scholarly journals Materials based o tricalcium phosphate as bone defects substitute (literature review)

2021 ◽  
pp. 100-107
Author(s):  
Mykola Korzh ◽  
Volodymyr Filipenko ◽  
Karolina Poplavska ◽  
Nataliya Ashukina
Keyword(s):  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Calcium Phosphates ◽  
Scientific Information ◽  
Slight Modification ◽  
Ceramic Materials ◽  
Bone Defects ◽  
Biological Properties ◽  
Filling Material ◽  
The Creation

The objective of the study is to determine the current tendencies in the use of osteoplastic materials based on tricalcium phosphate (TCP) in orthopedics and traumatology. Methods. The search of the scientific information for the analysis was carried out in the PubMed, Google Scholar, World Digital Library, ScienceDirect. Results. The development of biomaterials for reconstructive surgery on the skeleton remains an urgent issue of biomaterial engineering, biology and current traumatology and orthopedics. Calcium-phosphate ceramics have the excellent properties of biocompatibility, affinity with bone tissue, biodegradability as well as perfect osteoconductive and osteointegrative properties. They are used in orthopaedics and traumatology as a coating for endoprosthesis components in order to achieve a strong bond with the bone as well as a filling material for bone defects in the form of blocks, granules or powder. The optimal structure of ceramic materials in order to achieve the necessary hardness and control of the dissolution rate is still undetermined. The interest of researchers in the creation of osteoplastic materials containing TCP is explained by the advanced osteoinductive properties and the ability to quickly degrade with the formation of bone tissue. Due to different configurations and sizes of the bone defects, the creation of a material with osteoinductive and osteoconductive properties that could be inserted into the cavity in a liquid state and which would quickly harden and acquire the properties similar to those of the bone has been of great current interest. The material should be biodegradable while having sufficient time for bone formation at the implantation site. In view of the above, the creation of cements based on calcium phosphates has become more attractive. Unfortunately, this material is limited in use due to its brittleness and insufficient hardness. Certain reinforcing additives are expected to significantly improve the mechanical properties of the cement. It is desirable that these particles should have bioactive properties analogous to those of cement. A slight modification of the material can significantly change its properties, which makes it imperative to investigate experimentally the biological properties of the investigated material.

scholarly journals Cuttlefish Bone-Derived Biphasic Calcium Phosphate Scaffolds Coated with Sol-Gel Derived Bioactive Glass

Materials ◽  
2019 ◽  
Vol 12 (17) ◽  
pp. 2711
Author(s):  
Ana S. Neto ◽  
Daniela Brazete ◽  
José M.F. Ferreira
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphates ◽  
Sol Gel ◽  
Biological Properties ◽  
X Ray Diffraction ◽  
Bioactive Glasses ◽  
Hydrothermal Transformation

The combination of calcium phosphates with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The initial CB structure was maintained after hydrothermal transformation (HT) and the scaffold functionalization did not jeopardize the internal structure. The results of the in-vitro bioactivity after immersing the BG coated scaffolds in simulated body fluid (SBF) for 15 days showed the formation of apatite on the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties, but further assessment of the in-vitro biological properties is needed before being considered for their use in bone tissue engineering applications.

Reconstruction of Cranial Bone Defects Using a Compound of Bone Marrow Stromal Cells and Hydroxyapatite-Tricalcium Phosphate

2008 ◽  
Vol 368-372 ◽  
pp. 1235-1237 ◽  
Author(s):  
Lei Liu ◽  
Run Liang Chen ◽  
Yun Feng Lin ◽  
Wei Dong Tian ◽  
Sheng Wei Li
Keyword(s):  
Electron Microscopy ◽  
Tissue Engineering ◽  
Bone Marrow ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Stromal Cells ◽  
Tricalcium Phosphate ◽  
Bone Marrow Stromal Cells ◽  
Bone Defects ◽  
Marrow Stromal Cells

Hydroxyapatite-tricalcium phosphate (HA-TCP) is a new kind of material which shows good biocompatibility, biological degradability, and porosity. This study aimed to determine the effectiveness of HA-TCP as a bone tissue engineering scaffold. In this study, critical size cranial defects were reconstructed with compounds of autogenous bone marrow stromal cells (BMSCs) and HA-TCP. The resulting grafts were examined by X-ray, histological examination, semi-quantitative analysis of osteogenesis, immunochemical examination (collagen type I and III), scanning electron microscopy and transmission electron microscopy. The results showed that HA-TCP is a good bone tissue engineering scaffold and BMSCs/HA-TCP is a promising technique for reconstruction of bone defects.

Phosphate Glass Dental/medical Cement

1987 ◽  
Vol 110 ◽  
Author(s):  
Wei-Shi Chen ◽  
E. A. Monroe
Keyword(s):  
Calcium Phosphate ◽  
Clinical Application ◽  
Tricalcium Phosphate ◽  
Ceramic Materials ◽  
Bone Defects ◽  
Phosphate Glasses ◽  
Compositional Variation ◽  
Current Interest ◽  
Calcium Phosphate Ceramic ◽  
As Solubility

AbstractCurrent interest in the clinical application of alloplastic grafts for treating dental and orthopedic bone defects suggested this investigation on phosphate glasses. Particularly, the calcium phosphate ceramic materials of hydroxyapatite and tricalcium phosphate appear to be promising graft materials. Our interest in amorphous rather than crystalline ceramics centered on the potentially wide compositional variation that may be possible and their concomittant properties such as solubility.

Upgrading Calcium Phosphate Scaffolds for Tissue Engineering Applications

2008 ◽  
Vol 377 ◽  
pp. 19-42 ◽  
Author(s):  
Sandra Sánchez-Salcedo ◽  
Daniel Arcos ◽  
Maria Vallet-Regí
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Clinical Performance ◽  
Bone Ingrowth ◽  
Calcium Phosphates ◽  
Synthesis Methods ◽  
Charge Imbalance ◽  
Silicon Doped

The research on ceramic scaffolds for bone tissue engineering is, nowadays, one of the newest and most attractive topics in the field of materials for biomedical applications. These scaffolds are aimed to provide supporting or even enhance the reparative capacity of body. Biphasic calcium phosphates (BCPs) and silicon doped BCP are very interesting candidates to be used as materials for scaffolds fabrication in bone tissue engineering. BCPs and silicon doped BCP consist of a mixture of hydroxyapatite (HA) and β-tricalcium phosphate (β-TCP) or HA and α-tricalcium phosphate (α-TCP), respectively. For the regenerative purposes BCPs show better performance than HA because of the higher solubility of β-TCP compound, which facilitate the subsequent bone ingrowth in the implant. On the other, silicon doped BCP involve silicon that substituted into the apaptite crystal lattice for phosphorous with the subsequent charge imbalance. HA/α-TCP based bioceramics exhibits an important improvement of the bioactive behaviour with respect to non-substituted apatites. This work reviews the procedures to synthesise and fabricate scaffolds based on HA/β-TCP and silicon stabilised HA/α-TCP. Special attraction has been paid in the different synthesis methods and to the shaping of final scaffolds. By knowing the scaffold features at the crystallinity and macrostuctural level, the biocompatibility and clinical performance can be better understood, which will be also considered in this review.

Bioactive Cyanoacrylate-Based Filling Material for Bone Defects in Dental Applications

2005 ◽  
Vol 284-286 ◽  
pp. 933-936 ◽  
Author(s):  
Kyeong Jun Park ◽  
Ji Ho Park ◽  
Sang Bae Lee ◽  
Doug Youn Lee ◽  
Kyoung Nam Kim ◽  
...  
Keyword(s):  
Bond Strength ◽  
Temperature Change ◽  
Tricalcium Phosphate ◽  
Shear Bond Strength ◽  
Bone Defects ◽  
Distilled Water ◽  
Filling Material ◽  
Filling Materials ◽  
Bioactive Properties ◽  
Dental Applications

We tried to prepare a new filling material for bone defects using β-Tricalcium phosphate (β-TCP) particles and Histoacryl®. The aim of this study was to evaluate physical and bioactive properties of cyanoacrylate-based filling materials for bone defects in the dental field. The shear bond strength values of the Histoacryl® and β-TCP/ Histoacryl® compounds stored in double-distilled water decreased with the increase of the amount of added β-TCP. The temperature change of the β-TCP/ Histoacryl® compounds during polymerization decreased compared to that of the Histoacryl®. The cytotoxicity of the filling materials decreased when the amount of added β-TCP was increased. In the evaluation of bioactivity, hydroxyapatite (HA) was precipitated on the surface and inner space of the porous filling material 4 weeks after immersion in SBF. This precipitation of HA on the surface of the filling material was also confirmed in the XRD result. These results indicate that our novel β-TCP/Histoacryl® compounds have the potential to serve as filling materials for bone defects in the dental field.

scholarly journals Marine Collagen/Apatite Composite Scaffolds Envisaging Hard Tissue Applications

Marine Drugs ◽  
2018 ◽  
Vol 16 (8) ◽  
pp. 269 ◽  
Author(s):  
Gabriela Diogo ◽  
Estefania López-Senra ◽  
Rogério Pirraco ◽  
Raphael Canadas ◽  
Emanuel Fernandes ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Composite Structures ◽  
Calcium Phosphates ◽  
Donor Site ◽  
Bone Defects ◽  
Hexamethylene Diisocyanate ◽  
Shark Species ◽  
Hard Tissue ◽  
Prionace Glauca ◽  
By Products

The high prevalence of bone defects has become a worldwide problem. Despite the significant amount of research on the subject, the available therapeutic solutions lack efficiency. Autografts, the most commonly used approaches to treat bone defects, have limitations such as donor site morbidity, pain and lack of donor site. Marine resources emerge as an attractive alternative to extract bioactive compounds for further use in bone tissue-engineering approaches. On one hand they can be isolated from by-products, at low cost, creating value from products that are considered waste for the fish transformation industry. One the other hand, religious constraints will be avoided. We isolated two marine origin materials, collagen from shark skin (Prionace glauca) and calcium phosphates from the teeth of two different shark species (Prionace glauca and Isurus oxyrinchus), and further proposed to mix them to produce 3D composite structures for hard tissue applications. Two crosslinking agents, 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride/N-Hydroxysuccinimide (EDC/NHS) and hexamethylene diisocyanate (HMDI), were tested to enhance the scaffolds’ properties, with EDC/NHS resulting in better properties. The characterization of the structures showed that the developed composites could support attachment and proliferation of osteoblast-like cells. A promising scaffold for the engineering of bone tissue is thus proposed, based on a strategy of marine by-products valorisation.

scholarly journals Effect of implants of hydroxyapatite with tricalcium phosphates alloyed with Si on histomorphological and biochemical parameters in cases of bone defects of rabbits

2021 ◽  
Vol 12 (2) ◽  
pp. 281-288
Author(s):  
V. O. Chemerovskiy ◽  
M. V. Rublenko ◽  
S. V. Rublenko ◽  
N. V. Ulanchych ◽  
S. O. Firstov ◽  
...  
Keyword(s):  
General Anesthesia ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Biochemical Parameters ◽  
Bone Defects ◽  
Control Group ◽  
Tartrate Resistant Acid Phosphatase ◽  
Spongy Bone ◽  
Diaphyseal Bone ◽  
Bone Trabeculae

Complex comminuted fractures are accompanied by development of bone defects and loss of reparative potential of the bone tissue in the region of the trauma. This brings the necessity of using implants with optimum osteoconductive and osteointegration properties. The objective of the study was determining the condition of biochemical bone markers and peculiarities of histomorphological changes under the influence of ceramic hydroxyapatite (HA) implants with various physical-chemical properties in the conditions of diaphyseal bone defects in rabbits. We composed control and experimental groups of rabbits with 10 individuals in each with diaphyseal bone defects (3 mm) of the radial bones formed under general anesthesia. In one experimental group, they were filled with granules of hydroxyapatite with α-tricalcium phosphate, and in the second group – with β-tricalcium phosphate, alloyed with Si. In the control rabbits, the defects healed under a blood clot. Blood was analyzed on the 3rd, 7th, 14th, 21st and 42nd days, and as reference we used biochemical parameters of blood of clinically healthy rabbits (n = 10). Bone biopsied materials were taken on days 21–42 under general anesthesia. When using hydroxyapatite with β-tricalcium phosphate, alloyed with Si, we determined early intensification of the levels of nitrogen oxide, angiogenesis and development of bone regenerate in conditions of shortening of inflammatory resorption phase, which was verified according to the level of tartrate-resistant acid phosphatase. According to the level of bone isoenzyme of alkaline phosphatase in the blood serum of animals of the control group, the reparative osteogenesis developed slowly and peaked on day 42, whereas in animals implanted with α-tricalcium phosphate, its development peaked peaked on days 14–42, and when using Si-alloy – on days 7–14. Histomorphologically, on the 21st day, in the case of replacement of bone defect with hydroxyapatite with α-tricalcium phosphate, coarse-fibered type of bone regenerate developed with no dense contact with the elements of the regenerate, while spongy bone trabeculae occurred when hydroxyapatite was applied with β-tricalcium phosphate alloyed with Si, and the control rabbits were observed to be in the stage of cartilaginous callus. On the 42nd day, under the influence of implants of hydroxyapatite with α-tricalcium phosphate, the spongy bone tissue transformed into compact tissue with further mineralization. With implants alloyed with Si, there occurred compact bone tissue, and bone regenerates of the control animals were regions of coarse-fibered and spongy bone tissue without dense contact with the parent bone. This study revealed that hydroxyapatite with β-tricalcium phosphate alloyed with Si had notable osteoinductive and osteointegrating properties, as indicated by early angiogenesis and osteoblast reaction, positive dynamics of the marker biochemical parameters with faster and better development of bone regenerate as spongy bone trabeculae.

scholarly journals Early Results of the Study of Reparative Peculiarities of Various Osteoplastic Materials in Experimental Bone Defects

2017 ◽  
pp. 40-47
Author(s):  
K. A. Egiazaryan ◽  
G. D. Lazishvili ◽  
K. I. Akmataliev ◽  
A. P. Ettinger ◽  
A. P. Rat’Ev ◽  
...  
Keyword(s):  
Bone Cement ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Calcium Sulphate ◽  
Bone Defects ◽  
Spongy Bone ◽  
Early Results ◽  
Calcium Phosphate Bone Cement ◽  
Bone Trabeculae ◽  
Osteoplastic Material

Purpose. To determine the optimum osteoplastic material for activation of reparative osteogenesis and substitution of traumatic defects in metaepiphyseal spongy bone tissue.Material and methods.Comparative experimental morphological study was performed on 12 matured male Chinchilla rabbits with body weight 2500-2800g. A model of critical defects of spongy bone tissue was used. Bone defects were filled with 3 types of osteoplastic material: composite calcium sulphate bone cement; xenogenous hydroxyapatite-based material with granulated paste of synthetic peptides (P-15); β-tricalcium phosphate-based material with gauging liquid (calcium phosphate bone cement).Results.Implantation of calcium sulphate bone cement showed rapid osteogenesis stimulation at terms 1.5 months and reduction of newly formed bone tissue mass by 3rd month due to active resorption of the residual material. Implantation of hydroxyapatite-based material with P-15 resulted in osteogenesis stimulation on its surface however because of its mechanical instability and absence of active resorption of that material only a moderate formation of bone trabeculae was observed. At implantation of β-tricalcium phosphate-based material an active resorption of osteoplastic material, formation of trabecular system and its reorganization into trabecular network of femoral metaepiphyseal spongy bone accompanied by the formation of mature bone trabeculae was noted by month 3.Conclusion. Mechanical stability of osteoplastic material and subsequent gradual resorption as well as formation of mature bine trabeculae indicates the efficacy of β-tricalcium phosphate-based material.

Sign in / Sign up

Export Citation Format

Share Document