Meltwater generation in ice stream shear margins: case study in Antarctic ice streams

Liquid water within glacier ice and at the glacier beds exerts a significant control on ice flow and glacier stability through a number of processes, including altering the rheology of the ice and lubricating the bed. Some of this water is generated as melt in regions of rapid deformation, including shear margins, due to heating by viscous dissipation. However, how much meltwater is generated and drained from shear margins remains unclear. Here, we apply a model that describes the evolution of ice temperature, melting, and water transport within deforming ice to estimate the flux of meltwater from shear margins in glaciers. We derive analytical expressions for ice temperature, effective pressure, and porosity in zones of temperate ice, and we apply this model to estimate the flux from three Antarctic glaciers: Bindschadler and MacAyeal Ice Streams, Pine Island Glacier, and Byrd Glacier. We show that the flux of meltwater from shear margins in these regions may be as significant as the meltwater produced by frictional heating at the bed, with average fluxes of ~1000-2000 m^3 yr^ -1. This contribution of shear heating to meltwater flux at the bed may thus affect both the rheology of the ice as well as sliding at the bed, both key controls on fast ice flow.

Thymol and its Derivatives for Management of Phytopathogenic fungi of maize

Background: Thymol is a bioactive compound having many pharmacological activities. Objective: The present study was carried out to evaluate the fungi toxic effects of thymol and derivatives against phytopathogenic fungi of maize. Method: Thymol was derivatized to get formylated thymol, Mannich bases, and imine derivatives. All the synthesized thymol derivatives were characterized by their physical and spectral properties. Synthesized thymol derivatives were screened for their in vitro antifungal effects using poisoned food technique against three maize pathogenic fungi namely Fusarium moniliforme, Rhizoctonia solani and Dreschlera maydis. Results: Thymol and formylated thymol showed promising results for control of D. maydis with ED50 values less than standard carbendazim and comparable to standard mancozeb. These two compounds were further evaluated for control of D. maydis causative maydis leaf blight disease on maize plants grown in the field during the Kharif season (June to October) 2018. Conclusion: Thymol exhibited significant control of maydis leaf blight disease of maize and emerged as a potential alternative to synthetic fungicides used in cereal crops.

Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis

Francisella tularensis is a facultative intracellular bacterium and the etiological agent of tularemia, a zoonotic disease. Infection of monocytic cells by F. tularensis can be controlled after activation with IFN-γ; however, the molecular mechanisms whereby the control is executed are incompletely understood. Recently, a key role has been attributed to the Guanylate-binding proteins (GBPs), interferon-inducible proteins involved in the cell-specific immunity against various intracellular pathogens. Here, we assessed the responses of bone marrow-derived murine macrophages (BMDM) and GBP-deficient BMDM to F. tularensis strains of variable virulence; the highly virulent SCHU S4 strain, the human live vaccine strain (LVS), or the widely used surrogate for F. tularensis, the low virulent F. novicida. Each of the strains multiplied rapidly in BMDM, but after addition of IFN-γ, significant GBP-dependent control of infection was observed for the LVS and F. novicida strains, whereas there was no control of the SCHU S4 infection. However, no differences in GBP transcription or translation were observed in the infected cell cultures. During co-infection with F. novicida and SCHU S4, significant control of both strains was observed. Patterns of 18 cytokines were very distinct between infected cell cultures and high levels were observed for almost all cytokines in F. novicida-infected cultures and very low levels in SCHU S4-infected cultures, whereas levels in co-infected cultures for a majority of cytokines showed intermediate levels, or levels similar to those of F. novicida-infected cultures. We conclude that the control of BMDM infection with F. tularensis LVS or F. novicida is GBP-dependent, whereas SCHU S4 was only controlled during co-infection. Since expression of GBP was similar regardless of infecting agent, the findings imply that SCHU S4 has an inherent ability to evade the GBP-dependent anti-bacterial mechanisms.

Efficient control of IL-6, CRP and Ferritin in Covid-19 patients with two variants of Beta-1,3-1,6 glucans in combination, within 15 days in an open-label prospective clinical trial

Objective: Cytokine storm and coagulopathy being the major causes of morbidity in Covid 19 patients, based on an earlier pilot study yielding control of IL 6 and D-Dimer, when AFO 202 and N 163 strains of Aureobasidium Pullulans produced beta glucans, were studied separately and in combination for 30 days. In this study, we evaluated the efficiency of the two variants combinations in comparison with the control arm, which underwent a conventional regimen of treatment alone, for a shorter duration. Methods: A total of 40 RT-PCR positive Covid-19 patients divided into two groups (Gr): Gr. 1 control (n=22). Standard treatment; Gr. 2 (n =18) Standard treatment + combination of AFO 202 and N 163 beta glucans for 15 days. Biomarkers of relevance to cytokine storm and coagulopathy were evaluated at baseline on Day 7 and Day 15. Results: The C-reactive protein (CRP), which declined from 33.95 ng/ml to 5.07 ng/ml in control and from 33.95 ng/ml to 5.64 ng/ml in the treatment arm on Day 7, increased to 14.6 ng/ml in the former while it continued to be under control in the treatment arm at 5.68 ng/ml on Day 15. The same trend was observed in Ferritin, whose values were 560.58 pg/ml at baseline to 261.44 pg/ml (day 7) and 182.40 pg/ml (day 15) in the treatment group, while it was 535.24 pg/ml at baseline, 116.66 pg/ml on day 7 and 291.95 pg/ml on day 15 in the control group. IL-6 showed a higher decrease in treatment group compared to the control group. The difference between day 7 and day 15 values were statically significant. Conclusion: A statistically significant control of IL-6, CRP and Ferritin in Covid 19 patients who orally consumed AFO 202 and N 163 strains of Aureobasidium Pullulans produced Beta glucans together in 15 days make us recommend this safe food supplement be consumed by Covid 19 patients along with conventional treatments, especially to the vulnerable population, as a prophylaxis amidst the prolonged pandemic with evolution of mutated strains of SARS COV2.

Combinatorial mRNA vaccination enhances protection against SARS-CoV-2 delta variant

Emergence of SARS-CoV-2 variants of concern (VOC), including the highly transmissible delta strain, has posed challenges to current COVID-19 vaccines that principally target the viral spike protein (S). Here, we report a nucleoside-modified mRNA vaccine that expresses the more conserved viral nucleoprotein (mRNA-N). We show that mRNA-N alone was able to induce a modest but significant control of SARS-CoV-2 in mice and hamsters. Critically, by combining mRNA-N with the clinically approved S-expressing mRNA vaccine (mRNA-S-2P), we found that combinatorial mRNA vaccination (mRNA-S+N) led to markedly enhanced protection against the SARS-CoV-2 delta variant compared to mRNA-S. In a hamster model, we demonstrated that while mRNA-S alone elicited significant control of the delta strain in the lungs (~45-fold reduction in viral loads compared to un-vaccinated control), its effectiveness in the upper respiratory tract was weak, whereas combinatorial mRNA-S+N vaccination induced markedly more robust control of the delta variant infection in the lungs (~450-fold reduction) as well as in the upper respiratory tract (~20-fold reduction). Immune analyses indicated that induction of N-specific immunity as well as augmented S-specific T-cell response and neutralizing antibody activity were collectively associated the enhanced protection against SARS-CoV-2 delta strain by combinatorial mRNA vaccination. These findings suggest that the combined effects of protection in the lungs and upper respiratory tract could both reduce the risk of severe disease as well as of infection and transmission.

Wear analysis of natural-inorganic fiber reinforced automotive brake composites

Brake friction composite materials comprising varying proportions of natural (banana) and inorganic (lapinus) fibers were designed, fabricated by compression molding, and characterized for sliding wear performance. The sliding wear properties of the manufactured friction composites have been studied by the Taguchi method. An orthogonal array (L 16) was used to investigate the influence of sliding wear parameters. A series of tests were conducted on a pin-on-disc machine by considering four control parameters: composition, normal load, sliding velocity, and sliding distance, each having four levels. The results showed that the wear in terms of weight loss decreases with increasing banana fiber and increases with increasing lapinus fiber, normal load, sliding velocity, and sliding distance. The results indicate that the normal load emerges as the most significant control parameter affecting wear performance, followed by sliding distance and sliding velocity.

Control Strategies of DC Microgrids Cluster: A Comprehensive Review

Multiple microgrids (MGs) close to each other can be interconnected to construct a cluster to enhance reliability and flexibility. This paper presents a comprehensive and comparative review of recent studies on DC MG clusters’ control strategies. Different schemes regarding the two significant control aspects of networked DC MGs, namely DC-link voltage control and power flow control between MGs, are investigated. A discussion about the architecture configuration of DC MG clusters is also provided. All advantages and limitations of various control strategies of recent studies are discussed in this paper. Furthermore, this paper discusses three types of consensus protocol with different time boundaries, including linear, finite, and fixed. Based on the main findings from the reviewed studies, future research recommendations are proposed.

Electoral Reform and the Centralisation of the New Zealand National Party

<p>Political party organisations respond to the challenges of their environments. Different organisational structures have different capabilities and capacities and, therefore, some organisations are better suited to some environments. What happened to party organisations when New Zealand changed from a first-past-the-post to a mixed member proportional electoral system? Did all parties have the same capacities to meet the challenges raised by this new environment? This paper addresses these questions by examining the organisational responses of the New Zealand National Party to the introduction of the mixed member proportional electoral system after 1993. The National Party was constructed to operate in a first-past-the-post electoral system and it did so successfully, winning twelve of the nineteen elections it contested. In response to the challenges of the first-past-the-post environment, National decentralised both candidate selection and campaign structure. National's decentralised organisation proved to be a liability for National under the new mixed member proportional environment however. Mixed member proportional demanded the construction of a nationwide list and a coherent campaign for the nationwide party vote. With its existing organisational structure, National was unable to meet either of these demands and suffered the electoral repercussions of that failure. After four consecutive elections in which National lost vote share, the National Party centralised its organisation in 2003. This paper analyses the centralisation of the National Party's organisation and the reasons for it by examining the Party's efforts to reform candidate selection and management of campaigns. The two organisational structures which National used for selecting candidates and managing campaigns under mixed member proportional produced different results. The candidate pools for 1996, 1999 and 2002 failed to provide nationwide appeal and produced incentive for electorate candidates to ignore the party vote element. Further, the campaign structure for these three elections allowed electorate committees significant control and the ability to undermine the nationwide party vote campaign. In the 2005 election, however, candidate selection and campaign management showed significant changes. The candidate selection process provided incentives for electorate candidates to seek both electorate and party votes, although it arguably still failed to produce a nationally appealing party list. The management of the campaign was also significantly different. It demonstrated the benefit of central campaign control in a mixed member proportional electoral system. The 2003 centralisation gave National elites significant control and allowed National to almost double its 2002 result in the 2005 election. This thesis demonstrates that a mixed member proportional electoral system gave National strong incentives to centralise its party organisation.</p>

Electoral Reform and the Centralisation of the New Zealand National Party

<p>Political party organisations respond to the challenges of their environments. Different organisational structures have different capabilities and capacities and, therefore, some organisations are better suited to some environments. What happened to party organisations when New Zealand changed from a first-past-the-post to a mixed member proportional electoral system? Did all parties have the same capacities to meet the challenges raised by this new environment? This paper addresses these questions by examining the organisational responses of the New Zealand National Party to the introduction of the mixed member proportional electoral system after 1993. The National Party was constructed to operate in a first-past-the-post electoral system and it did so successfully, winning twelve of the nineteen elections it contested. In response to the challenges of the first-past-the-post environment, National decentralised both candidate selection and campaign structure. National's decentralised organisation proved to be a liability for National under the new mixed member proportional environment however. Mixed member proportional demanded the construction of a nationwide list and a coherent campaign for the nationwide party vote. With its existing organisational structure, National was unable to meet either of these demands and suffered the electoral repercussions of that failure. After four consecutive elections in which National lost vote share, the National Party centralised its organisation in 2003. This paper analyses the centralisation of the National Party's organisation and the reasons for it by examining the Party's efforts to reform candidate selection and management of campaigns. The two organisational structures which National used for selecting candidates and managing campaigns under mixed member proportional produced different results. The candidate pools for 1996, 1999 and 2002 failed to provide nationwide appeal and produced incentive for electorate candidates to ignore the party vote element. Further, the campaign structure for these three elections allowed electorate committees significant control and the ability to undermine the nationwide party vote campaign. In the 2005 election, however, candidate selection and campaign management showed significant changes. The candidate selection process provided incentives for electorate candidates to seek both electorate and party votes, although it arguably still failed to produce a nationally appealing party list. The management of the campaign was also significantly different. It demonstrated the benefit of central campaign control in a mixed member proportional electoral system. The 2003 centralisation gave National elites significant control and allowed National to almost double its 2002 result in the 2005 election. This thesis demonstrates that a mixed member proportional electoral system gave National strong incentives to centralise its party organisation.</p>

Policy Forum: A Critical Analysis of Property Taxation Under the First Nations Fiscal Management Act as a Self-Government Tool

The First Nations Fiscal Management Act (FMA) delegates the power to levy property taxes to band councils. The purpose of this article is to describe and analyze the effectiveness of the legislation as a self-government tool. Section 5(1) of the FMA allows band councils to levy property taxes both to increase their economic capacity—providing them with a source of income—and to improve self-government. However, this grant of power is subject to numerous conditions. These include compliance with the financial management requirements set out in the act, as well as approval of property tax laws by the First Nations Tax Commission (FNTC) (the majority of the members of which are appointed by the federal government). Also, the taxes imposed must comply with regulations set by the governor in council, which currently cover the property assessment process (including an appeal process), interest and penalties, and inspection of property. There have been two attempts by property taxpayers to overturn the decisions of the FNTC by way of judicial review. The fact that both were unsuccessful has somewhat mitigated criticism of the constraints on First Nation self-government imposed by the FMA. Overall, the federal government maintains significant control over the law-making process by which First Nations levy property taxes, both directly through regulations and indirectly through its dominant presence on the FNTC. Reform is needed: real powers need to be delegated to meet the stated objective of creating meaningful self-government for participating First Nations. The power to impose property taxes was first delegated to band councils by the Indian Act in 1951. Therefore, it is high time that First Nations be granted the right to exercise that power without federal intervention. Constitutional protection of the right to self-government must be the ultimate goal.