Association of the rs17250932, rs4794067 and rs2240017 polymorphism in the TBX21 gene with autoimmune diseases

Objective: To evaluate systematically the association between TBX21 gene polymorphisms (rs17250932, rs2240017, and rs4794067) and the risk of autoimmune diseases in Asian populations. Methods: The Medline, Web of Science, and Chinese Biomedical Literature Database were used to retrieve eligible studies that were published before July 2020. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated by using the dominant model, heterozygote contrast model, and allelic contrast model. Publication bias was evaluated using contour-enhanced funnel plots and Egger’s regression test. Sensitivity analysis was conducted to assess the robustness of this meta-analysis.Results: A total of 12 eligible studies, including 3834 patients and 4824 healthy controls, were recruited in this meta-analysis. The pooled data demonstrated that TBX21 rs2240017 and rs4794067 polymorphisms were significantly associated with the risk of autoimmune diseases in Asian populations in allelic contrast model (OR: 1.456, 95% CI: 1.131–1.875, P = 0.004; OR: 0.766, 95% CI: 0.615–0.954, P = 0.017), heterozygote comparison model (OR: 1.647, 95% CI: 1.239–2.189, P = 0.001; OR: 0.796, 95% CI: 0.634–0.999, P = 0.049), and dominant model (OR: 1.572, 95% CI: 1.194–2.071, P = 0.004; OR: 0.767, 95% CI: 0.607–0.970, P = 0.027). The G allele of rs2240017 may be a risk factor for autoimmune diseases, and the T allele of rs4794067 may increase the risk of autoimmune diseases. However, we failed to find evidence of the association between TBX21 rs17250932 polymorphism and susceptibility to autoimmune diseases. No publication bias was established in this meta-analysis.Conclusion: This meta-analysis indicated that TBX21 rs2240017 and rs4794067 polymorphism confer susceptibility to autoimmune diseases, but not rs17250932.

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Association of NLRP3 rs35829419 and rs10754558 Polymorphisms With Risks of Autoimmune Diseases: A Systematic Review and Meta-Analysis

Frontiers in Genetics ◽

10.3389/fgene.2021.690860 ◽

2021 ◽

Vol 12 ◽

Author(s):

Zubo Wu ◽

Suyuan Wu ◽

Tao Liang

Keyword(s):

Autoimmune Diseases ◽

Latin American ◽

Lupus Erythematosus ◽

Subgroup Analysis ◽

Meta Analysis ◽

Recessive Model ◽

Disease Type ◽

Dominant Model ◽

Asian Populations

The existing knowledge about the association between NLRP3 rs35829419/rs10754558 polymorphisms and susceptibility to autoimmune diseases (AIDs) remains controversial. Herein, a meta-analysis was performed to evaluate such association. We searched databases for relevant studies published in English up to February 2021. Stata14 was used to assess the odds ratio (OR). As for NLRP3 rs35829419, no significant association to overall AIDs was found in three genetic models [A vs. C: OR (95%CI) = 0.89 (0.69–1.14); AC vs. CC: 1.00 (0.77–1.30); AA/AC vs. CC: 0.93 (0.71–1.20)]. However, subgroup analysis by disease type showed that NLRP3 rs35829419 A allele may have a significant protective effect on rheumatoid arthritis (RA) susceptibility [A vs. C: 0.74 (0.57–0.96)]. NLRP3 rs10754558 polymorphism contributes to significantly reduce the risk of AIDs in the allelic model [G vs. C: 0.78 (0.71–0.87)], homozygote co-dominant model [GG vs. CC: 0.63 (0.51–0.77)], heterozygote co-dominant model [GC vs. CC: 0.78 (0.66–0.91)], dominant model [GG/GC vs. CC: 0.73 (0.63–0.84)], and recessive model [GG vs. GC/CC: 0.73 (0.62–0.88)]. In the subgroup analysis by ethnicity, association was observed between the NLRP3 rs10754558 G allele and AIDs in Latin Americans, but not in European, Arabian, or Asian populations. Stratification by disease type showed a significant association of the NLRP3 rs10754558 G allele with type 1 diabetes (T1D), RA, and systemic lupus erythematosus (SLE), but not with celiac disease (CD), multiple sclerosis (MS), or myasthenia gravis (MG). This meta-analysis suggests that the NLRP3 rs10754558, but not rs35829419, polymorphism is associated with susceptibility to AIDs, especially in Latin American individuals.

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Influence of Mindfulness and Relaxation on Treatment of Essential Hypertension: Meta-Analysis

Journal of Healthcare Engineering ◽

10.1155/2021/2272469 ◽

2021 ◽

Vol 2021 ◽

pp. 1-7

Author(s):

Fushun Zhang ◽

Yuanyuan Zhang ◽

Nan Jiang ◽

Qiao Zhai ◽

Juanjuan Hu ◽

...

Keyword(s):

Blood Pressure ◽

Essential Hypertension ◽

Systolic Blood Pressure ◽

Publication Bias ◽

Effect Size ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

Control Group ◽

Effect Model

Background. Some studies published previously have shown a strong correlation between hypertension and psychological nature including impulsion emotion or mindfulness and relaxation temperament, among which mindfulness and relaxation temperament might have a benign influence on blood pressure, ameliorating the hypertension. However, the conclusion was not confirmed. Objective. The meta-analysis was performed to investigate the influence of mindfulness and relaxation on essential hypertension interventions and confirm the effects. Methods. Systematic searches were conducted in common English and Chinese electronic databases (i.e., PubMed/MEDLINE, EMBASE, Web of Science, CINAHL, PsycINFO, Cochrane Library, and Chinese Biomedical Literature Database) from 1980 to 2020. A meta-analysis including 5 studies was performed using Rev Man 5.4.1 software to estimate the influence of mindfulness and relaxation on blood pressure, ameliorating the hypertension. Publication bias and heterogeneity of samples were tested using a funnel plot. Studies were analyzed using either a random-effect model or a fixed-effect model. Results. All the 5 studies investigated the influence of mindfulness and relaxation on diastolic and systolic blood pressure, with total 205 participants in the control group and 204 in the intervention group. The random-effects model (REM) was used to calculate the pooled effect for mindfulness and relaxation on diastolic blood pressure (I2 = 0%, t2 = 0.000, P = 0.41 ). The random pooled effect size (MD) was 0.30 (95% CI = −0.81–1.42, P = 0.59 ). REM was used to calculate the pooled effect for mindfulness and relaxation on systolic blood pressure (I2 = 49%, t2 = 3.05, P = 0.10 ). The random pooled effect size (MD) was −1.05 (95% CI = −3.29–1.18, P = 0.36 ). The results of this meta-analysis were influenced by publication bias to some degree. Conclusion. All the results showed less influence of mindfulness and relaxation might act on diastolic or systolic blood pressure, when mindfulness and relaxation are used to intervene in treating CVD and hypertension.

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Association between lncRNA GAS5, MEG3, and PCAT-1 Polymorphisms and Cancer Risk: A Meta-Analysis

Disease Markers ◽

10.1155/2020/6723487 ◽

2020 ◽

Vol 2020 ◽

pp. 1-13 ◽

Cited By ~ 3

Author(s):

Xiaoyan Dong ◽

Wenyan Gao ◽

Xiaoling LV ◽

Yazhen Wang ◽

Qing Wu ◽

...

Keyword(s):

Gastric Cancer ◽

Cancer Risk ◽

Publication Bias ◽

Fixed Effects ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Biomedical Literature ◽

Cochrane Library ◽

Gastric Cancer Risk ◽

Lncrna Gas5

Purpose. Long noncoding RNAs (lncRNAs) have been widely studied, and single nucleotide polymorphisms (SNPs) in lncRNAs are considered to be genetic factors that influence cancer susceptibility. The lncRNA GAS5, MEG3, and PCAT-1 polymorphisms are shown to be possibly associated with cancer risk. The aim of this meta-analysis was to systematically evaluate this association. Methods. Studies were selected from PubMed, Web of Science, Embase, Google Scholar, Cochrane Library, the Chinese National Knowledge Infrastructure (CNKI), and the Chinese Biomedical Literature Database (CBM) through inclusion and exclusion criteria. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using the random-effects model or fixed-effects model to assess the association between lncRNA polymorphisms and cancer susceptibility. Metaregression and publication bias analyses were also conducted. All analyses were performed using the Stata 12.0 software. Results. Sixteen articles (covering 13750 cases and 17194 controls) were included in this meta-analysis. A significant association between SNP rs145204276 and gastric cancer risk was observed (del vs. ins: OR=0.79, 95%CI=0.72‐0.86; del/del vs. ins/ins+del/ins: OR=0.74, 95%CI=0.59‐0.91; del/ins vs. ins/ins: OR=0.84, 95%CI=0.67‐1.05). For rs16901904, a decreased cancer risk was observed in three genetic models (C vs. T: OR=0.79, 95%CI=0.70‐0.90; CC vs. CT+TT: OR=0.49, 95%CI=0.37‐0.65; CC vs. TT: OR=0.49, 95%CI=0.37‐0.66). No statistical significance was found in the metaregression analysis. For all of the included SNPs, no publication bias was found in all genotype models. Conclusions. The rs145204276 SNP in lncRNA GAS5 is likely to be associated with gastric cancer risk, whereas the rs16901904 SNP in lncRNA PCAT-1 bears association with a decreased cancer risk.

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Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case–control studies

Bioscience Reports ◽

10.1042/bsr20190741 ◽

2019 ◽

Vol 39 (8) ◽

Cited By ~ 1

Author(s):

Xingliang Feng ◽

Dan Ji ◽

Chaozhao Liang ◽

Song Fan

Keyword(s):

Breast Cancer ◽

Cancer Risk ◽

Structure Prediction ◽

Genetic Model ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Case Control Studies ◽

Stem Loop ◽

Contrast Model ◽

Pooled Data

Abstract Piles of evidence have supported the relationship between miR-618 rs2682818 polymorphism and tumorigenesis, but the conclusion remains inconsistent. In the present study, we conducted a meta-analysis to sniff out the potential risk between miR-618 rs2682818 and overall cancers. Crude odds ratios (ORs) and 95% confidence intervals (CIs) analyzed by Z-test were employed to estimate the potential interrelation in five genetic models. We also prospected how the rs2682818 affects the second structure of miR-618. Finally, 10 independent studies meet the enrolled criteria, along with 4099 cancer cases and 5057 healthy controls. Overall, no exceeding interrelation was sniffed out in the pooled data among five inherited models, as well as stratified analyses. Whereas, the enhanced cancer risk of miR-618 rs2682818 variant stratified by breast cancer was revealed, in heterozygote genetic model (AC vs. CC: OR = 1.291, 95%CI = 1.012–1.648, P = 0.040) and dominant contrast model (AA + AC vs. CC: OR = 1.280, 95%CI = 1.009–1.623, P = 0.042). The second structure prediction result shown that the mutant A allele might change the first stem-loop of miR-618, and the free energy of it would turn from –39.1 to –35.1 kcal/mol. All in all, our meta-analysis had successfully chased down that miR-618 rs2682818 polymorphism is not linked with overall cancer risk, but in the dominant genotype of breast cancer.

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Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies

PLoS ONE ◽

10.1371/journal.pone.0255292 ◽

2021 ◽

Vol 16 (8) ◽

pp. e0255292

Author(s):

S. Jauhar ◽

L. Fortea ◽

A. Solanes ◽

A. Albajes-Eizagirre ◽

P. J. McKenna ◽

...

Keyword(s):

Publication Bias ◽

Meta Analysis ◽

Cingulate Cortex ◽

Cortical Activation ◽

Monetary Reward ◽

Pooled Data ◽

Reward Anticipation ◽

Combining Data ◽

Wide Range ◽

Meta Analyses

Background While multiple studies have examined the brain functional correlates of reward, meta-analyses have either focused on studies using the monetary incentive delay (MID) task, or have adopted a broad strategy, combining data from studies using both monetary and non-monetary reward, as probed using a wide range of tasks. Objective To meta-analyze fMRI studies that used monetary reward and in which there was a definable cue-reward contingency. Studies were limited to those using monetary reward in order to avoid potential heterogeneity from use of other rewards, especially social rewards. Studies using gambling or delay discounting tasks were excluded on the grounds that reward anticipation is not easily quantifiable. Study eligibility English-language fMRI studies (i) that reported fMRI findings on healthy adults; (ii) that used monetary reward; and (iii) in which a cue that was predictive of reward was compared to a no win (or lesser win) condition. Only voxel-based studies were included; those where brain coverage was incomplete were excluded. Data sources Ovid, Medline and PsycInfo, from 2000 to 2020, plus checking of review articles and meta-analyses. Data synthesis Data were pooled using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI). Heterogeneity among studies was examined using the I2 statistic. Publication bias was examined using funnel plots and statistical examination of asymmetries. Moderator variables including whether the task was pre-learnt, sex distribution, amount of money won and width of smoothing kernel were examined. Results Pooled data from 45 studies of reward anticipation revealed activations in the ventral striatum, the middle cingulate cortex/supplementary motor area and the insula. Pooled data from 28 studies of reward delivery again revealed ventral striatal activation, plus cortical activations in the anterior and posterior cingulate cortex. There was relatively little evidence of publication bias. Among moderating variables, only whether the task was pre-learnt exerted an influence. Conclusions According to this meta-analysis monetary reward anticipation and delivery both activate the ventral but not the dorsal striatum, and are associated with different patterns of cortical activation.

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A Meta-Analysis for Association of ACE I/D Polymorphism with Susceptibility to Preterm Birth

World Journal of Peri & Neonatology ◽

10.18502/wjpn.v3i2.6157 ◽

2021 ◽

Author(s):

Reza Bahrami ◽

Seyed Alireza Dastgheib ◽

Hossein Golestanpour ◽

Elahe Akbarian ◽

Alireza Emarati ◽

...

Keyword(s):

Preterm Birth ◽

Fixed Effects ◽

Meta Analysis ◽

Recessive Model ◽

Biomedical Literature ◽

Case Control Studies ◽

China National Knowledge Infrastructure ◽

Pooled Data ◽

Increased Risk ◽

Study Heterogeneity

Background: Preterm birth is one of the main contributors to newborn mortality, morbidity, and hospitalization in the first year of life globally. To date, several numbers of studies have reported that Angiotensin-Converting enzyme Insertion/Deletion polymorphism (ACE I/D) is linked with preterm birth. But those results are conflicting. Thus, we carried out this meta-analysis to summarize the existing data and evaluated the association. Methods: All eligible studies were collected from PubMed, Scopus, SciELO, MedRxiv, SID, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBLD) up to 01 March 2021. The pooled odds ratios (ORs) and 95% confidence interval (CIs) under all five genetic models were calculated using either random-effects or fixed-effects models dependent on study heterogeneity. Results: A total of five case-control studies with 480 preterm birth cases and 702 healthy subjects were included. Pooled data showed that the ACE I/D polymorphism was significantly associated with increased risk of preterm birth under the allele model (I vs. D: OR = 1.219, 95% CI 1.023-1.453, P = 0.027), homozygote model (II vs. DD: OR = 0.662, 95% CI 1.149-2.385, P = 0.007), and recessive model (DD vs. DI+II: OR = 0.707, 95% CI 1.082-1.948, P = 0.013). Stratified analysis by ethnicity indicated that the ACE I/D polymorphism was significantly associated with preterm birth in Caucasian descendants. Conclusion: Our pooled data revealed that ACE I/D polymorphism is associated with the risk of preterm birth. However, larger and more rigorous studies among different populations are needed to evaluate the association with preterm birth.

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Catechol-O-methyltransferase (COMT) Val158Met Polymorphism and susceptibility to alcohol dependence

10.1101/2020.04.26.20081273 ◽

2020 ◽

Author(s):

Amrita Chaudhary ◽

Pradeep Kumar ◽

Vandana Rai

Keyword(s):

Risk Factor ◽

Alcohol Dependence ◽

Keyword Search ◽

Meta Analysis ◽

Recessive Model ◽

Dominant Model ◽

Contrast Model ◽

Methyl Transferase ◽

Comt Val158met ◽

Val158met Polymorphism

Catechol-O-methyl transferase (COMT) enzyme catalyzes the metabolism of dopamine and other catechols in the brain. Several articles investigated catechol-O-methyltransferase (COMT) Val158Met polymorphism as risk factor for alcohol dependence (AD) but the results were inconclusive. The aim of present meta-analysis was to evaluate the association of Val158Met (COMT) polymorphism with AD. Authors performed keyword search of the four electronic databases- Pubmed, Google Scholar, Springer Link and Science Direct databases up to December 31,2019 . Total eighteen studies that investigated the association of Val158Met polymorphism with AD were retrieved. The pooled results from the meta-analysis (2,278 AD cases and 3717 healthy controls) did not show association with AD using all five genetic models (allele contrast model: OR = 1.02, 95% CI= 0.90-1.14, p= 0.03; homozygote model: OR = 1.06, 95% CI= 0.81-1.38, p= 0.69; dominant model: OR = 0.99, 95% CI= 0.85-1.14, p= 0.87; co-dominant model: OR = 0.97, 95% CI= 0.86-1.11, p= 0.71; recessive model: OR = 1.05;95% CI= 0.85-1.29, p=0.61). Results of subgroup analysis showed that Val158Met is not risk for AD in Asian and Caucasian population. In conclusion, COMT Val158Met is not a risk factor for alcohol dependence.

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Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis

10.21203/rs.3.rs-446988/v1 ◽

2021 ◽

Author(s):

Zhihua Hu ◽

Shaowen Cheng ◽

Xini Liu ◽

Lina Xian ◽

Xinyuan Liang ◽

...

Keyword(s):

Gene Polymorphism ◽

Publication Bias ◽

Meta Analysis ◽

Relevant Literature ◽

Recessive Model ◽

Mannose Binding Lectin ◽

Dominant Model ◽

Mannose Binding ◽

Binding Lectin ◽

Allele Model

Abstract Objective To assess the association between the Mannose-binding lectin (MBL) gene polymorphism and the susceptibility to sepsis using a meta-analysis.Methods The publications were searched on PubMed, Embase, and Web of Science databases up to December 1, 2019 for relevant literature. Results A total of 32 studies (21 adult and 11 pediatric studies) were selected for analysis. Overall, in the three models of MBL +54 A/B gene polymorphisms, namely the dominant model BB + AB vs. AA (p = 0.03), the recessive model BB vs. AB + AA (p < 0.00001), and the allele model B vs. A (p = 0.04), MBL +54A/B was significantly related to the risk of sepsis. In the adult group, the MBL A/O gene polymorphism was associated with the risk of sepsis in the dominant model AO + OO vs. AA (p = 0.006) as well as in the allele model O vs. A (p = 0.04). The MBL +54A/B gene polymorphism was significantly related to the risk of sepsis in the recessive model and, therefore, may increase the risk of sepsis. In the pediatric group, no polymorphic loci were significantly associated with sepsis in any of the three models. The results of the publication bias test demonstrated no publication bias in an unadjusted estimate of the relationship between MBL A/O and -211Y/X gene polymorphism and sepsis.

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Was Antiphospholipid Syndrome a Risk Factor of Stroke? A Systemic Review and Meta-Analysis of Cohort Studies

Disease Markers ◽

10.1155/2021/4431907 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Kai Zhao ◽

Ping Zhou ◽

Ling Xu ◽

Ruili Li ◽

Jincai Yang ◽

...

Keyword(s):

Risk Factor ◽

Autoimmune Diseases ◽

Cohort Studies ◽

Publication Bias ◽

Antiphospholipid Syndrome ◽

Meta Analysis ◽

Random Effect ◽

Random Effect Model ◽

Systemic Review ◽

Effect Model

Antiphospholipid syndrome (APS) is characterized by thrombosis. This systemic review and meta-analysis was to verify the hypothesis that APS might increase the risk of stroke. Studies were identified after literature searching of PubMed, Embase, and Cochrane. Newcastle-Ottawa Quality Assessment Scale Cohort Studies (NOQAS-C) was used to assess the quality of studies. The pooled effect with 95% confidence interval (95% CI) was calculated by random-effect model. I -square ( I 2 ) was used to test heterogeneity. Funnel plot was used to evaluate publication bias. A total of 17 cohort studies with overall high quality were included. There was no publication bias. Pooled hazard ratio of stroke occurrence in APS patients was 1.76 (1.39-2.21) with low heterogenicity and stable result from sensitivity analysis. In the analysis of subgroups, pooled risk ratios of stroke occurrence in patients with only positive antibodies of APS diagnosis were 1.75 (0.99-3.09), which for the APS patients with other autoimmune diseases were 14.70 (7.56-28.56). APS might be a risk factor of stroke, especially in patients with other autoimmune diseases.

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ADRB2 Arg16Gly Polymorphism and Pulmonary Function Response of Inhaled Corticosteroids plus Long-Acting Beta Agonists for Asthma Treatment: A Systematic Review and Meta-Analysis

Canadian Respiratory Journal ◽

10.1155/2018/5712805 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 1

Author(s):

Xi Wang ◽

Qian Li ◽

Ruming Liu ◽

Jin He ◽

Di Wu ◽

...

Keyword(s):

Systematic Review ◽

Pulmonary Function ◽

Publication Bias ◽

Inhaled Corticosteroids ◽

Meta Analysis ◽

Clinical Effectiveness ◽

Biomedical Literature ◽

Asthma Treatment ◽

Long Acting ◽

Arg16gly Polymorphism

Background. The beta-2 adrenergic receptor (ADRB2) Arg16Gly polymorphism may alter the bronchodilation response to long-acting beta2-agonists, thereby influencing the clinical effectiveness of LABAs plus corticosteroids (ICS) treatment. But the results of individual studies are inconclusive. Methods. A systematic search was conducted in PubMed, Embase, the Cochrane Database, WHO International Clinical Trials Registry Platform, Chinese National Knowledge Infrastructure, Wanfang, Chinese BioMedical Literature Database, and VIP databases. The meta-analysis was performed with RevMan statistical software (version 5.2), and potential publication bias was estimated by Egger’s test using STATA (version 12.0), with p<0.05 indicating significant publication bias. Results. We found 5 cohort studies with a total of 632 patients and included them in the meta-analysis. There are no significant differences in pulmonary function response between patients with the Arg/Arg and Arg/Gly phenotype (SMD −0.04, 95% CI −0.45 to 0.37; p=0.84). There were also no significant differences in the pulmonary function response between patients with the Arg/Arg and Gly/Gly phenotype (MD −0.03, 95% CI −0.07 to 0.02; p=0.28). Conclusions. Our systematic review and meta-analysis suggest that ADRB2 Arg16Gly polymorphism is not associated with pulmonary response to asthma treatment with ICS plus LABAs.

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