scholarly journals Multifocal atherosclerosis: focus on the prevention of ischemic events

2021 ◽  
Vol 26 (12) ◽  
pp. 4808
Author(s):  
A. G. Arutyunov ◽  
T. I. Batluk ◽  
R. A. Bashkinov ◽  
M. A. Trubnikova
Keyword(s):  
Quality Of Life ◽  
Life Expectancy ◽  
Literature Review ◽  
Anticoagulant Therapy ◽  
Cardiovascular Events ◽  
Adverse Outcomes ◽  
Multivessel Disease ◽  
Atherosclerotic Lesions ◽  
Ischemic Events

In patients with atherosclerotic lesions of two or more systems or multifocal atherosclerosis (MFA), the risks of ischemic events are extremely high. MFA leads not only to cardiovascular outcomes, but also to a decrease in the patient’s quality of life, life expectancy, and in most cases to disability. The prevalence of this pathology and the importance of preventing adverse outcomes are often underestimated. This literature review examines the problem of MFA in the context of key studies on the prevalence, course of multivessel disease and the reduction of the risk of cardiovascular events in this group of patients, with an emphasis on antiplatelet and anticoagulant therapy.

scholarly journals Sarcopenia: pathogenesis and diagnosis

2019 ◽  
Vol 4 (4) ◽  
pp. 105-116
Author(s):  
I. I. Grigorieva ◽  
T. A. Raskina ◽  
M. V. Letaeva ◽  
O. S. Malyshenko ◽  
Yu. V. Averkieva ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oxidative Stress ◽  
Life Expectancy ◽  
Skeletal Muscle Mass ◽  
Modern Medicine ◽  
Adverse Outcomes ◽  
Anabolic Hormones ◽  
Age Related ◽  
And Oxidative Stress

Increase in life expectancy is among the most significant achievements of modern medicine. Currently, the majority of patients are elderly, being characterised by multimorbidity and frailty. Sarcopenia, a progressive and generalized loss of skeletal muscle mass and strength, is associated with a reduced quality of life and high risk of adverse outcomes including disability and death in these patients. Age-related neuromuscular degeneration, decline of circulating anabolic hormones, chronic inflammation and oxidative stress considerably affect the development of sarcopenia. In addition, low intake of proteins and carbohydrates along with a decrease in physical activity also affect muscular homeostasis. Being combined with obesity, osteopenia/osteoporosis, and vitamin D deficiency, sarcopenia worsens the prognosis of the patient in terms of life expectancy. In this review, we discuss the current advances in epidemiology, pathophysiology, and diagnosis of sarcopenia.

scholarly journals INDEPENDENT PREDICTORS OF ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH CHF OF ISCHEMIC ORIGIN

2021 ◽  
Vol 1 (5(69)) ◽  
pp. 33-37
Author(s):  
V. Lysenko ◽  
V. Syvolap
Keyword(s):  
Internal Medicine ◽  
Quality Of Life ◽  
Heart Failure ◽  
Chronic Heart Failure ◽  
Cardiovascular Events ◽  
Adverse Outcomes ◽  
Important Task ◽  
Morbidity And Mortality ◽  
High Morbidity

Chronic heart failure (CHF) remains a major burden due to low quality of life, high morbidity, and mortality. An important aspect in the management of heart failure is to provide clinicians necessary knowledge and resources to make better decisions about treatment tactics of such patients. Thus, finding out independent predictors of adverse outcomes of heart failure is still insufficiently studied, and become an important task of internal medicine and cardiology.

Cancer pain management

2014 ◽  
Vol 155 (3) ◽  
pp. 93-99
Author(s):  
Péter Heigl
Keyword(s):  
Quality Of Life ◽  
Pain Management ◽  
Pain Relief ◽  
Life Expectancy ◽  
Cancer Pain ◽  
Cancer Pain Management ◽  
Medical Activity ◽  
Short Summary ◽  
Adequate Quality

Pain is a significant and alarming symptom of cancer seriously affecting the activity and quality of life of patients. Recent research proved that inadequate analgesia shortens life expectancy. Therefore, pain relief is not only a possibility but a professional, ethical and moral commitment to relieve patients from suffering, as well as ensure their adequate quality of life and human dignity. Proper pain relief can be achieved with medical therapy in most of the cases and the pharmacological alternatives are available in Hungary. Yet medical activity regarding pain relief is far from the desired. This paper gives a short summary of the guidelines on medical pain management focusing particularly on the use of opioids. Orv. Hetil., 2014, 155(3), 93–99.

“Position Paper” Timely Insulinisation in Type 2 Diabetes Patients

2012 ◽  
Vol 19 (4) ◽  
pp. 441-444
Author(s):  
László Barkai ◽  
Nicolae Hâncu ◽  
György Jermendy ◽  
Maya Konstantinova ◽  
Radu Lichiardopol ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Life Expectancy ◽  
Insulin Therapy ◽  
Metabolic Control ◽  
Current Medical ◽  
Position Paper ◽  
Medical Evidence

AbstractThe objective of this position paper is to review the current medical evidence andguidelines regarding the treatment of type 2 diabetes (T2DM) and to issue medicalrecommendations strengthening the timely use of insulin in patients with T2DMuncontrolled on noninsulin therapy. When noninsulin therapy fails to achieve or tomaintain HbA1c targets, insulin therapy is required. Timely insulin therapy couldprovide proper metabolic control that might prevent complications, lead toimprovement of life expectancy and quality of life.

Quality of life outcomes in cryoablation of atrial fibrillation ‐ A literature review

2021 ◽  
Author(s):  
Bert Vandenberk ◽  
Laurens Lauwers ◽  
Tomas Robyns ◽  
Christophe Garweg ◽  
Rik Willems ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
Literature Review ◽  
Life Outcomes ◽  
Quality Of Life Outcomes

scholarly journals Prediction of all-cause mortality from 24 month trajectories in patient-reported psychological, clinical and quality of life outcomes in uveal melanoma patients

2021 ◽  
Author(s):  
Stephen L. Brown ◽  
Peter L. Fisher ◽  
Laura Hope-Stone ◽  
Heinrich Heimann ◽  
Rumana Hussain ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Life Expectancy ◽  
Uveal Melanoma ◽  
Cox Regression ◽  
Multivariate Analyses ◽  
Tumor Diameter ◽  
Control Variables ◽  
Patient Reported ◽  
All Cause Mortality

AbstractA number of patient-reported outcomes (PROs) predict increased mortality after primary cancer treatment. Studies, though, are sometimes affected by methodological limitations. They often use control variables that poorly predict life expectancy, examine only one or two PROs thus not controlling potential confounding by unmeasured PROs, and observe PROs at only a single point in time. To predict all-cause mortality, this study used control variables affording good estimates of life expectancy, conducted multivariate analyses of multiple PROs to identify independent predictors, and monitored PROs two years after diagnosis. We recruited a consecutive sample of 824 patients with uveal melanoma between April 2008 and December 2014. PROs were variables shown to predict mortality in previous studies; anxiety, depression, visual and ocular symptoms, visual function impairment, worry about cancer recurrence, and physical, emotional, social and functional quality of life (QoL), measured 6, 12 and 24 months after diagnosis. We conducted Cox regression analyses with a census date of December 2018. Covariates were age, gender, marital and employment status, self-reported co-morbidities, tumor diameter and thickness, treatment modality and chromosome 3 mutation status, the latter a genetic mutation strongly associated with mortality. Single predictor analyses (with covariates), showed 6-month depression and poorer functional QoL predicting mortality, as did 6–12 month increases in anxiety and 6–12 month decreases in physical and functional QoL. Multivariate analyses using all PROs showed independent prediction by 6-month depression and decreasing QoL over 6–12 months and 12–24 months. Elevated depression scores six months post-diagnosis constituted an increased mortality risk. Early intervention for depressive symptoms may reduce mortality.

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