Scaffold Architecture and Properties for Osteoblasts Cell Culture: An Optimization Model and Application by Genetic Algorithm

2015 ◽  
Vol 1753 ◽  
Author(s):  
Maraolina Domínguez-Díaz ◽  
Marco Antonio Cruz-Chavez
Keyword(s):  
Genetic Algorithm ◽  
Cell Culture ◽  
Optimization Model ◽  
Pore Diameter ◽  
Fiber Diameter ◽  
Heuristic Method ◽  
Exact Methods ◽  
Polymeric Scaffolds ◽  
Fitness Value ◽  
Different Types

ABSTRACTIn the developing of scaffolds for cell culture, a large number of architectures with different combinations of properties should be tested to determine the best. This can be costly in time, money and materials. In this paper we have proposed an optimization model that aims to maximize the growth of osteoblasts on polymeric scaffolds by regulating their properties and architecture. Based on the optimization model it was implemented a genetic algorithm to calculate the architecture and properties of the scaffolds. The fiber diameter, pore diameter, porosity, Young's modulus and contact angle of the scaffolds were calculated through four electrospinning parameters: voltage (kV), concentration (% w/v), flow rate (ml/h) and distance (cm). A fitness value was assigned to each scaffold and the highest one was chosen as the best condition for osteoblast growth. The preliminary results obtained by the Genetic Algorithm were consistent with the tendencies reported experimentally in other studies. Also, the methodology established here can be easily adapted to different types of polymers and cells. Finally, the optimization model can be applied not only by means of heuristic method, like a Genetic Algorithm, but also by exact methods.

scholarly journals Heuristic rank selection with progressively searching tensor ring network

2021 ◽  
Author(s):  
Nannan Li ◽  
Yu Pan ◽  
Yaran Chen ◽  
Zixiang Ding ◽  
Dongbin Zhao ◽  
...  
Keyword(s):  
Genetic Algorithm ◽  
Compression Ratio ◽  
State Of The Art ◽  
Heuristic Method ◽  
Ring Networks ◽  
Ring Network ◽  
Narrow Region ◽  
Network Search ◽  
Deep Networks ◽  
Evolutionary Phase

AbstractRecently, tensor ring networks (TRNs) have been applied in deep networks, achieving remarkable successes in compression ratio and accuracy. Although highly related to the performance of TRNs, rank selection is seldom studied in previous works and usually set to equal in experiments. Meanwhile, there is not any heuristic method to choose the rank, and an enumerating way to find appropriate rank is extremely time-consuming. Interestingly, we discover that part of the rank elements is sensitive and usually aggregate in a narrow region, namely an interest region. Therefore, based on the above phenomenon, we propose a novel progressive genetic algorithm named progressively searching tensor ring network search (PSTRN), which has the ability to find optimal rank precisely and efficiently. Through the evolutionary phase and progressive phase, PSTRN can converge to the interest region quickly and harvest good performance. Experimental results show that PSTRN can significantly reduce the complexity of seeking rank, compared with the enumerating method. Furthermore, our method is validated on public benchmarks like MNIST, CIFAR10/100, UCF11 and HMDB51, achieving the state-of-the-art performance.

Minimization of total trim loss occurring in pipe cutting in shipbuilding with genetic algorithm

2021 ◽  
pp. 147509022199169
Author(s):  
Abdullah Türk ◽  
Dursun Saral ◽  
Murat Özkök ◽  
Ercan Köse
Keyword(s):  
Genetic Algorithm ◽  
Genetic Algorithms ◽  
Search Space ◽  
Cutting Process ◽  
Genetic Operators ◽  
Critical Stage ◽  
Different Types ◽  
Trim Loss ◽  
Pipe Systems

Outfitting is a critical stage in the shipbuilding process. Within the outfitting, the construction of pipe systems is a phase that has a significant effect on time and cost. While cutting the pipes required for the pipe systems in shipyards, the cutting process is usually performed randomly. This can result in large amounts of trim losses. In this paper, we present an approach to minimize these losses. With the proposed method it is aimed to base the pipe cutting process on a specific systematic. To solve this problem, Genetic Algorithms (GA), which gives successful results in solving many problems in the literature, have been used. Different types of genetic operators have been used to investigate the search space of the problem well. The results obtained have proven the effectiveness of the proposed approach.

COMPUTING AN ADAPTIVE MESH IN FLUID PROBLEMS USING NEURAL NETWORK AND GENETIC ALGORITHM WITH ADAPTIVE RELAXATION

2008 ◽  
Vol 17 (06) ◽  
pp. 1089-1108 ◽  
Author(s):  
NAMEER N. EL. EMAM ◽  
RASHEED ABDUL SHAHEED
Keyword(s):  
Neural Network ◽  
Genetic Algorithm ◽  
Numerical Experiments ◽  
Back Propagation ◽  
Adaptive Mesh ◽  
Learning System ◽  
Back Propagation Algorithm ◽  
Adaptive Smoothing ◽  
Different Types ◽  
Optimal Values

A method based on neural network with Back-Propagation Algorithm (BPA) and Adaptive Smoothing Errors (ASE), and a Genetic Algorithm (GA) employing a new concept named Adaptive Relaxation (GAAR) is presented in this paper to construct learning system that can find an Adaptive Mesh points (AM) in fluid problems. AM based on reallocation scheme is implemented on different types of two steps channels by using a three layer neural network with GA. Results of numerical experiments using Finite Element Method (FEM) are discussed. Such discussion is intended to validate the process and to demonstrate the performance of the proposed learning system on three types of two steps channels. It appears that training is fast enough and accurate due to the optimal values of weights by using a few numbers of patterns. Results confirm that the presented neural network with the proposed GA consistently finds better solutions than the conventional neural network.

Preparation of Porous Organically-Modified Silicate Hybrids for Cell Culture Matrix

2007 ◽  
Vol 330-332 ◽  
pp. 1177-1180 ◽  
Author(s):  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Yuki Shirosaki ◽  
T. Okayama ◽  
K. Kataoka ◽  
...  
Keyword(s):  
Cell Culture ◽  
Mammalian Cells ◽  
Pore Diameter ◽  
Sol Gel ◽  
Three Dimensional ◽  
Culture Methods ◽  
Organically Modified ◽  
Dimensional Cell

Porous & rubbery organic-inorganic hybrids were synthesized from tetraethoxysilane (TEOS) and polydimethylsiloxane (PDMS) through a sol-gel route using sieved sucrose granules as a porogen. The porous hybrids with a high content of PDMS behaved like polymer sponge. The porosity was over 90% irrespective of the hybrid composition and the pore diameter ranged from 100 to 500 μm. In the three-dimensional cell culture, mammalian cells were well cultured in the porous hybrids. The present results indicate that the hybrids may be a promising scaffold for developing such functional culture methods.

A Genetic Algorithm for Scheduling and Decomposition of Multidisciplinary Design Problems

1995 ◽  
Author(s):  
Stephen S. Altus ◽  
Ilan M. Kroo ◽  
Peter J. Gage
Keyword(s):  
Genetic Algorithm ◽  
Numerical Optimization ◽  
Heuristic Method ◽  
Merit Function ◽  
Multidisciplinary Design ◽  
Design Problems ◽  
Design Studies ◽  
Complex Design ◽  
Complex Engineering

Abstract Complex engineering studies typically involve hundreds of analysis routines and thousands of variables. The sequence of operations used to evaluate a design strongly affects the speed of each analysis cycle. This influence is particularly important when numerical optimization is used, because convergence generally requires many iterations. Moreover, it is common for disciplinary teams to work simultaneously on different aspects of a complex design. This practice requires decomposition of the analysis into subtasks, and the efficiency of the design process critically depends on the quality of the decomposition achieved. This paper describes the development of software to plan multidisciplinary design studies. A genetic algorithm is used, both to arrange analysis subroutines for efficient execution, and to decompose the task into subproblems. The new planning tool is compared with an existing heuristic method. It produces superior results when the same merit function is used, and it can readily address a wider range of planning objectives.

Solving Vibration Control Problems Using Reduced Order Models for Flexible Structures: A Genetic Algorithm Approach

1997 ◽  
Author(s):  
Sourav Kundu ◽  
Kentaro Kamagata ◽  
Shigeru Sugino ◽  
Takeshi Minowa ◽  
Kazuto Seto
Keyword(s):  
Genetic Algorithm ◽  
Vibration Control ◽  
Controller Design ◽  
Fitness Function ◽  
Flexible Structures ◽  
Design Solution ◽  
Reduced Order Models ◽  
Reduced Order ◽  
Fitness Value ◽  
Genetic Algorithm Approach

Abstract A Genetic Algorithm (GA) based approach for solution of optimal control design of flexible structures is presented in this paper. The method for modeling flexible structures with distributed parameters as reduced-order models with lumped parameters, which has been developed previously, is employed. Due to some restrictions on controller design it is necessary to make a reduced-order model of the structure. Once the model is established the design of flexible structures is considered as a feedback search procedure where a new solution is assigned some fitness value for the GA and the algorithm iterates till some satisfactory design solution is achieved. We propose a pole assignment method to determine the evaluation (fitness) function to be used by the GA to find optimal damping ratios in passive elements. This paper demonstrates the first results of a genetic algorithm approach to solution of the vibration control problem for practical control applications to flexible tower-like structures.

Towards Academic Successor Selection Modelling with Genetic Algorithm in Multi-Criteria Problems

2018 ◽  
Vol 7 (4.33) ◽  
pp. 130
Author(s):  
Atiqa Zukreena Zakuan ◽  
Shuzlina Abdul-Rahman ◽  
Hamidah Jantan ◽  
. .
Keyword(s):  
Genetic Algorithm ◽  
Decision Making ◽  
Succession Planning ◽  
Fitness Function ◽  
Academic Staff ◽  
Fitness Value ◽  
Selection Decision ◽  
The University ◽  
Hierarchy Process

Succession planning is a subset of talent management that deals with multi-criteria and uncertainties which are quite complicated, ambiguous, fuzzy and troublesome. Besides that, the successor selection involves the process of searching the best candidate for a successor for an optimal selection decision. In an academic scenario, the quality of academic staff contributes to achieving goals and improving the performance of the university at the international level. The process of selecting appropriate academic staff requires good criteria in decision-making. The best candidate's position and criteria for the selection of academic staff is the responsibility of the Human Resource Management (HRM) to select the most suitable candidate for the required position. The various criteria that are involved in selecting academic staff includes research publication, teaching skills, personality, reputation and financial performance. Previously, most studies on multi-criteria decision-making adopt Fuzzy Analytical Hierarchy Process (FAHP). However, this method is more complex because it involved many steps and formula and may not produce the optimum results. Therefore, Genetic Algorithm (GA) is proposed in this research to address this problem in which a fitness function for the successor selection is based on the highest fitness value of each chromosome.    

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