Influence of moderate cigarette-smoking on the peri-implant clinicoradiographic inflammatory parameters around cement- and screw-retained dental implants

Author(s):  
Mana Alqahtani

The aim was to assess the influence of moderate cigarette-smoking on the clinical (bleeding on probing [BoP] and probing depth [PD]) and radiographic (crestal bone resorption [CBR]) around cement- and screw-retained dental implants at 5 years’ follow-up. A questionnaire was used to collect information about age, gender, smoking history, duration of implants in function, jaw location of the implant, and daily toothbrushing and flossing. Peri-implant BoP, PD and CBR were measured in all groups. Group comparisons were performed using one-way analysis of variance and for multiple comparisons, the Bonferroni Post hoc adjustment test was performed. Level of significance was set at P<0.05. Forty-eight patients (25 smokers and 23 non-smokers) had cement-retained dental implants; and 48 (24 smokers and 24 non-smokers) had screw-retained dental implants. Among patients with cement and screw-retained dental implants, PD (P<0.05) and CBR (P<0.05) were significantly higher among smokers than non-smokers. The peri-implant sites that demonstrated BoP were statistically significantly higher among non-smokers (P<0.05) than smokers among patients with cement- and screw-retained dental implants. There was no statistically significant difference in peri-implant PD and CBR among smokers with cement- and screw-retained dental implants. Among non-smokers with cement and screw-retained dental implants, there was no statistically significant difference in BoP, PD and CBR. Cigarette-smoking is associated with an increased PD and CBR around cement- and screw-retained dental implants. Cigarette-smoking increases peri-implant soft tissue inflammation as well as loss of crestal bone and this relationship is independent of the type of implant retention protocol used.The author recommends that cement- and screw-retained dental implants are suitable for prosthesis restoration in non-smokers. Further studies on dual-smokers (individuals smoking cigarettes and other forms of tobacco products) are needed related to the clinicoradiographic inflammatory parameters around cement- and screw-retained dental implants

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 7573-7573
Author(s):  
V. A. Miller ◽  
G. J. Riely ◽  
M. G. Kris ◽  
D. Rosenbaum ◽  
J. Marks ◽  
...  

7573 Background: Somatic mutations in the epidermal growth factor receptor (EGFR) gene are more common in patients with adenocarcinoma, especially those who smoked < 15 pack years (py). KRAS mutations are found in ∼25% of lung adenocarcinomas, most commonly in codons 12 and 13 of exon 2 (∼85%) and have been associated with poor prognosis in resected disease [Winton NEJM 2005] and resistance to EGFR tyrosine kinase inhibitors [Pao PLoS Med 2005]. KRAS mutations are uncommon in non-small cell lung cancer histologies other than adenocarcinoma. We sought to determine the association between quantitative measures of cigarette smoking and presence of KRAS mutations in lung adenocarcinomas. Methods: Standard direct sequencing techniques were used to identify KRAS codon 12 and 13 mutations in lung adenocarcinoma specimens from surgical resections between 2001 and 2006 and tumor specimens sent for KRAS molecular analysis in 2006. Surgical specimens were obtained from an institutional tumor bank. Detailed smoking history (age at first cigarette, packs per day, years smoked, years since quitting smoking) was obtained from the medical record and a patient-completed smoking questionnaire. Results: KRAS mutational analysis was performed on 408 lung adenocarcinomas from 242 women and 166 men. Median age was 68 (range 33–89). KRAS mutations were present in 19% (78/408, 95% CI 15 to 23%). The frequency of KRAS mutation was not associated with age or gender. The presence of KRAS mutations was not related to smoking history with 15% (9/61) of never smokers having KRAS mutations compared with 19% (51/275) of former smokers. When compared with never smokers, there was no significant difference in frequency of KRAS mutations for tumors from patients with 1–5 py (5%, p=0.44), 6- 10 py (12%, p=0.99), 11–15 py (25%, p=0.45), 16–25 py (16%, p=0.99), 26–50 py (25%, p=0.129), 51–75 py (20%, p=0.48), >75 py (20%, p=0.47) history of cigarette smoking. Conclusions: While the incidence of EGFR mutations has a strong inverse relationship with the amount of cigarettes smoked, allowing the selective molecular testing for EGFR mutations, the frequency of KRAS mutations cannot be predicted by age, gender, or smoking history. KRAS mutational analysis of all adenocarcinomas is required to reliably identify patients with KRAS mutations. No significant financial relationships to disclose.


Author(s):  
Danijela Kuna ◽  
Sanjin Džajić

With the goal to form the hierarchical classification of the most important methodical exercises for teaching basic ski turn in ski schools and test differences between ski experts based on their different level of skiing education, there was conducted a survey on the total sample of 307 ski experts from different countries. Through the filling out the online survey they tried to distinguish the importance of the formed model of the most important methodical exercises for teaching basic ski turn. Expert model of the most important methodical exercises captured 6 variables: uphill turn and jumping into snowplough, basic turn with hand sideways, basic turn with clapping, ski poles in front, ski poles on neck, uphill turn with active ski guiding. In order to investigate the statistic meaning of differences in ranking the methodical exercises for teaching basic ski turn, participants are divided into three groups based on the degree of skiing education they posses. In relation to above mentioned, sums of ranks (∑R) of the most important methodical exercises for teaching basic ski turn have been calculated. Using non-parametric analogue post-hoc analysis, i.e. Kruskal-Wallis test (H-test) and appropriate empiric level of significance (p), statistic significance of sums of ranks (∑R) of the most important methodical exercises for teaching basic ski turn have been tested. Significant difference between the value of ranking the most methodical exercises have been obtained (H=138,62; p<0,001). Those variables which were not different in statistically significant way according to sums of rank were classified in one significant group, while variables which showed statistically significant difference were classified separately. Multiple statistically significant difference based on different degree ski education between the ski experts were not obvious. The results of this study provide an accurate and scientifically based methodological settings for teaching basic ski turn. This opens the directions for future research in the form of construction of measuring instruments whose application in practice should allow better selection and choice of modalities methodical exercises for training alpine skiers of different ages and levels of ski prior knowledge.


Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4717-4717
Author(s):  
Rafael Arteta-Bulos ◽  
Alva B. Weir ◽  
James Lewis

Abstract Abstract 4717 Background: Chronic idiopathic neutrophilia (CIN) is a poorly described disorder that must be distinguished from more serious disorders associated with neutrophilia in a cost-effective manner. The last thoroughly studied case review of CIN was published nearly 40 years ago (Ward HN, Reinhard Eh. Ann Internal Med 1971). Since this review, new testing capabilities, including JAK-2 mutation evaluation, bcr-abl testing and CT scans have become readily available, complicating the decision making process in the diagnostic evaluation of healthy patients with an elevated neutrophil count. The challenge to the diagnostician is how aggressive, inconvenient and expensive the search for a cause for elevated neutrophil counts in otherwise healthy individuals should be. Objective: To evaluate causes and consequences of CIN with a plan to develop effective diagnostic guidelines for the evaluation of CIN. Patients and Methods: We performed a retrospective 10-year review (1999-2008) of patients visiting a Veteran's Affairs Medical Center with ICD-9 codes suggesting the diagnosis of leukocytosis to ascertain the incidence of CIN and evaluate both causative factors and outcome over time. We also reviewed charts of patients presenting with codes suggesting the diagnosis of a myeloproliferative disorder from 2005 to 2010 to discover if their initial presentation might have been misdiagnosed as CIN. We classified patients as CIN if they fulfilled the following criteria: neutrophil counts of 8.0 × 109/L or greater on multiple determinations, persistence or recurrence of neutrophilia over a time period of greater than six months, followed medically for a minimum of two years, no unexplained abnormality in the red cell or platelet counts, and no identifiable medical illness or drug usage known to produce prolonged neutrophilia. Patients thus identified were evaluated for the following parameters: duration of neutrophilia, age, ethnicity, weight, smoking history, presence of immature neutrophils, thrombocytosis, erythrocytosis, basophilia, eosinophilia, monocytosis, development or discovery of a solid tumor or hematologic malignancy or myeloproliferative disorder, drugs known to cause neutrophilia (lithium, corticosteroids, beta agonists), chronic infection or inflammatory disorder, leukocyte alkaline phosphatase (LAP) score, bone marrow evaluation, CT scan evaluation, theater of military engagement, hepatitis B and C, diabetes, drug abuse, splenectomy, constitutional symptoms, incidence of myocardial infarction, stent or CABG, and psychiatric diagnoses. Results: Of 450 charts reviewed with diagnoses suggesting leukocytosis, 57 met criteria for CIN. They were followed for a mean of 7.3 years without progression to other serious disorders. Peak neutrophil counts ranged from 8.9 to 22.6 × 109/L. The mean peak neutrophil count was 12.1 × 109/L. None of the patients with CIN had evident chronic inflammatory disorders over a significant period of their neutrophilia. There was no increase in malignancy rate or myocardial infarction/CABG during follow up. Cigarette smoking stood out as a potential causative factor with (82.4%) of the 57 patients as active cigarette smokers compared to 27% of the patients cared for in our institution during the same time period. Of the 81 patients with myeloproliferative neoplasms, only chronic myeloid leukemia (CML) presented with laboratory data that might be confused with CIN (3 of 10). The average BMI of patients in our study was 29.5 kg/m2. The average BMI of all patients visiting VAMC Memphis in 2001 was 28 kg/m2, suggesting no significant difference. The average BMI of smokers with CIN in our series was the same at 29.9 kg/m2. However, the average BMI of never smokers and those who had quit smoking over ten years in our study was 35.5 kg/m2, suggesting obesity as an associated factor in non smokers. Conclusion: CIN occurs more commonly in white patients than in African Americans. Cigarette smoking and obesity are associated and possibly causative factors in the development of CIN. CIN is unlikely to be confused with an early myeloproliferative neoplasm, other than CML. Statistical analysis and guidelines for the diagnostic evaluation of neutrophilia in otherwise healthy patients will be presented. Disclosures: No relevant conflicts of interest to declare.


2020 ◽  
Author(s):  
Yang-Jun Gu ◽  
Jie Zhou ◽  
Jie Xiang ◽  
Shengmin Mei ◽  
Zhiwei Li ◽  
...  

Abstract Background Many pancreatic transplant donors have smoking history. We aimed to evaluate the effect of donors’ smoking on recipient survival rates and postoperative complications. Methods Patients(N=6564) from the Scientific Registry of Transplant Recipients database who underwent simultaneous pancreas-kidney transplants (SPK) were divided into a cigarette group (n=5465) and non-cigarette group (n=799) based on their donors’ smoking history. Patients’ rates of overall and graft survival were compared and analyzed using the log-rank test. Hazard ratios were estimated using Cox proportional hazards models, and postoperative complications and dialysis times were evaluated using logistics analysis. Results The overall survival and graft survival of the patients in the non-cigarette group were significantly higher compared to those in the cigarette group ( P <0.05 for both log-rank tests). Cigarette smoking among the donors was associated with a significant difference in the recipients’ rate of pancreas graft survival and kidney graft survival ( P <0.05 for both log rank-tests). However, multivariate analyses indicated that donors’ smoking history was not an independent factor, while the donors’ age was associated with reduced survival (hazard ratio [HR], 1.09; 95% confidence interval [CI], 0.93-1.28; P =0.287). The cigarette group had a higher postoperative infection rate than the non-cigarette group (HR, 1.45; 95% CI, 1.02-2.06; P =0.038). Conclusions Donors’ smoking history has no overall effect on rates of overall or graft survival of SPK transplant recipients. However, it should be evaluated before transplantation because of its higher rate of postoperative complications.


Author(s):  
Praneetha D Rani ◽  
Vijaya Hegde

Introduction: Fluoride toothpastes are a major reason for the decline in dental caries globally. For fluoride toothpaste to be effective, an adequate amount of Total Soluble Fluoride (TSF) must be available in the toothpastes. Aim: To determine and compare the Total Fluoride (TF), TSF and pH among various toothpaste brands. Materials and Methods: An in-vitro study was conducted during October 2019 on 20 toothpaste samples, which belonged to four groups namely, herbal toothpastes group, nonherbal toothpastes group, medicated toothpastes group and kids toothpastes group. Analysis of the samples was done at the Department of Environmental Engineering Laboratory, National Institute of Technology, Surathkal, Karnataka, India. The TF and the TSF concentration was determined using fluoride ion electrode. The pH was determined using pH meter. Statistical analysis was performed using Statistical Package for Social Sciences (SPSS version 19.0). Analysis of variance (ANOVA) was used by Tukey’s post-hoc test to determine the difference between groups. The level of significance was kept at 0.05. Results: The results showed that there was a significant difference between the toothpaste types for mean TF concentration (p=0.004). The post-hoc test showed that there was a significant difference between herbal and nonherbal toothpastes (p=0.041) where the mean TF concentration for nonherbal toothpastes was 1095.20 ppm when compared to herbal toothpastes was 704.40 ppm. The results showed that there was a siginificant difference between the toothpaste types for Mean TSF concentration (p<0.003). There was a significant difference between medicated and kids toothpastes (p=0.024) where the mean total soluble fluoride concentration for medicated toothpastes was 938.60 ppm when compared to the kids toothpastes was 521.20 ppm. Conclusion: The present study showed that pH of all the toothpastes were either neutral or alkaline and the TSF concentration was less when compared to TF concentrations.


2019 ◽  
Vol 8 (3) ◽  
pp. 16
Author(s):  
Sarah A. Sorensen ◽  
Cheryl R. Rock ◽  
Dustin M. Moore ◽  
Rachel E. Blaine ◽  
Christine B. Costa

With the increasing variety of snack foods containing probiotics infiltrating the market, it is important that consumers become more aware and knowledgeable about these products. The aim of the current study was to investigate potential consumers&rsquo; behavior by assessing knowledge about probiotics, awareness of snack foods containing probiotics, and frequently consumed snacks among student college departments within a university setting. Participants included 125 college students (n = 34 male, n = 91 female), all 18 years and older, and evaluated via a 19-item questionnaire using descriptive statistics, one-way analysis of variance (ANOVA) and Gabriel&rsquo;s post hoc test. Level of significance was set at p &le; 0.05. There was a statistically significant difference in knowledge about probiotics among the student college departments, p = 0.012. Specifically, students in the College of Health and Human Services (CHHS) were statistically significantly more knowledgeable than those in the Science, Technology, Engineering and Mathematics (STEM) college, p = 0.010. There was no statistically significant difference in awareness of snack foods containing probiotics, p = 0.262. On average, participants&rsquo; knowledge about probiotics was low (48.1%) and awareness of snack foods containing probiotics was very low (2.5%), though, a majority of participants (94.1%) were aware that yogurt may contain probiotics. Overall, these findings should guide food product developers and marketers to create products that are relevant and messages that enhance consumers&rsquo; knowledge and awareness to the existence of the probiotics in that product.


Author(s):  
Cordial M. Gillette ◽  
Scott T. Doberstein ◽  
Danielle L. DeSerano ◽  
Eric J. Linnell

Background: The empirical evidence for the use of RICE (rest, ice, compression, elevation) has been questioned regarding its   clinical effectiveness. The component of RICE that has the least literature regarding its effectiveness is elevation. Objective: The objective of this study was to determine if various positions of elevation result in volumetric changes of the lower extremity. Methodology: A randomized crossover design was used to determine the effects of the four following conditions on volumetric changes of the lower extremity: seated at the end of a table (seated), lying supine (flat), lying supine with the foot elevated 12 inches off the table (elevated), and lying prone with the knees bent to 90 degrees (prone). The conditions were randomized using a Latin Square. Each subject completed all conditions with at least 24 hours between each session. Pre and post volumetric measurements were taken using a volumetric tank. The subject was placed in one of the four described testing positions for 30 minutes. The change in weight of the displaced water was the main outcome measure. The data was analyzed using an ANOVA of the pre and post measurements with a Bonferroni post hoc analysis. The level of significance was set at P<.05 for all analyses. Results: The only statistically significant difference was between the gravity dependent position (seated) and all other positions (p <.001). There was no significant difference between lying supine (flat), on a bolster (elevated), or prone with the knees flexed to 90 degrees (prone). Conclusions: From these results, the extent of elevation does not appear to have an effect on changes in low leg volume. Elevation above the heart did not significantly improve reduction in limb volume, but removing the limb from a gravity dependent position might be beneficial.


2021 ◽  
Vol 10 (9) ◽  
pp. e5910917701
Author(s):  
Vanessa Sandini ◽  
Viviane Godoy ◽  
Marina Carvalho Prado ◽  
Ricardo Ferreira ◽  
Adriana De-Jesus-Soares ◽  
...  

Objective: This study evaluated the bacterial removal in flattened root canals after preparation with different tapers of ProDesign Logic instruments. Methodology: Fifty-five mandibular incisors with flattened root canals were contaminated with a pure culture of Enterococcus faecalis ATCC 29212 for 21 days at 37ºC. Root canals preparation was performed using ProDesign Logic and 0.9% sterile saline solution for irrigation. The specimens were randomly allocated to three experimental groups (n = 15) according to the taper of the instrument used: 25.03, 25.04, or 25.06. Intracanal bacteriological samples were taken before (S1) and after (S2) preparation and the number of colony-forming units per milliliter (CFU/mL) was calculated. Differences in bacterial counts before and after treatment, within each group, were analyzed by the paired t-test. Groups were compared by ANOVA with a post hoc test. The level of significance was set at p <0.05. Results: Mature biofilm formation was confirmed at root canal walls by scanning electron microscopy. Bacterial colonies were significantly reduced in all experimental groups at S2 compared to S1 (p <0.001). No significant difference was observed between groups regarding the percentage of bacterial reduction (p >0.05). Conclusion: Preparation of flattened root canals using ProDesign Logic instruments with tapers of 0.03, 0.04 and 0.06 resulted in similar planktonic and bacterial biofilm reduction. None of the instruments rendered root canals completely free of bacteria.


2019 ◽  
Vol 05 (04) ◽  
pp. e172-e176
Author(s):  
Savitha V. Nagaraj ◽  
Amit Mori ◽  
Madhavi Reddy

Abstract Background Hemorrhoids are vascular structures in the anal canal which are seldom used to evaluate vascular diseases. Cigarette smoking is well-known to cause both arterial and venous vascular injuries. However, the impact of smoking on hemorrhoid vasculature is unknown. Objective Considering that vasculature in the hemorrhoids has the same anatomy and pathophysiology of vascular damage as other systemic vasculatures, we conducted this study to evaluate the relation between smoking and incidence of hemorrhoidal vascular injury. Design and Data Analysis Retrospective review of all the screening colonoscopies performed at our Department of Gastroenterology (predominantly serving urban minority population) over 3 years was conducted and patients with recorded smoking history were included in the study (n = 242). Fisher's exact test with two-tailed p-value and odds ratio were used to evaluate for the association between smoking and incidence of hemorrhoids. Results We studied 242 subjects and found statistically significant association between smoking and hemorrhoids (p < 0.05) with the risk of developing hemorrhoids among smokers being 2.4 times that of a nonsmoker. We further noted no significant difference in the incidence of hemorrhoidal vascular injuries between the past versus current smokers and male versus female smokers. Conclusion This is one of the first studies to establish an association between smoking and hemorrhoids. Our study shows that the hemorrhoidal vasculature is impacted by smoking similar to other vascular systems. This study sheds light on the possibility of evaluating hemorrhoids for clues of other systemic and gastrointestinal vascular damage. This correlation can add clinical value especially given the flexibility of assessing hemorrhoids as an outpatient in a cost effective and comfortable manner.


2017 ◽  
Vol 5 (3) ◽  
pp. 238-246 ◽  
Author(s):  
Madhuri Nigudkar ◽  
Jagmeet Gurminder

Foods rich in resistant starch RS can play an important role in the management of chronic diseases. Legumes contain higher amount of RS than cereals, roots and tubers. Therefore the current study was undertaken to estimate RS content of some commonly consumed Indian legume preparations. 26 cooked legume based products including 6 readymade traditional snacks were tested for their RS content using Megazyme Assay Kit for Resistant Starch. RS content was estimated for 100 g cooked food and for the cooked portion obtained by using 30 g of major ingredient. One way ANOVA with post hoc Tukey’s test was used to compare the mean RS content in one portion of different categories of legume preparations. Level of significance was set at p<0.05. RS content of four types of plain pressure cooked dhal, common to Indian cooking, was in the range of 1.21 g% to 2.16 g% whereas aamti, a thinner preparation of dhal contained RS in the range of 0.42 g% to 0.69 g%. In both types of dhal preparations, red gram dhal showed highest RS content followed by bengal gram dhal. Usal made using bengal gram kabuli contained 2.38 g% RS followed by 1.42 g% RS in bengal gram brown usal. RS in bengal gram flour based traditional recipes like zunka, dhirda and pithle was 1.23 g%, 1.48 g% and 0.09 g% respectively. When mean RS content of one portion of different categories of legume preparations was compared, there was no significant difference p≥0.05 found among any of the categories. The results of the study generated useful data with respect to RS content in 100 g as well as RS in one portion of legume preparations and identified preparations with red gram dhal, bengal gram kabuli and brown variety and lentil as relatively higher in RS content.


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