Sleep deficiency in spaceflight is associated with degraded neurobehavioral functions and elevated stress in astronauts on six-month missions aboard the International Space Station

Astronauts are required to maintain optimal neurobehavioral functioning despite chronic exposure to the stressors and challenges of spaceflight. Sleep of adequate quality and duration is fundamental to neurobehavioral functioning, however astronauts commonly experience short sleep durations in spaceflight (<6 h). As humans embark on long-duration space exploration missions, there is an outstanding need to identify the consequences of sleep deficiency in spaceflight on neurobehavioral functions. Therefore, we conducted a longitudinal study that examined the sleep-wake behaviors, neurobehavioral functions, and ratings of stress and workload of N=24 astronauts before, during, and after 6-month missions aboard the International Space Station (ISS). The computerized, Reaction SelfTest (RST), gathered astronaut report of sleep-wake behaviors, stress, workload, and somatic behavioral states; the RST also objectively assessed vigilant attention (i.e., Psychomotor Vigilance Test-Brief). Data collection began 180 days before launch, continued every 4 days in-flight aboard the ISS, and up to 90 days post-landing, which produced N=2,856 RSTs. Consistent with previous ISS studies, astronauts reported sleeping ~6.5 h in-flight. The adverse consequences of short sleep were observed across neurobehavioral functions, where sleep durations <6 h were associated with significant reductions in psychomotor response speed, elevated stress, and higher workload. Sleep durations <5 h were associated with elevated negative somatic behavioral states. Furthermore, longer sleep durations had beneficial effects on astronaut neurobehavioral functions. Taken together, our findings highlight the importance of sleep for the maintenance of neurobehavioral functioning and as with humans on Earth, astronauts would likely benefit from interventions that promote sleep duration and quality.

Technical solutions for the evaluation of the effect of explosion pressure when detoning various explosive loads in view of increasing the degree of societal security

The scientific article highlights the synthesis of the research results to assess the effect of explosive pressure on the detonation of various quantities of explosives in order to ensure a predictable level of societal security. The results of the experimental researches highlighted in the scientific papers were obtained following the tests with explosive materials performed on different specially configured experimental assemblies in order to analyze the propagation of the pressure wave on a mobile platform with specially configured pressure and gas sensors as well as on the explosion pressure measuring sensors within two modern Kistler systems. The visualization of air pressure waves for the experiments performed with these working montages was done by using a high-speed camera based on the BOS effect applied on fast video filming with adequate quality characteristics on the number of frames per second and the resolution obtained.

A Study on the Usability of Open Spatial Data for Road Network-Based Analysis – Using Openstreetmap as an Example

For several years GIS software users could use for any purpose a dataset being to some extent an alternative to both products offered by commercial providers and official databases. It is OpenStreetMap (OSM for short) – a worldwide spatial dataset, created and edited by interested individuals and available for use by anyone with no limitations. It is built on the basis of data recorded with consumer grade GPS receivers, obtained through vectorization of aerial photographs and from other usable sources, including even sketches made in the field. The collected information is stored in a central database, the content of which is not only presented on the website as a digital map, but also offered for download as vector data. Such data can be used for, among other things, performing various analyses based on road networks, of which the most frequently used is the function of determining the optimal route connecting selected locations. The results of such analyses can only be considered reliable if the data used are of adequate quality. As the OSM database is built by enthusiasts, no plans for its systematic development are formulated and there are no built-in quality control mechanisms. Therefore, the paper proposes methods and tools to verify the usefulness of the data collected so far, as well as to correct detected errors. It focuses on the following categories of geographic data quality: location accuracy, topological consistency and temporal validity. In addition, a problem with determining the length of individual road network segments was noticed, related to data acquisition methods and ways of recording the shape of lines. Therefore, in order to carry out the so-called route calibration, it was suggested to use kilometer and hectometer posts used in transportation networks, the locations of which are successively added to the OSM database. BADANIE UŻYTECZNOŚCI OTWARTYCH DANYCH PRZESTRZENNYCH DO ANALIZ OPARTYCH NA SIECIACH DROGOWYCH – NA PRZYKŁADZIE OPENSTREETMAP Od kilkunastu już lat użytkownicy oprogramowania GIS mogą używać do dowolnych celów zbioru danych będącego do pewnego stopnia alternatywą zarówno dla produktów oferowanych przez dostawców komercyjnych, jak i urzędowych baz danych. Jest nim OpenStreetMap (w skrócie OSM) – obejmujący cały świat zbiór danych przestrzennych, tworzony i edytowany przez zainteresowane osoby i dostępny do stosowania przez każdego chętnego bez żadnych ograniczeń. Budowany jest na podstawie danych rejestrowanych turystycznymi odbiornikami GPS, pozyskiwanych poprzez wektoryzację zdjęć lotniczych oraz pochodzących z innych nadających się do wykorzystania źródeł, w tym nawet szkiców wykonywanych w terenie. Zgromadzona GEOINFORMATICA POLONICA 20: 2021 DOI 10.4467/21995923GP.21.007.14978 informacja zapisywana jest w centralnej bazie danych, której zawartość jest nie tylko prezentowana na stronie internetowej w postaci cyfrowej mapy, lecz również oferowana do pobrania jako dane wektorowe. Takie dane mogą mieć zastosowanie między innymi do przeprowadzania różnorodnych analiz bazujących na sieciach drogowych, z których najczęściej wykorzystywana jest funkcja wyznaczania optymalnej trasy łączącej wybrane lokalizacje. Wyniki takich analiz można uznać za wiarygodne tylko wtedy, gdy użyte w nich dane będą się charakteryzować odpowiednią jakością. Ponieważ baza danych OSM budowana jest przez pasjonatów, nie są formułowane żadne plany jej systematycznego rozwoju oraz brak jest wbudowanych mechanizmów kontroli jakości. Dlatego w artykule zaproponowano metody i narzędzia, które pozwolą na weryfikację przydatności zgromadzonych do tej pory danych, jak również na poprawę wykrytych błędów. Skupiono się na następujących kategoriach jakości danych geograficznych: dokładności położenia, spójności topologicznej oraz ważności czasowej. Dodatkowo dostrzeżono problem z wyznaczaniem długości poszczególnych obiektów sieci drogowej, związany z metodami pozyskiwania danych i sposobami rejestracji kształtu linii. W związku z tym do przeprowadzenia tak zwanej kalibracji trasy zasugerowano użycie stosowanych w sieciach transportowych słupków kilometrowych i hektometrowych, których lokalizacje są sukcesywnie wprowadzane do bazy danych OSM.

Brasil: Um País Desigual / Brazil: An Unequal Country

Segundo o Instituto de Pesquisa Econômica Aplicada (IPEA) e Pesquisa Nacional por Amostra de Domicílio (PNAD), a desigualdade no Brasil está intimamente relacionada com a pobreza, mormente em razão da considerável diferença na distribuição de renda no país. Nesse sentido, mesmo que o Brasil detenha grande crescimento econômico, isso não irá melhorar a condição social do país, sem um enfrentamento mais efetivo que leve em conta uma distribuição mais justa de renda. Esta realidade, que foi, histórica e culturalmente constituída, precisa com urgência elaborar políticas públicas estruturantes, capazes de atuar de forma articulada, ampliando o acesso dos cidadãos aos direitos legalmente postos, que possam proporcionar uma mais adequada qualidade de vida.---According to the Institute for Applied Economic Research (IPEA) and the National Household Sample Survey (PNAD), inequality in Brazil is closely related to poverty, mainly because of the importance of the difference in income distribution in the country. In this sense, even if Brazil has great economic growth, this will not improve the social condition of the country, without a more effective confrontation that takes into account a fairer distribution of income. This reality, which has been historically and culturally fulfilled, urgently needs to develop structuring public policies, capable of acting in an articulated manner, expanding citizens' access to legally established rights, which can provide a more adequate quality of life.

In Search of Antioxidant Peptides from Porcine Liver Hydrolysates Using Analytical and Peptidomic Approach

The search for antioxidant peptides as health-promoting agents is of great scientific interest for their biotechnological applications. Thus, the main goal of this study was to identify antioxidant peptides from pork liver using alcalase, bromelain, flavourzyme, and papain enzymes. All liver hydrolysates proved to be of adequate quality regarding the ratio EAA/NEAA, particularly flavourzyme hydrolysates. The peptidomic profiles were significantly different for each enzyme and their characterizations were performed, resulting in forty-four differentially abundant peptides among the four treatments. Porcine liver hydrolysates from alcalase and bromelain are demonstrated to have the most antioxidant capacity. On the other hand, hydrophobic amino acid residues (serine, threonine, histidine and aspartic acid) might be reducing the hydrolysates antioxidant capacity. Seventeen peptides from collagen, albumin, globin domain-containing protein, cytochrome β, fructose-bisphosphate aldolase, dihydropyrimidinase, argininosuccinate synthase, and ATP synthase seem to be antioxidant. Further studies are necessary to isolate these peptides and test them in in vivo experiments.

Oxidation of pyrite (FeS2) and troilite (FeS) impurities in kaolinitic clays after calcination

Valorisation of locally available clays for producing blended cements is crucial for a widespread adoption of sustainable binders incorporating these materials. In some places, clays can be intermixed with small amounts of iron sulfides, which could eventually expand in the alkaline media of concrete and lead to cracking if clay particles are sufficiently fine. This study explored the stability of iron sulfides, namely troilite and pyrite, during calcination of clays and their influence in reactivity. It was found that both troilite and pyrite decompose and oxidize into hematite under typical calcination conditions for clays. Furthermore, there is no negative influence of the presence of iron sulfide phases on the reactivity of calcined clays. This shows that these clays are suitable for use in blended cements, provided that adequate quality control is conducted to ensure a complete decomposition of the iron sulfide phases.

Indicators for Sanitation Quality in Low-Income Urban Settlements: Evidence from Kenya, Ghana, and Bangladesh

In recent years, shared facilities have contributed substantially to increased access to sanitation in urban areas. While shared sanitation is often the only viable option in densely-populated, low-income urban areas, it is currently considered a “limited" solution by the international community. In this paper, we analyze the conditions under which shared sanitation could be considered of adequate quality and propose a set of indicators associated with sanitation quality to be included in national household surveys. We conducted a survey with 3600 households and 2026 observational spot-checks of shared and individual household toilets in Kisumu (Kenya), Kumasi (Ghana), and Dhaka (Bangladesh). We develop a composite sanitation quality outcome measure based on observational data. Using regression analysis, we identify self-reported indicators that correlate with the spot-checked composite measure and are, therefore, robust with regard to reporting bias. Results show that (pour-) flush toilets are a highly informative indicator for sanitation quality compared to other toilet technologies. In contrast to previous arguments and depending on the context, sharing a toilet has a comparatively lower correlation with sanitation quality. Toilets still show good quality if shared among only 2–3 households. Toilet location and lighting, as well as the presence of a lockable door, are equally strong indicators for sanitation quality and could serve as alternative indicators. The findings suggest that the sanitation service levels defined by the WHO and UNICEF might be reconsidered to better capture the quality of sanitation facilities in low-income urban settlements.

Comparison of Telomere Length Between Buccal Cells and Blood Cells

Background Telomere length (TL) in blood has been extensively studied as a biomarker of aging and aging-associated disease. TL in blood cells is commonly used as a proxy for TL in other tissue types. The source of DNA of adequate quality and quantity is an important consideration in telomere length analysis. Compared to blood cells, buccal cells easy for genomic DNA preparation would facilitate the rapid and reliable telomere length analysis. However, the feasibility of buccal cells for TL analysis remains yet unestablished. Methods A total of 52 participants ranged in age from 18 to 80 years including 24 males and 28 females were included in this study. Both buccal and blood samples were taken at the same time by using buccal cell swabs and fingertip stick from each participant. Relative telomere length (RTL) was analyzed using the quantitative real-time polymerase chain reaction (qPCR) method. Results The results indicate that there is a strong positive correlation between buccal RTL and blood RTL and negative correlation between both buccal RTL and blood RTL with age. Conclusion The validity of sampling using buccal cell swabs provides simple operation and good reproducibility for telomere length analysis, which overcomes the discomfort and risk of infection caused by blood sampling.

PENGUATAN MEMBACA KITAB KUNING MENGGUNAKAN METODE BITHAQATIL JUMAL PADA PESANTREN MU’ALLIMIN MUHAMMADIYYAH SAWAH DANGKA KAB. AGAM, SUMATERA BARAT

One of the great traditions in Islamic education institutions in Indonesia is teaching by transmitting Islamic values as found in classical books written centuries ago. The majority in Indonesia, the classic book is better known as the Kitab Kuning. Teaching with the Kitab Kuning is usually done in Islamic Boarding Schools. Examining Kitab Kuning requires qualified Arabic language skills at least passively. Unfortunately, not all Islamic boarding schools that have a variety of superior programs in certain fields, are weak in the field of studying Kitab Kuning. One of them is the Islamic Boarding School Mu'allimin Muhammadiyyah Sawah Dangka which has the flagship Tahfizh Alquran program but is weak in the study of Kitab Kuning. One of the main factors is the lack of adequate quality of human resources. For this reason, this community service activity aims to provide training while introducing new, lightweight methods in learning Arabic, namely the Bihaqatil Jumal method. This method emphasizes learning Arabic using the right brain. After a series of community service activities, teachers and Islamic boarding schools felt helped and gained new experiences in learning Arabic methods to study Kitab Kuning. In addition, both the assisted object and the resource person requested that this kind of community service be continued.

Peer Review Declaration Form Guidance

On the following page you will find the declaration form. • Please answer each question. • You should submit the form along with the rest of your submission files. • The deadline is the submission date written in your publishing agreement. All conference organisers/editors are required to declare details about their peer review. We will published the information you provide as part of your proceedings. Peer review declaration All papers published in this volume of Journal of Physics: Conference Series have been peer reviewed through processes administered by the Editors. Reviews were conducted by expert referees to the professional and scientific standards expected of a proceedings journal published by IOP Publishing. • Type of peer review: Single-blind / Double-blind / Triple-blind / Open / Other (please describe) Each submission is anonymously reviewed by an average of three independent reviewers, to ensure the final high standard and quality of each accepted submission. • Conference submission management system: Online submission • Number of submissions received: 75 papers • Number of submissions sent for review: 75 papers • Number of submissions accepted: 52 papers • Acceptance Rate (Number of Submissions Accepted / Number of Submissions Received X 100): 69% • Average number of reviews per paper: 3 reviews per paper • Total number of reviewers involved: 40 reviewers • Any additional info on review process: We developed the strict peer review procedures and invite relevant experts to serve as editors in order to control the quality of the papers. First, all articles will be subjected to peer review administered by editors. Then, reviews will be conducted by expert referees, who have been requested to provide unbiased and constructive comments aimed, whenever possible, at improving the work. Final, editors will take all reasonable steps to ensure the quality of the materials they publish and their decision to accept or reject a paper for publication will be based only on the merits of the work and the relevance to the conference theme. The following criteria will be considered by the editors and referees in their evaluation: (1) Is the subject matter within the scope of the conference? (2) Does the paper contain enough original results to warrant publication? (3) Is the paper technically sound and free of errors? (4) Is the work clearly and concisely presented? Is it well organized? (5) Does the title clearly and sufficiently reflect its con tents? (6) Is the abstract informative? Are the main results and conclusions mentioned? (7) Are the illustrations of adequate quality, relevant and understandable? (8) Does the bibliography give a clear view of the current state-of-the-art in the domain? (9) Is the quality of the language satisfactory? • Contact person for queries: Name : Guosong Jiang Affiliation: Huanggang Normal University Email : [email protected]