scholarly journals Pharmacokinetics and pharmacodynamics of a β-adrenoblocker bisoprolol: from mechanisms of action to clinical features

2011 ◽  
Vol 10 (3) ◽  
pp. 76-82
Author(s):  
O. D. Ostroumova ◽  
E. A. Smolyarchuk
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Drug Interaction ◽  
Chronic Heart Failure ◽  
Arterial Hypertension ◽  
Clinical Features ◽  
Mechanisms Of Action ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Action Mechanisms

The authors discuss the action mechanisms of β-adrenoblockers (β-AB), as well as pharmacokinetics, pharmacodynamics, and drug interaction of a highly selective β-AB bisoprolol. The paper presents the data on bisoprolol effectiveness and safety in arterial hypertension, coronary heart disease, chronic heart failure, and their combination with other diseases.

scholarly journals GENE polymorphism of the renin angiotensin system in patients with arterial hypertension and coronary heart disease complicated by chronic heart failure

2005 ◽  
Vol 11 (4) ◽  
pp. 235-238
Author(s):  
N. P. Dorofeev ◽  
A. A. Kastanayan ◽  
S. V. Shlyk ◽  
V. V. Dorofeikov ◽  
A. A. Barbina ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Gene Polymorphism ◽  
Arterial Hypertension ◽  
Renin Angiotensin System ◽  
Type I ◽  
Hypertensive Disease ◽  
Angiotensin System

The purpose of the Study was to search for an association of the gene polymorphism of angiotensin-converting enzyme (ACE), angiotensinogen (ATG) and type I receptors of angiotensin II with the risk for chronic heart failure in patients with coronary heart disease (CHD) and arterial hypertension (AH). A hundred persons, including 80 patients with CHD, 10 patients with hypertensive disease, and 10 healthy Individuals were examined. There was no association of the ID gene polymorphism of ACE, MT gene polymorphism of ATG, and the AC gene polymorphism of ATR1 with the risk for heart failure in patients with CHD and AH.

scholarly journals A modern view of the place of b-blockers in the treatmentof cardiovascular disease: the choice of drug within a class is crucial

2015 ◽  
Vol 12 (4) ◽  
pp. 69-74
Author(s):  
O D Ostroumova ◽  
V M Fomina ◽  
E A Smolyarchuk
Keyword(s):  
Heart Failure ◽  
Cardiovascular Disease ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Arterial Hypertension ◽  
Clinical Studies ◽  
Metoprolol Succinate ◽  
Selection Of

In the article discusses questions of application of b-blockers (b-AB) for the treatment of arterial hypertension, coronary heart disease, chronic heart failure. The data from modern Russian and European recommendations about the place of b-AB in the treatment of cardiovascular diseases. Analyzed in detail the selection of b-AB inside the class from the standpoint of pharmacokinetics, selectivity, study in clinical studies. Data about efficiency and safety of application of metoprolol succinate for the treatment of arterial hypertension, coronary heart disease, chronic heart failure.

scholarly journals Dihydropyridine calcium antagonists: conscious choice

2017 ◽  
Vol 14 (1) ◽  
pp. 61-68
Author(s):  
O D Ostroumova ◽  
V V Vikentev ◽  
A G Abrosimov ◽  
E A Smoliarchuk
Keyword(s):  
Heart Failure ◽  
Heart Disease ◽  
Chronic Heart Failure ◽  
Ischemic Heart Disease ◽  
Arterial Hypertension ◽  
Calcium Antagonists ◽  
Evidence Based ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Conscious Choice ◽  
Application Characteristics

This article contains information concerning the aspects of pharmacokinetics and pharmacodynamics of dihydropyridine calcium antagonists. The authors have discussed the evidence-based amlodipine treatment of arterial hypertension, ischemic heart disease and chronic heart failure. The authors present the comparison of the efficacy, safety and application characteristics of the different dihydropyridine calcium antagonists that can be used in specific clinical cases.

scholarly journals Cognition and comorbidity in postmenopausal women

2020 ◽  
Vol 22 ◽  
pp. 01023
Author(s):  
Artem Popov ◽  
Nadezhda Izmozherova ◽  
Tatiana Oboskalova ◽  
Yelena Gavrilova ◽  
Yelena Safianik
Keyword(s):  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Chronic Heart Failure ◽  
Arterial Hypertension ◽  
Postmenopausal Women ◽  
Cross Sectional ◽  
Function Impairment

Objective: to assess frequency and clinical significance of cognitive function impairment in postmenopausal woman. Methods: A cross-sectional study included 462 women under the age of 65. Arterial hypertension, carbohydrate metabolism impairment, chronic heart failure, coronary heart disease frequency were registered. Mini Mental State Examination was used to assess cognitive function. Results: mild cognitive function impairment was found in 223 (48%) postmenopausal women, 28 cases (6%) of dementia were registered. Mild cognitive impairment was associated with arterial hypertension (OR 1.74; 95% CI 1.16 – 2.64), chronic heart failure (OR 1.70; 1.16 – 2.49), dementia was associated with coronary heart disease (3.49; 1.54>7.89). Conclusion: cognitive impairment is frequent in postmenopausal women and associated with arterial hypertension, chromic heart failure and coronary heart disease.

scholarly journals The use of potassium and magnesium supplements for cardiovascular diseases

2021 ◽  
pp. 27-33
Author(s):  
D. Motruk
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Diseases ◽  
Chronic Heart Failure ◽  
Arterial Hypertension ◽  
Magnesium Deficiency ◽  
Complex Therapy

The article substantiates the role of potassium and magnesium deficiency in the pathogenesis of cardiovascular diseases and the effectiveness of the use of combined preparations of these electrolytes, which has been confirmed in numerous clinical studies. The combination of potassium and magnesium aspartate has proven itself best in the complex therapy of arrhythmias, coronary heart disease (in particular, post-myocardial infarction), chronic heart failure, and arterial hypertension.

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