Tailoring Magnetic Microspheres with Controlled Porosity

AbstractThe synthesis of organic and inorganic nano- and microspheres has attracted much interest for a variety of applications ranging from drug delivery to chemical storage and catalysis. We recently demonstrated the assembly of magnetic nanoparticles and polycations into hybrid microspheres in a single-step synthesis via complex coacervation. These microspheres showed viability for bio-applications as indicated by toxicity tests, and are therefore potential targeted drug delivery devices, as they can be directed magnetically. This work reports the recent progress on the potential use of these assemblies in drug release by controlling their porosity. Fluorescein tagged dextran molecules with different MW have been infiltrated into these entities to determine critical pore size by confocal fluorescence microscopy. Different physicochemical characterization results are also presented.

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Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing

Pharmaceutics ◽

10.3390/pharmaceutics12020105 ◽

2020 ◽

Vol 12 (2) ◽

pp. 105 ◽

Cited By ~ 15

Author(s):

Sarah Stewart ◽

Juan Domínguez-Robles ◽

Victoria McIlorum ◽

Elena Mancuso ◽

Dimitrios Lamprou ◽

...

Keyword(s):

Drug Delivery ◽

3D Printing ◽

Three Dimensional ◽

In Vitro Models ◽

Implant Design ◽

The Past ◽

Drug Delivery Devices ◽

Potential Use ◽

Subcutaneous Implant

Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, the delivery of lower doses of drug, thus, potentially reducing side-effects and improving patient compliance. Three dimensional (3D) printing is a flexible technique, which has been subject to increasing interest in the past few years, especially in the area of medical devices. The present work focussed on the use of 3D printing as a tool to manufacture implantable drug delivery devices to deliver a range of model compounds (methylene blue, ibuprofen sodium and ibuprofen acid) in two in vitro models. Five implant designs were produced, and the release rate varied, depending on the implant design and the drug properties. Additionally, a rate controlling membrane was produced, which further prolonged the release from the produced implants, signalling the potential use of these devices for chronic conditions.

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Production of Drug Delivery Systems Using Fused Filament Fabrication: A Systematic Review

Pharmaceutics ◽

10.3390/pharmaceutics12060517 ◽

2020 ◽

Vol 12 (6) ◽

pp. 517 ◽

Cited By ~ 1

Author(s):

Bahaa Shaqour ◽

Aseel Samaro ◽

Bart Verleije ◽

Koen Beyers ◽

Chris Vervaet ◽

...

Keyword(s):

Systematic Review ◽

Drug Delivery ◽

Preparation Method ◽

Drug Loading ◽

Active Pharmaceutical Ingredient ◽

Healthcare Sector ◽

Polymeric Carrier ◽

Fused Filament Fabrication ◽

Drug Delivery Devices ◽

Potential Use

Fused filament fabrication (FFF) 3D printing technology is widely used in many fields. For almost a decade, medical researchers have been exploring the potential use of this technology for improving the healthcare sector. Advances in personalized medicine have been more achievable due to the applicability of producing drug delivery devices, which are explicitly designed based on patients’ needs. For the production of these devices, a filament—which is the feedstock for the FFF 3D printer—consists of a carrier polymer (or polymers) and a loaded active pharmaceutical ingredient (API). This systematic review of the literature investigates the most widely used approaches for producing drug-loaded filaments. It also focusses on several factors, such as the polymeric carrier and the drug, loading capacity and homogeneity, processing conditions, and the intended applications. This review concludes that the filament preparation method has a significant effect on both the drug homogeneity within the polymeric carrier and drug loading efficiency.

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Dental Drug-Delivery Devices: Local and Sustained-Release Applications

Critical Reviews in Therapeutic Drug Carrier Systems ◽

10.1615/critrevtherdrugcarriersyst.v16.i5.10 ◽

1999 ◽

Vol 16 (5) ◽

pp. 36 ◽

Cited By ~ 21

Author(s):

Doron Steinberg ◽

Michael Friedman

Keyword(s):

Drug Delivery ◽

Sustained Release ◽

Drug Delivery Devices

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Combinatorial design and development of biomaterials for use as drug delivery devices and immune adjuvants

10.31274/etd-180810-333 ◽

2011 ◽

Author(s):

Latrisha Kay Petersen

Keyword(s):

Drug Delivery ◽

Combinatorial Design ◽

Design And Development ◽

Immune Adjuvants ◽

Drug Delivery Devices

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Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

Current Pharmaceutical Design ◽

10.2174/1381612826666201112143230 ◽

2020 ◽

Vol 26 ◽

Author(s):

John Chen ◽

Andrew Martin ◽

Warren H. Finlay

Keyword(s):

Drug Delivery ◽

In Silico ◽

Local Drug Delivery ◽

In Vivo Studies ◽

Intranasal Drug Delivery ◽

Nasal Sprays ◽

In Silico Studies ◽

Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

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Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization

Current Neurovascular Research ◽

10.2174/1567202616666190619150956 ◽

2019 ◽

Vol 16 (3) ◽

pp. 258-265

Author(s):

Kei Takahashi ◽

Tomomi Masuda ◽

Mitsunori Harada ◽

Tadashi Inoue ◽

Shinsuke Nakamura ◽

...

Keyword(s):

Drug Delivery ◽

Choroidal Neovascularization ◽

Pigment Epithelium ◽

Drug Carrier ◽

Retinal Pigment ◽

Laser Coagulation ◽

Antiangiogenic Agents ◽

Drug Carrier System ◽

Novel Drug ◽

Drug Delivery Devices

Objective: This study aimed to examine whether DC101 (anti-VEGFR2 antibody)- modified micelles have applications as novel drug delivery devices, which allow small molecule antiangiogenic agents to deliver to angiogenic sites on a murine laser-induced choroidal neovascularization (CNV) model. Materials and Method: CNV was induced by photocoagulation on the unilateral eye of each mouse under anesthesia. Immediately after laser coagulation, E7974-loaded DC101-modified micelles and motesanib-loaded DC101-modified micelles were intravitreally administrated. Two weeks after photocoagulation, CNV was visualized using fluorescein-conjugated dextran (MW=2,000 kDa), and the CNV area was measured in retinal pigment epithelium (RPE)-choroidal flat mounts. Results: Intravitreal administration of both DC101-modified micelles loaded with E7974 at 2 µM and motesanib at 2 µM significantly reduced CNV area in the murine laser-induced CNV model at a clearly lower concentration than the effective dose of each agent. Conclusion: These results suggest that DC101-modified micelle might be effective drug carrier system for treating CNV and other ocular angiogenic diseases.

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Potential Use of Nanomedicine for Drug Delivery Across the Blood-Brain Barrier in Healthy and Diseased Brain

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527315666160915112210 ◽

2016 ◽

Vol 15 (9) ◽

pp. 1079-1091 ◽

Cited By ~ 6

Author(s):

Barbara Ruozi ◽

Daniela Belletti ◽

Francesca Pederzoli ◽

Flavio Forni ◽

Maria Angela Vandelli ◽

...

Keyword(s):

Drug Delivery ◽

Blood Brain Barrier ◽

Brain Barrier ◽

Blood Brain ◽

Potential Use

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Triggering Factors in Drug Delivery Devices

Current Pharmaceutical Design ◽

10.2174/138161282502190514121641 ◽

2019 ◽

Vol 25 (2) ◽

pp. 107-108

Author(s):

Anton Ficai

Keyword(s):

Drug Delivery ◽

Triggering Factors ◽

Drug Delivery Devices

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Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA

Cells ◽

10.3390/cells9092034 ◽

2020 ◽

Vol 9 (9) ◽

pp. 2034 ◽

Cited By ~ 5

Author(s):

Christian D. Siewert ◽

Heinrich Haas ◽

Vera Cornet ◽

Sara S. Nogueira ◽

Thomas Nawroth ◽

...

Keyword(s):

Small Angle ◽

Messenger Rna ◽

Physicochemical Characterization ◽

Single Step ◽

Model Systems ◽

Molecular Organization ◽

Hybrid Nanoparticles ◽

Polymer Mixture ◽

Internal Organization ◽

Transfection Efficacy

Hybrid nanoparticles from lipidic and polymeric components were assembled to serve as vehicles for the transfection of messenger RNA (mRNA) using different portions of the cationic lipid DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) and the cationic biopolymer protamine as model systems. Two different sequential assembly approaches in comparison with a direct single-step protocol were applied, and molecular organization in correlation with biological activity of the resulting nanoparticle systems was investigated. Differences in the structure of the nanoparticles were revealed by thorough physicochemical characterization including small angle neutron scattering (SANS), small angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryo-TEM). All hybrid systems, combining lipid and polymer, displayed significantly increased transfection in comparison to lipid/mRNA and polymer/mRNA particles alone. For the hybrid nanoparticles, characteristic differences regarding the internal organization, release characteristics, and activity were determined depending on the assembly route. The systems with the highest transfection efficacy were characterized by a heterogenous internal organization, accompanied by facilitated release. Such a system could be best obtained by the single step protocol, starting with a lipid and polymer mixture for nanoparticle formation.

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