeva ◽  
Temur Tojiboev ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bronchial Asthma ◽  
Clinical Course ◽  
Allergic Inflammation ◽  
Treatment And Prevention ◽  
Lowered Sensitivity ◽  
Asthma In Children ◽  
Barrier Tissues ◽  
Significant Factors

This article presents a study of the state of vegetative balance and prognostic possibilities of quantitative parameters of functional activity of VNS to estimate a state of bodily adaptive reserves in children with severe BA. Bronchial asthma, being one of the most common chronic diseases in childhood, requires further research into predisposing and causally-significant factors, mechanisms of pathogenesis and peculiarities of a clinical course, improvement of methods of diagnostics, treatment, and prevention. Great importance in the development of bronchial asthma in children is given to genetically-fixed functional insufficiency of barrier tissues of the respiratory system, increased ability to synthesize allergic antibodies and produce certain cytokines, high bronchopulmonary sensitivity to mediators of allergic inflammation, lowered sensitivity of 3g-adrenoreceptors to endogenous catecholamins, changes in immunologic responsiveness, and disorder of neuroendocrinal regulation of immune responses. Implementation of genetic predisposition to bronchial asthma development is promoted by influence of adverse environmental factors.

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