scholarly journals Typical relationships between the indexes of lipid peroxidation/ antioxidant protection and immune regulation in the patients with chronic atrophic gastritis and stomach cancer

2020 ◽  
Vol 22 (5) ◽  
pp. 897-906
Author(s):  
O. V. Smirnova ◽  
V. V. Tsukanov ◽  
A. A. Sinyakov ◽  
O. L. Moskalenko ◽  
N. G. Elmanova ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lipid Peroxidation ◽  
Atrophic Gastritis ◽  
Normal Distribution ◽  
Antioxidant Defense ◽  
Malonic Dialdehyde ◽  
Chronic Atrophic Gastritis ◽  
The Body ◽  
Control Group ◽  
Antioxidant Protection

Chronic atrophic gastritis and gastric cancer represent distinct steps of one pathogenic process. The risk of developing cancer of the stomach is directly proportional to the degree of atrophic changes simultaneously detected in antral segment and in the body of the stomach. The role of immune system in transformation of precancerous diseases into cancer is beyond doubt. During development of the malignant disease, the changes in lipid peroxidation systems – antioxidant defense become significant and contribute to the progression of the tumor and the development of metastases. A simultaneous study of lipid peroxidation and antioxidant defense indices along with phagocytic activity will allow us to evaluate relative contribution of these processes to development of chronic atrophic gastritis and gastric cancer. Purpose of the present study was to assess correlations between the lipid peroxidation indices, i.e. antioxidant protection, and chemiluminescent activity of neutrophilic granulocytes and monocytes in chronic atrophic gastritis and gastric cancer. Forty patients with chronic gastritis, 22 patients with chronic atrophic gastritis and 40 patients with gastric cancer were examined. The control group consisted of 50 practically healthy age-matched volunteers. Evaluation of spontaneous and induced production of reactive oxygen species by neutrophils and monocytes was carried out by chemiluminescent analysis. The parameters of lipid peroxidation/ antioxidant protection were determined by spectrophotometric methods. Statistical data processing was carried out using the Statistica v. 8.0 program (StatSoft Inc., USA). The normal distribution of indices was tested using the Kolmogorov–Smirnov method (adjusted by Lillefors). Quantitative indicators, given the normal distribution, were described using the median (Me) and interquartile scatter (Q0.25-Q0.75). To study statistical significance of differences between quantitative characteristics, the Mann–Whitney test was used. To study strength of relationships of these indicators, the Pearson rank correlation coefficient (r) was calculated. The critical significance level (p) when testing statistical hypotheses was taken equal to 0.05. Correlation analysis showed that the weight of positive correlations increases in patients with chronic atrophic gastritis, and it decreases in patients with gastric cancer, the strength of the correlation dependence and new relationships appear between chemiluminescent activity of neutrophils and monocytes in a spontaneous and induced state, and the amounts of malonic dialdehyde, enzyme activities of superoxide dismutase and catalase. In chronic atrophic gastritis and gastric cancer we have established the features of correlation patterns between lipid peroxidation/antioxidant protection indices, and activity of neutrophils and monocytes.

scholarly journals A COMPLEX DIAGNOSTICS OF EARLY GASTRIC CANCER ASSOCIATED WITH HELICOBACTER PYLORI INFECTION IN THE ADULT POPULATION OF THE KRASNOYARSK TERRITORY

2021 ◽  
Author(s):  
O. V. Smirnova ◽  
V. V. Tsukanov ◽  
A. A. Sinyakov ◽  
O. L. Moskalenko ◽  
N. G. Elmanova ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Helicobacter Pylori ◽  
Early Gastric Cancer ◽  
Glutathione Peroxidase ◽  
Atrophic Gastritis ◽  
Antioxidant Defense ◽  
Adult Population ◽  
Chronic Atrophic Gastritis

The aim of our study was to evaluate the clinical-anamnestic, serological, immunological and biochemical tests used for early diagnostics of gastric cancer associated with Helicobacter pylori infection in the adult population of the Krasnoyarsk Territory.Materials and methods: The control group consisted of 104 apparently healthy blood donors, the comparison group – 97 patients with chronic atrophic gastritis as well as a group of patients with early gastric cancer comprising 98 subjects. Assessment of monocyte and neutrophil spontaneous and induced chemiluminescence (CL) was carried out on a 36-channel biochemiluminometer "BLM - 3607". Phagocytosis was measured by using a Beckman Coulter FC 500 flow cytometer. A Varyan Cary Eclipse spectrofluorometer was used to study lipid peroxidation and factors of the antioxidant defense system.Results and discussion: While studying the phagocytic arm of immunity, it was found that all patients with early gastric cancer were reported to have parameters of the maximum intensity for neutrophil spontaneous CL from 17831 c.u. and lower, whereas induced CL reached at least 30,000 c.u.. Phagocytic activity of neutrophilic granulocytes in patients with early gastric cancer was 36% or less. While studying the indicators of monocytes, it was found that spontaneous and induced CL decreased from 454 c.u. and 1186 c.u., respectively, in the patients with early gastric cancer. Monocytic activity in early gastric cancer was 34% or less. In the study of lipid peroxidation, an antioxidant defense in patients with chronic atrophic gastritis and gastric cancer had increased malondialdehyde (MDA) level. Patients with gastric cancer had decreased activity of the enzyme catalase (CAT), whereas subjects with chronic atrophic gastritis had reduced glutathione peroxidase (GPO) level. In contrast, patients with early gastric cancer were featured with increased GPO activity. We have proposed coefficients for assessing the factors of the AOD system in patients: the ratio for superoxide dismutase to catalase activity (SOD / CAT) as well as the ratio for superoxide dismutase to glutathione peroxidase activity (SOD / GPO).Conclusion: During the study, threshold values of parameters were obtained for assigning groups at high risk of developing early gastric cancer, which can be used for screening in adult population.

scholarly journals INFLUENCE OF «METISEVIT» ON THE ACTIVITY OF ENZYME AND NONENZYME LINK OF ANTIOXIDANT PROTECTION UNDER THE BULL’S BODY CADMIUM LOADING

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 52-59
Author(s):  
B.V. Gutyj ◽  
Y. Lavryshyn ◽  
V. Binkevych ◽  
O. Binkevych ◽  
О. Paladischuk ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Vitamin E ◽  
Glutathione Peroxidase ◽  
Antioxidant Defense ◽  
Cadmium Stress ◽  
Antioxidant Defense System ◽  
The Body ◽  
Antioxidant Protection ◽  
Young Cattle

The article contains the research results of the effect of cadmium chloride on the indexes of enzyme and nonenzyme systems of  antioxidant defense system in young cattle, such as the activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels of vitamins A and E. It is established that feeding calves at a dose of toxicant 0.04 mg / kg activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels of vitamins A and E in the blood of experimental animals decreased throughout the experiment. The lowest indicators of antioxidant in the blood of young cattle is set on the twenty -fourth day of the experiment, which is associated with increased activation of lipid peroxidation and the balance between antioxidant system and lipid peroxidation intensity. Given the cadmium load of young cattle it is used a new integrated drug with antioxidant action «Metisevit», which includes metifen, sodium selenite and vitamin E wich is founded as stimulating effects on the activity of antioxidant protection. In particular,it is established probable increase in activity of catalase, superoxide dismutase, glutathione peroxidase, glutathione levels, vitamin A and vitamin E in the blood of young cattle, which has performed cadmium stress. These changes occur through comprehensive action components of the drug «Metisevit» that leads to the normalization of metabolic processes and free radical in the body of the bull. The results of the research indicate antioxidant drug «Metisevit» in the application of its young cattle and the validity of his administration to improve the body's antioxidant status of chronic cadmium toxicosis.

scholarly journals Characteristics of lipid peroxidation processes and factors of the antioxidant defense system in chronic atrophic gastritis and gastric cancer

2022 ◽  
Vol 20 (4) ◽  
pp. 63-70
Author(s):  
O. V. Smirnova ◽  
V. V. Tsukanov ◽  
A. A. Sinyakov ◽  
O. L. Moskalenko ◽  
N. G. Elmanova ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Cancer ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Control Group ◽  
Defense System ◽  
Glutathione S Transferase

Background. The problem of gastric cancer remains unresolved throughout the world, while chronic atrophic gastritis (CAG) increases the likelihood of its development by 15 times. In the Russian Federation, the incidence of gastric cancer (GC) is among the highest, with it prevailing among males. One of the leading mechanisms in molecular pathology of membranes is lipid peroxidation (LPO). The severity of oxidative membrane damage depends on concomitant diseases, contributing to emergence and progression of pathological processes and development of cancer. Currently, the problem of LPO is unsolved in biological systems.The aim of this study was to investigate the state of LPO and antioxidant defense system in CAG and GC. Materials and methods. The parameters were studied in 45 patients with CAG and 50 patients with GC. The control group included 50 practically healthy volunteers without gastrointestinal complaints, who did not have changes in the gastric mucosa according to the fibroesophagogastroduodenoscopy (FEGDS) findings.Results. In patients with CAG, an increase in malondialdehyde, superoxide dismutase, catalase, glutathione S-transferase, and glutathione peroxidase was found in the blood plasma compared with the control group. In patients with CAG, lipid peroxidation was activated, and the malondialdehyde level increased by 3.5 times relative to normal values. At the same time, the body fought against oxidative stress by increasing the activity of antioxidant enzymes, such as superoxide dismutase, catalase, glutathione S-transferase, and glutathione peroxidase. All patients with GC showed pronounced oxidative stress in the blood plasma in the form of a 45-fold increase in malondialdehyde. The activity of the main antioxidant enzyme superoxide dismutase was reduced in GC. Catalase was activated, which indicated pronounced oxidative stress, significant damage to blood vessels, and massive cell death. Glutathione-related enzymes (glutathione S-transferase and glutathione peroxidase) and the antioxidant protein ceruloplasmin were activated, which also indicated significant oxidative stress and severe intoxication in patients with GC.Conclusion. Depending on the stage and type of cancer, an in-depth study of lipid peroxidation and factors of the antioxidant defense system can be used to correct therapy and prevent cancer and can serve as markers of progression and prognosis in gastric cancer. 

scholarly journals Evaluation of the lipid peroxidation reactions activity in middle-aged men with chronic gastritis on the background of H. pylori infection

2019 ◽  
Vol 74 (3) ◽  
pp. 149-156
Author(s):  
Marina A. Darenskaya ◽  
Olga V. Smirnova ◽  
Edward V. Kasparov ◽  
Lyudmila A. Grebenkina ◽  
Aleksandr A. Sinyakov ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Atrophic Gastritis ◽  
Chronic Gastritis ◽  
Antioxidant Defense ◽  
Chronic Atrophic Gastritis ◽  
Stress Reactions ◽  
Middle Aged ◽  
Glutathione S Transferase ◽  
Group 2 ◽  
H Pylori

Background: There is not enough information about the course of the processes of lipid peroxidation-antioxidant defense in middle-aged men who are at risk of developing gastric cancer on the Correa cascade. Aims: To analyze of the processes of lipid peroxidation activity and antioxidant defense in men with chronic gastritis and chronic atrophic gastritis in combination with and without the presence of Helicobacter pylori. Materials and methods: 173 middle-aged men with an established diagnosis of chronic gastritis were examined, which were divided into 4 groups: group 1 ― patients with chronic gastritis without H. pylori (n=58), group 2 ― patients with chronic gastritis in combination with H. pylori (n=61), group 3 ― patients with chronic atrophic gastritis without H. pylori (n=28), group 4 ― patients with chronic atrophic gastritis in combination with H. pylori (n=26). Evaluation of the content of parameters of the lipid peroxidation system and the antioxidant components activity using spectrophotometric research methods was carried out. For statistical analysis, the software package Statistica 7.0 (Stat Soft, USA) was used. The study was conducted during 20132015. Results: Infection H. pylori with chronic and chronic atrophic gastritis accompanied by significant changes in the system of lipid peroxidation, and antioxidant defense components in the form of primary and accumulation of end products, insufficient activity of antioxidant enzymes ― superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase and reducing content of reduced glutathione. The use of an integrating factor to assess the severity of prooxidant activity confirms the development of antioxidant deficiency in patients of these groups. Conclusions: In patients with chronic and chronic atrophic gastritis, combined with H. Pylori infection, a more pronounced progression of oxidative stress reactions and a significant lack of antioxidant factors were found in comparison with patients with these forms of gastritis without H. pylori.

scholarly journals Про-антиокcидантна рівновага в печінці та м’язах cтерляді за дії штучного гіпобіозу й анестезії

2017 ◽  
Vol 7 (3) ◽  
pp. 43-49
Author(s):  
V. V. Gryshchenko ◽  
N. Vovk ◽  
О. Shlapak
Keyword(s):  
Carbon Dioxide ◽  
Lipid Peroxidation ◽  
Malonic Dialdehyde ◽  
Thiobarbituric Acid ◽  
The Body ◽  
Stress Factors ◽  
Control Group ◽  
Experimental Conditions ◽  
Colored Complex ◽  
Group I

<p>The pro-antioxidant balance in the liver and muscles of sterlet under the influence of artificial carbonic dioxyde hibernation and anaesthesia have been studied. In experiments were used two-years old sterlet weighing 170–210 g which were grown under conditions of a closed water supply. Four groups of five copies of each fish were formed: Control group I (fish remained intact); Group II (the clove oil was used for fish anaesthesia, which was added to the water); Group III (fish were hibernated by carbon dioxide); Group IV - control of hibernation (after complete recovery from carbon dioxide hibernation, these groups of fish were returned to the pool of incubation shop for her follow–up). The research of intensity of the formation products of peroxide oxidation of lipids (POL) in the body of sterlet in the experimental conditions were conducted by determining the content of thiobarbituric acid active products (TBA–active products) in the muscles and liver that are generated at the final stages of lipid peroxidation. The content of malonic dialdehyde (MDA), one of the intermediate products of lipid peroxidation of membrane was determined photometrically by the concentration of colored complex formed by its reaction in the acidic environment of the two molecules of thiobarbituric acid (TBA). Catalase activity was determined by the ability of hydrogen peroxide to form the stable colored complex with Molybdenum salts. The results support the adaptive character in fluctuations in the antioxidant protection system by the actions of carbon dioxide hibernation and anaesthesia on the sterlet body. This also contributes to usage of these conditions in fish transportation at long distances without stress factors.</p>

scholarly journals State of antioxidant protection system in carp hepatopancrease affected by associative Aeromonas Hydrophila infection with Saprolegnia Sp.

2020 ◽  
pp. 85-89
Author(s):  
Kh. Ya. Solopova ◽  
◽  
O. I. Vishchur ◽  
M. Z. Korylyak ◽  
I. Ye. Solovodzinska ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Aeromonas Hydrophila ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
The Body ◽  
Control Group ◽  
Research Station ◽  
Defense System ◽  
Peroxidation Processes ◽  
Experimental Group

Bacterial diseases are responsible for heavy mortality in both wild and cultured fish. Co-infections are very common in nature and occur when hosts are infected by two or more different pathogens either by simultaneous or secondary infections so that two or more infectious agents are active together in the same host. Associative infections pose a significant threat to fish farming, so it is necessary to develop effective means of prevention and treatment of these infections; it is advisable to study in detail their impact on various fish. The aim of the study was to determine the intensity of lipid peroxidation processes and the activity of the antioxidant defense system in the body of carp suffering from aeromonosis and the associated infection of aeromonosis with saprolegniosis. The research was conducted at the Lviv Research Station of the Institute of Fisheries of NAAS. There were three groups of fish, 5 in each. The control group consisted of clinically healthy fish, the first experimental group (D1) – carps affected by Aeromonas hydrophila infection, the second experimental group (D2), which consisted of carps affected by associative Aeromonas hydrophila infection with Saprolegnia Sp. The results of studies have shown that carp with associative infection ‒ of Aeromonas hydrophila infection with Saprolegnia Sp. leads to the activation of lipid peroxidation processes, especially the primary product of LPO. Thus, in the hepatopancreas of fish there was an increase of 1.4 (p <0.05) in the reasonable content of diene conjugates and there was a tendency to increase the content of TBA-active products. At the same time, the inhibitory effect of pathogenic factors of this disease on the activity of the enzymatic link of the antioxidant defense system was stated. In particular, carp patients with associative infection ‒ of Aeromonas hydrophila infection with Saprolegnia Sp. had higher catalase and superoxide dismutase activity, respectively, 1.3 (p <0.05) and 2.3 (p <0.01) times. The results of experimental studies made it possible to expand and deepen the mechanisms of the pathogenesis of the co-infection of Aeromonas hydrophila infection with Saprolegnia Sp. and to use the data to develop effective treatments.

scholarly journals The Use of IR Fourier Spectroscopy of Saliva for Rapid Assessment of the Level of Lipid Peroxidation Products

2019 ◽  
Vol 2 (2) ◽  
pp. e00094
Author(s):  
L.V. Bel’skaya ◽  
E.A. Sarf
Keyword(s):  
Lipid Peroxidation ◽  
Ir Spectra ◽  
Schiff Bases ◽  
Malonic Dialdehyde ◽  
Total Lipid Content ◽  
The Body ◽  
Control Group ◽  
Ir Absorption ◽  
Regression Equations ◽  
Absorption Bands

Infrared spectroscopy of saliva is an express and non-invasive method of analysis, applicable for diagnostics of various diseases and for studying metabolic processes and adaptive changes in the body. The goal of this study was to determine possibility of analyzing the products of lipid peroxidation (LPO) by using IR spectroscopy of saliva on the example of oncological diseases. The study involved 203 patients with lung cancer (n = 40), breast cancer (n = 50) and the control group (n = 113). Saliva samples were collected in the morning after overnight fast. The content of LPO products (conjugated dienes, and trienes, Schiff bases, malonic dialdehyde MDA) was determined in all samples and the IR absorption spectra were recorded in the range of 500–4000 cm–1. In the IR spectra, an increase in the intensity of the absorption bands of lipids was observed; it corresponded to an increase in the total lipid content and correlated with the content of MDA, and a decrease in the intensity of vibrations of oxygen-containing groups, which corresponded to a negative correlation with secondary LPO products. Apparently, on the IR spectra, we simultaneously register both primary, intermediate, and final LPO products. Statistically significant regression equations were obtained, allowing to estimate the content of intermediate LPO products - conjugated triene, and Schiff bases. The proposed method allows to monitor LPO processes, as well as to characterize the direction of the equilibrium shift in these processes.

Lipid peroxidation and antioxidant defense in chronic atrophic gastritis associated with Helicobacter pylori

Vrach ◽  
2019 ◽  
Vol 30 (11) ◽  
Author(s):  
O. Smirnova ◽  
V. Tsukanov ◽  
A. Sinyakov ◽  
O. Moskalenko ◽  
N. Elmanova ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Helicobacter Pylori ◽  
Atrophic Gastritis ◽  
Antioxidant Defense ◽  
Chronic Atrophic Gastritis

scholarly journals Study of biomarkers for damage of renal tissue in patients with oxalate urolithiasis after transurethral contact ureterolithotripsy

2019 ◽  
pp. 62-69
Author(s):  
А.К. Масальцев ◽  
В.Б. Бородулин
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Defense ◽  
Malonic Dialdehyde ◽  
Renal Tissue ◽  
Pathological Process ◽  
Control Group ◽  
Urinary Concentration ◽  
Diene Conjugates ◽  
Biochemical Indices ◽  
Treatment Control Group

Выявление маркеров патологии почек и введение биохимических индексов, объективно отражающих развитие патологического процесса при мочекаменной болезни, может существенно облегчить диагностику данного заболевания и способствовать выработке правильного и адекватного лечения оксалатного уролитиаза. Известно, что при мочекаменной болезни обнаруживается увеличение продуктов липопероксидации. В таком случае, определение метаболитов перекисного окисления липидов в сыворотке крови может служить одним из критериев прогноза и течения различных форм данного заболевания. Методы. Проведено исследование концентрации липокалина (NGAL) в моче, малонового диальдегида (МДА) и диеновых конъюгатов (ДК) в плазме крови, а также активность ферментов каталазы и глутатионпероксидазы (ГПО) у больных оксалатным уролитиазом, после трансуретральной контактной уретеролитотрипсии (КУЛТ). В исследование включены 72 пациента - у 42 человек выполнена КУЛТ, и 30 пациентов с ранее подтвержденный оксалатный уролитиазом, без оперативного лечения. Контролем служили 10 здоровых испытуемых. Был осуществлен забор крови и мочи пациентов, предварительно разделенных на группы в зависимости от стадии лечения. Результаты. Обнаружено достоверное повышение содержания МДА и ДК, также увеличение активности ГПО во время операции и в первые послеоперационные сутки в сравнении с контрольной группой. Возрастание активности каталазы и увеличение содержания стресс-пептида NGAL в моче выявлено на всех этапах заболевания. Заключение. Активация ПОЛ и усиление каталазной активности можно рассматривать в качестве дополнительного критерия оценки степени антиоксидантной защиты у больных с оксалатным уролитиазом. Identification of markers for renal pathology and implementation of biochemical indices objectively reflecting the development of pathological process in urolithiasis disease would significantly facilitate detection of this disease and contribute to development of proper and adequate treatments in oxalic urolithiasis. Increased lipid peroxidation products are known to be present in urolithiasis. Therefore, detection of lipid peroxidation metabolites in serum could serve as a criterion for course and outcome of various forms of this disease. Materials and methods. Concentrations of urinary lipocalin (NGAL), plasma malonic dialdehyde (MDA) and diene conjugates (DC), and activities of catalase and glutathione peroxidase (GPO) were measured in patients with oxalate urolithiasis after transurethral contact ureterolithotrization (CULT). The study included 72 patients; 42 of them underwent CULT and 30 patients had documented oxalate urolithiasis without surgical treatment. Control group consisted of 10 healthy subjects. Patients were divided into groups based of the stage of treatment, and blood samples were collected. Results. Concentrations of MDA and DK and GPO activity were increased during the surgery and first postoperative days compared to the control group. Catalase activity and urinary concentration of the NGAL stress peptide were increased at all stages of the disease. Conclusion: Activation of lipid peroxidation and catalase can be considered as an additional criterion for evaluating the degree of antioxidant defense in patients with oxalate urolithiasis.

scholarly journals DYNAMICS OF ANTI-ANTIOXIDANT SYSTEM INDICATORS IN THE POSTOPERATIVE PERIOD IN PATIENTS WITH PERIODONTITIS ACCOMPANIED BY DIFFERENT REACTIVATY OF THE ORGANISM

2021 ◽  
Vol 74 (9) ◽  
pp. 2187-2191
Author(s):  
Yurii Yu. Yarov ◽  
Iryna I. Tkachenko
Keyword(s):  
Lipid Peroxidation ◽  
Malonic Dialdehyde ◽  
Initial Therapy ◽  
The Body ◽  
Antioxidant Protection ◽  
Two Phase ◽  
Diene Conjugates ◽  
Periodontal Tissues ◽  
Total Antioxidant ◽  
Protection Activity

The aim is to study the dynamics of lipid peroxidation and antioxidant protection in the blood of patients with generalized periodontitis accompanied by normo-, hyper- and hyporeactivity of the body after patch surgery. Materials and methods: 216 people aged 45 between 55 years with a diagnosis of generalized periodontitis of II, III degree of severity, chronic course were examined. Depending on the condition of reactivity of the organism, patients were divided into three groups: the first consisted of people with normoreaction; the second included patients with hyperreaction; the third group was made up by people with hyporeaction. Patients after initial therapy, underwent patch surgery. Blood sampling was performed after surgery on the 1st, 2nd, 4th, 6th and 9th day. The content of diene conjugates, malonic dialdehyde and peroxide hemolysis of erythrocytes, superoxide dismutase activity, catalase, and total antioxidant activity was determined by the biochemical method. Results: Normoreaction was characterized by two-phase moderate activation of lipid peroxidation with maxima on the 1st and 6th day against the normalization of the balance of oxidative systems by the end of observations. For hyperreaction pronounced activation of lipid peroxidation (significant increase in the content of diene conjugates and malonic dialdehyde with a maximum on the 1st day) accompanied by depletion of antioxidant protection activity was typical. Hyporeaction was characterized by slow activation of lipid peroxidation (increase in diene conjugates and malonic dialdehyde with a maximum on the 4th day) accompanied by insufficient activity of antioxidant protection. Conclusion: Correction of altered parameters in patients with generalized periodontitis accompanied by impaired (hyper- and hypo-) reactivity of the body with bringing them to values of normoreactivity is considered to be a condition for optimizing mucosal wound healing after surgery and further stabilization of the periodontal tissues.

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