scholarly journals ASSOCIATION OF THE VARIANTS OF NUCLEOTIDE SEQUENCE OF THE GENE ADIPOQ WITH PLASMATIC LEVEL OF ADIPONECTIN, THE GRADE OF CORONARY ATHEROSCLEROSIS SEVERITY AND RATE OF CARDIOVASCULAR DISEASES

2018 ◽  
pp. 25-31
Author(s):  
S. A. Smetnev ◽  
A. N. Meshkov ◽  
M. V. Klimushina ◽  
N. E. Gavrilova ◽  
A. I. Ershova ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Coronary Atherosclerosis ◽  
Coronary Arteriography ◽  
Test System ◽  
Enzyme Analysis ◽  
Gensini Score ◽  
Genetic Score ◽  
Plasmatic Level ◽  
Atherosclerosis Severity

Aim. The search for genetic markers of ADIPOQ, associated with the level of adiponectin and development of coronary atherosclerosis.Material and methods. To the study, patients included, who had undergone diagnostic coronary arteriography in 2011-2012 in the NMRCPM with assessment of the severity of coronary atherosclerosis. The level of adiponectin was measured in plasma with the test-system based on the immune enzyme analysis. Genetic variants rs17300539, rs182052 and rs266729 gene ADIPOQ were measured realtime (Applied Biosystems, 7500 Real Time PCR System). Alleles of the studied variants were summarized by a unified score of genetic risk (SGR).Results. To the study, 447 patients included, of those 319 males (70,7%). Median of age was 61 [55-69] y.o. All patients were selected to 2 groups by SGR (≤2 and >2, respectively). Groups differed by the level of adiponectin 7,64 vs 8,29 mcg/mL (р=0,01), total cholesterol 4,60 vs 5,00 mM/L (p=0,03), cholesterol of low density lipoproteides 2,8 vs 3,09 mM/L (p=0,03), and the rate of unstable angina development 2,15% vs 6,8% (р=0,02) and type 2 diabetes 11,8% vs 21,1% (р=0,01), respectively. There was no difference in the groups by Syntax and Gensini score.Conclusion. Genetic score based on the three variants of ADIPOQ does determine the plasmatic level of adiponectin and risk of unstable angina and diabetes, but not the grade of coronary atherosclerosis.

scholarly journals MULTIMARKER DIAGNOSTIC PANELS FOR ATHEROSCLEROSIS

2018 ◽  
pp. 65-73 ◽  
Author(s):  
V. A. Metelskaya
Keyword(s):  
Coronary Atherosclerosis ◽  
Analysis Data ◽  
Coronary Arteriography ◽  
Gensini Score ◽  
Apo B ◽  
Non Invasive ◽  
Atherosclerotic Lesions ◽  
Atherosclerosis Risk ◽  
Diagnostic Panel ◽  
Prevention Activities

Aim. To consider an opportunity for application of different combinations of biochemical and bioimaging parameters to create different multimarker diagnostic panels designed for assessment of risk of coronary atherosclerosis and its complications.Material and methods. To the analysis, data included, obtained from patients 18 y.o. and older (n=502), investigated at NMRCPR of the Ministry of Health in 2011-2013, who had undergone diagnostic coronary arteriography and duplex carotid scanning. Atherosclerosis burden was measured according the Gensini score. Subfractional spectrum of apoB-lipoproteides was assessed with the Quantimetrix Lipoprint LDL System (USA), biochemistry was done with standard lab. methods. Statistics was done with software Statistica v.10, IBM SPSS Statistics v.20, SAS v.9.4.Results. Several multimarker combinations (panels) for non-invasive estimation of risk of coronary atherosclerosis detection and its severity were proposed. These are 1) an index K, calculated as ratio of the sum of potentially atherogenic subfractions to the large physiologically active LDL1 particles; index K >1,7 indicates an increased atherogenic potential of apo B-containing particles even with normal lipid profile, and can be used for non-invasive prediction of coronary atherosclerosis; 2) duplex complexes as adiponectin to endothelin ratio which <7,0 is associated with coronary atherosclerosis risk only in men, and as leptin to insulin ratio which <3,5 is associated with elevated atherosclerosis risk only in women; 3) integrated biomarker BIO represented the combination of individual visual and biochemical variables and permitted to discriminate patients from those with no coronary atherosclerosis or having subclinical or severe atherosclerotic lesions.Conclusion. Proposed multimarker diagnostic panel could be regarded as novel potential biomarkers of coronary atherosclerosis risk and severity, however validation of these markers is necessary. The problem of cardiovascular risk stratification and further prevention activities should be solved with the search for novel markers and combinations of markers.

scholarly journals Is HBA1C reliable in diagnosing diabetes in the acute phase of acute coronary syndromes?

2021 ◽  
Vol 10 (Supplement_1) ◽  
Author(s):  
M Stratinaki ◽  
K Milaki ◽  
S Stavrakis ◽  
M Pitarokoilis ◽  
E Charitakis ◽  
...  
Keyword(s):  
Acute Phase ◽  
Acute Coronary Syndromes ◽  
Rank Correlation ◽  
Mean Value ◽  
Gensini Score ◽  
Funding Sources ◽  
Spearman’S Rank Correlation ◽  
Coronary Syndromes ◽  
One Way Anova

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Hospitalization due to acute coronary syndromes (ACS) usually is the occasion that leads to diagnosis of type 2 diabetes mellitus (T2DM). Current literature suggests that the severity of the ACS could be associated with the presence and the severity of DM. Purpose To study the reliability of HbA1c in the diagnosis of T2DM in the acute phase of ACS, as well as the presence of possible correlation between the HbA1c and the severity of ACS. Methods We evaluated 160 consecutive patients admitted due to ACS. HbA1c was measured on day 1 and day 90. HbA1c &gt;6.5% was used to diagnose T2DM and HbA1c 5.7-6.4% was used to diagnose pre-diabetes. The severity of ACS was assessed via Gensini score. Results are interpreted as mean ± SD. Comparisons were made by one way ANOVA(p &lt; 0.05 was regarded statistically significant).Spearman’s rank correlation was used to study the correlation between Gensini score and the other parameters. Results Mean age was 59.73 ± 12.21 years. 103/160(64.37%) were male and 57/160(35.63%) were female. 19/160(11.87%) were diagnosed as STEMI and 141/160(88.13%) as NSTEMI. Mean BMI was 29.55 ± 8.41 kg/m2 and mean Hb 12.62 ± 2.08 g/dl. On day 1, 43/160 (26.87%) had HbA1c &gt; 6.5% and 41/160(25.62%) HbA1c 5.7-6.4%. On day 90, 28/160 (17.5%) had HbA1c &gt; 6.5% and 52/160(32.5%) HbA1c 5.7-6.4%. Gensini score varied between 0-144 with mean value 40.26 ±35.9. A strong correlation was found between Gensini score and HbA1c on admission as well as on day 90 (rho-0.36, p &lt; 0.05 and rho = 0.32, p &lt; 0.05 respectively). Conclusion HbA1c seems to be reliable in the identification of pre-diabetes but not T2DM in the acute phase of ACS. The correlation of the severity between ACS and HbA1c seems to relate with the worst prognosis of T2DM patients.

scholarly journals Circulating miRNAs Are Associated with the Systemic Extent of Atherosclerosis: Novel Observations for miR-27b and miR-146

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 318
Author(s):  
Tiago Pereira-da-Silva ◽  
Patrícia Napoleão ◽  
Marina C. Costa ◽  
André F. Gabriel ◽  
Mafalda Selas ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Coronary Atherosclerosis ◽  
Carotid Atherosclerosis ◽  
Area Under The Curve ◽  
Circulating Mirnas ◽  
Age And Sex ◽  
Potential Biomarkers ◽  
Atherosclerosis Severity

The mechanisms that regulate the systemic extent of atherosclerosis are not fully understood. We investigated whether the expression of circulating miRNAs is associated with the extent of stable atherosclerosis to a single territory or multiple territories (polyvascular) and with the severity of atherosclerosis in each territory. Ninety-four participants were prospectively recruited and divided into five age- and sex-matched groups: presenting no atherosclerosis, isolated coronary atherosclerosis, coronary and lower extremity atherosclerosis, coronary and carotid atherosclerosis, and atherosclerosis of the coronary, lower extremity, and carotid territories. The expression of six circulating miRNAs with distinct biological roles was assessed. The expression of miR-27b and miR-146 differed across groups (p < 0.05), showing a decrease in the presence of atherosclerosis, particularly in the three territories. miR-27b and miR-146 expression decreased in association with a higher severity of coronary, lower extremity, and carotid atherosclerosis. Polyvascular atherosclerosis involving the three territories was independently associated with a decreased miR-27b and miR-146 expression. Both miRNAs presented an area under the curve of ≥0.75 for predicting polyvascular atherosclerosis involving the three territories. To conclude, miR-27b and miR-146 were associated with the presence of severe polyvascular atherosclerosis and with the atherosclerosis severity in each territory. Both are potential biomarkers of severe systemic atherosclerosis.

scholarly journals Composite Primary End Points in Cardiovascular Outcomes Trials Involving Type 2 Diabetes Patients: Should Unstable Angina Be Included in the Primary End Point?

Diabetes Care ◽  
2017 ◽  
Vol 40 (9) ◽  
pp. 1144-1151 ◽  
Author(s):  
Nikolaus Marx ◽  
Darren K. McGuire ◽  
Vlado Perkovic ◽  
Hans-Juergen Woerle ◽  
Uli C. Broedl ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Unstable Angina ◽  
Cardiovascular Outcomes ◽  
End Points ◽  
End Point ◽  
Diabetes Patients

scholarly journals Cytokine status in patients with myocardial infarction as a possible predictor of coronary atherosclerosis severity

2020 ◽  
Vol 19 (3) ◽  
pp. 2316
Author(s):  
O. V. Khlynova ◽  
E. A. Shishkina ◽  
N. I. Abgaryan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Atherosclerosis ◽  
Tnf Α ◽  
Atherosclerosis Severity

Aim. To study the association of cytokine status with coronary atherosclerosis severity in patients with myocardial infarction (MI).Material and methods. Between 11.2018 and 07.2019, 92 patients hospitalized with MI in Perm Clinical Cardiology Dispensary were included in the study. The control group consisted of 23 patients with stable coronary artery disease. In addition to the standard examination, enzyme-linked immunosorbent assay was used to determine the levels of interleukins (IL)-6, -10, tumor necrosis factor alpha (TNF-α), C-reactive protein.Results. Significant increase in plasma IL-6, TNF-α and C-reactive protein levels in MI patients compared with the control group. The increase in the concentration of IL-6, TNF-α, as well as the IL-6/IL-10 ratio occurs in proportion to coronary atherosclerosis severity. A direct correlation of Gensini score with IL-6, TNF-α, and IL-6/IL-10 ratio was established.Conclusion. Further study of cytokine profile parameters in MI patients will help a clearer understanding pathogenesis of coronary artery atherosclerosis. An increase in concentrations of IL-6, TNF-α, and IL-6/IL-10 ratio is associated with an increase in coronary atherosclerosis severity and can be used in practice for its prediction.

Sign in / Sign up

Export Citation Format

Share Document