From lipid target values to JUPITER study. Importance of the achievement of lipid levels specified by the guidelines and deficiencies in the present practice

Magyarországon 1993 és 2006 között a születéskor várható élettartam 4,14 évvel nőtt, és ehhez a cardiovascularis halandóság javulása 1,85 évvel járult hozzá. A lipidszintcsökkentő kezelés, a lipidcélértékek elérése az utóbbi években a cardiovascularis prevenció egyik súlyponti kérdése lett. A javuló tendencia ellenére az LDL-koleszterin-szint célértékének elérési aránya nem nagyobb egyharmadnál, és ebben leginkább az játszik szerepet, hogy a nem megfelelő szintű lipidcsökkentést igazoló eredménybe az orvosok nagyobb része (2007-ben 56%-a) beletörődik, nem igyekszik módosítani a kezelésen, pedig egyre több adat igazolja, hogy az alacsonyabb LDL-koleszterin-szint elérése nemcsak a klinikai kimenetelt javítja szignifikánsan, hanem költséghatékony is. Az utóbbi időszak legjelentősebb, statinnal végzett új vizsgálata a JUPITER, amely lipidszintjeik miatt statinkezelést nem igénylő, magas hs-CRP-szintű, nem ismert érbetegeken igazolta, hogy 20 mg rosuvastatin adásával szignifikánsan, 44%-kal csökkenthető a primer végpont (a cardiovascularis halálozás, nem halálos stroke és szívinfarktus, instabil angina vagy revascularisatio) és 20%-kal az összhalálozás előfordulása. Egy primer végpont megelőzéséhez 23 beteg 5 éves kezelése szükséges. Az eredmények felvetik a primer prevenció elvei és célértékei átgondolásának szükségességét, valamint azt, hogy minden lipidcsökkentő kezelésben nagyobb figyelmet kellene fordítani a betegek hs-CRP szintjére.

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Relationship of Hypothyroidism with Lipid Levels, hs-CRP and BMI

International Journal of Current Research and Review ◽

10.31782/ijcrr.2021.132317 ◽

2021 ◽

Vol 13 (23) ◽

pp. 104-107

Author(s):

Naved Ahmad ◽

Shahid Iqbal ◽

Mohd Javed ◽

Mushir Ahmad ◽

Sana Nafees ◽

...

Keyword(s):

Lipid Levels ◽

Hs Crp ◽

Relationship Of

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Alterations of serum high sensitive C reactive protein and lipid levels in newly diagnosed myocardial infarction subjects

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20195538 ◽

2019 ◽

Vol 7 (12) ◽

pp. 4682

Author(s):

R. R. Aparna ◽

D. Raja Rajeswari ◽

K. Ramalingam ◽

R. Viswa Kumar ◽

D. Balakrishna

Keyword(s):

Myocardial Infarction ◽

Significant Positive Correlation ◽

Ldl Cholesterol ◽

Hdl Cholesterol ◽

P Value ◽

Newly Diagnosed ◽

Lipid Levels ◽

Positive Correlation ◽

Hs Crp ◽

Inflammatory Component

Background: Acute Myocardial Infarction (AMI) is one of the major causes of mortality in the world. Atherosclerosis leading to AMI is the most common and severe clinical manifestation observed. Dyslipidemia is one of main traditional risk factor for MI, but in more than 50% of CHD events dyslipidemia was absent. Atherosclerosis is considered as both a chronic inflammatory condition and a disorder of lipid metabolism. The present study was aimed to estimate the levels of serum lipids (total cholesterol, LDL cholesterol, HDL cholesterol) and hs-CRP an inflammatory marker in newly diagnosed AMI cases and to find out any correlation between these two.Methods: The study was conducted on 50 newly diagnosed myocardial infarction cases, admitted in Cardiology Department Narayana Medical College, Nellore. Both the sexes were included. Fifty age and sex matched healthy individuals were selected as controls. Lipid levels are estimated by end point colorimetric assay (HUMANSTAR kit) and hs-CRP was estimated by immunofluorescence technique (Boditechkit).Results: Significant raised levels of hs-CRP (p value <0.0001) and low HDL cholesterol (p value =0.0085) levels among the cases was noticed. A significant positive correlation was observed between LDL cholesterol and hsCRP (r=0.109, p=0.040). A non-significant positive correlation between hsCRP and HDL cholesterol (r=0.291, p=0.453) was observed.Conclusions: The results of the study implicate the role of inflammatory component in causing atherosclerosis or coronary artery disease rather than dyslipidaemias alone to be attributed for atherogenesis. Concomitantly HDL cholesterol levels were found to be low in cases that results from the inflammatory component in atherogenesis.

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Plasma Retinol Levels and High-Sensitivity C-Reactive Protein in Prepubertal Children

Nutrients ◽

10.3390/nu10091257 ◽

2018 ◽

Vol 10 (9) ◽

pp. 1257 ◽

Cited By ~ 2

Author(s):

Olaya de Dios ◽

Pilar Navarro ◽

Henar Ortega-Senovilla ◽

Leticia Herrero ◽

Teresa Gavela-Pérez ◽

...

Keyword(s):

Pearson Correlation ◽

Plasma Concentrations ◽

High Sensitivity ◽

Healthy Children ◽

Lipid Levels ◽

C Reactive Protein ◽

Prepubertal Children ◽

Reactive Protein ◽

Hs Crp ◽

Plasma Retinol

The relationship between C-reactive protein (CRP) levels and plasma antioxidants has been established in adults. However, the association has been rarely investigated in healthy children. Thus, we examined the cross-sectional association of high-sensitivity CRP (hs-CRP) levels with fat-soluble plasma antioxidant concentrations in a cohort of healthy prepubertal children. We determined hs-CRP levels in 543 healthy six–eight-year-old children using a high-sensitivity CRP enzyme-linked immuno sorbent assay (ELISA) kit. The plasma concentrations of lipids, apolipoproteins and lipid-soluble antioxidants (α-tocopherol, γ-tocopherol, lycopene, α-carotene, β-carotene and retinol) were determined using standardized methods. Pearson correlation analysis showed significant correlations between plasma hs-CRP and α-carotene and retinol concentrations. After adjusting by sex, body mass index (BMI) and lipid levels, only the association with retinol remains significant, with children in the highest hs-CRP tertile group (hs-CRP ≥ 0.60 mg/dL) showing significantly lower levels of retinol than those from the tertiles 1 and 2. A stepwise linear regression selected retinol, BMI, apo A-I and sex as predictors of hs-CRP levels, in a model explaining 19.2% of the variability of hs-CRP. In conclusion, in healthy prepubertal children, after adjusting by sex, BMI and lipid levels, hs-CRP concentrations were highly associated with plasma retinol, which is transported in blood bound to retinol-binding protein but were not associated with the lipoprotein-bound antioxidants.

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Abstract #511: HS CRP in Acute Coronary Syndrome

Endocrine Practice ◽

10.1016/s1530-891x(20)45069-4 ◽

2016 ◽

Vol 22 ◽

pp. 121-122

Author(s):

Mukhyaprana Prabhu ◽

Shyny Reddy ◽

Ranjan Shetty ◽

V.B. Mohan ◽

Weena Stanley

Keyword(s):

Acute Coronary Syndrome ◽

Coronary Syndrome ◽

Hs Crp

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Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity, and serum insulin level

Archives of Internal Medicine ◽

10.1001/archinte.130.6.833 ◽

1972 ◽

Vol 130 (6) ◽

pp. 833-843 ◽

Cited By ~ 35

Author(s):

R. J. Santen

Keyword(s):

Diabetes Mellitus ◽

Serum Lipid ◽

Serum Insulin ◽

Insulin Level ◽

Serum Insulin Level ◽

Lipid Levels ◽

Serum Lipid Levels

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C-reactive protein as a marker of progression of carotid atherosclerosis in subjects with type 2 diabetes mellitus

VASA ◽

10.1024/0301-1526/a000614 ◽

2017 ◽

Vol 46 (3) ◽

pp. 187-192 ◽

Cited By ~ 7

Author(s):

Aleš Pleskovič ◽

Marija Šantl Letonja ◽

Andreja Cokan Vujkovac ◽

Jovana Nikolajević Starčević ◽

Katarina Gazdikova ◽

...

Keyword(s):

Diabetes Mellitus ◽

Carotid Atherosclerosis ◽

Inflammatory Marker ◽

Progression Rate ◽

C Reactive Protein ◽

Reactive Protein ◽

Hs Crp ◽

Unstable Plaques

Abstract. Background: This prospective study was designed to evaluate the effect of inflammatory markers on the presence and progression of subclinical markers of carotid atherosclerosis in a 3.8-year follow-up period in patients with type 2 diabetes mellitus (T2DM). Patients and methods: A total of 595 subjects with T2DM were enrolled. Subclinical markers of carotid atherosclerosis (carotid intima media thickness (CIMT), plaque thickness, and plaques presence) were assessed with ultrasound at the time of recruitment and again after 3.8 years. Subjects with T2DM were divided into 2 groups according to the plasma high sensitive C-reactive protein (hs-CRP) levels (subjects with hs-CRP ≥ 2 mg/L and subjects with hs-CRP below 2 mg/L). Results: Subjects with T2DM and hs-CRP levels ≥ 2 mg/L had higher CIMT in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L, and higher incidence of plaques/unstable plaques in comparison with subjects with T2DM and hs-CRP levels below 2 mg/L. Multivariate logistic regression analysis found the association between the HDL cholesterol level and presence of plaques, whereas the inflammatory marker hs-CRP was not associated with subclinical markers of progression of carotid atherosclerosis. Multiple linear regression analysis found the association between the hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up. Conclusions: We demonstrated an association between the inflammatory marker hs-CRP and either CIMT or incidence of plaques/unstable plaques at the time of recruitment in Caucasians with T2DM. Moreover, we found the association between hs-CRP levels and either CIMT progression rate or a change in the number of sites with plaques in a 3.8-year follow-up in subjects with T2DM.

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