Fragmented QRS as a marker of coronary atherosclerosis severity evaluated by the Gensini score

2021 ◽  
Author(s):  
Y. Fedulaev ◽  
I. Makarova ◽  
T. Pinchuk
Keyword(s):  
Coronary Atherosclerosis ◽  
Gensini Score ◽  
Fragmented Qrs ◽  
Atherosclerosis Severity

scholarly journals ASSOCIATION OF THE VARIANTS OF NUCLEOTIDE SEQUENCE OF THE GENE ADIPOQ WITH PLASMATIC LEVEL OF ADIPONECTIN, THE GRADE OF CORONARY ATHEROSCLEROSIS SEVERITY AND RATE OF CARDIOVASCULAR DISEASES

2018 ◽  
pp. 25-31
Author(s):  
S. A. Smetnev ◽  
A. N. Meshkov ◽  
M. V. Klimushina ◽  
N. E. Gavrilova ◽  
A. I. Ershova ◽  
...  
Keyword(s):  
Unstable Angina ◽  
Coronary Atherosclerosis ◽  
Coronary Arteriography ◽  
Test System ◽  
Enzyme Analysis ◽  
Gensini Score ◽  
Genetic Score ◽  
Plasmatic Level ◽  
Atherosclerosis Severity

Aim. The search for genetic markers of ADIPOQ, associated with the level of adiponectin and development of coronary atherosclerosis.Material and methods. To the study, patients included, who had undergone diagnostic coronary arteriography in 2011-2012 in the NMRCPM with assessment of the severity of coronary atherosclerosis. The level of adiponectin was measured in plasma with the test-system based on the immune enzyme analysis. Genetic variants rs17300539, rs182052 and rs266729 gene ADIPOQ were measured realtime (Applied Biosystems, 7500 Real Time PCR System). Alleles of the studied variants were summarized by a unified score of genetic risk (SGR).Results. To the study, 447 patients included, of those 319 males (70,7%). Median of age was 61 [55-69] y.o. All patients were selected to 2 groups by SGR (≤2 and >2, respectively). Groups differed by the level of adiponectin 7,64 vs 8,29 mcg/mL (р=0,01), total cholesterol 4,60 vs 5,00 mM/L (p=0,03), cholesterol of low density lipoproteides 2,8 vs 3,09 mM/L (p=0,03), and the rate of unstable angina development 2,15% vs 6,8% (р=0,02) and type 2 diabetes 11,8% vs 21,1% (р=0,01), respectively. There was no difference in the groups by Syntax and Gensini score.Conclusion. Genetic score based on the three variants of ADIPOQ does determine the plasmatic level of adiponectin and risk of unstable angina and diabetes, but not the grade of coronary atherosclerosis.

scholarly journals Circulating miRNAs Are Associated with the Systemic Extent of Atherosclerosis: Novel Observations for miR-27b and miR-146

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 318
Author(s):  
Tiago Pereira-da-Silva ◽  
Patrícia Napoleão ◽  
Marina C. Costa ◽  
André F. Gabriel ◽  
Mafalda Selas ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Coronary Atherosclerosis ◽  
Carotid Atherosclerosis ◽  
Area Under The Curve ◽  
Circulating Mirnas ◽  
Age And Sex ◽  
Potential Biomarkers ◽  
Atherosclerosis Severity

The mechanisms that regulate the systemic extent of atherosclerosis are not fully understood. We investigated whether the expression of circulating miRNAs is associated with the extent of stable atherosclerosis to a single territory or multiple territories (polyvascular) and with the severity of atherosclerosis in each territory. Ninety-four participants were prospectively recruited and divided into five age- and sex-matched groups: presenting no atherosclerosis, isolated coronary atherosclerosis, coronary and lower extremity atherosclerosis, coronary and carotid atherosclerosis, and atherosclerosis of the coronary, lower extremity, and carotid territories. The expression of six circulating miRNAs with distinct biological roles was assessed. The expression of miR-27b and miR-146 differed across groups (p < 0.05), showing a decrease in the presence of atherosclerosis, particularly in the three territories. miR-27b and miR-146 expression decreased in association with a higher severity of coronary, lower extremity, and carotid atherosclerosis. Polyvascular atherosclerosis involving the three territories was independently associated with a decreased miR-27b and miR-146 expression. Both miRNAs presented an area under the curve of ≥0.75 for predicting polyvascular atherosclerosis involving the three territories. To conclude, miR-27b and miR-146 were associated with the presence of severe polyvascular atherosclerosis and with the atherosclerosis severity in each territory. Both are potential biomarkers of severe systemic atherosclerosis.

scholarly journals Cytokine status in patients with myocardial infarction as a possible predictor of coronary atherosclerosis severity

2020 ◽  
Vol 19 (3) ◽  
pp. 2316
Author(s):  
O. V. Khlynova ◽  
E. A. Shishkina ◽  
N. I. Abgaryan
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Coronary Artery Atherosclerosis ◽  
Tnf Α ◽  
Atherosclerosis Severity

Aim. To study the association of cytokine status with coronary atherosclerosis severity in patients with myocardial infarction (MI).Material and methods. Between 11.2018 and 07.2019, 92 patients hospitalized with MI in Perm Clinical Cardiology Dispensary were included in the study. The control group consisted of 23 patients with stable coronary artery disease. In addition to the standard examination, enzyme-linked immunosorbent assay was used to determine the levels of interleukins (IL)-6, -10, tumor necrosis factor alpha (TNF-α), C-reactive protein.Results. Significant increase in plasma IL-6, TNF-α and C-reactive protein levels in MI patients compared with the control group. The increase in the concentration of IL-6, TNF-α, as well as the IL-6/IL-10 ratio occurs in proportion to coronary atherosclerosis severity. A direct correlation of Gensini score with IL-6, TNF-α, and IL-6/IL-10 ratio was established.Conclusion. Further study of cytokine profile parameters in MI patients will help a clearer understanding pathogenesis of coronary artery atherosclerosis. An increase in concentrations of IL-6, TNF-α, and IL-6/IL-10 ratio is associated with an increase in coronary atherosclerosis severity and can be used in practice for its prediction.

scholarly journals Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile

2019 ◽  
Vol 39 (11) ◽  
pp. 2338-2352 ◽  
Author(s):  
Ayla Hoogendoorn ◽  
Sandra den Hoedt ◽  
Eline M.J. Hartman ◽  
Ilona Krabbendam-Peters ◽  
Maaike te Lintel Hekkert ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Profile ◽  
Atherosclerosis Severity

P1547Circulating lipoprotein subfractions as new non-invasive biomarkers of coronary atherosclerosis

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Saether ◽  
E Madssen ◽  
E Vesterbekkmo ◽  
G Giskeodegaard ◽  
S Gjaere ◽  
...  
Keyword(s):  
Risk Prediction ◽  
Coronary Atherosclerosis ◽  
Prediction Models ◽  
Statistical Tests ◽  
Added Value ◽  
Gensini Score ◽  
Lipoprotein Subfractions ◽  
Risk Prediction Models ◽  
Blood Samples ◽  
Ldl Particles

Abstract Objectives Coronary artery disease (CAD) is the most common cause of death globally. In the next decade, the number of people at risk is expected to increase, due to obesity, inactivity and diabetes. Therefore, precise risk-prediction models will be increasingly important for the healthcare system, to be able to initiate cost-efficient prevention strategies. One of the first steps in CAD-development is sub-clinical atherosclerosis. Biomarkers that could reflect the presence of coronary atherosclerosis would be extremely valuable for risk prediction of myocardial infarction (MI). Serum cholesterol levels are key variables in risk prediction; however, there is growing interest for exploring the potential of other lipid subclasses. The aim of this study is to identify specific lipoprotein subfractions that are associated with the extent of coronary atherosclerosis. Methods 60 patients with suspected CAD were enrolled. Blood samples were collected before the partiens underwent coronary angiography. The extent of coronary atherosclerosis were quantified using the Gensini score. The partients were classified into three groups based on their Gensini score (<20.5: normal, 20.6–30: non-significant CAD and >30.1: significant CAD). The blood samples were analyzed by nucelar magnetic resonance (NMR) lipidomics. Univariate and multivariate statistical tests were used to determine whether lipoprotein subfractions were associated with the extent of coronary atherosclerosis. Results and discussion Of the 117 lipoprotein subfractions quantified, 10 were different in patients with significant CAD compared to patients with normal vessels in non-statin users (p=0.005). Despite no difference in total cholesterol, LDL and HDL cholesterol between the three Gensini groups, NMR lipidomics revealed that patients with significant CAD had twice as many circulating LDL-5 and LDL-6 particles as patients with normal vessels. Furthermore, three types of small LDL-subfractions, called LDL-5-TG, LDL-5-ApoB and LDL-6-ApoB, were significantly increased in patients with significant CAD. Interestingly, previous studies have suggested that small LDL particles are more atherogenic than larger particles. In addition, patients with significant CAD had low levels of ApoA1 containing HDL particles, and high levels of two different small VLDL particles. Previous studies have indicated that small VLDLs are more atherogenic than larger VLDLs, and does to a greater extent penetrate the vessel intima. Conclusions This study reveals strong associations between serum lipoprotein subfractions and the degree of coronary atherosclerosis quantified by Gensini score. Especially, the high levels of certain types of small LDL-particles in patients with CAD, indicates that measuring lipoprotein subfractions may provide added value to risk prediction models for MI. However, these findings needs to be further explored and validated in large cohort studies. Acknowledgement/Funding Norwegian Health Association, the Liaison Committee between the Central Norway Regional Health Authority (RHA) and NTNU

scholarly journals The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events

2007 ◽  
Vol 92 (7) ◽  
pp. 2532-2537 ◽  
Author(s):  
Dao-Fu Dai ◽  
Jou-Wei Lin ◽  
Jia-Horng Kao ◽  
Chih-Neng Hsu ◽  
Fu-Tien Chiang ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Metabolic Syndrome ◽  
Coronary Artery ◽  
Cardiovascular Events ◽  
Coronary Atherosclerosis ◽  
Major Adverse Cardiovascular Events ◽  
Gensini Score ◽  
Clinical Predictors ◽  
Artery Disease ◽  
Infectious Burden

Abstract Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients: Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome (MS) score (0–5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0–7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P &lt; 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P &lt; 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease.

scholarly journals Combined markers of initial stages of coronary atherosclerosis

2017 ◽  
Vol 63 (3) ◽  
pp. 272-277 ◽  
Author(s):  
N.G. Gumanova ◽  
M.V. Klimushina ◽  
N.E. Gavrilova ◽  
V.A. Metelskaya
Keyword(s):  
Heart Disease ◽  
Diagnostic Tests ◽  
Coronary Atherosclerosis ◽  
Predictive Power ◽  
Serum Levels ◽  
Functional Markers ◽  
Gensini Score ◽  
Male And Female ◽  
Male Patients ◽  
Coronary Lesions

Abnormalities in energy metabolism and endothelial dysfunction contribute to signaling processes associated with atherogenesis. The goal of our study was to develop diagnostic tests based on endothelial functional markers and adiponectin to differentiate early stages of coronary lesions during atherogenesis. The cohort included male and female patients from 25 to 86 years of age. All subjects underwent coronary angiography and severity of coronary lesions was quantified by the Gensini score that assigns points depending on location and extent of the lesions. We have estimated associations between the Gensini score and some known primary and secondary diagnostic parameters and have found that the ratio of serum levels of adiponectin to endothelin strongly correlates with severity of coronary lesions and can be used for differentiation of male patients lacking coronary atherosclerosis (despite symptoms of ischemic heart disease) from patients that have severe coronary lesions. Predictive power of adiponectin to endothelin ratio did not depend on drug therapy.

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