scholarly journals Impact of ranolazine on exercise tolerance and arrhythmias in patients with INOCA

2021 ◽  
pp. 10-15
Author(s):  
Vira Tseluyko ◽  
Tetyana Pylova
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries ◽  
Exercise Test ◽  
Exercise Tolerance ◽  
Ventricular Arrhythmias ◽  
Ecg Monitoring ◽  
Holter Ecg ◽  
Group I ◽  
Group Ii

The aim of the study to evaluate the effect of supplementation of basic therapy by ranolazine in patients with INOCA on exercise test parameters and Holter ECG monitoring. Materials and methods. 53 patients with stable coronary heart disease were examined, including 18 men (33.9 %) and 35 (66 %) women, the average age of patients was 57 (±9.68) years. According to the results of coronary angiography all patients had non-obstructive coronary arteries. In addition to physical and laboratory examination, bicycle ergometry, Holter ECG monitoring and echocardiography were included in the examination of patients. Patients were divided into 2 groups: group I - patients who in addition to standard therapy received ranolazine at a dose of 1000 mg twice a day for 6 months, and group II patients with standard coronary heart disease therapy. After 6 months from the beginning of the observation an objective examination, echocardiography, exercise test, Holter ECG monitoring were repeated. Results. The study found that patients receiving ranolazine in addition to standard therapy had a statistically significant increase in exercise duration after 6 months compared with baseline and group II. Before treatment in group I, the duration of the exercise test was 356.51±180.24s, and after treatment 414.32±142.10s (p=0.03). In group II, the duration of the test before treatment was 361.4±160.24 c, and after 380.5±152.2 s (p=0.15). It was also found that the duration of the test differed significantly in group I after treatment of patients from group II after treatment of patients with a standard treatment regimen (p=0.04). According to the results of Holter ECG monitoring in group I found a positive effect of ranolazine on the frequency of ventricular arrhythmias: before treatment n=1142 [30; 2012], after treatment n=729 [23; 1420], while in group II a significant difference between the number of extrasystoles before treatment and after not detected (n=1026 [17; 1920], n=985 [15; 1680], respectively) p=0.18. Conclusions. The addition of ranolazine to the basic therapy of patients with non-obstructive coronary arteries disease helps to increase exercise tolerance (according to the loading stress test) and contributes to a significant reduction in the number of ventricular arrhythmias (according to Holter-ECG) compared with both baseline and group II

scholarly journals Results of holter monitoring in patients with coronary heart disease depending on the severity of atherosclerotic lesions of the coronary arteries

2021 ◽  
pp. 15-19
Author(s):  
Tetiana Pylova
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Comparative Analysis ◽  
Myocardial Ischemia ◽  
Coronary Arteries ◽  
Holter Monitoring ◽  
Group I ◽  
St Segment ◽  
Stable Coronary Heart Disease ◽  
Group Ii

The aim – to conduct a comparative analysis of the presence, frequency and duration of episodes of myocardial ischemia and arrhythmias based on the results of Holter monitoring in patients with coronary heart disease depending on the condition of the coronary arteries. Materials and methods. We examined 53 patients (group I) with stable coronary heart disease (CHD) and slightly altered coronary arteries (INOCA), who were hospitalized in the period from October 2018 to February 2021 at the “City Clinical Hospital № 8” of Kharkiv City Council. Group II included 52 patients with a diagnosis of stable coronary heart disease, and according to coronary angiography (CAG) had stenosis of coronary arteries (CA) more than 50 %. Results. According to the results of comparative analysis, it was found that in group I there were signs of myocardial ischemia – depression of the ST segment in 62.3 % (n=33) and elevation of the ST segment in 11.3 % (n=6), compared with group II -73 % (n=38) and 5.66 % (n=3), respectively. Ventricular arrhythmias (VA) have been reported in 52 patients of group I, and in 44 patients of group II. VA 4 and 5 type according to Laun, was significantly higher in group II compared with group I (p=0.0324). The occurrence of ventricular tachycardia was recorded in 5.7 % (n=3) of patients in group I and 9.3 % (n=5) patients of group II (p=0.347). In group II, there was a tendency to more episodes of ischemia compared with group I (p=0.072). The duration of ischemia was significantly longer in group I, compared with group II (p=0.042). Conclusions. The results of the study did not show significant differences in the development of the number of episodes of myocardial ischemia according to Holter monitoring depending on the condition of the coronary arteries. The duration of episodes of ischemia in patients with INOCA is significantly longer than in patients with obstructive atherosclerosis. In patients with coronary heart disease with obstructive coronary arteries, ventricular arrhythmia was statistically significantly more severe according to Lown

scholarly journals Effect of Mobile Internet on Attitude and Self-Efficacy of Patients with Coronary Heart Disease Diagnosed by 12-Lead Holter ECG

2022 ◽  
Vol 2022 ◽  
pp. 1-7
Author(s):  
Haitao Sun ◽  
Jing Li ◽  
Yue Wang ◽  
Xiaoke Ma
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Clinical Data ◽  
Self Efficacy ◽  
Mobile Internet ◽  
Control Group ◽  
Study Group ◽  
Holter Ecg ◽  
Group I ◽  
Group Ii

Objective. To explore the effect of mobile Internet on attitude and self-efficacy of patients with coronary heart disease (CHD) diagnosed by 12-lead Holter ECG. Methods. The clinical data of 62 patients with CHD who underwent routine ECG examination (control group I) and 12-lead dynamic electrocardiogram (control group II) in our hospital (June 2017–December 2020) were retrospectively analyzed, and the clinical data of another 62 patients with CHD who received 12-lead Holter ECG examination combined with mobile Internet in our hospital at the same time (study group) were retrospectively analyzed. The clinical observation indexes of the three groups were compared. Results. No obvious difference in general data among groups ( P > 0.05 ). Compared with the control group I, the positive detection rate (PDR) of the study group and the control group II was obviously higher ( P < 0.05 ), and the PDR of the study group was obviously higher than that of the control group II, without remarkable difference between both groups ( P > 0.05 ). Compared with the control group, the scores of CAS-R of the study group were obviously higher ( P < 0.05 ), and self-efficacy of daily life, health behaviors, medication compliance, and compliance behavior of the study group was obviously better ( P < 0.05 ). The diagnostic efficacy was derived by ROC curve analysis, 12-lead Holter ECG combined with mobile Internet + routine ECG > 12-lead Holter ECG combined with mobile Internet > 12-lead Holter ECG > routine ECG. Conclusion. Compared with the routine ECG, the sensitivity of 12-lead Holter ECG in the diagnosis of CHD is conspicuously higher. Meanwhile, 12-lead Holter ECG combined with mobile Internet can enhance the diagnostic efficiency and improve patients’ perceived control attitude and self-efficacy.

scholarly journals Different tactics of single-stent endovascular treatment among coronary heart disease patients with coronary artery bifurcation lesions

2012 ◽  
Vol 11 (2) ◽  
pp. 39-43
Author(s):  
Z. Kh. Shugushev ◽  
Yu. V. Tarichko ◽  
Yu. A. Vasyuk
Keyword(s):  
Coronary Heart Disease ◽  
Blood Flow ◽  
Heart Disease ◽  
Coronary Artery ◽  
Balloon Angioplasty ◽  
Ecg Changes ◽  
Timi Grade ◽  
Group I ◽  
Bifurcation Lesions ◽  
Group Ii

Aim. To analyze the results of different tactics of single-stent endovascular treatment among patients with coronary heart disease (CHD) and coronary artery bifurcation lesions (CABL). Material and methods. The study included 135 CHD patients with CABL. All participants were divided into 2 groups: Group I (n=77; 58,3 %) consisted of patients who underwent coronary artery (CA) main branch (MB) stenting and subsequent kissing balloon angioplasty of a CA side branch (SB). Group II (n=55) included patients with “genuine” CABL, who underwent only MB stenting with SB protection, but without SB balloon angioplasty. Results. In all 132 CABL patients, drug-eluting stents were successfully implanted, with technical effectiveness of 100 % and in-hospital survival of 100 %. Clinical outcomes were similar in both groups, with no major cardiovascular events registered. At the same time, such an important angiographic index as SB diameter was significantly higher in Group I, compared to Group II. At later stages, Group II patients required SB angioplasty and demonstrated habitual angina symptoms, ischemic electrocardiographic (ECG) changes, and slow SB blood flow (TIMI grade <III) after CA MB stenting. Conclusion. MB stenting of CA bifurcation without SB kissing balloon angioplasty cannot be recommended to all CABL patients. Development of habitual angina symptoms, ischemic ECG changes, and slow SB blood flow (TIMI grade <III) often requires subsequent SB kissing balloon angioplasty.

scholarly journals Clinical Course of Coronary Heart Disease Concomitant with Asthma

2020 ◽  
Vol 10 (2) ◽  
pp. 131-138
Author(s):  
N. Y. Grigoryeva ◽  
T. P. Ilyushina ◽  
K. S. Kolosova ◽  
N. B. Koroleva ◽  
A. A. Streltsova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bronchial Asthma ◽  
Left Ventricular ◽  
Ecg Monitoring ◽  
Holter Ecg ◽  
Arterial Blood ◽  
Significant Difference

The research purpose: to study features of clinical process of a coronary heart disease when it combines with a bronchial asthma.The materials and methods: 180 people were included in the research, 90 of them suffer from both CHD and BA (the first group), and also 90 people have only CHD without BA (the second group). The examination included complaint collection process, studying medical history, medical examination, percussion, auscultation, blood pressure measurement with the Korotkov’s method twice a day (in the morning and in the evening), heart rate measurement, 24-hour Holter ECG monitoring, echodoplercardiography. Besides, standard laboratory biochemical testing, including total cholesterol and lowdensity lipoprotein cholesterol, were made with the enzymatic colorimetric method.The results. Dyspnoea is the main complaint among 86 patients with both CHD and asthma, humans have (95,5%), moreover, dyspnoea combines with heartbeating in 73,8%, and is accompanied by angina pectoris only in 20%. There is a significant difference between systolic and diastolic blood pressure (р=0,001) that becomes higher if CHD combines with asthma. The signs of left ventricular and interventricular septum hypertrophy were discovered in the first group, these signs statistically significantly differ from the ones in the second group. The medium pulmonary arterial pressure is significantly higher in the combined group than in the group with only CHD (р=0,001). It is revealed with 24-hour Holter ECG monitoring that cases of myocardial ischemia are more frequent in the group which consists of patients with CHD. Besides, duration of ischemic depression per day is longer in this group too. It might be that if patients have both CHD and asthma they do not reach an ischemic threshold because of dyspnoea due to a respiratory failure.The conclusion. According to our findings bronchial asthma occurs among patients with coronary heart disease in 16.6% of cases. It is a distinctive feature of a bronchial asthma associated with coronary heart disease, that a patient often complaints to dyspnea (cardiopulmonary) and palpitation, increase in arterial blood pressure and heart rate, which appropriately indicates the activation of rennin-angiotensin-aldosteron and sympathicoadrenal systems. It requires the inclusion of appropriate drug groups in the treatment of patients.

scholarly journals Importance of early diagnostics of chronic obstructive pulmonary disease in patients with coronary heart disease

2011 ◽  
Vol 10 (3) ◽  
pp. 47-50
Author(s):  
A. N. Kuznetsov ◽  
N. Yu. Grigoryeva ◽  
E. G. Sharabrinv
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Early Diagnostics ◽  
Obstructive Pulmonary Disease ◽  
Group I ◽  
Study Results ◽  
Group Ii

Aim. To study the specific clinical features in patients with coronary heart disease, CHD (stable effort angina, SEA) and chronic obstructive pulmonary disease (COPD), in order to improve early diagnostics of this combined pathology. Material and methods. The study was a retrospective analysis of 958 medical histories. Co-existing COPD was registered in 251 patients (26,3 %). Therefore, Group I included 251 patients with SEA and COPD (26,3 %), while Group II included 707 SEA patients without COPD (73,7 %). Results. In Group I, there were more men than women, by 5,7 % (р<0,05). No significant differences in age and angina functional class were observed between Groups I and II. In patients with SEA and COPD, the prevalence of arterial hypertension and myocardial infarction was higher than in Group II (р<0,05). In addition, Group I was characterised by higher prevalence of dyspnoea, palpitation, C-reactive protein elevation, and lipid metabolism disturbances. Conclusion. Among chronic CHD patients hospitalized to the cardiology unit, co-existing COPD was registered in 26,3 %. The combination with COPD aggravated the clinical course of CHD. The study results support the use of lung function assessment in smoking CHD patients, to diagnose co-existing COPD.

scholarly journals Clinical Course of Coronary Heart Disease Concomitant with Asthma

2020 ◽  
Vol 10 (2) ◽  
pp. 131-138
Author(s):  
N. Y. Grigoryeva ◽  
T. P. Ilyushina ◽  
K. S. Kolosova ◽  
N. B. Koroleva ◽  
A. A. Streltsova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Bronchial Asthma ◽  
Left Ventricular ◽  
Ecg Monitoring ◽  
Holter Ecg ◽  
Arterial Blood ◽  
Significant Difference

The research purpose: to study features of clinical process of a coronary heart disease when it combines with a bronchial asthma.The materials and methods: 180 people were included in the research, 90 of them suffer from both CHD and BA (the first group), and also 90 people have only CHD without BA (the second group). The examination included complaint collection process, studying medical history, medical examination, percussion, auscultation, blood pressure measurement with the Korotkov’s method twice a day (in the morning and in the evening), heart rate measurement, 24-hour Holter ECG monitoring, echodoplercardiography. Besides, standard laboratory biochemical testing, including total cholesterol and lowdensity lipoprotein cholesterol, were made with the enzymatic colorimetric method.The results. Dyspnoea is the main complaint among 86 patients with both CHD and asthma, humans have (95,5%), moreover, dyspnoea combines with heartbeating in 73,8%, and is accompanied by angina pectoris only in 20%. There is a significant difference between systolic and diastolic blood pressure (р=0,001) that becomes higher if CHD combines with asthma. The signs of left ventricular and interventricular septum hypertrophy were discovered in the first group, these signs statistically significantly differ from the ones in the second group. The medium pulmonary arterial pressure is significantly higher in the combined group than in the group with only CHD (р=0,001). It is revealed with 24-hour Holter ECG monitoring that cases of myocardial ischemia are more frequent in the group which consists of patients with CHD. Besides, duration of ischemic depression per day is longer in this group too. It might be that if patients have both CHD and asthma they do not reach an ischemic threshold because of dyspnoea due to a respiratory failure.The conclusion. According to our findings bronchial asthma occurs among patients with coronary heart disease in 16.6% of cases. It is a distinctive feature of a bronchial asthma associated with coronary heart disease, that a patient often complaints to dyspnea (cardiopulmonary) and palpitation, increase in arterial blood pressure and heart rate, which appropriately indicates the activation of rennin-angiotensin-aldosteron and sympathicoadrenal systems. It requires the inclusion of appropriate drug groups in the treatment of patients.

Ventricular tachyarrhythmias

2019 ◽  
pp. 265-276
Author(s):  
Eduard Guasch ◽  
Lluís Mont
Keyword(s):  
Heart Disease ◽  
Exercise Test ◽  
Ventricular Arrhythmias ◽  
Competitive Sport ◽  
Ventricular Tachyarrhythmias ◽  
Holter Ecg ◽  
Exploratory Testing ◽  
Increased Risk ◽  
Cardiac Condition ◽  
Exercise Induced

The identification of ventricular arrhythmias in athletes should always be carefully considered because of the increased risk of SCD. The main factor determining this risk is the presence of an underlying structural or primary arrhythmic heart disease. Consequently, the identification of ventricular arrhythmias in an athlete should prompt exploratory testing, most commonly involving 24-hour Holter ECG, echocardiography, and an exercise test. Other tests should be considered on an individual basis. In general, the more frequent and complex the ventricular arrhythmias, the higher are the risks of a heart disease, and a more thorough examination is required. While most arrhythmias in athletes without heart disease are idiopathic ventricular arrhythmias, considerable attention has been paid recently to an exercise-induced substrate for ventricular arrhythmias, similar to classic forms of arrhythmogenic ventricular cardiomyopathy. Overall, the identification of a cardiac condition will determine the prognosis, therapeutic approach, and eligibility for competitive sport.

scholarly journals Coronary artery status in patients with coronary heart disease and chronic obstructive pulmonary disease: results of selective coronary angiography

2012 ◽  
Vol 11 (5) ◽  
pp. 29-32
Author(s):  
N. Yu. Grigorieva ◽  
E. G. Sharavrin ◽  
A. N. Kuznetsov ◽  
T. V. Koroleva ◽  
P. A. Blinov ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Selective Coronary Angiography ◽  
Group I ◽  
Group Ii

Aim. To study the specifics of coronary artery pathology in patients with coronary heart disease (CHD) and chronic obstructive pulmonary disease (COPD), using the data of selective coronary angiography (CAG). Material and methods. In total, 907 CHD patients were examined. Group I included 251 participants with CHD and COPD; Group II included 656 individuals with CHD only. CAG was performed in 582 patients (64,2%): 184 from Group I (73,3%) and 398 from Group II (60,7%). Results. In patients with the combination of cardiac and pulmonary disease, the prevalence of two- and three-vessel pathology was higher, compared to CHD-only patients: 70,6% in Group I vs. 53,8% in Group II (p=0,002). In Group I, the Syntax Scale score was significantly higher than in Group II (24,7±4,1 vs. 18,7±3,1, respectively). Conclusion. Patients with combined cardiac and pulmonary pathology demonstrated a more severe coronary artery atherosclerosis, based on such CAG parameters as stenosis degree, number of involved vessels, size and location of lesions, and proximal stenosis.

scholarly journals Сompliance in patients with coronary heart disease and erosive-ulcerative gastroduodenopathy

2020 ◽  
pp. 82-87
Author(s):  
A. R. Molchanova ◽  
A. I. Dolgushina ◽  
A. A. Seljanina
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Rating Scale ◽  
Group I ◽  
Group Ii ◽  
Ulcerative Lesions ◽  
Artery Disease ◽  
Gastroduodenal Zone

Aim: To study the compliance features of patients with coronary artery disease and erosive-ulcerative lesions of the gastroduodenal zone.Methods: The study included 93 patients: 55 (59%) men and 38 (41%) women. Comorbidity indices Charlson, Kaplan-Feinstein and CIRS-G (Cumulative lllness Rating Scale for Geriatrics) system, anxiety and depression scores were calculated for all patients. The questionnaire Kadyrov R. V. et al. “The level of compliance was used to evaluate patient adherence. Statistical processing was performed using PAST (v. 3.21; Hammer et al., 2001) and MedCalc (v. 13.0; MedCalc®).Results: All patients are divided into two groups: group I—30 (32%) patients with coronary artery disease with erosive and ulcerative lesions of the stomach and duodenum, group II—63 (68%) patients with coronary artery disease without erosive-ulcerative gastroduodenopathies. We found significant intergroup differences in patients according to the CIRS-G and KAPLAN-FEINSTEIN comorbidity indices.In patients with coronary heart disease with erosive-ulcerative gastroduodenopathies the level of general compliance and its components was significantly higher than in patients without pathology of the gastroduodenal zone. It should be noted that high compliance according to the questionnaire was observed in 22 (73.3%) patients in group I and in 19 (30.2%) patients of group II (p <0.001), while with a low level of compliance—in 1 (3.3%) in group I and 17 (27.0%) in group II (p = 0.009). The level of compliance did not correlate with age, duration of disease, and comorbidity indices.Conclusion: In the study group of patients the frequency of erosive and ulcerative gastroduodenopathies was 32%. Patients with ischemic heart disease and erosive-ulcerative gastroduodenopathies are characterized by higher levels of compliance and anxiety. 

Calcification of the coronary arteries among the males with coronary heart disease and osteoporosis

2013 ◽  
Author(s):  
Elena Malyuta ◽  
Tatiana Raskina ◽  
Olga Barbarash ◽  
Alexandr Kokov
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Arteries
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