Prolactin and Cortisol Levels in Various Paroxysmal Disorders in Childhood

PEDIATRICS ◽  
1991 ◽  
Vol 88 (3) ◽  
pp. 486-489
Author(s):  
Nathanel Zelnik ◽  
Luna Kahana ◽  
Anat Rafael ◽  
Irit Besner ◽  
Theodore C. lancu
Keyword(s):  
Epileptic Seizures ◽  
Serum Cortisol ◽  
Febrile Seizures ◽  
Stressful Events ◽  
Serum Prolactin ◽  
Breath Holding ◽  
Control Group ◽  
Cortisol Secretion ◽  
Paroxysmal Disorders ◽  
Cortisol Levels

The hormonal response of the anterior pituitary to various epileptic and nonepileptic events in children was studied. Postictal serum prolactin and cortisol levels were measured in 17 children with epilepsy, 23 with febrile seizures, and 10 with syncope or breath-holding spells. The levels were compared with those of 30 children with nonspecific fever, and 23 afebrile children served as control subjects. Significantly higher (P <.01) prolactin levels (26.5 ± 3.3 ng/mL, mean ± SEM) were found in the epileptic group, compared with levels in children with febrile seizures (13.2±1.0 ng/mL), fever (11.2±0.9 ng/mL), syncope (7.3±0.9 ng/mL), and the control group (7.9± 0.6 ng/mL). In contrast, serum cortisol levels were nonspecifically elevated in the epileptics and patients with febrile seizures or fever only. These findings suggest that elevated prolactin levels may be found after epileptic seizures and much less after febrile seizures, but not after breath-holding spells or syncopal events. Cortisol secretion appears to be nonselectively triggered by all stressful events, such as epileptic and febrile seizures, and fever. Elevated prolactin levels (>15 ng/mL) associated with seizures may help in differentiating epileptic from febrile seizures or syncope.

scholarly journals Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome

2021 ◽  
Vol 38 (1) ◽  
Author(s):  
Humaira Fayyaz ◽  
Shazadi Ambreen ◽  
Hammad Raziq ◽  
Azmat Hayyat
Keyword(s):  
Vasovagal Syncope ◽  
Serum Cortisol ◽  
Tilt Test ◽  
Control Group ◽  
Postural Tachycardia Syndrome ◽  
P Value ◽  
Cross Sectional ◽  
Postural Tachycardia ◽  
Significant Difference ◽  
Cortisol Levels

Objectives: To compare the levels of cortisol in patients of vasovagal syncope (VVS) and postural tachycardia syndrome (POTS). Methods: A cross-sectional analytical study was conducted at Islamic International Medical College, Rawalpindi and Electrophysiology Department at (AFIC). This study included 80 subjects, comprising of 35 patients in each group of vasovagal syncope and postural tachycardia syndrome and 10 healthy subjects. Patients with complaint of syncope was evaluated for vasovagal syncope and postural tachycardia syndrome using Head Up Tilt Test (HUTT). Blood samples of all the participants were taken and serum cortisol was analyzed using ELISA method. Results were analyzed on SPSS Statistics 21 using ANOVA with a p-value of ≤0.05 regarded as significant. Results: Hormonal analysis shows that cortisol levels in the vasovagal, postural tachycardia syndrome and in control group was 153±16.7pg/ml, 160.17±pg/ml, and 69.65±5.8pg/ml respectively. Cortisol levels were significantly higher in both vasovagal and POTS groups as compared to controls with a p-value of 0.04 and 0.023 respectively. However, there was no significant difference between vasovagal and POTS patients with p value 0.570. Conclusion: It is concluded from the study that cortisol responses of VVS and POTS were positive. doi: https://doi.org/10.12669/pjms.38.1.4122 How to cite this:Khan HF, Ambreen S, Raziq H, Hayat A. Comparison of cortisol levels in patients with vasovagal syncope and postural tachycardia syndrome. Pak J Med Sci. 2022;38(1):---------. doi: https://doi.org/10.12669/pjms.38.1.4122 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cortisol secretion pattern in overweight/obese and normal-weight infants: a cross-sectional study

2020 ◽  
Vol 33 (2) ◽  
pp. 241-246
Author(s):  
Ana Cristina Resende Camargos ◽  
Pedro Henrique Scheidt Figueiredo ◽  
Sueli Ferreira da Fonseca ◽  
Mariana Aguiar de Matos ◽  
Katherine Simone Caires Oliveira ◽  
...  
Keyword(s):  
Salivary Cortisol ◽  
Area Under The Curve ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Control Group ◽  
Cortisol Secretion ◽  
Cross Sectional ◽  
Increased Risk ◽  
Highly Sensitive ◽  
Cortisol Levels

AbstractBackgroundThe salivary circadian diurnal cortisol plays an important role in growth and development. Inappropriate levels may induce changes associated with an increased risk of obesity later in life. It is unknown if there are differences in cortisol secretion pattern between overweight/obese infants when compared with theirs peers in infancy. Thus, this study aimed to compare the salivary cortisol secretion pattern in overweight/obese and normal-weight infants.MethodsThirty-three (overweight/obese = 17 and normal weight = 16) infants between 6 and 24 months of age had saliva samples collected upon awakening (T1), 30 min after waking (T2), at 12:00 am or before the baby’s meal (T3), and prior to bedtime (T4). Highly sensitive enzyme immunoassays were used for cortisol analyses.ResultsSalivary cortisol levels were similar between the groups: T1 (p = 0.22; 95% confidence interval [CI]: −5.65, 1.37), T2 (p = 0.24; 95% CI: −8.23, 2.17), T3 (p = 0.95; 95% CI: −3.16, 2.96), and T4 (p = 0.81; 95% CI: −1.39, 1.08); and no differences were observed between area under the curve (AUC) (p = 0.80; 95% CI: −4.58–13.66). The cortisol level reduced in T4 (95% CI: 1.35–2.96) compared to T1 (95% CI: 5.15–8.49) and T2 in the overweight/obese group (p < 0.001; 95% CI: 6.02–11.04). In the normal-weight group, the cortisol reduced in T3 (95% CI: 2.86–8.18) compared to T1 (95% CI: 5.64–12.28) and decreased until T4 (p = 0.001; 95% CI: 1.25–3.37).ConclusionsThe overweight/obese infant group presented a different pattern of cortisol secretion, although cortisol levels did not differ between the control group.

Effect of experimental manipulation of circulatory cortisol levels in lambs on their growth rate and carcass quality

1973 ◽  
Vol 24 (6) ◽  
pp. 927 ◽  
Author(s):  
RW Purchas
Keyword(s):  
Growth Rate ◽  
Serum Cortisol ◽  
Experimental Manipulation ◽  
Control Group ◽  
Acute Administration ◽  
Meat Tenderness ◽  
Melengestrol Acetate ◽  
Endogenous Cortisol ◽  
Cortisol Levels ◽  
Negative Relationships

Relationships between the activity of the adrenal cortex and the productivity of lambs were investigated by administering cortisol acetate or melengestrol acetate. Initial experiments indicated that cortisol acetate administered every second day effectively maintained elevated levels of serum cortisol and that the administration of melengestrol acetate brought about some suppression in the levels of serum cortisol. However, when administered to growing lambs over an 8-week period, melengestrol acetate at a rate of 0.6 mg every second day had no measurable effect on serum cortisol. Cortisol acetate at a dosage of 50 mg every second day increased serum cortisol concentrations for the first 4 weeks only, after which they declined to the levels in the control lambs. In the group treated with cortisol acetate, serum and adrenal levels of cortisol at slaughter were significantly lower than the control group, but there were no differences in meat tenderness. Elevated levels of cortisol at slaughter were obtained by acute administration of cortisol acetate at the rate of 150 mg/day for 3 days. Meat from these animals was appreciably more tender than that from the controls. It is concluded that the negative relationships reported to exist between endogenous cortisol levels and growth rate or meat tenderness of cattle, either do not exist in lambs or they are not the simple cause and effect type.

scholarly journals Serum Cortisol Levels Modifications in Patients with Depression and Irritable Bowel Syndrome

2019 ◽  
Vol 70 (9) ◽  
pp. 3383-3386 ◽  
Author(s):  
Luminita Diana Hritcu ◽  
Manuela Padurariu ◽  
Alin Ciobica ◽  
Cristina Horhogea ◽  
Mihaela Claudia Spataru ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Major Depression ◽  
Present Report ◽  
Serum Cortisol ◽  
Control Group ◽  
Major Depression Disorder ◽  
Related Factors ◽  
Cortisol Levels ◽  
Irritable Bowel ◽  
Depression Disorder

The correlations between depression and stress are quite accepted nowadays, as well as the fact that cortisol levels could also represent fundamental risk factors for major depressive disorder. However, when it comes to the modifications of cortisol levels in depression, the results are controversial. Same goes for the cortisol modifications in irritable bowel syndrome (IBS), which is a functional digestive disorder characterized by a strong biopsychological component, being highly influenced or exacerbated by stressful stimuli. Thus, in the present report we were interested in seeing if there are any serum cortisol levels variations in patients with depression and irritable bowel syndrome, by looking at cortisol modifications in two different groups of patients: a control group with major depression disorder and another study group composed by major depression disorder + IBS patients. Thus, our data presented here are suggesting that there is a significant increase in cortisol levels in the morning serum of the patients with major depression disorder + IBS, as compared to the group having only depression. The results presented here could have an important relevance in the context of managing the stress-related factors in the pathological entities described above.

scholarly journals The Effects of Traditional East Java Indonesia Sirep on Cortisol Level, IFN- and IL-10 in Folk Home Elderly Disturbed Sleep Needs

Jurnal NERS ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. 277
Author(s):  
Joni Haryanto
Keyword(s):  
Immune Modulation ◽  
Sleep Disturbances ◽  
Serum Cortisol ◽  
Nursing Intervention ◽  
Control Group ◽  
Immune Modulator ◽  
Significant Control ◽  
Disturbed Sleep ◽  
Control Intervention ◽  
Cortisol Levels

Background: Sirep, is one of the traditional intervention of people in East Java Indonesia, especially Tengger tribe using spells to meet the needs of human sleep. In context Indonesia, Elderly is human being aged 60 years and older who experience sleep disturbances fulfillment. Furthermore, sirep as immunomodulator effect on levels of cortisol, IFN-gRα and IL-10 is still unknown in nursing perspective.Method: The population of this study were 70 elderly with the number ofrespondents were 43 elderly. They were divided into two groups that are (1) 23 elderly with 6-month sirep intervention (mean age, 69.6 ± 5.2 years) as an experiment group, and  (2) 20 elderly as control group (65.8 ± 5.4 years). The need of sleep is implemented to Evaluate the sample of immune modulation, cortisol levels, IFN-gRα  and IL-10. The molecular biology of the samples was determined using  ELISA analysis. The statistical analysis of the data used Determine ANOVA and t-test.Results: After the 6 -month intervention, there re is significant changes in serum cortisol levels (p = 0.0001) and a different test with a control intervention was also significant (p = 0.00 1 3). Significant changes in serumlevels of IFN-gRα  is (p = 0.0003) and a different test with a control intervention is also significant (p = 0.016 4), while the change in the levels of IL-10 in serum is significant (p = 0.0003) and test different intervention with no significant control (p = 0.1143).Conclusion: This study supports the hypothesis that sirepcan improve immune modulator in elderly. However, immune modulator showed a slight improvement in the nursing intervention of sirep group, suggesting that a longer or more frequent sessions of intervention might have an effect..

scholarly journals Effects of Serum Cortisol Levels on Perinatal Prognosis in Patients with Hypertensive Disorder

2020 ◽  
Vol 4 (2) ◽  
Author(s):  
Gaoxiang Huo ◽  
Yeqiang Qin ◽  
Xiucui Bao ◽  
Xiaoling Yao ◽  
Zhangwei Pu ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Cortisol Level ◽  
Gestational Hypertension ◽  
Serum Cortisol ◽  
The Other ◽  
Serum Cortisol Level ◽  
Control Group ◽  
Hypertensive Disorder ◽  
Cortisol Levels ◽  
Case Number

Objective: To investigate the effect of serum cortisol level on perinatal prognosis in patients with hypertensive disorder during pregnancy. Methods: In this study, different degrees of patients with hypertensive disorder during pregnancy who were admitted from August 2018 to August 2019 in our hospital were selected as the research subjects, and divided into groups according to the severity of the patients' conditions. The 120 patients were divided into gestational hypertension group, preeclampsia group and eclampsia group, with 40 cases each, and another 40 healthy pregnant women were selected. The detection of serum cortisol levels was carried out for the above 4 groups of pregnant women. Results: The serum cortisol level in the control group was (260.35 ± 10.96) nmol / L. The case number of neonatal asphyxia was 1 (2.50%), the case number of premature births was 1 (2.50%), the number of fetal growth restriction was 1 (2.50%), the number of deaths was 0, and the other three groups were higher than this. It showed as gestational hypertension <preeclampsia <eclampsia. The Apgar score of pregnant women in the control group was (9.13 ± 0.29), the ZL index was (1.07 ± 0.07), and the other three groups were lower than this. It showed as gestational hypertension> preeclampsia> eclampsia. There were significant differences between groups (all P<0.05). Conclusion: Early detection of serum cortisol levels in pregnant women is beneficial to timely improve the symptoms of gestational hypertension, thereby suppressing the effects of serum cortisol on perinatal infants and improving the prognosis of newborns.

Serum Prolactin Level in Children with Febrile Seizure and Epileptic Seizure; Comparative Study

2017 ◽  
Vol 37 (1) ◽  
pp. 67-71
Author(s):  
Kotyal B. Mahendrappa ◽  
S. Perumal Sathya ◽  
M.N. Suma
Keyword(s):  
Comparative Study ◽  
Epileptic Seizure ◽  
Prolactin Level ◽  
Age Groups ◽  
Epileptic Seizures ◽  
Febrile Seizures ◽  
Significant Rise ◽  
Serum Prolactin ◽  
Cns Infection ◽  
Serum Prolactin Level

Introduction: Transient hyperprolactinaemia has been reported to follow unprovoked seizures, a finding proposed to be useful in the differential diagnosis of epilepsy. On this basis we conducted a study with an objective to compare the postictal serum prolactin level in children with febrile seizures (FS) and epileptic seizures (ES) to evaluate, whether serum prolactin (PL) could be used a predictor in the diagnosis of ES.Material and Methods: This was a prospective comparative study was conducted on 52 children (26 in febrile seizures group and 26 in epileptic seizure group) in the age group of six months to five years. Children with CNS infection, developmental delay, structural CNS defects or neurological abnormality, metabolic disorders and those on drugs, known to have altered serum prolactin level were excluded. Blood for estimation of serum prolactin was collected within 180 minutes of occurrence of seizure. Level of serum prolactin was quantitatively assayed by chemiluminescence method and the levels were considered high, if values were greater than 23 ng/ml, which is the upper limit of normal for all age groups and both sex.Results: The mean serum prolactin level in epileptic seizures group was 25 ng/ml and that of febrile seizures group was 10.72 ng/ml. High level of serum prolactin was noted in 17 children (77.2%) with GTCS and 3 children (75%) with CPS. None of the children with febrile seizures had significant raise in the level of serum prolactin.Conclusion: There is a significant rise in serum prolactin level in children with epileptic seizures compared to febrile seizures, if measured within 3 hours of occurrence of seizures. Thus, the post-ictal serum prolactin level can be used as an additional investigation to diagnose or predict epileptic seizures in children.

scholarly journals Hypertension associated with unhealthy lifestyle and marked by serum cortisol levels

2021 ◽  
Author(s):  
Chunsong Hu ◽  
Yanqing Wu ◽  
Juxiang Li ◽  
Menghong Wang ◽  
Yuzhi Ge ◽  
...  
Keyword(s):  
Serum Cortisol ◽  
Major Adverse Cardiovascular Events ◽  
Control Group ◽  
Unhealthy Lifestyle ◽  
Heavy Smoking ◽  
Long Time ◽  
Psychological Pressure ◽  
History Of ◽  
New Type ◽  
Cortisol Levels

Abstract There are more and more individuals with hypertension due to major risk factors (mRFs) related to unhealthy lifestyle. Here, we report that a new type of hypertension associates with unhealthy lifestyle and marks by serum cortisol levels, which is termed C-type hypertension (CtH). All subjects collected at random at outpatient department between 2012 and 2017, with or without family history of hypertension, with or without unhealthy “environment-sleep-emotion-exercise-diet” intervention [E(e)SEEDi] related mRFs, were screened and measured serum cortisol levels (8:00 AM and 4:00 PM) and blood pressure. Typical cases with CtH have unhealthy E(e)SEEDi related mRFs, such as stay up later or OSA (+++), psychological pressure or bad emotion, lack of physical exercise or sitting for a long time, heavy smoking and/or liquor drinking. Day serum cortisol levels (8:00 AM and 4:00 PM) in this group were significantly elevated (vs control group, P<0.01). Follow-up analysis showed that the outcomes were closely linked to these individuals’ lifestyle and adherence to treatment. In conclusion, this study suggested that there is indeed CtH. Most are young and middle-aged individuals and easy to suffer from major adverse cardiovascular events (MACEs).

scholarly journals Association of Psoriasis Severity with Serum Prolactin, Thyroid Hormones, and Cortisol before and after Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Reza M. Robati ◽  
Parviz Toossi ◽  
Mohammad Rahmati-Roodsari ◽  
Sara Khalilazar ◽  
Ehsan Abolhasani ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Serum Cortisol ◽  
Severity Index ◽  
Thyroid Stimulating Hormone ◽  
Serum Prolactin ◽  
Significant Difference ◽  
Before And After ◽  
Pasi Score ◽  
Cortisol Levels ◽  
Normal Controls

Background. Prolactin (PRL) level is proposed to be associated with the severity of psoriasis although the previous studies reported different results.Objective. To find the association between PRL levels and severity of psoriasis before and after treatment. In addition, we aimed to find a difference in prolactin, thyroid stimulating hormone (TSH), thyroid hormones (T3and T4), and cortisol levels between patients with psoriasis and normal controls.Methods. First, the levels of hormones were measured in 30 patients with psoriasis and 30 matched controls. The severity was assessed by psoriasis area and severity index (PASI). Then, patients were treated, and PASI was assessed every week until achieving PASI-75 response. At this time, the hormones were measured again and compared to the baseline.Results. No statistical significant difference was observed in the mean PRL, T3, T4, TSH, and cortisol levels between cases and controls. Comparing to the baseline, a significant decrease in PRL levels and a significant increase in T3and serum cortisol levels were observed after treatment (P<0.05), while the changes in other hormones were not significant.Conclusion. After treatment, PRL significantly decreased, and T3and cortisol levels significantly increased. No correlation between hormone levels and improvement of PASI score existed.

scholarly journals Changes in serum cortisol and some innate immunity parameters after exhaustive exercise in male dogs

2019 ◽  
Vol 22 (3) ◽  
pp. 275-284
Author(s):  
P. Dzhelebov ◽  
D. Gundasheva ◽  
M. Andonova ◽  
E. Slavov
Keyword(s):  
Innate Immunity ◽  
Serum Cortisol ◽  
Neutrophil Function ◽  
Exhaustive Exercise ◽  
Strenuous Exercise ◽  
Phagocytic Index ◽  
Control Group ◽  
Classical Pathway ◽  
Experimental Animals ◽  
Cortisol Levels

The aim of the present study was to investigate the influence of exhaustive exercise on some innate immunity parameters and cortisol levels. Twelve male, mongrel dogs were divided into an experimental group, submitted to prolonged, strenuous exercise with exhaustion as the end-point, and a control group without any exposure to exercise. Serum cortisol levels were measured before exercise (BE), right after (0 h) and on 2nd hour and 4th hour after exercise. The neutrophil function (phagocytosis, phagocytic index, hydrogen peroxide production-H2O2) and classical pathway of complement activation (CPCA) were measured as followеd: BE, right after exercise and on 2, 4, 24, 48, 72 h, and 7, 14 day after exercise. In experimental animals cortisol decreased on hour 4 after exercise (P<0.05), compared to BE level, and on hour 2, compared to controls (P<0.05). Percentage of H2O2 producing neutrophils in experimental animals dropped significantly on hour 4 and day 7 after exercise (P<0.05), compared to BE level and on hour 4 (P<0.01) vs control group. Percentage of phago-cytising neutrophils decreased slightly on hour 48 (P<0.05), compared to BE level. Phagocytic index and CPCA had an insignificant increase after exercise. Inappropriate changes in cortisol levels could indicate inadequate adaptive response to exercise. Overtraining could make animals more susceptible to infection.

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